JP2013510853A5 - - Google Patents
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- Publication number
- JP2013510853A5 JP2013510853A5 JP2012538863A JP2012538863A JP2013510853A5 JP 2013510853 A5 JP2013510853 A5 JP 2013510853A5 JP 2012538863 A JP2012538863 A JP 2012538863A JP 2012538863 A JP2012538863 A JP 2012538863A JP 2013510853 A5 JP2013510853 A5 JP 2013510853A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- imidazol
- azabicyclo
- amino
- carbamate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 (2S) -2- (5- (7- (2-((2S) -1-((2S) -2-((methoxycarbonyl) amino) -3-methyl Butanoyl) -2-pyrrolidinyl) -1H-benzimidazol-5-yl) -2-naphthyl) -1H-benzimidazol-2-yl) -1-pyrrolidinyl Chemical group 0.000 claims 164
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 130
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 86
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 72
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 20
- 150000001875 compounds Chemical class 0.000 claims 18
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 claims 11
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 9
- 108010050904 Interferons Proteins 0.000 claims 8
- 102000014150 Interferons Human genes 0.000 claims 8
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 8
- 229940079322 interferon Drugs 0.000 claims 8
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 7
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 5
- QPTTYIGXMQFXIZ-FJZBIBNSSA-N (2r)-2-phenyl-1-[(2s)-2-[6-[6-[2-[(2s)-1-[(2r)-2-phenyl-2-piperidin-1-ylacetyl]pyrrolidin-2-yl]-3h-benzimidazol-5-yl]naphthalen-2-yl]-1h-benzimidazol-2-yl]pyrrolidin-1-yl]-2-piperidin-1-ylethanone Chemical compound N1([C@@H](C(=O)N2[C@@H](CCC2)C=2NC3=CC=C(C=C3N=2)C=2C=C3C=CC(=CC3=CC=2)C=2C=C3N=C(NC3=CC=2)[C@H]2N(CCC2)C(=O)[C@H](N2CCCCC2)C=2C=CC=CC=2)C=2C=CC=CC=2)CCCCC1 QPTTYIGXMQFXIZ-FJZBIBNSSA-N 0.000 claims 4
- 108010047761 Interferon-alpha Proteins 0.000 claims 4
- 102000006992 Interferon-alpha Human genes 0.000 claims 4
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims 4
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 208000015181 infectious disease Diseases 0.000 claims 4
- 229960000329 ribavirin Drugs 0.000 claims 4
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
- UBCHPRBFMUDMNC-UHFFFAOYSA-N 1-(1-adamantyl)ethanamine Chemical compound C1C(C2)CC3CC2CC1(C(N)C)C3 UBCHPRBFMUDMNC-UHFFFAOYSA-N 0.000 claims 2
- 108020005544 Antisense RNA Proteins 0.000 claims 2
- 229940124186 Dehydrogenase inhibitor Drugs 0.000 claims 2
- HAEJPQIATWHALX-KQYNXXCUSA-N ITP Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1N1C(N=CNC2=O)=C2N=C1 HAEJPQIATWHALX-KQYNXXCUSA-N 0.000 claims 2
- 101710200424 Inosine-5'-monophosphate dehydrogenase Proteins 0.000 claims 2
- 102100040018 Interferon alpha-2 Human genes 0.000 claims 2
- 108010079944 Interferon-alpha2b Proteins 0.000 claims 2
- 102000013462 Interleukin-12 Human genes 0.000 claims 2
- 108010065805 Interleukin-12 Proteins 0.000 claims 2
- 102000000588 Interleukin-2 Human genes 0.000 claims 2
- 108010002350 Interleukin-2 Proteins 0.000 claims 2
- 102000004889 Interleukin-6 Human genes 0.000 claims 2
- 108090001005 Interleukin-6 Proteins 0.000 claims 2
- 102000005741 Metalloproteases Human genes 0.000 claims 2
- 108010006035 Metalloproteases Proteins 0.000 claims 2
- 108060004795 Methyltransferase Proteins 0.000 claims 2
- 101800001019 Non-structural protein 4B Proteins 0.000 claims 2
- 101800001014 Non-structural protein 5A Proteins 0.000 claims 2
- 102000012479 Serine Proteases Human genes 0.000 claims 2
- 108010022999 Serine Proteases Proteins 0.000 claims 2
- 230000005867 T cell response Effects 0.000 claims 2
