JP2013514279A - 変更された空間構成を有する結晶性組換型インターフェロン、その三次元構造、およびその使用 - Google Patents

変更された空間構成を有する結晶性組換型インターフェロン、その三次元構造、およびその使用 Download PDF

Info

Publication number
JP2013514279A
JP2013514279A JP2012543445A JP2012543445A JP2013514279A JP 2013514279 A JP2013514279 A JP 2013514279A JP 2012543445 A JP2012543445 A JP 2012543445A JP 2012543445 A JP2012543445 A JP 2012543445A JP 2013514279 A JP2013514279 A JP 2013514279A
Authority
JP
Japan
Prior art keywords
interferon
recombinant interferon
mimetic
rsifn
dimensional structure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2012543445A
Other languages
English (en)
Japanese (ja)
Inventor
光 文 魏
大 成 王
Original Assignee
四川▲輝▼▲陽▼生命工程股▲分▼有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 四川▲輝▼▲陽▼生命工程股▲分▼有限公司 filed Critical 四川▲輝▼▲陽▼生命工程股▲分▼有限公司
Publication of JP2013514279A publication Critical patent/JP2013514279A/ja
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/555Interferons [IFN]
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
    • G16B15/30Drug targeting using structural data; Docking or binding prediction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/555Interferons [IFN]
    • C07K14/56IFN-alpha
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16CCOMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/20Identification of molecular entities, parts thereof or of chemical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2299/00Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/04Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16CCOMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/50Molecular design, e.g. of drugs
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Physics & Mathematics (AREA)
  • Communicable Diseases (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Biotechnology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Evolutionary Biology (AREA)
  • Neurology (AREA)
  • Computing Systems (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
JP2012543445A 2009-12-18 2010-12-16 変更された空間構成を有する結晶性組換型インターフェロン、その三次元構造、およびその使用 Pending JP2013514279A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN200910259339.2 2009-12-18
CN2009102593392A CN102101886A (zh) 2009-12-18 2009-12-18 构象改变的重组干扰素晶体、其三维结构及应用
PCT/CN2010/002055 WO2011072487A1 (zh) 2009-12-18 2010-12-16 空间构象改变的重组干扰素的晶体、其三维结构及应用

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016058155A Division JP2016128507A (ja) 2009-12-18 2016-03-23 変更された空間構成を有する結晶性組換型インターフェロン、その三次元構造、およびその使用

Publications (1)

Publication Number Publication Date
JP2013514279A true JP2013514279A (ja) 2013-04-25

Family

ID=44154975

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2012543445A Pending JP2013514279A (ja) 2009-12-18 2010-12-16 変更された空間構成を有する結晶性組換型インターフェロン、その三次元構造、およびその使用
JP2016058155A Pending JP2016128507A (ja) 2009-12-18 2016-03-23 変更された空間構成を有する結晶性組換型インターフェロン、その三次元構造、およびその使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2016058155A Pending JP2016128507A (ja) 2009-12-18 2016-03-23 変更された空間構成を有する結晶性組換型インターフェロン、その三次元構造、およびその使用

Country Status (11)

Country Link
US (3) US8846025B2 (cg-RX-API-DMAC7.html)
EP (1) EP2514761B1 (cg-RX-API-DMAC7.html)
JP (2) JP2013514279A (cg-RX-API-DMAC7.html)
KR (1) KR20120108985A (cg-RX-API-DMAC7.html)
CN (2) CN102101886A (cg-RX-API-DMAC7.html)
AU (1) AU2010333574B2 (cg-RX-API-DMAC7.html)
CA (1) CA2784624C (cg-RX-API-DMAC7.html)
ES (1) ES2631028T3 (cg-RX-API-DMAC7.html)
MY (1) MY169650A (cg-RX-API-DMAC7.html)
SG (1) SG181785A1 (cg-RX-API-DMAC7.html)
WO (1) WO2011072487A1 (cg-RX-API-DMAC7.html)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102101886A (zh) 2009-12-18 2011-06-22 四川辉阳生命工程股份有限公司 构象改变的重组干扰素晶体、其三维结构及应用
TWI726291B (zh) * 2013-01-07 2021-05-01 英屬維爾京群島商遠東超級實驗室有限公司 通過干擾素的經皮和/或經粘膜給藥治療骨癌、皮膚癌、皮下癌、粘膜癌和/或粘膜下癌的方法和組合物
US9830422B1 (en) * 2013-07-22 2017-11-28 The Curators Of The University Of Missouri In silico biological and pharmaceutical modeling
US10533044B2 (en) 2014-01-06 2020-01-14 The General Hospital Corporation Integrin Antagonists
WO2016180335A1 (en) * 2015-05-12 2016-11-17 Superlab Far East Limited Methods of determining interferon having direct inhibitory effects on tumors and uses thereof
WO2019134318A1 (zh) * 2018-05-09 2019-07-11 深圳晶泰科技有限公司 药物晶体结构全景分析系统及其全景分析方法
CN111508568B (zh) * 2020-04-20 2023-08-29 腾讯科技(深圳)有限公司 分子生成方法、装置及计算机可读存储介质和终端设备
CN111658779A (zh) * 2020-06-22 2020-09-15 四川大学华西医院 治疗新型冠状病毒肺炎的联合用药物
CN113223631B (zh) * 2021-05-06 2024-05-24 吉林大学 一种晶体结构解析方法及系统
CN119670712B (zh) * 2024-11-28 2025-10-03 中国人民解放军总医院 基于bert模型的临床知情同意书智能推荐装置

