JP2013517279A - 化合物及び方法 - Google Patents

化合物及び方法 Download PDF

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Publication number
JP2013517279A
JP2013517279A JP2012549065A JP2012549065A JP2013517279A JP 2013517279 A JP2013517279 A JP 2013517279A JP 2012549065 A JP2012549065 A JP 2012549065A JP 2012549065 A JP2012549065 A JP 2012549065A JP 2013517279 A JP2013517279 A JP 2013517279A
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Japan
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alkyl
optionally substituted
compound
cycloalkyl
substituted
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Japanese (ja)
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JP2013517279A5 (enExample
Inventor
エルカン、バログル
ショミール、ゴーシュ
メルセデス、ロベラ
ダービー、シュミット
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Tempero Pharmaceuticals Inc
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Tempero Pharmaceuticals Inc
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Publication of JP2013517279A publication Critical patent/JP2013517279A/ja
Publication of JP2013517279A5 publication Critical patent/JP2013517279A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • AIDS & HIV (AREA)
  • Psychiatry (AREA)
JP2012549065A 2010-01-13 2011-01-13 化合物及び方法 Pending JP2013517279A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29464310P 2010-01-13 2010-01-13
US61/294,643 2010-01-13
PCT/US2011/021099 WO2011088187A1 (en) 2010-01-13 2011-01-13 Compounds and methods

Publications (2)

Publication Number Publication Date
JP2013517279A true JP2013517279A (ja) 2013-05-16
JP2013517279A5 JP2013517279A5 (enExample) 2014-02-27

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JP2012549065A Pending JP2013517279A (ja) 2010-01-13 2011-01-13 化合物及び方法

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US (1) US20120322827A1 (enExample)
EP (1) EP2523560A4 (enExample)
JP (1) JP2013517279A (enExample)
WO (1) WO2011088187A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2523664A4 (en) 2010-01-13 2013-06-26 Tempero Pharmaceuticals Inc COMPOUNDS AND METHODS
WO2011088181A1 (en) 2010-01-13 2011-07-21 Tempero Pharmaceuticals, Inc. Compounds and methods
WO2013008162A1 (en) 2011-07-08 2013-01-17 Novartis Ag Novel trifluoromethyl-oxadiazole derivatives and their use in the treatment of disease
WO2013009830A1 (en) * 2011-07-13 2013-01-17 Tempero Pharmaceuticals, Inc. Methods of treatment
WO2013009810A1 (en) * 2011-07-13 2013-01-17 Tempero Pharmaceuticals, Inc. Methods of treatment
WO2013009812A1 (en) * 2011-07-13 2013-01-17 Tempero Pharmaceuticals, Inc Methods of treatment
WO2013009827A1 (en) * 2011-07-13 2013-01-17 Tempero Pharmaceuticals, Inc. Methods of treatment
WO2013066834A1 (en) * 2011-10-31 2013-05-10 Glaxosmithkline Llc Compounds and methods
WO2013066832A1 (en) * 2011-10-31 2013-05-10 Glaxosmithkline Llc Compounds and methods
WO2013066836A1 (en) * 2011-10-31 2013-05-10 Glaxosmithkline Llc Compounds and methods
US10357493B2 (en) 2017-03-10 2019-07-23 Selenity Therapeutics (Bermuda), Ltd. Metalloenzyme inhibitor compounds

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JP2007508318A (ja) * 2003-10-09 2007-04-05 エートン ファーマ インコーポレーティッド チオフェンおよびベンゾチオフェンヒドロキサム酸誘導体
JP2008526957A (ja) * 2005-01-14 2008-07-24 エスケー ホルディングス カンパニー リミテッド オキサゾールヒドロキサム酸誘導体及びその使用
JP2009507065A (ja) * 2005-09-07 2009-02-19 イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー ヒストン脱アセチル化酵素（ｈｄａｃ）阻害剤としてのチオフェン及びチアゾール置換トリフルオロエタノン誘導体
JP2009526830A (ja) * 2006-02-15 2009-07-23 イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー ヒストン脱アセチル化酵素（ｈｄａｃ）阻害剤としてのチオフェン及びチアゾール置換トリフルオロエタノン誘導体

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DE60034688T2 (de) * 1999-09-08 2008-01-17 Sloan-Kettering Institute For Cancer Research Kristallstruktur einer deacetylase und deren inhibitoren
US7863294B2 (en) * 2004-12-10 2011-01-04 Instituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa Heterocycle derivatives as histone deacetylase (HDAC) inhibitors
WO2006075888A1 (en) * 2005-01-14 2006-07-20 Sk Corporation Oxazole hydroxamic acid derivatives and use thereof

Patent Citations (4)

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JP2007508318A (ja) * 2003-10-09 2007-04-05 エートン ファーマ インコーポレーティッド チオフェンおよびベンゾチオフェンヒドロキサム酸誘導体
JP2008526957A (ja) * 2005-01-14 2008-07-24 エスケー ホルディングス カンパニー リミテッド オキサゾールヒドロキサム酸誘導体及びその使用
JP2009507065A (ja) * 2005-09-07 2009-02-19 イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー ヒストン脱アセチル化酵素（ｈｄａｃ）阻害剤としてのチオフェン及びチアゾール置換トリフルオロエタノン誘導体
JP2009526830A (ja) * 2006-02-15 2009-07-23 イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー ヒストン脱アセチル化酵素（ｈｄａｃ）阻害剤としてのチオフェン及びチアゾール置換トリフルオロエタノン誘導体

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* Cited by examiner, † Cited by third party
Title
JPN6014052025; Ｊｏｎｅｓ　Ｐ　ｅｔ　ａｌ: Ｂｉｏｏｒｇ　Ｍｅｄ　Ｃｈｅｍ　Ｌｅｔｔ Ｖｏｌ．１８, 2008, ｐ．３４５６-６１ *
JPN6014052027; Ｓｃａｒｐｅｌｌｉ　Ｒ　ｅｔ　ａｌ: Ｂｉｏｏｒｇ　Ｍｅｄ　Ｃｈｅｍ　Ｌｅｔｔ Ｖｏｌ．１８, 2008, ｐ．６０７８-８２ *
JPN6014052028; Ｍｕｒａｇｌｉａ　Ｅ　ｅｔ　ａｌ: Ｂｉｏｏｒｇ　Ｍｅｄ　Ｃｈｅｍ　Ｌｅｔｔ Ｖｏｌ．１８, 2008, ｐ．６０８３-７ *

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WO2011088187A1 (en) 2011-07-21
US20120322827A1 (en) 2012-12-20
EP2523560A4 (en) 2013-07-03
EP2523560A1 (en) 2012-11-21

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