JP2013519413A5 - - Google Patents
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- Publication number
- JP2013519413A5 JP2013519413A5 JP2012552468A JP2012552468A JP2013519413A5 JP 2013519413 A5 JP2013519413 A5 JP 2013519413A5 JP 2012552468 A JP2012552468 A JP 2012552468A JP 2012552468 A JP2012552468 A JP 2012552468A JP 2013519413 A5 JP2013519413 A5 JP 2013519413A5
- Authority
- JP
- Japan
- Prior art keywords
- canister
- filled
- air
- ethyl
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000003814 drug Substances 0.000 claims description 23
- 238000000034 method Methods 0.000 claims description 18
- 229940079593 drug Drugs 0.000 claims description 17
- 238000007789 sealing Methods 0.000 claims description 12
- 239000003380 propellant Substances 0.000 claims description 10
- -1 4-hydroxy-2-oxo-3H-1,3-benzothiazol-7-yl Chemical group 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 8
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 8
- 239000004812 Fluorinated ethylene propylene Substances 0.000 claims description 4
- 239000006184 cosolvent Substances 0.000 claims description 4
- 239000000314 lubricant Substances 0.000 claims description 4
- 229940071648 metered dose inhaler Drugs 0.000 claims description 4
- 229920009441 perflouroethylene propylene Polymers 0.000 claims description 4
- 229920013653 perfluoroalkoxyethylene Polymers 0.000 claims description 4
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims description 4
- 239000004810 polytetrafluoroethylene Substances 0.000 claims description 4
- 239000004094 surface-active agent Substances 0.000 claims description 4
- XWTYSIMOBUGWOL-UHFFFAOYSA-N (+-)-Terbutaline Chemical compound CC(C)(C)NCC(O)C1=CC(O)=CC(O)=C1 XWTYSIMOBUGWOL-UHFFFAOYSA-N 0.000 claims description 2
- YFMFNYKEUDLDTL-UHFFFAOYSA-N 1,1,1,2,3,3,3-heptafluoropropane Chemical compound FC(F)(F)C(F)C(F)(F)F YFMFNYKEUDLDTL-UHFFFAOYSA-N 0.000 claims description 2
- LBLYYCQCTBFVLH-UHFFFAOYSA-M 2-methylbenzenesulfonate Chemical compound CC1=CC=CC=C1S([O-])(=O)=O LBLYYCQCTBFVLH-UHFFFAOYSA-M 0.000 claims description 2
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims description 2
- LSLYOANBFKQKPT-DIFFPNOSSA-N 5-[(1r)-1-hydroxy-2-[[(2r)-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]benzene-1,3-diol Chemical compound C([C@@H](C)NC[C@H](O)C=1C=C(O)C=C(O)C=1)C1=CC=C(O)C=C1 LSLYOANBFKQKPT-DIFFPNOSSA-N 0.000 claims description 2
- KUVIULQEHSCUHY-XYWKZLDCSA-N Beclometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O KUVIULQEHSCUHY-XYWKZLDCSA-N 0.000 claims description 2
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims description 2
- VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 claims description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 2
- GIIZNNXWQWCKIB-UHFFFAOYSA-N Serevent Chemical compound C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 GIIZNNXWQWCKIB-UHFFFAOYSA-N 0.000 claims description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 2
- MZVQCMJNVPIDEA-UHFFFAOYSA-N [CH2]CN(CC)CC Chemical group [CH2]CN(CC)CC MZVQCMJNVPIDEA-UHFFFAOYSA-N 0.000 claims description 2
- WOVFJBGKJQEQQD-UHFFFAOYSA-N acridine;hydrobromide Chemical compound [Br-].C1=CC=CC2=CC3=CC=CC=C3[NH+]=C21 WOVFJBGKJQEQQD-UHFFFAOYSA-N 0.000 claims description 2
- 239000004480 active ingredient Substances 0.000 claims description 2
- NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 claims description 2
- 229950000210 beclometasone dipropionate Drugs 0.000 claims description 2