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 claims 2
- DKNWSYNQZKUICI-UHFFFAOYSA-N amantadine Chemical compound C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 claims 2
- 229960003805 amantadine Drugs 0.000 claims 2
- 239000003184 complementary RNA Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims 2
- 210000002443 helper t lymphocyte Anatomy 0.000 claims 2
- DOUYETYNHWVLEO-UHFFFAOYSA-N imiquimod Chemical compound C1=CC=CC2=C3N(CC(C)C)C=NC3=C(N)N=C21 DOUYETYNHWVLEO-UHFFFAOYSA-N 0.000 claims 2
- 229960002751 imiquimod Drugs 0.000 claims 2
- 230000002452 interceptive effect Effects 0.000 claims 2
- 229940117681 interleukin-12 Drugs 0.000 claims 2
- 229940100601 interleukin-6 Drugs 0.000 claims 2
- 150000004712 monophosphates Chemical class 0.000 claims 2
- 229960000888 rimantadine Drugs 0.000 claims 2
- XJKLOZJUFFQPCQ-FJZBIBNSSA-N (2r)-2-phenyl-1-[(2s)-2-[6-[7-[2-[(2s)-1-[(2r)-2-phenyl-2-piperidin-1-ylacetyl]pyrrolidin-2-yl]-3h-benzimidazol-5-yl]naphthalen-2-yl]-1h-benzimidazol-2-yl]pyrrolidin-1-yl]-2-piperidin-1-ylethanone Chemical compound N1([C@@H](C(=O)N2[C@@H](CCC2)C=2NC3=CC=C(C=C3N=2)C=2C=C3C=C(C=CC3=CC=2)C=2C=C3N=C(NC3=CC=2)[C@H]2N(CCC2)C(=O)[C@H](N2CCCCC2)C=2C=CC=CC=2)C=2C=CC=CC=2)CCCCC1 XJKLOZJUFFQPCQ-FJZBIBNSSA-N 0.000 claims 1
- JHMWCRILHMZZDK-OEZRKNEGSA-N 1-[(2s,5s)-2-[5-[4-[6-[2-[(2s,5s)-1-acetyl-5-methylpyrrolidin-2-yl]-1h-imidazol-5-yl]naphthalen-2-yl]phenyl]-1h-imidazol-2-yl]-5-methylpyrrolidin-1-yl]ethanone Chemical compound CC(=O)N1[C@@H](C)CC[C@H]1C1=NC(C=2C=CC(=CC=2)C=2C=C3C=CC(=CC3=CC=2)C=2N=C(NC=2)[C@H]2N([C@@H](C)CC2)C(C)=O)=CN1 JHMWCRILHMZZDK-OEZRKNEGSA-N 0.000 claims 1
- ZCVAUEFQQGJOAF-BFCBZKQHSA-N 3-methyl-1-[(2s,4s)-4-methyl-2-[5-[4-[6-[2-[(2s,4s)-4-methyl-1-(3-methylbutanoyl)pyrrolidin-2-yl]-1h-imidazol-5-yl]naphthalen-2-yl]phenyl]-1h-imidazol-2-yl]pyrrolidin-1-yl]butan-1-one Chemical compound CC(C)CC(=O)N1C[C@@H](C)C[C@H]1C1=NC(C=2C=CC(=CC=2)C=2C=C3C=CC(=CC3=CC=2)C=2N=C(NC=2)[C@H]2N(C[C@@H](C)C2)C(=O)CC(C)C)=CN1 ZCVAUEFQQGJOAF-BFCBZKQHSA-N 0.000 claims 1
- PCBZRNYXXCIELG-WYFCWLEVSA-N COC1=CC=C(C[C@H](NC(=O)OC2CCCC3(C2)OOC2(O3)C3CC4CC(C3)CC2C4)C(=O)N[C@@H]2[C@@H](CO)O[C@H]([C@@H]2O)N2C=NC3=C2N=CN=C3N(C)C)C=C1 Chemical compound COC1=CC=C(C[C@H](NC(=O)OC2CCCC3(C2)OOC2(O3)C3CC4CC(C3)CC2C4)C(=O)N[C@@H]2[C@@H](CO)O[C@H]([C@@H]2O)N2C=NC3=C2N=CN=C3N(C)C)C=C1 PCBZRNYXXCIELG-WYFCWLEVSA-N 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims 1
- DNSISZSEWVHGLH-UHFFFAOYSA-N butanamide Chemical compound CCCC(N)=O DNSISZSEWVHGLH-UHFFFAOYSA-N 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Substances C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- IIYZHZDLGGHLBE-ZQWQDMLBSA-N methyl n-[(2s)-1-[(2s)-2-[5-[4-[6-[2-[(2s)-1-[(2s)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidin-2-yl]-1h-imidazol-5-yl]naphthalen-2-yl]phenyl]-1h-imidazol-2-yl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate Chemical compound COC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C1=NC=C(C=2C=CC(=CC=2)C=2C=C3C=CC(=CC3=CC=2)C=2NC(=NC=2)[C@H]2N(CCC2)C(=O)[C@@H](NC(=O)OC)C(C)C)N1 IIYZHZDLGGHLBE-ZQWQDMLBSA-N 0.000 claims 1
- LCHMHYPWGWYXEL-ZYADHFCISA-N methyl n-[(2s)-1-[(2s)-2-[5-[6-[2-[(2s)-1-[(2s)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidin-2-yl]-3h-benzimidazol-5-yl]naphthalen-2-yl]-1h-imidazol-2-yl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate Chemical compound COC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C1=NC=C(C=2C=C3C=CC(=CC3=CC=2)C=2C=C3NC(=NC3=CC=2)[C@H]2N(CCC2)C(=O)[C@@H](NC(=O)OC)C(C)C)N1 LCHMHYPWGWYXEL-ZYADHFCISA-N 0.000 claims 1
