JP2013527242A5 - - Google Patents
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- Publication number
- JP2013527242A5 JP2013527242A5 JP2013513339A JP2013513339A JP2013527242A5 JP 2013527242 A5 JP2013527242 A5 JP 2013527242A5 JP 2013513339 A JP2013513339 A JP 2013513339A JP 2013513339 A JP2013513339 A JP 2013513339A JP 2013527242 A5 JP2013527242 A5 JP 2013527242A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- coor
- group
- formula
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- ZKHRHUDBEOGJKP-UBVMEDRPSA-N CC(C)([C@@H]1CC2)C(c(cc3)cc(F)c3C(O)=O)=CC[C@]1(C)[C@@H](CC1)[C@]2(C)[C@](C)(CC2)[C@H]1C([C@@H](CC1)C(C)=C)[C@@]21C(O)=O Chemical compound CC(C)([C@@H]1CC2)C(c(cc3)cc(F)c3C(O)=O)=CC[C@]1(C)[C@@H](CC1)[C@]2(C)[C@](C)(CC2)[C@H]1C([C@@H](CC1)C(C)=C)[C@@]21C(O)=O ZKHRHUDBEOGJKP-UBVMEDRPSA-N 0.000 description 1
- ZVGBPYAQHAAOIJ-JSQNMCMJSA-N CC(C)([C@@H]1CC2)C(c(cc3)ccc3O)=CC[C@]1(C)[C@@H](CC1)[C@]2(C)[C@](C)(CC2)[C@H]1C([C@@H](CC1)C(C)=C)[C@@]21C(O)=O Chemical compound CC(C)([C@@H]1CC2)C(c(cc3)ccc3O)=CC[C@]1(C)[C@@H](CC1)[C@]2(C)[C@](C)(CC2)[C@H]1C([C@@H](CC1)C(C)=C)[C@@]21C(O)=O ZVGBPYAQHAAOIJ-JSQNMCMJSA-N 0.000 description 1
- NKEWSATXYFJBFR-VVKNDMMDSA-N CC(C)([C@@H]1CC2)C(c3c[s]c(C(O)=O)c3)=CC[C@]1(C)[C@@H](CC1)[C@]2(C)[C@@]2(C)[C@H]1[C@@H]([C@@H](CC1)C(C)=C)[C@@]1(CO)CC2 Chemical compound CC(C)([C@@H]1CC2)C(c3c[s]c(C(O)=O)c3)=CC[C@]1(C)[C@@H](CC1)[C@]2(C)[C@@]2(C)[C@H]1[C@@H]([C@@H](CC1)C(C)=C)[C@@]1(CO)CC2 NKEWSATXYFJBFR-VVKNDMMDSA-N 0.000 description 1
- OKJOFJMJARSCOJ-KFDFSFHFSA-N CC(C)([C@@H]1CC2)C(c3ccc(C(O)=O)[s]3)=CC[C@]1(C)[C@@H](CC1)[C@]2(C)[C@@]2(C)[C@H]1[C@@H]([C@@H](CC1)C(C)=C)[C@@]1(CO)CC2 Chemical compound CC(C)([C@@H]1CC2)C(c3ccc(C(O)=O)[s]3)=CC[C@]1(C)[C@@H](CC1)[C@]2(C)[C@@]2(C)[C@H]1[C@@H]([C@@H](CC1)C(C)=C)[C@@]1(CO)CC2 OKJOFJMJARSCOJ-KFDFSFHFSA-N 0.000 description 1
- PMSBJRSKUCXXTO-LRAKCVRGSA-N CC(C)([C@@H]1CC2)C(c3ccc(C4(CC4)C(O)=O)cc3)=CC[C@]1(C)[C@@H](CC1)[C@]2(C)[C@](C)(CC2)[C@H]1C([C@@H](CC1)C(C)=C)[C@@]21C(O)=O Chemical compound CC(C)([C@@H]1CC2)C(c3ccc(C4(CC4)C(O)=O)cc3)=CC[C@]1(C)[C@@H](CC1)[C@]2(C)[C@](C)(CC2)[C@H]1C([C@@H](CC1)C(C)=C)[C@@]21C(O)=O PMSBJRSKUCXXTO-LRAKCVRGSA-N 0.000 description 1
- RSCIRZGZSJQQPF-JKOHZOSMSA-N CC(C)([C@@H]1CC2)C(c3cccc([IH](NC)(=O)=O)c3)=CC[C@]1(C)[C@@H](CC1)[C@]2(C)[C@](C)(CC2)[C@H]1C([C@@H](CC1)C(C)=C)[C@@]21C(O)=O Chemical compound CC(C)([C@@H]1CC2)C(c3cccc([IH](NC)(=O)=O)c3)=CC[C@]1(C)[C@@H](CC1)[C@]2(C)[C@](C)(CC2)[C@H]1C([C@@H](CC1)C(C)=C)[C@@]21C(O)=O RSCIRZGZSJQQPF-JKOHZOSMSA-N 0.000 description 1
- QCRHUOLNTGLHIE-DRUPEPCTSA-N CC(C)([C@@H]1CC2)C(c3cnc(C(O)=O)nc3)=CC[C@]1(C)[C@@H](CC1)[C@]2(C)[C@@]2(C)[C@H]1C([C@@H](CC1)C(C)=C)[C@@]1(CO)CC2 Chemical compound CC(C)([C@@H]1CC2)C(c3cnc(C(O)=O)nc3)=CC[C@]1(C)[C@@H](CC1)[C@]2(C)[C@@]2(C)[C@H]1C([C@@H](CC1)C(C)=C)[C@@]1(CO)CC2 QCRHUOLNTGLHIE-DRUPEPCTSA-N 0.000 description 1
- 0 CC1[C@](CC2(C)[C@@](C)(CCC(**)[C@@]3C)C3C(C)[C@](C)[C@@](CCC3(*)CCCC3)C2)C1 Chemical compound CC1[C@](CC2(C)[C@@](C)(CCC(**)[C@@]3C)C3C(C)[C@](C)[C@@](CCC3(*)CCCC3)C2)C1 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35133810P | 2010-06-04 | 2010-06-04 | |
| US61/351,338 | 2010-06-04 | ||