- 229960004436 budesonide Drugs 0.000 claims description 2
- 229960001117 clenbuterol Drugs 0.000 claims description 2
- STJMRWALKKWQGH-UHFFFAOYSA-N clenbuterol Chemical compound CC(C)(C)NCC(O)C1=CC(Cl)=C(N)C(Cl)=C1 STJMRWALKKWQGH-UHFFFAOYSA-N 0.000 claims description 2
- 239000011248 coating agent Substances 0.000 claims description 2
- 238000000576 coating method Methods 0.000 claims description 2
- HQQADJVZYDDRJT-UHFFFAOYSA-N ethene;prop-1-ene Chemical group C=C.CC=C HQQADJVZYDDRJT-UHFFFAOYSA-N 0.000 claims description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 2
- 125000000031 ethylamino group Chemical group [H]C([H])([H])C([H])([H])N([H])[*] 0.000 claims description 2
- 229960001022 fenoterol Drugs 0.000 claims description 2
- 229960000676 flunisolide Drugs 0.000 claims description 2
- 229920002313 fluoropolymer Polymers 0.000 claims description 2
- 239000004811 fluoropolymer Substances 0.000 claims description 2
- 229960000289 fluticasone propionate Drugs 0.000 claims description 2
- WMWTYOKRWGGJOA-CENSZEJFSA-N fluticasone propionate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)CC)[C@@]2(C)C[C@@H]1O WMWTYOKRWGGJOA-CENSZEJFSA-N 0.000 claims description 2
- 229960004078 indacaterol Drugs 0.000 claims description 2
- QZZUEBNBZAPZLX-QFIPXVFZSA-N indacaterol Chemical compound N1C(=O)C=CC2=C1C(O)=CC=C2[C@@H](O)CNC1CC(C=C(C(=C2)CC)CC)=C2C1 QZZUEBNBZAPZLX-QFIPXVFZSA-N 0.000 claims description 2
- 229960001361 ipratropium bromide Drugs 0.000 claims description 2
- KEWHKYJURDBRMN-ZEODDXGYSA-M ipratropium bromide hydrate Chemical compound O.[Br-].O([C@H]1C[C@H]2CC[C@@H](C1)[N@@+]2(C)C(C)C)C(=O)C(CO)C1=CC=CC=C1 KEWHKYJURDBRMN-ZEODDXGYSA-M 0.000 claims description 2
- 229960001664 mometasone Drugs 0.000 claims description 2
- QLIIKPVHVRXHRI-CXSFZGCWSA-N mometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CCl)(O)[C@@]1(C)C[C@@H]2O QLIIKPVHVRXHRI-CXSFZGCWSA-N 0.000 claims description 2
- GHQXRNRNBBBEQN-UHFFFAOYSA-N n-cyclohexyl-3-[2-(3-fluorophenyl)ethylamino]-n-[2-[2-(4-hydroxy-2-oxo-3h-1,3-benzothiazol-7-yl)ethylamino]ethyl]propanamide Chemical compound C1=2SC(=O)NC=2C(O)=CC=C1CCNCCN(C(=O)CCNCCC=1C=C(F)C=CC=1)C1CCCCC1 GHQXRNRNBBBEQN-UHFFFAOYSA-N 0.000 claims description 2
- RQTOOFIXOKYGAN-UHFFFAOYSA-N nedocromil Chemical compound CCN1C(C(O)=O)=CC(=O)C2=C1C(CCC)=C1OC(C(O)=O)=CC(=O)C1=C2 RQTOOFIXOKYGAN-UHFFFAOYSA-N 0.000 claims description 2
- 229960004398 nedocromil Drugs 0.000 claims description 2
- MIXMJCQRHVAJIO-TZHJZOAOSA-N qk4dys664x Chemical compound O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O MIXMJCQRHVAJIO-TZHJZOAOSA-N 0.000 claims description 2
- 229960002720 reproterol Drugs 0.000 claims description 2
- WVLAAKXASPCBGT-UHFFFAOYSA-N reproterol Chemical compound C1=2C(=O)N(C)C(=O)N(C)C=2N=CN1CCCNCC(O)C1=CC(O)=CC(O)=C1 WVLAAKXASPCBGT-UHFFFAOYSA-N 0.000 claims description 2
- IXTCZMJQGGONPY-XJAYAHQCSA-N rofleponide Chemical compound C1([C@@H](F)C2)=CC(=O)CC[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H]3O[C@@H](CCC)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O IXTCZMJQGGONPY-XJAYAHQCSA-N 0.000 claims description 2
- 229950004432 rofleponide Drugs 0.000 claims description 2
- 229960002052 salbutamol Drugs 0.000 claims description 2
- 229960004017 salmeterol Drugs 0.000 claims description 2
- 229910052708 sodium Inorganic materials 0.000 claims description 2
- 239000011734 sodium Substances 0.000 claims description 2
- 238000005507 spraying Methods 0.000 claims description 2
- 229960000195 terbutaline Drugs 0.000 claims description 2