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002044197A2 (en) * 2000-12-01 2002-06-06 Fish Eleanor N Cytokine receptor binding peptides
JP2004533240A (ja) * 2001-04-24 2004-11-04 ジェンオディセ IFNα−17遺伝子の新規のポリヌクレオチドおよびポリペプチド
JP2005508848A (ja) * 2001-02-28 2005-04-07 シセン バイオテクノロジー リサーチ センター コンセンサスインターフェロンのB型肝炎表面抗原とe抗原の抑制剤としての応用
JP2006083126A (ja) * 2004-09-17 2006-03-30 Institute Of Physical & Chemical Research タンパク質の結晶化試薬キット及び試薬キットを利用した結晶化スクリーニング方法
JP2007503812A (ja) * 2003-08-28 2007-03-01 ヒュイヤンテック(ユーエスエー),インク. 空間構造によるタンパク質の機能の調節
JP2007055931A (ja) * 2005-08-24 2007-03-08 Institute Of Physical & Chemical Research ゼオライトを用いたタンパク質結晶化方法
JP2008050225A (ja) * 2006-08-25 2008-03-06 National Institute Of Advanced Industrial & Technology たんぱく質の合理的な結晶化条件探索法
JP2008532995A (ja) * 2005-03-09 2008-08-21 ウェイ グアンウェン 組換え高効率複合インターフェロンの使用方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4672108A (en) 1981-12-07 1987-06-09 Hoffmann-La Roche Inc. Crystalline human leukocyte interferon
US6936694B1 (en) 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
US5372808A (en) 1990-10-17 1994-12-13 Amgen Inc. Methods and compositions for the treatment of diseases with consensus interferon while reducing side effect
US5441734A (en) 1993-02-25 1995-08-15 Schering Corporation Metal-interferon-alpha crystals
JP2758154B2 (ja) 1995-04-06 1998-05-28 エフ・ホフマン−ラ ロシユ アーゲー インターフェロンを含む液体製剤
US5480640A (en) 1995-05-02 1996-01-02 Schering Corporation Alpha interferon for treating prostate cancer
US5972331A (en) 1995-12-22 1999-10-26 Schering Corporation Crystalline interferon alpha for pulmonary delivery and method for producing the same
WO1999045389A2 (en) 1998-03-06 1999-09-10 Abbott Lab Ligand screening and design by x-ray crystallography
CN1062565C (zh) 1998-06-29 2001-02-28 深圳九先生物工程有限公司 重组人α型复合干扰素及其制备方法和用途
US6833256B1 (en) * 1999-06-22 2004-12-21 University Of Maryland Interferon tau mutants and methods for making them
AU2888602A (en) 2000-11-03 2002-05-15 Pbl Biomedical Lab Interferons, uses and compositions related thereto
US20060035327A1 (en) 2001-02-28 2006-02-16 Guangwen Wei Recombinant super-compound interferon and uses thereof
CN1910195A (zh) * 2003-08-28 2007-02-07 辉阳科技美国公司 通过空间构象调节蛋白质功能
US7585647B2 (en) * 2003-08-28 2009-09-08 Guangwen Wei Nucleic acid encoding recombinant interferon
DK2325202T3 (en) 2003-08-28 2015-01-19 Superlab Far East Ltd Uses of interferons with changed spatial structure
WO2005067963A1 (en) 2003-12-23 2005-07-28 Intermune, Inc. Use of polyethylene glycol-modified interferon-alpha in therapeutic dosing regimens
CN1740197B (zh) 2004-08-26 2010-05-12 辉阳科技美国公司 具有全新空间构象且功效增强的重组干扰素、其制备方法及应用
CN1710197B (zh) * 2005-06-17 2011-06-22 徐州师范大学 可变色彩色纤维防伪纸
CN102101886A (zh) 2009-12-18 2011-06-22 四川辉阳生命工程股份有限公司 构象改变的重组干扰素晶体、其三维结构及应用
US20130184437A9 (en) 2011-06-08 2013-07-18 Guangwen Wei Design and use of new recombinant interferons with altered spatial configuration and three-dimensional structure