| PCT/US2011/038879 WO2011153315A1 (en) | 2010-06-04 | 2011-06-02 | Modified c-3 betulinic acid derivatives as hiv maturation inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013527242A JP2013527242A (ja) | 2013-06-27 |
| JP2013527242A5 true JP2013527242A5 (https=) | 2014-07-17 |
| JP5752789B2 JP5752789B2 (ja) | 2015-07-22 |
Family
ID=44627236
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013513339A Expired - Fee Related JP5752789B2 (ja) | 2010-06-04 | 2011-06-02 | Ｈｉｖ成熟阻害剤としての修飾ｃ−３ベツリン酸誘導体 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8754068B2 (https=) |
| EP (1) | EP2576585B8 (https=) |
| JP (1) | JP5752789B2 (https=) |
| CN (1) | CN103038245B (https=) |
| AR (1) | AR081637A1 (https=) |
| BR (1) | BR112012030818A2 (https=) |
| CA (1) | CA2801487C (https=) |
| EA (1) | EA022393B1 (https=) |
| ES (1) | ES2612452T3 (https=) |
| MX (1) | MX2012013703A (https=) |
| TW (1) | TW201201793A (https=) |
| WO (1) | WO2011153315A1 (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11090313B2 (en) | 2010-05-20 | 2021-08-17 | University Of Iowa Research Foundation | Methods for inhibiting muscle atrophy |
| WO2011146768A1 (en) | 2010-05-20 | 2011-11-24 | University Of Iowa Research Foundation | Methods for inhibiting muscle atrophy |
| PL2670764T3 (pl) * | 2011-01-31 | 2016-02-29 | Bristol Myers Squibb Co | C-28 aminy zmodyfikowanych C-3 pochodnych kwasu betulinowego jako inhibitory dojrzewania HIV |
| KR101886467B1 (ko) * | 2011-01-31 | 2018-08-07 | 비브 헬스케어 유케이 (넘버4) 리미티드 | Hiv 성숙 억제 활성을 갖는 c-17 및 c-3 변형 트리테르페노이드 |
| AU2012268036B2 (en) | 2011-06-06 | 2017-04-06 | THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF STATE OF THE DEPARTMENT OF VETERANS AFFAIRS | Methods of inhibiting muscle atrophy |
| WO2013043778A1 (en) | 2011-09-21 | 2013-03-28 | Bristol-Myers Squibb Company | Novel betulinic acid derivatives with antiviral activity |
| US8906889B2 (en) * | 2012-02-15 | 2014-12-09 | Bristol-Myers Squibb Company | C-3 cycloalkenyl triterpenoids with HIV maturation inhibitory activity |
| US8889854B2 (en) | 2012-05-07 | 2014-11-18 | Bristol-Myers Squibb Company | C-17 bicyclic amines of triterpenoids with HIV maturation inhibitory activity |
| US9637516B2 (en) | 2012-12-31 | 2017-05-02 | Hetero Research Foundation | Betulinic acid proline derivatives as HIV inhibitors |
| SG11201505639SA (en) * | 2013-02-06 | 2015-08-28 | Bristol Myers Squibb Co | C-19 modified triterpenoids with hiv maturation inhibitory activity |
| SG11201506445PA (en) * | 2013-02-25 | 2015-09-29 | Bristol Myers Squibb Co | C-3 alkyl and alkenyl modified betulinic acid derivatives useful in the treatment of hiv |
| SI3129392T1 (sl) | 2014-04-11 | 2020-11-30 | VIIV Healthcare UK(No.4) Limited | Triterpenoidi z inhibitorno aktivnostjo maturacije HIV-a, substituirani na položaju 3 z nearomatskim obročem, ki nosi haloalkilni substituent |
| WO2015195776A1 (en) | 2014-06-19 | 2015-12-23 | Bristol-Myers Squibb Company | Betulinic acid derivatives with hiv maturation inhibitory activity |
| US20170129916A1 (en) | 2014-06-26 | 2017-05-11 | Hetero Research Foundation | Novel betulinic proline imidazole derivatives as hiv inhibitors |
| CN107250153A (zh) * | 2014-11-14 | 2017-10-13 | Viiv保健英国第五有限公司 | 氧代羽扇豆烯衍生物 |