- 229960005105 terbutaline sulfate Drugs 0.000 claims description 2
- KFVSLSTULZVNPG-UHFFFAOYSA-N terbutaline sulfate Chemical compound [O-]S([O-])(=O)=O.CC(C)(C)[NH2+]CC(O)C1=CC(O)=CC(O)=C1.CC(C)(C)[NH2+]CC(O)C1=CC(O)=CC(O)=C1 KFVSLSTULZVNPG-UHFFFAOYSA-N 0.000 claims description 2
- 229940110309 tiotropium Drugs 0.000 claims description 2
- LERNTVKEWCAPOY-DZZGSBJMSA-N tiotropium Chemical compound O([C@H]1C[C@@H]2[N+]([C@H](C1)[C@@H]1[C@H]2O1)(C)C)C(=O)C(O)(C=1SC=CC=1)C1=CC=CS1 LERNTVKEWCAPOY-DZZGSBJMSA-N 0.000 claims description 2
- OBRNDARFFFHCGE-PERKLWIXSA-N (S,S)-formoterol fumarate Chemical compound OC(=O)\C=C\C(O)=O.C1=CC(OC)=CC=C1C[C@H](C)NC[C@@H](O)C1=CC=C(O)C(NC=O)=C1.C1=CC(OC)=CC=C1C[C@H](C)NC[C@@H](O)C1=CC=C(O)C(NC=O)=C1 OBRNDARFFFHCGE-PERKLWIXSA-N 0.000 claims 1
- 150000003863 ammonium salts Chemical class 0.000 claims 1
- 239000000032 diagnostic agent Substances 0.000 claims 1
- 229940039227 diagnostic agent Drugs 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 229960000193 formoterol fumarate Drugs 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 description 1
- 229960002848 formoterol Drugs 0.000 description 1
- 229940050411 fumarate Drugs 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30298810P | 2010-02-10 | 2010-02-10 | |
| US61/302,988 | 2010-02-10 | ||
| PCT/GB2011/050222 WO2011098798A1 (en) | 2010-02-10 | 2011-02-09 | Process for providing a filled canister for an inhaler |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013519413A JP2013519413A (ja) | 2013-05-30 |
| JP2013519413A5 true JP2013519413A5 (https=) | 2014-03-27 |
Family
ID=43971143
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012552468A Ceased JP2013519413A (ja) | 2010-02-10 | 2011-02-09 | 充填された吸入器用キャニスターを提供する方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20130112194A1 (https=) |
| EP (1) | EP2534054A1 (https=) |
| JP (1) | JP2013519413A (https=) |
| KR (1) | KR20130004266A (https=) |
| CN (1) | CN102858640B (https=) |
| AR (1) | AR080159A1 (https=) |
| AU (1) | AU2011214124B2 (https=) |
| BR (1) | BR112012019878A2 (https=) |
| CA (1) | CA2788015A1 (https=) |
| MX (1) | MX2012008906A (https=) |
| NZ (2) | NZ625734A (https=) |
| RU (1) | RU2562017C2 (https=) |
| WO (1) | WO2011098798A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201118188D0 (en) * | 2011-10-21 | 2011-12-07 | 3M Innovative Properties Co | Manufacture of medicinal aerosol canisters |
| EP2819669B1 (de) * | 2012-02-28 | 2021-04-21 | Boehringer Ingelheim International GmbH | Neue treibgashaltige tiotropium-formulierung |
| GB201402513D0 (en) | 2014-02-13 | 2014-04-02 | Cardiff Scintigraphics Ltd | Pressurised metered dose inhalers and method of manufacture |
| EP3021033B1 (de) * | 2014-11-12 | 2019-04-24 | CleanTech Swiss AG | Abfüllstation für Gasflaschen nebst Abfüllverfahren |
| GB2554857A (en) * | 2016-09-29 | 2018-04-18 | Mexichem Fluor Sa De Cv | A propellant filling apparatus |
| GB2561898A (en) * | 2017-04-28 | 2018-10-31 | Mexichem Fluor Sa De Cv | Improvements in or relating to propellant conditioning assemblies |
| GB2584686A (en) * | 2019-06-11 | 2020-12-16 | Mexichem Fluor Sa De Cv | Methods |
| IT202200002657A1 (it) * | 2022-02-14 | 2023-08-14 | Mox Lab S R L | Sistema di ricarica perfezionato portatile da banco per bombolette bag-on-valve pressurizzate con aria compressa. |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU286738A1 (ru) * | 1970-01-05 | 1976-08-25 | Специальное Конструкторское Бюро Химизации Народного Хозяйства Латвийской Сср | Устройство дл заполнени пропеллнтом аэрозольного сосуда |
