JP2013513632A5 - - Google Patents
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- JP2013513632A5 JP2013513632A5 JP2012543599A JP2012543599A JP2013513632A5 JP 2013513632 A5 JP2013513632 A5 JP 2013513632A5 JP 2012543599 A JP2012543599 A JP 2012543599A JP 2012543599 A JP2012543599 A JP 2012543599A JP 2013513632 A5 JP2013513632 A5 JP 2013513632A5
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- JP
- Japan
- Prior art keywords
- group
- carbon atoms
- linear
- alkyl chain
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical group O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 38
- 125000004432 carbon atom Chemical group C* 0.000 claims 26
- 239000002105 nanoparticle Substances 0.000 claims 22
- 125000000217 alkyl group Chemical group 0.000 claims 20
- 239000000377 silicon dioxide Substances 0.000 claims 19
- 150000001875 compounds Chemical class 0.000 claims 12
- 239000000203 mixture Substances 0.000 claims 11
- 239000002202 Polyethylene glycol Substances 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 6
- 125000003827 glycol group Chemical group 0.000 claims 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 6
- 229920001223 polyethylene glycol Polymers 0.000 claims 6
- GKWLILHTTGWKLQ-UHFFFAOYSA-N 2,3-dihydrothieno[3,4-b][1,4]dioxine Chemical group O1CCOC2=CSC=C21 GKWLILHTTGWKLQ-UHFFFAOYSA-N 0.000 claims 4
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 4
- GNVMUORYQLCPJZ-UHFFFAOYSA-M Thiocarbamate Chemical compound NC([S-])=O GNVMUORYQLCPJZ-UHFFFAOYSA-M 0.000 claims 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 4
- 150000001408 amides Chemical class 0.000 claims 4
- 125000004104 aryloxy group Chemical group 0.000 claims 4
- 239000004202 carbamide Substances 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 125000005553 heteroaryloxy group Chemical group 0.000 claims 4
- 125000005647 linker group Chemical group 0.000 claims 4
- 230000008685 targeting Effects 0.000 claims 4
- 150000001450 anions Chemical class 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 239000003504 photosensitizing agent Substances 0.000 claims 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical group OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 2
- 229910019142 PO4 Inorganic materials 0.000 claims 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 2
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical group C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000002837 carbocyclic group Chemical group 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 2
- 239000010452 phosphate Substances 0.000 claims 2
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims 2
- 238000002059 diagnostic imaging Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001613 neoplastic effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000010791 quenching Methods 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
- 230000009897 systematic effect Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09306238 | 2009-12-15 | ||
| EP09306238.8 | 2009-12-15 | ||
| PCT/EP2010/069035 WO2011073054A1 (en) | 2009-12-15 | 2010-12-07 | Biphotonic photosensitizers, nanoparticles containing the same and their use as drugs |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013513632A JP2013513632A (ja) | 2013-04-22 |
| JP2013513632A5 true JP2013513632A5 (enExample) | 2014-01-30 |
| JP5926685B2 JP5926685B2 (ja) | 2016-05-25 |
Family
ID=42021128
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012543599A Expired - Fee Related JP5926685B2 (ja) | 2009-12-15 | 2010-12-07 | 二光子光増感剤、それらを含むナノ粒子および薬物としてのそれらの使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8709747B2 (enExample) |
| EP (1) | EP2513083B1 (enExample) |
| JP (1) | JP5926685B2 (enExample) |
| CA (1) | CA2784212C (enExample) |
| WO (1) | WO2011073054A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2988721B1 (fr) | 2012-03-27 | 2014-04-04 | Centre Nat Rech Scient | Nanoparticules de silicium poreux fonctionnalisees et leurs utilisations en therapie photodynamique |
| FR3044676B1 (fr) * | 2015-12-04 | 2017-11-24 | Univ Rennes | Dendrimeres photosensibilisateurs biphotoniques, procede de fabrication et utilisations |
| US20210000955A1 (en) * | 2017-12-08 | 2021-01-07 | Nanyang Technological University | Photodynamically active organosilica nanoparticles and medical uses thereof |
| CN114504551B (zh) * | 2020-11-16 | 2024-01-02 | 北京厚燊维康科技有限责任公司 | 可用于光动力治疗或诊断的制剂 |
| CN117327098B (zh) * | 2023-09-28 | 2025-11-11 | 江汉大学 | 一种以用于i型光动力治疗为主的aie型光敏剂的制备方法与应用 |
| WO2025207959A1 (en) | 2024-03-27 | 2025-10-02 | Biogen Ma Inc. | Anti-transferrin receptor antibodies and uses thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITFI940095A1 (it) | 1994-05-23 | 1995-11-23 | Molteni & C | Coniugati fotodinamici aventi proprieta' biocide |
| CA2513759C (en) | 2003-01-24 | 2014-05-13 | The Research Foundation Of State University Of New York | Ceramic based nanoparticles for entrapping therapeutic agents for photodynamic therapy and method of using same |
| WO2008030624A2 (en) * | 2006-09-08 | 2008-03-13 | The Research Foundation Of State University Of New York | Nanoparticles for two-photon activated photodynamic therapy and imaging |
-
2010
- 2010-12-07 JP JP2012543599A patent/JP5926685B2/ja not_active Expired - Fee Related
- 2010-12-07 US US13/516,010 patent/US8709747B2/en active Active
- 2010-12-07 WO PCT/EP2010/069035 patent/WO2011073054A1/en not_active Ceased
- 2010-12-07 CA CA2784212A patent/CA2784212C/en active Active
- 2010-12-07 EP EP10790539.0A patent/EP2513083B1/en not_active Not-in-force
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