JP2013517847A5 - - Google Patents
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- JP2013517847A5 JP2013517847A5 JP2012550219A JP2012550219A JP2013517847A5 JP 2013517847 A5 JP2013517847 A5 JP 2013517847A5 JP 2012550219 A JP2012550219 A JP 2012550219A JP 2012550219 A JP2012550219 A JP 2012550219A JP 2013517847 A5 JP2013517847 A5 JP 2013517847A5
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- cardiac glycoside
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- 239000008194 pharmaceutical composition Substances 0.000 claims 64
- 210000002569 neurons Anatomy 0.000 claims 16
- LPMXVESGRSUGHW-HBYQJFLCSA-N Ouabain Chemical group O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]1C[C@@]2(O)CC[C@H]3[C@@]4(O)CC[C@H](C=5COC(=O)C=5)[C@@]4(C)C[C@@H](O)[C@@H]3[C@@]2(CO)[C@H](O)C1 LPMXVESGRSUGHW-HBYQJFLCSA-N 0.000 claims 10
- 239000002368 cardiac glycoside Substances 0.000 claims 10
- 210000003061 neural cell Anatomy 0.000 claims 5
- 229940053128 Nerve Growth Factor Drugs 0.000 claims 4
- 102000015336 Nerve Growth Factor Human genes 0.000 claims 4
- 108010025020 Nerve Growth Factor Proteins 0.000 claims 4
- 230000027455 binding Effects 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 230000002708 enhancing Effects 0.000 claims 4
- 150000002500 ions Chemical class 0.000 claims 4
- 239000003446 ligand Substances 0.000 claims 4
- 230000001537 neural Effects 0.000 claims 4
- 230000002276 neurotropic Effects 0.000 claims 4
- LTMHDMANZUZIPE-PUGKRICDSA-N Digoxin Chemical group C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O LTMHDMANZUZIPE-PUGKRICDSA-N 0.000 claims 3
- LTMHDMANZUZIPE-AMTYYWEZSA-N Digoxin Natural products O([C@H]1[C@H](C)O[C@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@](C)([C@H](O)C4)[C@H](C4=CC(=O)OC4)CC5)CC3)CC2)C[C@@H]1O)[C@H]1O[C@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@H](O)[C@@H](O)C2)[C@@H](O)C1 LTMHDMANZUZIPE-AMTYYWEZSA-N 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 3
- 229960005156 digoxin Drugs 0.000 claims 3
- 210000003867 nerve cell Anatomy 0.000 claims 3
- HTIQEAQVCYTUBX-UHFFFAOYSA-N Amlodipine Chemical compound CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl HTIQEAQVCYTUBX-UHFFFAOYSA-N 0.000 claims 2
- 206010059512 Apoptosis Diseases 0.000 claims 2
- FFGPTBGBLSHEPO-UHFFFAOYSA-N Carbamazepine Chemical compound C1=CC2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 FFGPTBGBLSHEPO-UHFFFAOYSA-N 0.000 claims 2
- HSUGRBWQSSZJOP-RTWAWAEBSA-N Diltiazem Chemical compound C1=CC(OC)=CC=C1[C@H]1[C@@H](OC(C)=O)C(=O)N(CCN(C)C)C2=CC=CC=C2S1 HSUGRBWQSSZJOP-RTWAWAEBSA-N 0.000 claims 2
- VZFRNCSOCOPNDB-AJKFJWDBSA-N Domoic Acid Chemical compound OC(=O)[C@@H](C)\C=C\C=C(/C)[C@H]1CN[C@H](C(O)=O)[C@H]1CC(O)=O VZFRNCSOCOPNDB-AJKFJWDBSA-N 0.000 claims 2
- -1 Puroshirarijin Substances 0.000 claims 2
- SGTNSNPWRIOYBX-UHFFFAOYSA-N Verapamil Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 claims 2
- 230000036982 action potential Effects 0.000 claims 2
- 239000005409 aflatoxin Substances 0.000 claims 2
- 229960000528 amlodipine Drugs 0.000 claims 2
- 102000004965 antibodies Human genes 0.000 claims 2
- 108090001123 antibodies Proteins 0.000 claims 2
- 230000006907 apoptotic process Effects 0.000 claims 2
- 229960000623 carbamazepine Drugs 0.000 claims 2
- 230000002860 competitive Effects 0.000 claims 2
- 229960004166 diltiazem Drugs 0.000 claims 2
- WHUUTDBJXJRKMK-VKHMYHEASA-L glutamate group Chemical group N[C@@H](CCC(=O)[O-])C(=O)[O-] WHUUTDBJXJRKMK-VKHMYHEASA-L 0.000 claims 2
- WHXSMMKQMYFTQS-UHFFFAOYSA-N lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 claims 2
- 229910052744 lithium Inorganic materials 0.000 claims 2
- 239000002207 metabolite Substances 0.000 claims 2
- 230000002336 repolarization Effects 0.000 claims 2
- 230000002588 toxic Effects 0.000 claims 2
- 231100000331 toxic Toxicity 0.000 claims 2
- 229960001722 verapamil Drugs 0.000 claims 2
- 230000002964 excitative Effects 0.000 claims 1
- 230000004936 stimulating Effects 0.000 claims 1