| EP3218388A1 (en) | 2014-11-14 | 2017-09-20 | VIIV Healthcare UK (No.5) Limited | C17-aryl substituted betulinic acid analogs |
| KR20170092580A (ko) * | 2014-11-14 | 2017-08-11 | 비브 헬스케어 유케이 (넘버5) 리미티드 | 연장된 베툴린산 유사체 |
| MA40886B1 (fr) | 2015-02-09 | 2020-03-31 | Hetero Research Foundation | Nouveau triterpénone en c-3 avec des dérivés d'amide inverse en c-28 en tant qu'inhibiteurs du vih |
| US10370405B2 (en) | 2015-03-16 | 2019-08-06 | Hetero Labs Limited | C-3 novel triterpenone with C-28 amide derivatives as HIV inhibitors |
| RU2018105352A (ru) | 2015-07-28 | 2019-08-29 | ГлаксоСмитКлайн Интеллекчуал Проперти (N2) Лимитед | Производные бетулина для предупреждения или лечения ВИЧ-инфекций |
| WO2017017609A1 (en) | 2015-07-28 | 2017-02-02 | Glaxosmithkline Intellectual Property (No.2) Limited | Betuin derivatives for preventing or treating hiv infections |
| RU2018112958A (ru) | 2015-09-24 | 2019-10-28 | ГлаксоСмитКлайн Интеллекчуал Проперти (N2) Лимитед | Соединения с ингибирующей созревание ВИЧ активностью |
| WO2017125870A1 (en) | 2016-01-20 | 2017-07-27 | Glaxosmithkline Intellectual Property (No.2) Limited | Amine derivatives of lupanes with hiv maturation inhibitory activity |
| AR107512A1 (es) | 2016-02-04 | 2018-05-09 | VIIV HEALTHCARE UK Nº 5 LTD | Triterpenoides modificados en c-3 y c-17 como inhibidores del vih-1 |
| US20190307776A1 (en) | 2016-06-30 | 2019-10-10 | Viiv Healthcare Uk (No. 5) Limited | Aza-substituted inhibitors of human immunodeficiency virus replication |
| WO2018002848A1 (en) * | 2016-06-30 | 2018-01-04 | VIIV Healthcare UK (No.5) Limited | Azadecalin derivatives as inhibitors of human immunodeficiency virus replication |
| US20190135857A1 (en) * | 2016-06-30 | 2019-05-09 | Viiv Healthcare Uk (No. 5) Limited | Triterpenoid inhibitors of human immunodeficiency virus replication |
| ES2970042T3 (es) | 2018-04-24 | 2024-05-24 | Viiv Healthcare Uk No 5 Ltd | Compuestos con actividad inhibidora de la maduración del VIH |
| PL237998B1 (pl) | 2018-05-28 | 2021-06-28 | Narodowy Inst Lekow | Fosfonowe pochodne kwasu 3-karboksyacylobetulinowego, sposób ich otrzymywania oraz ich zastosowanie |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5413999A (en) | 1991-11-08 | 1995-05-09 | Merck & Co., Inc. | HIV protease inhibitors useful for the treatment of AIDS |
| US5962527A (en) | 1995-03-21 | 1999-10-05 | The Board Of Trustees Of The University Of Illinois | Method and composition for treating cancers |
| US5869535A (en) | 1995-03-21 | 1999-02-09 | The Board Of Trustees Of The University Of Illinois | Method and composition for selectively inhibiting melanoma |
| US5679828A (en) * | 1995-06-05 | 1997-10-21 | Biotech Research Labs, Inc. | Betulinic acid and dihydrobetulinic acid derivatives and uses therefor |
| AU762404B2 (en) * | 1998-03-02 | 2003-06-26 | Panacos Pharmaceuticals, Inc. | Acylated betulin and dihydrobetulin derivatives, preparation thereof and use thereof |
| US20040110785A1 (en) | 2001-02-02 | 2004-06-10 | Tao Wang | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives |
