JP2013517330A - 抗ｉｌｔ５抗体およびｉｌｔ５結合抗体断片 - Google Patents

抗ｉｌｔ５抗体およびｉｌｔ５結合抗体断片 Download PDF

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JP2013517330A
JP2013517330A JP2012550125A JP2012550125A JP2013517330A JP 2013517330 A JP2013517330 A JP 2013517330A JP 2012550125 A JP2012550125 A JP 2012550125A JP 2012550125 A JP2012550125 A JP 2012550125A JP 2013517330 A JP2013517330 A JP 2013517330A
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seq
ilt5
antibody
amino acid
acid sequence
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Japanese (ja)
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JP2013517330A5 (OSRAM
Inventor
イリーナ アポーストルー
ポール ポナス
ジョセ エフ． ポンテ
マイケル ローゼンツワイク
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トーラックス インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54—F(ab')2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2012550125A 2010-01-20 2011-01-20 抗ｉｌｔ５抗体およびｉｌｔ５結合抗体断片 Pending JP2013517330A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29679110P 2010-01-20 2010-01-20
US61/296,791 2010-01-20
PCT/US2011/021939 WO2011091177A1 (en) 2010-01-20 2011-01-20 Anti-ilt5 antibodies and ilt5-binding antibody fragments

Publications (2)

Publication Number Publication Date
JP2013517330A true JP2013517330A (ja) 2013-05-16
JP2013517330A5 JP2013517330A5 (OSRAM) 2014-03-06

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JP2012550125A Pending JP2013517330A (ja) 2010-01-20 2011-01-20 抗ｉｌｔ５抗体およびｉｌｔ５結合抗体断片

Country Status (6)

Country Link
US (2) US9023997B2 (OSRAM)
EP (1) EP2525813B1 (OSRAM)
JP (1) JP2013517330A (OSRAM)
AU (1) AU2011207253B2 (OSRAM)
CA (1) CA2787783A1 (OSRAM)
WO (1) WO2011091177A1 (OSRAM)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013517331A (ja) * 2010-01-20 2013-05-16 トーラックス インコーポレイテッド 抗ｉｌｔ５抗体およびｉｌｔ５結合抗体断片による免疫調節
WO2020196926A1 (ja) * 2019-03-28 2020-10-01 学校法人早稲田大学 細胞競合の制御剤
JP2022517809A (ja) * 2019-01-18 2022-03-10 ユニバーシティ ヘルス ネットワーク Ｌｉｌｒｂ３結合分子とその使用
JP2023515398A (ja) * 2020-02-12 2023-04-13 バイオインベント インターナショナル アクティエボラーグ Ｌｉｌｒｂ３抗体分子およびその使用

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CN105177091A (zh) 2006-03-31 2015-12-23 中外制药株式会社 用于纯化双特异性抗体的抗体修饰方法
CA2647846C (en) 2006-03-31 2016-06-21 Chugai Seiyaku Kabushiki Kaisha Methods for controlling blood pharmacokinetics of antibodies
CN106519025B (zh) 2007-09-26 2021-04-23 中外制药株式会社 利用cdr的氨基酸取代来改变抗体等电点的方法
KR102339457B1 (ko) 2007-09-26 2021-12-14 추가이 세이야쿠 가부시키가이샤 항체 정상영역 개변체
US9228017B2 (en) 2009-03-19 2016-01-05 Chugai Seiyaku Kabushiki Kaisha Antibody constant region variant
WO2010107109A1 (ja) 2009-03-19 2010-09-23 中外製薬株式会社 抗体定常領域改変体
US10150808B2 (en) 2009-09-24 2018-12-11 Chugai Seiyaku Kabushiki Kaisha Modified antibody constant regions
EP2543730B1 (en) 2010-03-04 2018-10-31 Chugai Seiyaku Kabushiki Kaisha Antibody constant region variant
CN113527469A (zh) 2012-02-09 2021-10-22 中外制药株式会社 抗体的Fc区变异体
US20150174203A1 (en) * 2012-05-30 2015-06-25 Icahn School Of Medicine At Mount Sinai Compositions And Methods For Modulating Pro-Inflammatory Immune Response
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CN105764922B (zh) 2013-09-27 2020-07-17 中外制药株式会社 多肽异源多聚体的制备方法
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WO2016159213A1 (ja) 2015-04-01 2016-10-06 中外製薬株式会社 ポリペプチド異種多量体の製造方法
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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013517331A (ja) * 2010-01-20 2013-05-16 トーラックス インコーポレイテッド 抗ｉｌｔ５抗体およびｉｌｔ５結合抗体断片による免疫調節
JP2022517809A (ja) * 2019-01-18 2022-03-10 ユニバーシティ ヘルス ネットワーク Ｌｉｌｒｂ３結合分子とその使用
JP7631203B2 (ja) 2019-01-18 2025-02-18 ユニバーシティ ヘルス ネットワーク Ｌｉｌｒｂ３結合分子とその使用
US12404327B2 (en) 2019-01-18 2025-09-02 University Health Network LILRB3-binding molecules and uses therefor
WO2020196926A1 (ja) * 2019-03-28 2020-10-01 学校法人早稲田大学 細胞競合の制御剤
JPWO2020196926A1 (OSRAM) * 2019-03-28 2020-10-01
CN113939316A (zh) * 2019-03-28 2022-01-14 学校法人早稻田大学 细胞竞争调控剂
JP7696617B2 (ja) 2019-03-28 2025-06-23 剛 丸山 細胞競合の制御剤
JP2023515398A (ja) * 2020-02-12 2023-04-13 バイオインベント インターナショナル アクティエボラーグ Ｌｉｌｒｂ３抗体分子およびその使用

Also Published As

Publication number Publication date
WO2011091177A1 (en) 2011-07-28
CA2787783A1 (en) 2011-07-28
EP2525813B1 (en) 2017-01-04
AU2011207253A1 (en) 2012-08-16
EP2525813A1 (en) 2012-11-28
EP2525813A4 (en) 2013-07-10
US20130030156A1 (en) 2013-01-31
US9828425B2 (en) 2017-11-28
AU2011207253B2 (en) 2015-02-12
US9023997B2 (en) 2015-05-05
US20150197570A1 (en) 2015-07-16

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