Claims (32)
- 哺乳動物の標的神経細胞を死滅させるための、増強薬と刺激薬とを含む医薬組成物であって、前記増強薬が、刺激薬により誘導される興奮シグナルの毒性作用を増強するのに十分な量で、前記神経細胞に局所的に送達され、前記刺激薬が、前記神経細胞を過度に刺激して前記神経細胞のアポトーシスを促進するのに十分な量で、前記神経細胞に局所的に送達されることを特徴とする医薬組成物。
- 請求項１に記載の医薬組成物において、前記増強薬が強心配糖体であることを特徴とする医薬組成物。
- 請求項２に記載の医薬組成物において、前記強心配糖体がジゴキシン、プロシラリジン、又はウアビン（ｏｕａｂｉｎ）であることを特徴とする医薬組成物。
- 請求項１に記載の医薬組成物において、前記刺激薬がグルタメート又はドーモイ酸であることを特徴とする医薬組成物。
- 請求項１に記載の医薬組成物において、前記刺激薬が強心配糖体であることを特徴とする医薬組成物。
- 請求項１に記載の医薬組成物において、前記刺激薬が神経成長因子（ＮＧＦ）受容体に対する抗体であることを特徴とする医薬組成物。
- 請求項１に記載の医薬組成物において、前記増強薬が、神経特異的受容体に対して親和性を有する向神経性リガンドに連結されることを特徴とする医薬組成物。
- 請求項１に記載の医薬組成物において、前記刺激薬が、神経特異的受容体に対して親和性を有する向神経性リガンドに連結されることを特徴とする医薬組成物。
- 哺乳動物の標的神経細胞を死滅させるための、増強薬とチャネル遮断薬とを含む医薬組成物であって、前記増強薬が、前記チャネル遮断薬の毒性作用を増強するのに十分な量で、前記神経細胞に局所的に送達され、前記チャネル遮断薬が、前記神経細胞の活動電位及び再分極を遮断するのに十分な量で、前記神経細胞に局所的に送達されることを特徴とする医薬組成物。
- 請求項９に記載の医薬組成物において、前記増強薬が強心配糖体であることを特徴とする医薬組成物。
- 請求項１０に記載の医薬組成物において、前記強心配糖体がジゴキシン、プロシラリジン、又はウアビン（ｏｕａｂｉｎ）であることを特徴とする医薬組成物。
- 請求項９に記載の医薬組成物において、前記チャネル遮断薬が代謝産物であることを特徴とする医薬組成物。
- 請求項９に記載の医薬組成物において、前記チャネル遮断薬がベラパミル、カルバマゼピン、アムロジピン、又はジルチアゼムであることを特徴とする医薬組成物。
- 請求項９に記載の医薬組成物において、前記チャネル遮断薬が競合イオンであることを特徴とする医薬組成物。
- 請求項１４に記載の医薬組成物において、前記競合イオンがリチウムであることを特徴とする医薬組成物。
- 請求項９に記載の医薬組成物において、前記増強薬が、神経特異的受容体に対して親和性を有する向神経性リガンドに連結されることを特徴とする医薬組成物。
- 哺乳動物の標的神経細胞を死滅させるための、刺激薬とチャネル遮断薬とを含む医薬組成物であって、前記刺激薬が、前記神経細胞を過度に刺激して前記神経細胞のアポトーシスを促進するのに十分な量で、前記神経細胞に局所的に送達され、前記チャネル遮断薬が前記神経細胞の活動電位及び再分極を遮断するのに十分な量で、前記神経細胞に局所的に送達されることを特徴とする医薬組成物。
- 請求項１７に記載の医薬組成物において、前記刺激薬がグルタメート又はドーモイ酸であることを特徴とする医薬組成物。
- 請求項１７に記載の医薬組成物において、前記刺激薬が強心配糖体であることを特徴とする医薬組成物。
- 請求項１７に記載の医薬組成物において、前記刺激薬が、神経成長因子（ＮＧＦ）受容体に対する抗体であることを特徴とする医薬組成物。
- 請求項１７に記載の医薬組成物において、前記チャネル遮断薬が代謝産物であることを特徴とする医薬組成物。
- 請求項１７に記載の医薬組成物において、前記チャネル遮断薬がベラパミル、カルバマゼピン、アムロジピン、又はジルチアゼムであることを特徴とする医薬組成物。
- 請求項１７に記載の医薬組成物において、前記チャネル遮断薬が競合イオンであることを特徴とする医薬組成物。
- 請求項２３に記載の医薬組成物において、前記競合イオンがリチウムであることを特徴とする医薬組成物。
- 請求項１７に記載の医薬組成物において、前記刺激薬が、神経特異的受容体に対して親和性を有する向神経性リガンドに連結されることを特徴とする医薬組成物。
- 哺乳動物の標的神経細胞を死滅させるための、強心配糖体を含む医薬組成物であって、前記強心配糖体が、前記神経細胞を死滅させるのに十分な量で、前記神経細胞に局所的に送達されることを特徴とする医薬組成物。
- 請求項２６に記載の医薬組成物において、前記強心配糖体がジゴキシンであることを特徴とする医薬組成物。
- 請求項２７に記載の医薬組成物において、前記量が０．０００１〜１０ｍＭであることを特徴とする医薬組成物。
- 請求項２６に記載の医薬組成物において、前記強心配糖体がプロシラリジンであることを特徴とする医薬組成物。
- 請求項２９に記載の医薬組成物において、前記量が０．０００１〜１０ｍＭであることを特徴とする医薬組成物。
- 哺乳動物の標的神経細胞を死滅させるための、アフラトキシンを含む医薬組成物であって、前記アフラトキシンが、前記神経細胞を死滅させるのに十分な量で、前記神経細胞に局所的に送達されることを特徴とする医薬組成物。
- 請求項３１に記載の医薬組成物において、前記量が０．００００１〜０．００３ｍＭであることを特徴とする医薬組成物。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33683810P | 2010-01-26 | 2010-01-26 | |
| US61/336,838 | 2010-01-26 | ||
| PCT/US2011/022653 WO2011094367A1 (en) | 2010-01-26 | 2011-01-26 | Methods, devices, and agents for denervation |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016115237A Division JP2016199559A (ja) | 2010-01-26 | 2016-06-09 | 除神経のための方法、装置、及び薬剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013517847A JP2013517847A (ja) | 2013-05-20 |
| JP2013517847A5 true JP2013517847A5 (ja) | 2014-03-13 |
| JP5952195B2 JP5952195B2 (ja) | 2016-07-13 |
Family
ID=43735722
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012550219A Expired - Fee Related JP5952195B2 (ja) | 2010-01-26 | 2011-01-26 | 除神経のための方法、装置、及び薬剤 |
| JP2016115237A Pending JP2016199559A (ja) | 2010-01-26 | 2016-06-09 | 除神経のための方法、装置、及び薬剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016115237A Pending JP2016199559A (ja) | 2010-01-26 | 2016-06-09 | 除神経のための方法、装置、及び薬剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US20110184337A1 (ja) |
| EP (2) | EP3246035A1 (ja) |
| JP (2) | JP5952195B2 (ja) |
| CN (2) | CN105640501A (ja) |
| CA (1) | CA2787062C (ja) |
| WO (1) | WO2011094367A1 (ja) |
Families Citing this family (92)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6302875B1 (en) | 1996-10-11 | 2001-10-16 | Transvascular, Inc. | Catheters and related devices for forming passageways between blood vessels or other anatomical structures |
| US20070135875A1 (en) | 2002-04-08 | 2007-06-14 | Ardian, Inc. | Methods and apparatus for thermally-induced renal neuromodulation |
