JP2013526611A5 - - Google Patents

Info

Publication number

JP2013526611A5

JP2013526611A5 JP2013512175A JP2013512175A JP2013526611A5 JP 2013526611 A5 JP2013526611 A5 JP 2013526611A5 JP 2013512175 A JP2013512175 A JP 2013512175A JP 2013512175 A JP2013512175 A JP 2013512175A JP 2013526611 A5 JP2013526611 A5 JP 2013526611A5

Authority

JP

Japan

Prior art keywords

oral formulation

extract

sinensis

subject

item

Prior art date

2011-05-24

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000000203 mixture Substances 0.000 claims description 109
• 238000009472 formulation Methods 0.000 claims description 105
• 229940109529 Pomegranate Extract Drugs 0.000 claims description 38
• 230000014509 gene expression Effects 0.000 claims description 34
• 235000020710 ginseng extract Nutrition 0.000 claims description 31
• 230000000694 effects Effects 0.000 claims description 26
• GZYPWOGIYAIIPV-JBDTYSNRSA-N ginsenoside Rb1 Chemical compound C([C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)O[C@@](C)(CCC=C(C)C)[C@@H]1[C@@H]2[C@@]([C@@]3(CC[C@H]4C(C)(C)[C@@H](O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O)CC[C@]4(C)[C@H]3C[C@H]2O)C)(C)CC1)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O GZYPWOGIYAIIPV-JBDTYSNRSA-N 0.000 claims description 14
• 210000001519 tissues Anatomy 0.000 claims description 13
• 244000251905 Pseudocydonia sinensis Species 0.000 claims description 12
• 239000003795 chemical substances by application Substances 0.000 claims description 10
• -1 chewables Substances 0.000 claims description 10
• 241001416980 Paecilomyces hepiali Species 0.000 claims description 9
• 150000008442 polyphenolic compounds Chemical class 0.000 claims description 9
• 235000013824 polyphenols Nutrition 0.000 claims description 9
• 210000004556 Brain Anatomy 0.000 claims description 8
• YURJSTAIMNSZAE-KFVUSEMXSA-N Ginsenoside Rg1 Natural products O([C@](CC/C=C(\C)/C)(C)[C@@H]1[C@H]2[C@@H](O)C[C@H]3[C@](C)([C@]2(C)CC1)C[C@H](O[C@@H]1[C@@H](O)[C@H](O)[C@H](O)[C@H](CO)O1)[C@H]1C(C)(C)[C@@H](O)CC[C@]31C)[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O1 YURJSTAIMNSZAE-KFVUSEMXSA-N 0.000 claims description 7
• 210000003205 Muscles Anatomy 0.000 claims description 7
• 230000032683 aging Effects 0.000 claims description 7
• 239000002552 dosage form Substances 0.000 claims description 7
• YURJSTAIMNSZAE-HHNZYBFYSA-N ginsenoside Rg1 Chemical compound O([C@@](C)(CCC=C(C)C)[C@@H]1[C@@H]2[C@@]([C@@]3(C[C@@H]([C@H]4C(C)(C)[C@@H](O)CC[C@]4(C)[C@H]3C[C@H]2O)O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)C)(C)CC1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O YURJSTAIMNSZAE-HHNZYBFYSA-N 0.000 claims description 7
• 235000020934 caloric restriction Nutrition 0.000 claims description 6
• JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 claims description 5
• RZALONVQKUWRRY-FYZOBXCZSA-N 2,3-dihydroxybutanedioic acid;(3R)-3-hydroxy-4-(trimethylazaniumyl)butanoate Chemical compound OC(=O)C(O)C(O)C(O)=O.C[N+](C)(C)C[C@H](O)CC([O-])=O RZALONVQKUWRRY-FYZOBXCZSA-N 0.000 claims description 5
• ACTIUHUUMQJHFO-UPTCCGCDSA-N Coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 claims description 5
• 229940067606 Lecithin Drugs 0.000 claims description 5
• 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 5
• 240000005648 Rhodiola rosea Species 0.000 claims description 5
• 235000003713 Rhodiola rosea Nutrition 0.000 claims description 5
• 239000000654 additive Substances 0.000 claims description 5
• 230000000996 additive Effects 0.000 claims description 5
• 235000021028 berry Nutrition 0.000 claims description 5
• 235000013361 beverage Nutrition 0.000 claims description 5
• 239000000090 biomarker Substances 0.000 claims description 5
• 239000002775 capsule Substances 0.000 claims description 5
• 239000008298 dragée Substances 0.000 claims description 5
• 239000006196 drop Substances 0.000 claims description 5
• 230000037149 energy metabolism Effects 0.000 claims description 5
• 239000000499 gel Substances 0.000 claims description 5
• 229940038487 grape extract Drugs 0.000 claims description 5
• 229920000591 gum Polymers 0.000 claims description 5
• 239000000787 lecithin Substances 0.000 claims description 5
• 235000010445 lecithin Nutrition 0.000 claims description 5
• 239000007937 lozenge Substances 0.000 claims description 5
• 239000008108 microcrystalline cellulose Substances 0.000 claims description 5
• 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 5
• 229940016286 microcrystalline cellulose Drugs 0.000 claims description 5
• 239000000843 powder Substances 0.000 claims description 5
• 230000035936 sexual power Effects 0.000 claims description 5
• 239000000741 silica gel Substances 0.000 claims description 5
• 229910002027 silica gel Inorganic materials 0.000 claims description 5
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 5
• 229960001866 silicon dioxide Drugs 0.000 claims description 5
• 239000006188 syrup Substances 0.000 claims description 5
• 235000020357 syrup Nutrition 0.000 claims description 5
• 239000003826 tablet Substances 0.000 claims description 5
• 235000012431 wafers Nutrition 0.000 claims description 5
• 230000003679 aging effect Effects 0.000 claims description 3
• 239000000796 flavoring agent Substances 0.000 claims description 3
• 235000013355 food flavoring agent Nutrition 0.000 claims description 3
• 235000002791 Panax Nutrition 0.000 claims 1
• 241000208343 Panax Species 0.000 claims 1