JP2013531072A5 - - Google Patents
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- Publication number
- JP2013531072A5 JP2013531072A5 JP2013520840A JP2013520840A JP2013531072A5 JP 2013531072 A5 JP2013531072 A5 JP 2013531072A5 JP 2013520840 A JP2013520840 A JP 2013520840A JP 2013520840 A JP2013520840 A JP 2013520840A JP 2013531072 A5 JP2013531072 A5 JP 2013531072A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl group
- substituted
- pharmaceutical composition
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 56
- 239000008194 pharmaceutical composition Substances 0.000 claims 33
- 125000003118 aryl group Chemical group 0.000 claims 28
- 150000001875 compounds Chemical class 0.000 claims 24
- 125000003545 alkoxy group Chemical group 0.000 claims 21
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 21
- 125000000753 cycloalkyl group Chemical group 0.000 claims 14
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 14
- 201000000980 schizophrenia Diseases 0.000 claims 13
- 208000024891 symptom Diseases 0.000 claims 11
- 125000002252 acyl group Chemical group 0.000 claims 7
- 125000004442 acylamino group Chemical group 0.000 claims 7
- 125000004423 acyloxy group Chemical group 0.000 claims 7
- 125000003342 alkenyl group Chemical group 0.000 claims 7
- 125000004466 alkoxycarbonylamino group Chemical group 0.000 claims 7
- 125000000304 alkynyl group Chemical group 0.000 claims 7
- 125000003277 amino group Chemical group 0.000 claims 7
- 230000000561 anti-psychotic effect Effects 0.000 claims 7
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims 7
- 125000004093 cyano group Chemical group *C#N 0.000 claims 7
- 125000005843 halogen group Chemical group 0.000 claims 7
- 125000000623 heterocyclic group Chemical group 0.000 claims 7
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 7
- 125000002950 monocyclic group Chemical group 0.000 claims 7
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 7
- 125000003367 polycyclic group Chemical group 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 239000012453 solvate Substances 0.000 claims 7
- 125000001424 substituent group Chemical group 0.000 claims 7
- 208000019901 Anxiety disease Diseases 0.000 claims 2
- 206010060891 General symptom Diseases 0.000 claims 2
- 230000036506 anxiety Effects 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 150000004677 hydrates Chemical class 0.000 claims 2
- CEUORZQYGODEFX-UHFFFAOYSA-N Aripirazole Chemical compound ClC1=CC=CC(N2CCN(CCCCOC=3C=C4NC(=O)CCC4=CC=3)CC2)=C1Cl CEUORZQYGODEFX-UHFFFAOYSA-N 0.000 claims 1
- 108010001237 Cytochrome P-450 CYP2D6 Proteins 0.000 claims 1
- 102100021704 Cytochrome P450 2D6 Human genes 0.000 claims 1
- 206010012239 Delusion Diseases 0.000 claims 1
- 206010014557 Emotional poverty Diseases 0.000 claims 1
- 208000004547 Hallucinations Diseases 0.000 claims 1
- 206010020400 Hostility Diseases 0.000 claims 1
- 229960004372 aripiprazole Drugs 0.000 claims 1
- 239000003693 atypical antipsychotic agent Substances 0.000 claims 1
- 229940127236 atypical antipsychotics Drugs 0.000 claims 1
- 230000001149 cognitive effect Effects 0.000 claims 1
- 231100000868 delusion Toxicity 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 208000013403 hyperactivity Diseases 0.000 claims 1
- 238000007654 immersion Methods 0.000 claims 1
- 230000005032 impulse control Effects 0.000 claims 1
- 230000008450 motivation Effects 0.000 claims 1
- 229960005017 olanzapine Drugs 0.000 claims 1