| US8150519B2 (en) | 2002-04-08 | 2012-04-03 | Ardian, Inc. | Methods and apparatus for bilateral renal neuromodulation |
| US6978174B2 (en) | 2002-04-08 | 2005-12-20 | Ardian, Inc. | Methods and devices for renal nerve blocking |
| US20080213331A1 (en) | 2002-04-08 | 2008-09-04 | Ardian, Inc. | Methods and devices for renal nerve blocking |
| US20070129761A1 (en) | 2002-04-08 | 2007-06-07 | Ardian, Inc. | Methods for treating heart arrhythmia |
| US9636174B2 (en) | 2002-04-08 | 2017-05-02 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for therapeutic renal neuromodulation |
| US7653438B2 (en) | 2002-04-08 | 2010-01-26 | Ardian, Inc. | Methods and apparatus for renal neuromodulation |
| US7617005B2 (en) | 2002-04-08 | 2009-11-10 | Ardian, Inc. | Methods and apparatus for thermally-induced renal neuromodulation |
| US20040082859A1 (en) | 2002-07-01 | 2004-04-29 | Alan Schaer | Method and apparatus employing ultrasound energy to treat body sphincters |
| WO2006063199A2 (en) | 2004-12-09 | 2006-06-15 | The Foundry, Inc. | Aortic valve repair |
| EP2376011B1 (en) | 2009-01-09 | 2019-07-03 | ReCor Medical, Inc. | Apparatus for treatment of mitral valve insufficiency |
| EP3132828B1 (en) | 2009-10-30 | 2017-10-11 | ReCor Medical, Inc. | Apparatus for treatment of hypertension through percutaneous ultrasound renal denervation |
| WO2013169741A1 (en) * | 2012-05-08 | 2013-11-14 | Stein Emily A | Agents and devices for affecting nerve function |
| US11214610B2 (en) | 2010-12-01 | 2022-01-04 | H. Lundbeck A/S | High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris |
| US9067988B2 (en) | 2010-12-01 | 2015-06-30 | Alderbio Holdings Llc | Methods of preventing or treating pain using anti-NGF antibodies |
| US9078878B2 (en) | 2010-12-01 | 2015-07-14 | Alderbio Holdings Llc | Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75 |
| US9884909B2 (en) | 2010-12-01 | 2018-02-06 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
| JP6190723B2 (ja) | 2010-12-01 | 2017-08-30 | アルダーバイオ ホールディングス エルエルシー | 抗ｎｇｆ組成物およびその使用 |
| US9539324B2 (en) | 2010-12-01 | 2017-01-10 | Alderbio Holdings, Llc | Methods of preventing inflammation and treating pain using anti-NGF compositions |
| CN103517731B (zh) | 2011-04-08 | 2016-08-31 | 柯惠有限合伙公司 | 用于去除肾交感神经和离子电渗式药物传递的离子电渗式药物传递系统和方法 |
| US9237925B2 (en) | 2011-04-22 | 2016-01-19 | Ablative Solutions, Inc. | Expandable catheter system for peri-ostial injection and muscle and nerve fiber ablation |
| US8663190B2 (en) | 2011-04-22 | 2014-03-04 | Ablative Solutions, Inc. | Expandable catheter system for peri-ostial injection and muscle and nerve fiber ablation |
| US8909316B2 (en) * | 2011-05-18 | 2014-12-09 | St. Jude Medical, Cardiology Division, Inc. | Apparatus and method of assessing transvascular denervation |
| US9492113B2 (en) | 2011-07-15 | 2016-11-15 | Boston Scientific Scimed, Inc. | Systems and methods for monitoring organ activity |
| US20130274674A1 (en) * | 2011-08-24 | 2013-10-17 | Ablative Solutions, Inc. | Intravascular ablation catheter with precision depth of penetration calibration |
| US9056185B2 (en) | 2011-08-24 | 2015-06-16 | Ablative Solutions, Inc. | Expandable catheter system for fluid injection into and deep to the wall of a blood vessel |
| US9278196B2 (en) | 2011-08-24 | 2016-03-08 | Ablative Solutions, Inc. | Expandable catheter system for vessel wall injection and muscle and nerve fiber ablation |
| US20130053792A1 (en) | 2011-08-24 | 2013-02-28 | Ablative Solutions, Inc. | Expandable catheter system for vessel wall injection and muscle and nerve fiber ablation |
| US8702619B2 (en) * | 2011-08-26 | 2014-04-22 | Symap Holding Limited | Mapping sympathetic nerve distribution for renal ablation and catheters for same |
| US9014821B2 (en) * | 2011-08-26 | 2015-04-21 | Symap Holding Limited | System and method for locating and identifying the functional nerves innervating the wall of arteries and catheters for same |
