JP2013520166A - Ｒａｇｅ融合タンパク質及びその使用方法 - Google Patents
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| USPCT/US2010/032270 | 2010-04-23 | ||
| PCT/US2010/032270 WO2011102845A1 (en) | 2010-02-18 | 2010-04-23 | Rage fusion protein compositions and methods of use |
| PCT/US2010/053157 WO2011102860A1 (en) | 2010-02-18 | 2010-10-19 | Rage fusion protein compositions and methods of use |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015166885A1 (ja) * | 2014-04-28 | 2015-11-05 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Ｈｇｆ凍結乾燥製剤 |
| JP2022500086A (ja) * | 2018-09-14 | 2022-01-04 | バイオエイジ ラブス， インコーポレイテッド | 改善された安定性およびリガンド結合親和性を有するｒａｇｅ融合タンパク質ならびにその使用 |
| US11548926B2 (en) | 2016-03-17 | 2023-01-10 | Eisai R&D Management Co., Ltd. | Method for producing an active hepatocyte growth factor (HGF) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP2723370A4 (en) | 2011-06-24 | 2015-06-03 | Univ Colorado Regents | COMPOSITIONS, PROCESS AND USE OF ALPHA-1-ANTITRYPHIN FUSION MOLECULES |
| WO2013106589A1 (en) | 2012-01-10 | 2013-07-18 | The Regents Of The University Of Colorado, A Body Corporate | Compositions, methods and uses for alpha-1 antitrypsin fusion molecules |
| CA3004695C (en) | 2012-04-30 | 2020-08-04 | Biocon Limited | Targeted/immunomodulatory fusion proteins and methods for making same |
| CA2902830C (en) * | 2013-03-12 | 2023-09-19 | Biocon Ltd. | Fusion immunomodulatory proteins and methods for making same |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2007525171A (ja) * | 2003-04-10 | 2007-09-06 | ピーディーエル バイオファーマ，インコーポレイティド | 変異誘発による抗体のＦｃＲｎ結合親和力又は血清半減期の改変 |
| JP2008512988A (ja) * | 2004-08-03 | 2008-05-01 | トランステック ファーマ，インコーポレイティド | Ｒａｇｅ融合タンパク質及びその使用方法 |
| WO2008157378A2 (en) * | 2007-06-14 | 2008-12-24 | Galactica Pharmaceuticals | Page fusion proteins |
| JP2009536201A (ja) * | 2006-05-05 | 2009-10-08 | トランステック ファーマ，インコーポレイティド | Ｒａｇｅ融合タンパク質、製剤及びその使用方法 |
| JP2009232856A (ja) * | 2001-05-24 | 2009-10-15 | Zymogenetics Inc | Ｔａｃｉ−免疫グロブリン融合タンパク質 |
| JP2009261394A (ja) * | 2000-12-12 | 2009-11-12 | Medimmune Llc | 延長した半減期を有する分子ならびにその組成物および用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US7258857B2 (en) | 1996-11-22 | 2007-08-21 | The Trustees Of Columbia University In The City Of New York | Rage-related methods for treating inflammation |
| US6908741B1 (en) | 2000-05-30 | 2005-06-21 | Transtech Pharma, Inc. | Methods to identify compounds that modulate RAGE |
| US6825164B1 (en) | 2000-08-14 | 2004-11-30 | The Trustees Of Columbia University In The City Of New York | Method to increase cerebral blood flow in amyloid angiopathy |
| WO2004100890A2 (en) * | 2003-05-09 | 2004-11-25 | The Trustees Of Columbia University In The City Of New York | Rage g82s-related methods and compositions for treating inflammatory disorders |
| WO2005000295A1 (en) | 2003-05-20 | 2005-01-06 | Transtech Pharma, Inc. | Rage antagonists as agents to reverse amyloidosis and diseases associated therewith |
| US20070087406A1 (en) * | 2005-05-04 | 2007-04-19 | Pei Jin | Isoforms of receptor for advanced glycation end products (RAGE) and methods of identifying and using same |