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002044197A2 (en) * 2000-12-01 2002-06-06 Fish Eleanor N Cytokine receptor binding peptides
JP2005508848A (ja) * 2001-02-28 2005-04-07 シセン バイオテクノロジー リサーチ センター コンセンサスインターフェロンのB型肝炎表面抗原とe抗原の抑制剤としての応用
JP2004533240A (ja) * 2001-04-24 2004-11-04 ジェンオディセ IFNα−17遺伝子の新規のポリヌクレオチドおよびポリペプチド
JP2007503812A (ja) * 2003-08-28 2007-03-01 ヒュイヤンテック(ユーエスエー),インク. 空間構造によるタンパク質の機能の調節
JP2007516214A (ja) * 2003-08-28 2007-06-21 ヒュイヤンテック(ユーエスエー),インク. 空間構造が変えられるインターフェロン及びその応用
JP2006083126A (ja) * 2004-09-17 2006-03-30 Institute Of Physical & Chemical Research タンパク質の結晶化試薬キット及び試薬キットを利用した結晶化スクリーニング方法
JP2008532995A (ja) * 2005-03-09 2008-08-21 ウェイ グアンウェン 組換え高効率複合インターフェロンの使用方法
JP2007055931A (ja) * 2005-08-24 2007-03-08 Institute Of Physical & Chemical Research ゼオライトを用いたタンパク質結晶化方法
JP2008050225A (ja) * 2006-08-25 2008-03-06 National Institute Of Advanced Industrial & Technology たんぱく質の合理的な結晶化条件探索法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JPN6015001906; Journal of Interferon Research Vol.14, No.1, 1994, p.1-9 *
JPN6015046917; 志波智生: '"結晶化条件の最適化"' タンパク質科学会アーカイブ,[online] Vol.1, 2008, e033 *
JPN6015046918; The Journal of Biological Chemistry Vol.280, No.29, 2005, p.27222-27229 *

Also Published As

Publication number Publication date
CN102770447A (zh) 2012-11-07
KR20120108985A (ko) 2012-10-05
WO2011072487A1 (zh) 2011-06-23
EP2514761B1 (en) 2016-11-23
US9273109B2 (en) 2016-03-01
AU2010333574B2 (en) 2017-03-09
US20120308520A1 (en) 2012-12-06
MY169650A (en) 2019-04-25
EP2514761A4 (en) 2013-08-28
US20110158941A1 (en) 2011-06-30
CA2784624A1 (en) 2011-06-23
US8415151B2 (en) 2013-04-09
ES2631028T3 (es) 2017-08-25
EP2514761A9 (en) 2013-02-06
AU2010333574A1 (en) 2012-07-19
EP2514761A1 (en) 2012-10-24
SG181785A1 (en) 2012-07-30
HK1177749A1 (en) 2013-08-30
CA2784624C (en) 2021-05-04
US20140356324A1 (en) 2014-12-04
US8846025B2 (en) 2014-09-30
CN102101886A (zh) 2011-06-22
CN102770447B (zh) 2015-03-11
JP2016128507A (ja) 2016-07-14

Similar Documents

Publication Publication Date Title
JP2016128507A (ja) 変更された空間構成を有する結晶性組換型インターフェロン、その三次元構造、およびその使用
JP2003511467A (ja) アンドロゲンレセプターリガンド結合ドメインの結晶構造
US8287852B2 (en) Treatment of viral diseases with recombinant interferon α
US20070032637A1 (en) Egf/egfr complex
US20150031859A1 (en) Use of new recombinant interferons with altered spatial configuration and three-dimensional structure
US20180258151A1 (en) Recombinant super-compound interferon and uses thereof
US20150174206A1 (en) Uses of interferons with altered spatial structure
TWI513706B (zh) The spatial conformation changes the reconstructed interferon crystal, its three - dimensional structure and its application
EP1663110A2 (en) Uses of interferons with altered spatial structure
HK1177749B (en) Crystalline recombinant interferon with altered spatial configuration, three-dimensional structure and uses thereof
US20060035327A1 (en) Recombinant super-compound interferon and uses thereof
AU2011202683B2 (en) Uses of interferons with altered spatial structure
Gupta et al. In silico Molecular Modelling and Docking Studies on Kinase Inhibitors as Potential Anti-Cancer Target in HER2-associated Breast Cancer
KR101467634B1 (ko) 스네일 및 임포틴베타 단백질 복합체 3차원 결정구조 및 결정화 방법
Skariyachan et al. In silico investigation and docking studies of E2F3 tumour marker: discovery and evaluation of potential inhibitors for prostate and breast cancer

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20131022

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20150127

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20150408

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20150518

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20150616

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150724

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20151124

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20160113

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20160113