| US9820811B2 (en) | 2011-08-26 | 2017-11-21 | Symap Medical (Suzhou), Ltd | System and method for mapping the functional nerves innervating the wall of arteries, 3-D mapping and catheters for same |
| EP2750765A4 (en) * | 2011-09-01 | 2015-07-01 | Perseus Biomed Inc | METHOD AND SYSTEM FOR MODULATING TISSUE |
| US20140343590A1 (en) | 2011-09-16 | 2014-11-20 | Syntach Ag | Device, And A Method For Treatment Of Increased Blood Pressure |
| WO2013052852A1 (en) * | 2011-10-07 | 2013-04-11 | Boston Scientific Scimed, Inc. | Methods and systems for detection and thermal treatment of lower urinary tract conditions |
| US20150202220A1 (en) * | 2011-10-26 | 2015-07-23 | Northwind Medical, Inc. | Agents, methods, and devices for affecting nerve function |
| AU2013229776B2 (en) | 2012-03-08 | 2016-12-15 | Medtronic Af Luxembourg S.A.R.L. | Biomarker sampling in the context of neuromodulation devices and associated systems |
| US20150151077A1 (en) * | 2012-06-13 | 2015-06-04 | Douglas C. Harrington | Devices And Methods For Renal Denervation |
| US8951296B2 (en) * | 2012-06-29 | 2015-02-10 | Medtronic Ardian Luxembourg S.A.R.L. | Devices and methods for photodynamically modulating neural function in a human |
| US9333035B2 (en) | 2012-09-19 | 2016-05-10 | Denervx LLC | Cooled microwave denervation |
| US9554849B2 (en) | 2012-10-29 | 2017-01-31 | Ablative Solutions, Inc. | Transvascular method of treating hypertension |
| US8740849B1 (en) * | 2012-10-29 | 2014-06-03 | Ablative Solutions, Inc. | Peri-vascular tissue ablation catheter with support structures |
| US9526827B2 (en) | 2012-10-29 | 2016-12-27 | Ablative Solutions, Inc. | Peri-vascular tissue ablation catheter with support structures |
| US10736656B2 (en) | 2012-10-29 | 2020-08-11 | Ablative Solutions | Method for painless renal denervation using a peri-vascular tissue ablation catheter with support structures |
| US9301795B2 (en) | 2012-10-29 | 2016-04-05 | Ablative Solutions, Inc. | Transvascular catheter for extravascular delivery |
| US10881458B2 (en) | 2012-10-29 | 2021-01-05 | Ablative Solutions, Inc. | Peri-vascular tissue ablation catheters |
| US10945787B2 (en) | 2012-10-29 | 2021-03-16 | Ablative Solutions, Inc. | Peri-vascular tissue ablation catheters |
| US10226278B2 (en) | 2012-10-29 | 2019-03-12 | Ablative Solutions, Inc. | Method for painless renal denervation using a peri-vascular tissue ablation catheter with support structures |
| US10537375B2 (en) | 2015-04-24 | 2020-01-21 | Neurotronic, Inc. | Chemical ablation and method of treatment for various diseases |
| US20150272666A1 (en) * | 2012-11-02 | 2015-10-01 | Lixiao Wang | Chemical Ablation Formulations and Methods of Treatments for Various Diseases |
| US9770593B2 (en) | 2012-11-05 | 2017-09-26 | Pythagoras Medical Ltd. | Patient selection using a transluminally-applied electric current |
| CN107334525B (zh) | 2012-11-05 | 2019-10-08 | 毕达哥拉斯医疗有限公司 | 受控组织消融 |
| CA2894718A1 (en) * | 2012-11-21 | 2014-05-30 | Circuit Therapeutics, Inc. | System and method for optogenetic therapy |
| CN104000998A (zh) * | 2013-02-26 | 2014-08-27 | 陈清群 | 虎眼万年青植物茶 |
| US10076384B2 (en) | 2013-03-08 | 2018-09-18 | Symple Surgical, Inc. | Balloon catheter apparatus with microwave emitter |
| EP2971232A1 (en) | 2013-03-14 | 2016-01-20 | ReCor Medical, Inc. | Methods of plating or coating ultrasound transducers |
| EP3111994B1 (en) | 2013-03-14 | 2020-12-02 | ReCor Medical, Inc. | Ultrasound-based neuromodulation system |
| CA2909793A1 (en) * | 2013-03-15 | 2014-09-18 | Kondapavulur T. Venkateswara-Rao | Methods and devices for affecting nerve function |
| EP3010581B1 (en) * | 2013-06-18 | 2023-10-11 | Nalu Medical, Inc. | Apparatus for minimally invasive implantable modulators |
| US9949652B2 (en) | 2013-10-25 | 2018-04-24 | Ablative Solutions, Inc. | Apparatus for effective ablation and nerve sensing associated with denervation |
| US10517666B2 (en) | 2013-10-25 | 2019-12-31 | Ablative Solutions, Inc. | Apparatus for effective ablation and nerve sensing associated with denervation |
