JP2013525286A5 - - Google Patents
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- Publication number
- JP2013525286A5 JP2013525286A5 JP2013504076A JP2013504076A JP2013525286A5 JP 2013525286 A5 JP2013525286 A5 JP 2013525286A5 JP 2013504076 A JP2013504076 A JP 2013504076A JP 2013504076 A JP2013504076 A JP 2013504076A JP 2013525286 A5 JP2013525286 A5 JP 2013525286A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- heterocyclyl
- membered
- heteroaryl
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 125000000623 heterocyclic group Chemical group 0.000 claims 42
- 150000001875 compounds Chemical class 0.000 claims 17
- 239000000203 mixture Substances 0.000 claims 9
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 125000001072 heteroaryl group Chemical group 0.000 claims 7
- 125000003118 aryl group Chemical group 0.000 claims 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims 6
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 4
- GLUUGHFHXGJENI-UHFFFAOYSA-N diethylenediamine Natural products C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 239000000463 material Substances 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- -1 —O-aryl Chemical group 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 150000001768 cations Chemical class 0.000 claims 2
- 150000004885 piperazines Chemical class 0.000 claims 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 1
- 108091000080 Phosphotransferase Proteins 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 208000030533 eye disease Diseases 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- PQIOSYKVBBWRRI-UHFFFAOYSA-N methylphosphonyl difluoride Chemical group CP(F)(F)=O PQIOSYKVBBWRRI-UHFFFAOYSA-N 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 102000020233 phosphotransferase Human genes 0.000 claims 1
- 150000003053 piperidines Chemical class 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N tetrahydropyridine hydrochloride Natural products C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 1
- QBZWEKYGTKGIBI-IUHJOZFDSA-N C=C(CCC(/C(/SC1)=C/CNC/C=C1/OCC/C=C(\C=C\F)/N[C@H](NC1CC1)O)=N)CN1CCNCC1 Chemical compound C=C(CCC(/C(/SC1)=C/CNC/C=C1/OCC/C=C(\C=C\F)/N[C@H](NC1CC1)O)=N)CN1CCNCC1 QBZWEKYGTKGIBI-IUHJOZFDSA-N 0.000 description 1
- FFBIOFNKFSXVLF-KRWDZBQOSA-N C[C@@H](CN(Cc1ccc(-c2cc3nccc(Oc(ccc(NC(NC4CC4)=O)c4)c4F)c3[s]2)nc1)CC1)N1C(N)=O Chemical compound C[C@@H](CN(Cc1ccc(-c2cc3nccc(Oc(ccc(NC(NC4CC4)=O)c4)c4F)c3[s]2)nc1)CC1)N1C(N)=O FFBIOFNKFSXVLF-KRWDZBQOSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32480310P | 2010-04-16 | 2010-04-16 | |
| US61/324,803 | 2010-04-16 | ||
| PCT/CA2011/000394 WO2011127567A1 (en) | 2010-04-16 | 2011-04-08 | Inhibitors of protein tyrosine kinase activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013525286A JP2013525286A (ja) | 2013-06-20 |
| JP2013525286A5 true JP2013525286A5 (US07846941-20101207-C00217.png) | 2014-05-15 |
Family
ID=44788641
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013504076A Ceased JP2013525286A (ja) | 2010-04-16 | 2011-04-08 | タンパク質チロシンキナーゼ活性の阻害剤 |
| JP2013504075A Ceased JP2013523846A (ja) | 2010-04-16 | 2011-04-08 | タンパク質チロシンキナーゼ活性の阻害剤および眼部の障害を治療するためのそれらの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013504075A Ceased JP2013523846A (ja) | 2010-04-16 | 2011-04-08 | タンパク質チロシンキナーゼ活性の阻害剤および眼部の障害を治療するためのそれらの使用 |
Country Status (18)
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2183254T3 (pl) * | 2007-08-29 | 2017-10-31 | Methylgene Inc | Inhibitory aktywności białkowej kinazy tyrozynowej |
| RU2498988C2 (ru) * | 2008-03-05 | 2013-11-20 | Метилджин, Инк. | Ингибиторы активности протеинтирозинкиназы |
| SG184883A1 (en) * | 2010-04-16 | 2012-11-29 | Methylgene Inc | Inhibitors of protein tyrosine kinase activity and use thereof to treat ophthalmic disorders |
| US20130096088A1 (en) * | 2011-09-30 | 2013-04-18 | Methylgene Inc. | Inhibitors of Protein Tyrosine Kinase Activity |
| US20130096135A1 (en) * | 2011-09-30 | 2013-04-18 | Methylgene Inc. | Selected Inhibitors of Protein Tyrosine Kinase Activity |
| WO2013044360A1 (en) * | 2011-09-30 | 2013-04-04 | Methylgene Inc. | Inhibitors of protein tyrosine kinase activity |
| EP2791108B1 (en) | 2011-12-15 | 2016-07-27 | Pfizer Limited | Sulfonamide derivatives |
| US10544117B2 (en) | 2014-09-10 | 2020-01-28 | Temple University—Of the Commonwealth System of Higher Education | 5-hydroxytryptamine receptor 7 activity modulators and their method of use |