- KVWDHTXUZHCGIO-UHFFFAOYSA-N olanzapine Chemical compound C1CN(C)CCN1C1=NC2=CC=CC=C2NC2=C1C=C(C)S2 KVWDHTXUZHCGIO-UHFFFAOYSA-N 0.000 claims 1
- 229960004431 quetiapine Drugs 0.000 claims 1
- URKOMYMAXPYINW-UHFFFAOYSA-N quetiapine Chemical compound C1CN(CCOCCO)CCN1C1=NC2=CC=CC=C2SC2=CC=CC=C12 URKOMYMAXPYINW-UHFFFAOYSA-N 0.000 claims 1
- 229960001534 risperidone Drugs 0.000 claims 1
- RAPZEAPATHNIPO-UHFFFAOYSA-N risperidone Chemical compound FC1=CC=C2C(C3CCN(CC3)CCC=3C(=O)N4CCCCC4=NC=3C)=NOC2=C1 RAPZEAPATHNIPO-UHFFFAOYSA-N 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
- 208000022925 sleep disturbance Diseases 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 0 B*C1CC(*)*(C)C(*)C1 Chemical compound B*C1CC(*)*(C)C(*)C1 0.000 description 16
- RNRYULFRLCBRQS-UHFFFAOYSA-N O=C(CN1CCC(CN(Cc2ccccc22)C2=O)CC1)c(cc1)ccc1F Chemical compound O=C(CN1CCC(CN(Cc2ccccc22)C2=O)CC1)c(cc1)ccc1F RNRYULFRLCBRQS-UHFFFAOYSA-N 0.000 description 3
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36607510P | 2010-07-20 | 2010-07-20 | |
| US61/366,075 | 2010-07-20 | ||
| PCT/US2011/044697 WO2012012542A1 (en) | 2010-07-20 | 2011-07-20 | Methods of use of cyclic amide derivatives to treat schizophrenia |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016163049A Division JP6200561B2 (ja) | 2010-07-20 | 2016-08-23 | 統合失調症を処置するための環状アミド誘導体の使用の方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013531072A JP2013531072A (ja) | 2013-08-01 |
| JP2013531072A5 true JP2013531072A5 (enExample) | 2014-09-04 |
| JP6053678B2 JP6053678B2 (ja) | 2016-12-27 |
Family
ID=45497166
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013520840A Active JP6053678B2 (ja) | 2010-07-20 | 2011-07-20 | 統合失調症を処置するための環状アミド誘導体の使用の方法 |
| JP2016163049A Active JP6200561B2 (ja) | 2010-07-20 | 2016-08-23 | 統合失調症を処置するための環状アミド誘導体の使用の方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016163049A Active JP6200561B2 (ja) | 2010-07-20 | 2016-08-23 | 統合失調症を処置するための環状アミド誘導体の使用の方法 |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US20180155318A1 (enExample) |
| EP (4) | EP3335731B1 (enExample) |
| JP (2) | JP6053678B2 (enExample) |
| KR (1) | KR101867633B1 (enExample) |
| CN (1) | CN103220910B (enExample) |
| BR (1) | BR112013001303A2 (enExample) |
| CA (2) | CA2806017C (enExample) |
| DK (2) | DK2595484T3 (enExample) |
| ES (2) | ES2963362T3 (enExample) |
| FI (1) | FI3135286T3 (enExample) |
| HR (1) | HRP20231446T1 (enExample) |
| HU (1) | HUE064157T2 (enExample) |
| LT (1) | LT3135286T (enExample) |
| NO (1) | NO2595484T3 (enExample) |
| PL (2) | PL3135286T3 (enExample) |
| PT (2) | PT3135286T (enExample) |
| RS (1) | RS64819B1 (enExample) |
| RU (1) | RU2576611C2 (enExample) |
| SI (1) | SI3135286T1 (enExample) |
| SM (1) | SMT202300413T1 (enExample) |
| TW (1) | TWI583679B (enExample) |
| WO (1) | WO2012012542A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL301320B2 (en) * | 2014-12-02 | 2024-11-01 | Minerva Neurosciences Inc | Compositions comprising 2-((1-(2(4-fluorophenyl)-2-oxoethyl)piperidin-4-yl)methyl)isoindolin-1-one for treating schizophrenia |
| CN113694065A (zh) * | 2016-05-25 | 2021-11-26 | 田边三菱制药株式会社 | 用于治疗非精神分裂症患者中的阴性症状的组合物和方法 |
| JP2020525436A (ja) | 2017-06-21 | 2020-08-27 | ミネルバ・ニューロサイエンシズ・インコーポレイテッド | 胃耐性制御放出経口剤形 |
| US20200230127A1 (en) | 2017-10-10 | 2020-07-23 | Neurocrine Biosciences, Inc. | Methods for the Administration of Certain VMAT2 Inhibitors |