| US10390881B2 (en) | 2013-10-25 | 2019-08-27 | Denervx LLC | Cooled microwave denervation catheter with insertion feature |
| US9931046B2 (en) | 2013-10-25 | 2018-04-03 | Ablative Solutions, Inc. | Intravascular catheter with peri-vascular nerve activity sensors |
| JP2015112114A (ja) * | 2013-12-06 | 2015-06-22 | 株式会社グッドマン | 神経電位測定用カテーテル |
| US10286190B2 (en) | 2013-12-11 | 2019-05-14 | Cook Medical Technologies Llc | Balloon catheter with dynamic vessel engaging member |
| US20150209107A1 (en) | 2014-01-24 | 2015-07-30 | Denervx LLC | Cooled microwave denervation catheter configuration |
| US10004913B2 (en) | 2014-03-03 | 2018-06-26 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and apparatus for power conversion and data transmission in implantable sensors, stimulators, and actuators |
| EP3139853B1 (en) | 2014-05-07 | 2018-12-19 | Pythagoras Medical Ltd. | Controlled tissue ablation apparatus |
| WO2015171213A1 (en) | 2014-05-09 | 2015-11-12 | The Board Of Trustees Of The Leland Stanford Junior University | Autofocus wireless power transfer to implantable devices in freely moving animals |
| WO2016028753A1 (en) * | 2014-08-20 | 2016-02-25 | Yale University | Novel compositions and methods useful for treating or preventing liver diseases or disorders, and promoting weight loss |
| US11154712B2 (en) | 2014-08-28 | 2021-10-26 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for assessing efficacy of renal neuromodulation and associated systems and devices |
| US10231778B2 (en) * | 2014-10-20 | 2019-03-19 | Biosense Webster (Israel) Ltd. | Methods for contemporaneous assessment of renal denervation |
| WO2016065245A1 (en) | 2014-10-24 | 2016-04-28 | Incept, Llc | Extra luminal scaffold |
| US10286191B2 (en) | 2014-10-30 | 2019-05-14 | Neurotronic, Inc. | Chemical ablation and method of treatment for various diseases |
| EP3069719B1 (de) * | 2015-03-19 | 2019-10-09 | B. Braun Melsungen AG | Renale denervierung |
| CN104759117B (zh) * | 2015-03-25 | 2016-05-25 | 上海交通大学 | 软骨藻酸分子印迹固相萃取小柱及其制备方法和应用 |
| US10383685B2 (en) | 2015-05-07 | 2019-08-20 | Pythagoras Medical Ltd. | Techniques for use with nerve tissue |
| US9918822B2 (en) * | 2015-10-20 | 2018-03-20 | Abbott Cardiovascular Systems Inc. | System and method for renal neuromodulation by oversized stent |
| CN108367162A (zh) * | 2015-12-10 | 2018-08-03 | 圣犹达医疗用品心脏病学部门有限公司 | 血管隔离消融设备 |
| GB201602576D0 (en) | 2016-02-12 | 2016-03-30 | Bergen Teknologioverforing As | Process |
| US9861504B2 (en) | 2016-03-25 | 2018-01-09 | Abbott Cardiovascular Systems Inc. | System and method for renal neuromodulation by adjustable oversized stent |
| US11678932B2 (en) | 2016-05-18 | 2023-06-20 | Symap Medical (Suzhou) Limited | Electrode catheter with incremental advancement |
| EP3484577A4 (en) | 2016-07-18 | 2020-03-25 | Nalu Medical, Inc. | METHODS AND SYSTEMS FOR THE TREATMENT OF PELVIC DISORDERS AND PAINFUL CONDITIONS |
| WO2018026766A1 (en) | 2016-08-01 | 2018-02-08 | The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Compositions and methods for treating cardiac injury |
| EP3585475B1 (en) | 2017-02-24 | 2024-04-03 | Nalu Medical, Inc. | Apparatus with sequentially implanted stimulators |
| US10595842B2 (en) * | 2017-03-16 | 2020-03-24 | William Joseph Drasler | Expandable cardiac access catheter |
| US11229810B2 (en) * | 2017-05-17 | 2022-01-25 | University Of Virginia Patent Foundation | Methods and systems for producing neuronal lesions using magnetic resonance and acoustic energy |
| US11116561B2 (en) | 2018-01-24 | 2021-09-14 | Medtronic Ardian Luxembourg S.A.R.L. | Devices, agents, and associated methods for selective modulation of renal nerves |
| US10849685B2 (en) | 2018-07-18 | 2020-12-01 | Ablative Solutions, Inc. | Peri-vascular tissue access catheter with locking handle |
| CN211300299U (zh) | 2018-10-06 | 2020-08-21 | 苏州信迈医疗器械有限公司 | 一种具有肾神经标测功能的导管 |