| DE102008037312B3 (de) | 2008-08-11 | 2010-02-18 | Emz-Hanauer Gmbh & Co. Kgaa | Elektrischer Schalter, insbesondere in Mikroschalter-Bauform |
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2010
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-
2011
- 2011-02-18 TW TW100105575A patent/TW201141507A/zh unknown
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009261394A (ja) * | 2000-12-12 | 2009-11-12 | Medimmune Llc | 延長した半減期を有する分子ならびにその組成物および用途 |
| JP2009232856A (ja) * | 2001-05-24 | 2009-10-15 | Zymogenetics Inc | Ｔａｃｉ−免疫グロブリン融合タンパク質 |
| JP2007525171A (ja) * | 2003-04-10 | 2007-09-06 | ピーディーエル バイオファーマ，インコーポレイティド | 変異誘発による抗体のＦｃＲｎ結合親和力又は血清半減期の改変 |
| JP2008512988A (ja) * | 2004-08-03 | 2008-05-01 | トランステック ファーマ，インコーポレイティド | Ｒａｇｅ融合タンパク質及びその使用方法 |
| JP2009536201A (ja) * | 2006-05-05 | 2009-10-08 | トランステック ファーマ，インコーポレイティド | Ｒａｇｅ融合タンパク質、製剤及びその使用方法 |
| WO2008157378A2 (en) * | 2007-06-14 | 2008-12-24 | Galactica Pharmaceuticals | Page fusion proteins |
Non-Patent Citations (5)
| Title |
|---|
| JPN5013003310; ＳＲＩＫＲＩＳＨＮＡ: 'ＣＡＲＢＯＸＹＬＡＴＥＤ Ｎ-ＧＬＹＣＡＮＳ ＯＮ ＲＡＧＥ ＡＲＥ ＣＲＩＴＩＣＡＬ ＤＥＴＥＲＭＩＮＡＮＴＳ ＯＦ Ｓ１００Ａ１２ ＢＩＮＤＩＮＧ' ＡＢＳＴＲＡＣＴＳ ＳＵＢＭＩＴＴＥＤ ＦＯＲ ＴＨＥ ２００５ ＭＥＥＴＩＮＧ ＯＦ ＴＨＥ ＳＯＣＩＥＴＹ ＦＯＲ ＧＬＹＣＯＢＩＯＬＯＧＹ ［ＯＮＬＩＮＥ］ , 200511 * |
| JPN6014054972; Ｂｉｏｃｈｅｍｉｃａ ｅｔ Ｂｉｏｐｈｙｓｉｃａ Ａｃｔａ （２００７） Ｖｏｌ．１７７０， Ｎｏ．１０， ｐｐ．１４６８-１４７４ * |
| JPN6014054975; Ｊ． Ｂｉｏｌ． Ｃｈｅｍ． （１９９２） Ｖｏｌ．２６７， Ｎｏ．２３， ｐｐ．１６３９６-１６４０２ * |
| JPN6014054976; Ｊｏｕｒｎａｌ ｏｆ Ｃｅｌｌｕｌａｒ Ｂｉｏｃｈｅｍｉｓｔｒｙ （２０１０） Ｖｏｌ．１１０， Ｎｏ．３， ｐｐ．６４５-６５９ * |
| JPN6014054978; Ｊ． Ｂｉｏｌ． Ｃｈｅｍ． （２００８） Ｖｏｌ．２８３， Ｎｏ．４０， ｐｐ．２７２５５-２７２６９ * |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015166885A1 (ja) * | 2014-04-28 | 2015-11-05 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Ｈｇｆ凍結乾燥製剤 |
| CN106456695A (zh) * | 2014-04-28 | 2017-02-22 | 卫材R&D管理有限公司 | Hgf的冻干配制品 |
| JPWO2015166885A1 (ja) * | 2014-04-28 | 2017-04-20 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Ｈｇｆ凍結乾燥製剤 |
| AU2015254307B2 (en) * | 2014-04-28 | 2019-11-07 | Eisai R&D Management Co., Ltd. | Lyophilized formulation of HGF |
| CN106456695B (zh) * | 2014-04-28 | 2019-11-12 | 卫材R&D管理有限公司 | Hgf的冻干配制品 |
| US11547743B2 (en) | 2014-04-28 | 2023-01-10 | Eisai R&D Management Co., Ltd. | Lyophilized formulation of HGF |
| US11548926B2 (en) | 2016-03-17 | 2023-01-10 | Eisai R&D Management Co., Ltd. | Method for producing an active hepatocyte growth factor (HGF) |
| US12384824B2 (en) | 2016-03-17 | 2025-08-12 | Eisai R&D Management Co., Ltd. | Method for producing an active hepatocyte growth factor (HGF) |
| JP2022500086A (ja) * | 2018-09-14 | 2022-01-04 | バイオエイジ ラブス， インコーポレイテッド | 改善された安定性およびリガンド結合親和性を有するｒａｇｅ融合タンパク質ならびにその使用 |
| JP7307178B2 (ja) | 2018-09-14 | 2023-07-11 | バイオエイジ ラブス， インコーポレイテッド | 改善された安定性およびリガンド結合親和性を有するｒａｇｅ融合タンパク質ならびにその使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2011102860A1 (en) | 2011-08-25 |
| US20130142792A1 (en) | 2013-06-06 |
| WO2011102845A1 (en) | 2011-08-25 |
| EP2536750A1 (en) | 2012-12-26 |
| TW201141507A (en) | 2011-12-01 |
| CA2789244A1 (en) | 2011-08-25 |
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