| WO2016183150A1 (en) * | 2015-05-12 | 2016-11-17 | Temple University-Of The Commonwealth System Of Higher Education | Novel sigma-2 receptor binders and their method of use |
| CN108530464B (zh) * | 2017-03-02 | 2020-10-27 | 深圳海王医药科技研究院有限公司 | 一种多靶点激酶抑制剂 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050020619A1 (en) * | 2003-07-24 | 2005-01-27 | Patrick Betschmann | Thienopyridine kinase inhibitors |
| US7772247B2 (en) * | 2004-07-30 | 2010-08-10 | Methylgene Inc. | Substituted thieno[3,2-d]pyridines as inhibitors of the VEGF receptor and HGF receptor |
| AU2006229343A1 (en) * | 2005-03-28 | 2006-10-05 | Kirin Pharma Kabushiki Kaisha | Thienopyridine derivative, or quinoline derivative, or quinazoline derivative, having c-Met autophosphorylation inhibiting potency |
| JO2787B1 (en) * | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
| MX2007014616A (es) * | 2005-05-20 | 2009-08-12 | Methylgene Inc | Inhibidores de señalizacion del receptor del factor a de crecimiento endotelial vascular y del receptor del factor de crecimiento de hepatocitos. |
| MX2007014617A (es) * | 2005-05-20 | 2008-02-11 | Methylgene Inc | Inhibidores de senalizacion de receptor de factor de crecimiento endotelial bascular y receptor de factor de crecimiento de hepatocitos. |
| PL2183254T3 (pl) * | 2007-08-29 | 2017-10-31 | Methylgene Inc | Inhibitory aktywności białkowej kinazy tyrozynowej |
| EP2426108B1 (en) * | 2007-08-29 | 2016-08-10 | MethylGene Inc. | Processes and intermediates for preparing fused heterocyclic kinase inhibitors |
| RU2498988C2 (ru) * | 2008-03-05 | 2013-11-20 | Метилджин, Инк. | Ингибиторы активности протеинтирозинкиназы |
| SG184883A1 (en) * | 2010-04-16 | 2012-11-29 | Methylgene Inc | Inhibitors of protein tyrosine kinase activity and use thereof to treat ophthalmic disorders |
| US20130096088A1 (en) * | 2011-09-30 | 2013-04-18 | Methylgene Inc. | Inhibitors of Protein Tyrosine Kinase Activity |
-
2011
- 2011-04-08 SG SG2012076733A patent/SG184883A1/en unknown
- 2011-04-08 MY MYPI2012004621A patent/MY157319A/en unknown
- 2011-04-08 UA UAA201211687A patent/UA108878C2/ru unknown
- 2011-04-08 CA CA2796054A patent/CA2796054A1/en not_active Abandoned
- 2011-04-08 CN CN201180029735.1A patent/CN103025740B/zh not_active Expired - Fee Related
- 2011-04-08 US US13/082,944 patent/US8455484B2/en not_active Expired - Fee Related
- 2011-04-08 KR KR1020127029841A patent/KR20130100234A/ko not_active Application Discontinuation
- 2011-04-08 NZ NZ602948A patent/NZ602948A/en not_active IP Right Cessation
- 2011-04-08 EP EP11768307.8A patent/EP2563795A4/en not_active Withdrawn
- 2011-04-08 WO PCT/CA2011/000390 patent/WO2011127565A1/en active Application Filing
- 2011-04-08 SG SG2012076725A patent/SG184882A1/en unknown
- 2011-04-08 WO PCT/CA2011/000394 patent/WO2011127567A1/en active Application Filing
- 2011-04-08 AR ARP110101195A patent/AR080875A1/es unknown
- 2011-04-08 EP EP20110768305 patent/EP2563794A4/en not_active Withdrawn
- 2011-04-08 JP JP2013504076A patent/JP2013525286A/ja not_active Ceased
- 2011-04-08 TW TW100112308A patent/TW201204735A/zh unknown
- 2011-04-08 KR KR1020127030161A patent/KR20130058006A/ko not_active Application Discontinuation
- 2011-04-08 JP JP2013504075A patent/JP2013523846A/ja not_active Ceased
- 2011-04-08 AU AU2011241420A patent/AU2011241420B2/en not_active Ceased
- 2011-04-08 NZ NZ602954A patent/NZ602954A/en not_active IP Right Cessation
- 2011-04-08 EA EA201291052A patent/EA201291052A1/ru unknown
- 2011-04-08 AR ARP110101191A patent/AR080871A1/es unknown
- 2011-04-08 US US13/082,923 patent/US8906852B2/en not_active Expired - Fee Related
- 2011-04-08 EA EA201291055A patent/EA201291055A1/ru unknown
- 2011-04-08 MX MX2012012031A patent/MX2012012031A/es active IP Right Grant
- 2011-04-08 CN CN2011800297313A patent/CN102947315A/zh active Pending
- 2011-04-08 MX MX2012012032A patent/MX2012012032A/es not_active Application Discontinuation
- 2011-04-08 CA CA2796008A patent/CA2796008A1/en not_active Abandoned
- 2011-04-08 AU AU2011241422A patent/AU2011241422B2/en not_active Ceased
- 2011-04-08 TW TW100112307A patent/TW201204734A/zh unknown
-
2012
- 2012-10-05 ZA ZA2012/07482A patent/ZA201207482B/en unknown
- 2012-10-09 ZA ZA2012/07557A patent/ZA201207557B/en unknown
- 2012-11-15 CO CO12207317A patent/CO6640224A2/es active IP Right Grant
- 2012-11-15 CO CO12207310A patent/CO6630193A2/es active IP Right Grant
-
2014
- 2014-06-18 US US14/308,408 patent/US20140315801A1/en not_active Abandoned
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