| US20220409257A1 (en) * | 2018-10-17 | 2022-12-29 | University Of Florida Research Foundation, Inc. | Controlling esophageal temperature during cardiac ablation |
| WO2021100316A1 (ja) * | 2019-11-18 | 2021-05-27 | 株式会社カネカ | 薬液拡散システムおよび薬液拡散促進装置 |
Family Cites Families (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4578061A (en) | 1980-10-28 | 1986-03-25 | Lemelson Jerome H | Injection catheter and method |
| GB8308126D0 (en) | 1983-03-24 | 1983-05-05 | Bloch M | Pharmaceutical compositions |
| IT1251540B (it) * | 1991-05-31 | 1995-05-17 | Fidia Spa | Uso di un derivato gangliosidico. |
| DE4235506A1 (de) | 1992-10-21 | 1994-04-28 | Bavaria Med Tech | Katheter zur Injektion von Arzneimitteln |
| US5746716A (en) | 1995-07-10 | 1998-05-05 | Interventional Technologies Inc. | Catheter for injecting fluid medication into an arterial wall |
| US5693029A (en) | 1995-07-10 | 1997-12-02 | World Medical Manufacturing Corporation | Pro-cell intra-cavity therapeutic agent delivery device |
| US6283951B1 (en) | 1996-10-11 | 2001-09-04 | Transvascular, Inc. | Systems and methods for delivering drugs to selected locations within the body |
| US6802841B2 (en) | 1998-06-04 | 2004-10-12 | Curon Medical, Inc. | Systems and methods for applying a selected treatment agent into contact with tissue to treat sphincter dysfunction |
| US6217554B1 (en) | 1999-02-12 | 2001-04-17 | Pharmaspec Corporation | Methods and apparatus for delivering substances into extravascular tissue |
| EP1169060B1 (en) * | 1999-04-09 | 2005-08-31 | Euro-Celtique S.A. | Sodium channel blocker compositions and the use thereof |
| US6302870B1 (en) | 1999-04-29 | 2001-10-16 | Precision Vascular Systems, Inc. | Apparatus for injecting fluids into the walls of blood vessels, body cavities, and the like |
| WO2001047558A1 (fr) | 1999-12-28 | 2001-07-05 | Kaken Pharmaceutical Co., Ltd. | Medicaments protegeant les nerfs |
| US6464986B1 (en) | 2000-04-14 | 2002-10-15 | Allegan Sales, Inc. | Method for treating pain by peripheral administration of a neurotoxin |
| US20020072706A1 (en) | 2000-12-11 | 2002-06-13 | Thomas Hiblar | Transluminal drug delivery catheter |
| US6692466B1 (en) | 2000-12-21 | 2004-02-17 | Advanced Cardiovascular Systems, Inc. | Drug delivery catheter with retractable needle |
| CA2435418A1 (en) | 2001-01-24 | 2002-08-01 | Mestex Ag | Use of neurotoxic substances in producing a medicament for treating joint pains |
| US7127284B2 (en) | 2001-06-11 | 2006-10-24 | Mercator Medsystems, Inc. | Electroporation microneedle and methods for its use |
| US20060116736A1 (en) | 2001-07-23 | 2006-06-01 | Dilorenzo Daniel J | Method, apparatus, and surgical technique for autonomic neuromodulation for the treatment of obesity |
| US7615049B2 (en) | 2001-09-19 | 2009-11-10 | Mederi Therapeutics, Inc. | Devices, systems and methods for treating tissue regions of the body |
| US7547294B2 (en) | 2001-09-20 | 2009-06-16 | The Regents Of The University Of California | Microfabricated surgical device for interventional procedures |
| US6860867B2 (en) | 2001-09-20 | 2005-03-01 | The Regents Of The University Of California | Method of interventional surgery |
| US20030171734A1 (en) | 2002-01-22 | 2003-09-11 | Endobionics, Inc. | Methods and kits for delivering pharmaceutical agents into the coronary vascular adventitia |
| US7744584B2 (en) | 2002-01-22 | 2010-06-29 | Mercator Medsystems, Inc. | Methods and kits for volumetric distribution of pharmaceutical agents via the vascular adventitia and microcirculation |
| US20060189941A1 (en) | 2002-01-22 | 2006-08-24 | Mercator Medsystems, Inc. | Methods and kits for volumetric distribution of pharmaceutical agents via the vascular adventitia and microcirculation |
| US7155284B1 (en) | 2002-01-24 | 2006-12-26 | Advanced Bionics Corporation | Treatment of hypertension |
| US20110207758A1 (en) | 2003-04-08 | 2011-08-25 | Medtronic Vascular, Inc. | Methods for Therapeutic Renal Denervation |