| WO2004028455A2 (en) * | 2002-09-26 | 2004-04-08 | Panacos Pharmaceuticals, Inc. | Monoacylated betulin and dihydrobetulin derivatives, preparation thereof and use thereof |
| US7365221B2 (en) | 2002-09-26 | 2008-04-29 | Panacos Pharmaceuticals, Inc. | Monoacylated betulin and dihydrobetulin derivatives, preparation thereof and use thereof |
| JP4722031B2 (ja) * | 2003-02-11 | 2011-07-13 | ノベリックス・ファーマシューティカルズ・インコーポレイテッド | 腫瘍増殖を阻害するための医薬 |
| US20050014730A1 (en) | 2003-04-02 | 2005-01-20 | Carlson Robert M. | Anti-fungal formulation of triterpene and essential oil |
| US7745625B2 (en) | 2004-03-15 | 2010-06-29 | Bristol-Myers Squibb Company | Prodrugs of piperazine and substituted piperidine antiviral agents |
| EP1730163A4 (en) * | 2004-03-17 | 2009-12-30 | Panacos Pharmaceuticals Inc | Pharmaceutical salts of 3-O- (3,3-dimethylsuccinyl) betulinic acid |
| WO2005112929A2 (en) * | 2004-05-20 | 2005-12-01 | Cornell Research Foundation, Inc. | Anti-hiv-1 activity of betulinol derivatives |
| TW200628161A (en) * | 2004-11-12 | 2006-08-16 | Panacos Pharmaceuticals Inc | Novel betulin derivatives, preparation thereof and use thereof |
| JP2009527563A (ja) * | 2006-02-21 | 2009-07-30 | アキリオン ファーマシューティカルズ，インコーポレーテッド | ウイルス感染症を治療するのに有用な置換タラキサスタン |
| WO2008127364A2 (en) | 2006-10-13 | 2008-10-23 | Myriad Genetics, Inc. | Antiviral compounds and use thereof |
| WO2008115281A2 (en) * | 2006-10-16 | 2008-09-25 | Myriad Genetics, Inc. | Compounds for treating viral infections |
| US20090062243A1 (en) * | 2007-08-03 | 2009-03-05 | Advanced Life Sciences, Inc. | Lupane-Type Triterpenoids Modified at 30-Position and Analogues Thereof |
| WO2009042166A1 (en) | 2007-09-25 | 2009-04-02 | Panacos Pharmaceuticals, Inc. | Liquid bevirimat dosage forms for oral administration |
| CA2714049A1 (en) | 2008-02-14 | 2009-08-20 | Virochem Pharma Inc. | Novel 17.beta. lupane derivatives |
| WO2009114083A2 (en) | 2008-03-03 | 2009-09-17 | Panacos Pharmaceuticals, Inc. | Determinants of antiviral response |
| RS55631B1 (sr) * | 2008-04-18 | 2017-06-30 | Reata Pharmaceuticals Inc | Antioksidansni modulatori upale: c-17 homologisani derivati oleanolinske kiseline |
| CN102883608A (zh) * | 2010-02-11 | 2013-01-16 | 葛兰素史密丝克莱恩有限责任公司 | 白桦脂醇衍生物 |
-
2011
- 2011-06-02 CN CN201180038211.9A patent/CN103038245B/zh not_active Expired - Fee Related
- 2011-06-02 ES ES11726563.7T patent/ES2612452T3/es active Active
- 2011-06-02 MX MX2012013703A patent/MX2012013703A/es active IP Right Grant
- 2011-06-02 CA CA2801487A patent/CA2801487C/en not_active Expired - Fee Related
- 2011-06-02 BR BR112012030818A patent/BR112012030818A2/pt not_active IP Right Cessation
- 2011-06-02 US US13/151,706 patent/US8754068B2/en not_active Expired - Fee Related
- 2011-06-02 JP JP2013513339A patent/JP5752789B2/ja not_active Expired - Fee Related
- 2011-06-02 EP EP11726563.7A patent/EP2576585B8/en not_active Not-in-force
- 2011-06-02 EA EA201270780A patent/EA022393B1/ru not_active IP Right Cessation
- 2011-06-02 WO PCT/US2011/038879 patent/WO2011153315A1/en not_active Ceased
- 2011-06-03 AR ARP110101944A patent/AR081637A1/es not_active Application Discontinuation
- 2011-06-03 TW TW100119644A patent/TW201201793A/zh unknown
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