| US4271875A (en) * | 1978-09-21 | 1981-06-09 | Philip Meshberg | Dispenser adapted for fast pressure filling |
| US5143260A (en) * | 1990-06-05 | 1992-09-01 | Nozone Dispenser Systems, Inc. | Aerosol adapter clamp and power system |
| US20030183224A1 (en) * | 2000-03-01 | 2003-10-02 | Hailey Mark Andrew | Metered dose inhaler |
| US6637430B1 (en) * | 2000-06-16 | 2003-10-28 | Ponwell Enterprises Limited | Respiratory delivery system with power/medicament recharge assembly |
| WO2002024552A2 (en) * | 2000-09-18 | 2002-03-28 | Glaxo Group Limited | Coated can for a metered dose inhaler |
| FR2814200B1 (fr) * | 2000-09-21 | 2005-08-05 | Marwal Systems | Dispositif de puisage et de jaugeage pour reservoir de carburant de vehicule automobile |
| GB0125380D0 (en) * | 2001-10-23 | 2001-12-12 | Glaxo Group Ltd | Medicament dispenser |
| SE0104251D0 (sv) | 2001-12-14 | 2001-12-14 | Astrazeneca Ab | Novel compounds |
| MXPA05002248A (es) * | 2002-08-27 | 2005-06-08 | Schering Corp | Procedimiento para producir formulaciones de inhalador de dosis medida. |
| US20050121025A1 (en) * | 2003-12-04 | 2005-06-09 | Gamard Stephan C.F. | Portable gas operating inhaler |
| DE10361735A1 (de) * | 2003-12-29 | 2005-07-28 | Boehringer Ingelheim International Gmbh | Vorrichtung zum Ausbringen eins inhalierfähigen Aerosols mit Teilchen niedriger Anfangsgeschwindigkeit |
| EP1595531A1 (en) * | 2004-05-13 | 2005-11-16 | CHIESI FARMACEUTICI S.p.A. | Stable pharmaceutical solution formulations for pressurized metered dose inhalers |
| SE0401773D0 (sv) * | 2004-07-02 | 2004-07-02 | Astrazeneca Ab | An inhalation and a method for assemnling said inhalation device |
| USH2205H1 (en) * | 2004-07-22 | 2007-11-06 | Andersen Jason D | Method and apparatus for purging a propellant from a filling head during the filling of an aerosol container |
| WO2006026754A2 (en) | 2004-09-03 | 2006-03-09 | Plexxikon, Inc. | Bicyclic heteroaryl pde4b inhibitors |
| CN101238047B (zh) * | 2005-08-08 | 2010-06-16 | 诺瓦提斯公司 | 用于定量吸入器的隔热筒罐 |
| GB0518355D0 (en) * | 2005-09-08 | 2005-10-19 | Glaxo Group Ltd | An inhaler |
| CA2657639A1 (en) | 2006-07-19 | 2008-01-24 | Astrazeneca Ab | Novel tricyclic spiropiperidine compounds, their synthesis and their uses as modulators of chemokine receptor activity |
| US8225790B2 (en) | 2007-01-02 | 2012-07-24 | Astrazeneca Ab | Inhaler 624 |
-
2011
- 2011-02-09 CN CN201180018359.6A patent/CN102858640B/zh not_active Expired - Fee Related
- 2011-02-09 JP JP2012552468A patent/JP2013519413A/ja not_active Ceased
- 2011-02-09 NZ NZ625734A patent/NZ625734A/en not_active IP Right Cessation
- 2011-02-09 MX MX2012008906A patent/MX2012008906A/es active IP Right Grant
- 2011-02-09 RU RU2012135067/13A patent/RU2562017C2/ru not_active IP Right Cessation
- 2011-02-09 EP EP11707695A patent/EP2534054A1/en not_active Withdrawn
- 2011-02-09 US US13/577,766 patent/US20130112194A1/en not_active Abandoned
- 2011-02-09 KR KR1020127020892A patent/KR20130004266A/ko not_active Ceased
- 2011-02-09 NZ NZ601454A patent/NZ601454A/en not_active IP Right Cessation
- 2011-02-09 AU AU2011214124A patent/AU2011214124B2/en not_active Ceased
- 2011-02-09 CA CA2788015A patent/CA2788015A1/en not_active Abandoned
- 2011-02-09 WO PCT/GB2011/050222 patent/WO2011098798A1/en not_active Ceased
- 2011-02-09 BR BR112012019878A patent/BR112012019878A2/pt not_active IP Right Cessation
- 2011-02-10 AR ARP110100417A patent/AR080159A1/es unknown
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