| US7853333B2 (en) | 2002-04-08 | 2010-12-14 | Ardian, Inc. | Methods and apparatus for multi-vessel renal neuromodulation |
| US8145317B2 (en) | 2002-04-08 | 2012-03-27 | Ardian, Inc. | Methods for renal neuromodulation |
| US7653438B2 (en) * | 2002-04-08 | 2010-01-26 | Ardian, Inc. | Methods and apparatus for renal neuromodulation |
| US8175711B2 (en) | 2002-04-08 | 2012-05-08 | Ardian, Inc. | Methods for treating a condition or disease associated with cardio-renal function |
| US8347891B2 (en) | 2002-04-08 | 2013-01-08 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen |
| US8131371B2 (en) | 2002-04-08 | 2012-03-06 | Ardian, Inc. | Methods and apparatus for monopolar renal neuromodulation |
| US8150519B2 (en) | 2002-04-08 | 2012-04-03 | Ardian, Inc. | Methods and apparatus for bilateral renal neuromodulation |
| US8774913B2 (en) | 2002-04-08 | 2014-07-08 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and apparatus for intravasculary-induced neuromodulation |
| US7620451B2 (en) | 2005-12-29 | 2009-11-17 | Ardian, Inc. | Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach |
| US6978174B2 (en) * | 2002-04-08 | 2005-12-20 | Ardian, Inc. | Methods and devices for renal nerve blocking |
| US20070129761A1 (en) | 2002-04-08 | 2007-06-07 | Ardian, Inc. | Methods for treating heart arrhythmia |
| US8145316B2 (en) | 2002-04-08 | 2012-03-27 | Ardian, Inc. | Methods and apparatus for renal neuromodulation |
| US7617005B2 (en) | 2002-04-08 | 2009-11-10 | Ardian, Inc. | Methods and apparatus for thermally-induced renal neuromodulation |
| US7756583B2 (en) | 2002-04-08 | 2010-07-13 | Ardian, Inc. | Methods and apparatus for intravascularly-induced neuromodulation |
| US20080213331A1 (en) | 2002-04-08 | 2008-09-04 | Ardian, Inc. | Methods and devices for renal nerve blocking |
| US7162303B2 (en) | 2002-04-08 | 2007-01-09 | Ardian, Inc. | Renal nerve stimulation method and apparatus for treatment of patients |
| AU2003245344A1 (en) | 2002-05-28 | 2003-12-12 | Endobionics, Inc. | Methods and apparatus for aspiration and priming of inflatable structures in catheters |
| US7465298B2 (en) | 2002-06-28 | 2008-12-16 | Mercator Medsystems, Inc. | Methods and systems for delivering liquid substances to tissues surrounding body lumens |
| CA2493041C (en) * | 2002-07-19 | 2011-08-16 | Dominik Meyer | Injectable pharmaceutical composition for treating post-operative joint pain comprising an amide local anesthetic |
| US6991617B2 (en) | 2002-08-21 | 2006-01-31 | Hektner Thomas R | Vascular treatment method and device |
| US7063679B2 (en) * | 2002-09-20 | 2006-06-20 | Flowmedica, Inc. | Intra-aortic renal delivery catheter |
| AU2003294226A1 (en) * | 2002-09-20 | 2004-04-23 | Flowmedica, Inc. | Method and apparatus for intra aortic substance delivery to a branch vessel |
| US20040162542A1 (en) | 2002-12-03 | 2004-08-19 | Endobionics, Inc. | Methods and systems for treating the vasculature with estrogens |
| WO2004056305A2 (en) | 2002-12-18 | 2004-07-08 | Algorx | Administration of capsaicinoids |
| US7149574B2 (en) | 2003-06-09 | 2006-12-12 | Palo Alto Investors | Treatment of conditions through electrical modulation of the autonomic nervous system |
| AU2004252150B2 (en) * | 2003-06-26 | 2008-11-20 | Merck Sharp & Dohme Corp. | Benzodiazepine CGRP receptor antagonists |
| US20050182071A1 (en) | 2003-09-16 | 2005-08-18 | Endobionics, Inc. | Methods and systems for inhibiting arrhythmia |
| US7273469B1 (en) * | 2003-12-31 | 2007-09-25 | Advanced Cardiovascular Systems, Inc. | Modified needle catheter for directional orientation delivery |
| US20050245862A1 (en) | 2004-04-28 | 2005-11-03 | Endobionics, Inc. | Torque mechanism for interventional catheters |
| EP1799302B1 (en) * | 2004-07-28 | 2015-03-04 | Ardian, Inc. | Devices for renal nerve blocking |
| US20070083239A1 (en) | 2005-09-23 | 2007-04-12 | Denise Demarais | Methods and apparatus for inducing, monitoring and controlling renal neuromodulation |