| EP3840835A1 (en) * | 2018-08-21 | 2021-06-30 | Minerva Neurosciences, Inc. | Use of roluperidone to treat negative symptoms and disorders, increase neuroplasticity, and promote neuroprotection |
| GB202416895D0 (en) * | 2024-11-18 | 2025-01-01 | Phytoquest Ltd | Treatment of sleep disorders |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE102482T1 (de) * | 1988-01-21 | 1994-03-15 | Merrell Dow Pharma | Verwendung von 1,4-disubstituierten-piperidinyl- verbindungen zur herstellung eines arzneimittels zur behandlung von schlaflosigkeit. |
| NZ235841A (en) * | 1989-10-27 | 1993-03-26 | Du Pont | (n-phthalimidoalkyl) piperidine derivatives and pharmaceutical compositions |
| EP0497843A4 (en) * | 1989-10-27 | 1992-09-23 | The Du Pont Merck Pharmaceutical Company | (n-phthalimidoalkyl) piperidines |
| NZ521576A (en) * | 2000-02-29 | 2005-06-24 | Mitsubishi Pharma Corp | Novel cyclic amide derivatives |
| US6335371B1 (en) * | 2000-11-28 | 2002-01-01 | Orion Corporation | Method for inducing cognition enhancement |
| JP5281395B2 (ja) * | 2005-06-06 | 2013-09-04 | メルク シャープ エンド ドーム リミテッド | 統合失調症の治療用のｇｌｙｔ１阻害剤としてのシクロヘキサンスルホニル誘導体 |
| TW200817400A (en) * | 2006-05-30 | 2008-04-16 | Elbion Ag | Pyrido [3,2-e] pyrazines, their use as inhibitors of phosphodiesterase 10, and processes for preparing them |
-
2011
- 2011-07-20 WO PCT/US2011/044697 patent/WO2012012542A1/en not_active Ceased
- 2011-07-20 FI FIEP16181339.9T patent/FI3135286T3/fi active
- 2011-07-20 BR BR112013001303A patent/BR112013001303A2/pt not_active Application Discontinuation
- 2011-07-20 HU HUE16181339A patent/HUE064157T2/hu unknown
- 2011-07-20 KR KR1020137004217A patent/KR101867633B1/ko active Active
- 2011-07-20 SM SM20230413T patent/SMT202300413T1/it unknown
- 2011-07-20 PT PT161813399T patent/PT3135286T/pt unknown
- 2011-07-20 EP EP17196800.1A patent/EP3335731B1/en active Active
- 2011-07-20 CA CA2806017A patent/CA2806017C/en active Active
- 2011-07-20 DK DK11810349.8T patent/DK2595484T3/en active
- 2011-07-20 JP JP2013520840A patent/JP6053678B2/ja active Active
- 2011-07-20 SI SI201132096T patent/SI3135286T1/sl unknown
- 2011-07-20 ES ES16181339T patent/ES2963362T3/es active Active
- 2011-07-20 HR HRP20231446TT patent/HRP20231446T1/hr unknown
- 2011-07-20 PT PT118103498T patent/PT2595484T/pt unknown
- 2011-07-20 RS RS20231061A patent/RS64819B1/sr unknown
- 2011-07-20 PL PL16181339.9T patent/PL3135286T3/pl unknown
- 2011-07-20 PL PL11810349T patent/PL2595484T3/pl unknown
- 2011-07-20 EP EP11810349.8A patent/EP2595484B1/en active Active
- 2011-07-20 LT LTEP16181339.9T patent/LT3135286T/lt unknown
- 2011-07-20 NO NO11810349A patent/NO2595484T3/no unknown
- 2011-07-20 RU RU2013107382/15A patent/RU2576611C2/ru active
- 2011-07-20 EP EP16181339.9A patent/EP3135286B1/en active Active
- 2011-07-20 CA CA3117855A patent/CA3117855C/en active Active
- 2011-07-20 EP EP24197877.4A patent/EP4494704A3/en active Pending
- 2011-07-20 CN CN201180045067.1A patent/CN103220910B/zh active Active
- 2011-07-20 DK DK16181339.9T patent/DK3135286T3/da active
- 2011-07-20 TW TW100125661A patent/TWI583679B/zh active
- 2011-07-20 ES ES11810349.8T patent/ES2656313T3/es active Active
-
2016
- 2016-08-23 JP JP2016163049A patent/JP6200561B2/ja active Active
-
2017
- 2017-07-21 US US15/656,062 patent/US20180155318A1/en not_active Abandoned
-
2022
- 2022-05-16 US US17/745,024 patent/US20220274951A1/en not_active Abandoned
-
2024
- 2024-08-30 US US18/821,656 patent/US20250179044A1/en active Pending
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