| US7879011B2 (en) | 2004-11-18 | 2011-02-01 | Silk Road Medical, Inc. | Endoluminal delivery of anesthesia |
| US7837670B2 (en) | 2005-03-22 | 2010-11-23 | Boston Scientific Scimed, Inc. | Methods and devices for delivering therapeutic agents into the prostate gland |
| US10076641B2 (en) | 2005-05-11 | 2018-09-18 | The Spectranetics Corporation | Methods and systems for delivering substances into luminal walls |
| US20070021803A1 (en) | 2005-07-22 | 2007-01-25 | The Foundry Inc. | Systems and methods for neuromodulation for treatment of pain and other disorders associated with nerve conduction |
| US10716749B2 (en) | 2005-11-03 | 2020-07-21 | Palo Alto Investors | Methods and compositions for treating a renal disease condition in a subject |
| ES2335520T3 (es) | 2006-02-24 | 2010-03-29 | National University Of Ireland, Galway | Dispositivo de tratamiento intravascular minimamente invasivo. |
| US20070250035A1 (en) | 2006-04-19 | 2007-10-25 | El-Nounou Fozan O | Devices and methods for intravascular drug delivery |
| EP2019649A4 (en) | 2006-04-27 | 2012-09-19 | Narmada R Shenoy | COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING BODILUM DISORDER DISORDERS |
| US20080004596A1 (en) | 2006-05-25 | 2008-01-03 | Palo Alto Institute | Delivery of agents by microneedle catheter |
| EP3395409B1 (en) * | 2006-06-28 | 2022-08-31 | Medtronic Ardian Luxembourg S.à.r.l. | Systems for thermally-induced renal neuromodulation |
| US7691080B2 (en) | 2006-09-21 | 2010-04-06 | Mercator Medsystems, Inc. | Dual modulus balloon for interventional procedures |
| US8579956B2 (en) | 2007-09-28 | 2013-11-12 | Abbott Cardiovascular Systems Inc. | Methods and devices for treating lesions |
| WO2009103932A1 (en) * | 2008-02-19 | 2009-08-27 | Henderson Morley Plc | Use of a cardiac glycoside and/or a diuretic for the treatment of neuropathic pain |
| US7925352B2 (en) * | 2008-03-27 | 2011-04-12 | Synecor Llc | System and method for transvascularly stimulating contents of the carotid sheath |
| US8808345B2 (en) | 2008-12-31 | 2014-08-19 | Medtronic Ardian Luxembourg S.A.R.L. | Handle assemblies for intravascular treatment devices and associated systems and methods |
| US20100168739A1 (en) | 2008-12-31 | 2010-07-01 | Ardian, Inc. | Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation |
| CA2759929C (en) | 2009-04-22 | 2017-03-21 | Mercator Medsystems, Inc. | Use of guanethidine for treating hypertension by local vascular delivery |
| US20110112400A1 (en) | 2009-11-06 | 2011-05-12 | Ardian, Inc. | High intensity focused ultrasound catheter apparatuses, systems, and methods for renal neuromodulation |
| WO2011091069A1 (en) | 2010-01-19 | 2011-07-28 | Ardian, Inc. | Methods and apparatus for renal neuromodulation via stereotactic radiotherapy |
| US20110208173A1 (en) | 2010-02-24 | 2011-08-25 | Medtronic Vascular, Inc. | Methods for Treating sleep apnea via renal Denervation |
| US8870863B2 (en) | 2010-04-26 | 2014-10-28 | Medtronic Ardian Luxembourg S.A.R.L. | Catheter apparatuses, systems, and methods for renal neuromodulation |
-
2011
- 2011-01-26 CN CN201511021256.1A patent/CN105640501A/zh active Pending
- 2011-01-26 EP EP17154220.2A patent/EP3246035A1/en not_active Withdrawn
- 2011-01-26 US US13/014,702 patent/US20110184337A1/en not_active Abandoned
- 2011-01-26 WO PCT/US2011/022653 patent/WO2011094367A1/en active Application Filing
- 2011-01-26 CA CA2787062A patent/CA2787062C/en not_active Expired - Fee Related
- 2011-01-26 CN CN201180006941.0A patent/CN102892454B/zh not_active Expired - Fee Related
- 2011-01-26 JP JP2012550219A patent/JP5952195B2/ja not_active Expired - Fee Related
- 2011-01-26 US US13/014,700 patent/US8975233B2/en not_active Expired - Fee Related
- 2011-01-26 EP EP11703963A patent/EP2528649A1/en not_active Withdrawn
- 2011-04-28 US US13/096,446 patent/US9056184B2/en not_active Expired - Fee Related
-
2016
- 2016-06-09 JP JP2016115237A patent/JP2016199559A/ja active Pending
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