- LTRAHHIJHWEYPT-ZYADHFCISA-N methyl n-[(2s)-1-[(2s)-2-[5-[7-[2-[(2s)-1-[(2s)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidin-2-yl]-3h-benzimidazol-5-yl]naphthalen-2-yl]-1h-imidazol-2-yl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate Chemical compound COC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C1=NC=C(C=2C=C3C=C(C=CC3=CC=2)C=2C=C3NC(=NC3=CC=2)[C@H]2N(CCC2)C(=O)[C@@H](NC(=O)OC)C(C)C)N1 LTRAHHIJHWEYPT-ZYADHFCISA-N 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26011509P | 2009-11-11 | 2009-11-11 | |
| US61/260,115 | 2009-11-11 | ||
| US37880610P | 2010-08-31 | 2010-08-31 | |
| US61/378,806 | 2010-08-31 | ||
| PCT/US2010/055565 WO2011059887A1 (en) | 2009-11-11 | 2010-11-05 | Hepatitis c virus inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013510853A JP2013510853A (ja) | 2013-03-28 |
| JP2013510853A5 true JP2013510853A5 (https=) | 2013-11-28 |
Family
ID=43466793
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012538863A Pending JP2013510853A (ja) | 2009-11-11 | 2010-11-05 | Ｃ型肝炎ウイルス阻害剤 |
Country Status (21)
| Country | Link |
|---|---|
| US (6) | US20110274648A1 (https=) |
| EP (1) | EP2499127B1 (https=) |
| JP (1) | JP2013510853A (https=) |
| KR (1) | KR20130036173A (https=) |
| CN (1) | CN102712623B (https=) |
| AR (1) | AR078976A1 (https=) |
| AU (1) | AU2010319801A1 (https=) |
| BR (1) | BR112012011100A2 (https=) |
| CA (1) | CA2780812A1 (https=) |
| CL (1) | CL2012001230A1 (https=) |
| EA (1) | EA201270622A1 (https=) |
| ES (1) | ES2690660T3 (https=) |
| IL (1) | IL219516A (https=) |
| MA (1) | MA33731B1 (https=) |
| MX (1) | MX2012005190A (https=) |
| NZ (1) | NZ600505A (https=) |
| PE (1) | PE20121354A1 (https=) |
| PH (1) | PH12012500922A1 (https=) |
| TN (1) | TN2012000214A1 (https=) |
| TW (1) | TWI475019B (https=) |
| WO (1) | WO2011059887A1 (https=) |
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2373172T1 (sl) | 2008-12-03 | 2013-12-31 | Presidio Pharmaceuticals, Inc. | Inhibitorji HCV NS5A |
| EP2367823A1 (en) | 2008-12-23 | 2011-09-28 | Abbott Laboratories | Anti-viral compounds |
| CA2740193A1 (en) | 2008-12-23 | 2010-07-01 | Abbott Laboratories | Anti-viral compounds |
| US8394968B2 (en) | 2009-02-17 | 2013-03-12 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8796466B2 (en) | 2009-03-30 | 2014-08-05 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| TW201038559A (en) | 2009-04-09 | 2010-11-01 | Bristol Myers Squibb Co | Hepatitis C virus inhibitors |
| US8143414B2 (en) | 2009-04-13 | 2012-03-27 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| CN102459165B (zh) * | 2009-04-15 | 2015-09-02 | Abbvie公司 | 抗病毒化合物 |
| PT3309157T (pt) | 2009-05-13 | 2019-12-02 | Gilead Pharmasset Llc | Compostos antivirais |
| US8138215B2 (en) | 2009-05-29 | 2012-03-20 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8211928B2 (en) | 2009-05-29 | 2012-07-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8937150B2 (en) | 2009-06-11 | 2015-01-20 | Abbvie Inc. | Anti-viral compounds |
| US8716454B2 (en) | 2009-06-11 | 2014-05-06 | Abbvie Inc. | Solid compositions |
| UA118080C2 (uk) * | 2009-06-11 | 2018-11-26 | Еббві Айрленд Анлімітед Компані | Противірусні сполуки |
| US9394279B2 (en) | 2009-06-11 | 2016-07-19 | Abbvie Inc. | Anti-viral compounds |
| IN2012DN00999A (https=) | 2009-07-16 | 2015-04-10 | Vertex Pharma | |
| US20110269956A1 (en) | 2009-11-11 | 2011-11-03 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| US20110274648A1 (en) | 2009-11-11 | 2011-11-10 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| US20110281910A1 (en) | 2009-11-12 | 2011-11-17 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| US8653070B2 (en) * | 2009-12-14 | 2014-02-18 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| US8377980B2 (en) | 2009-12-16 | 2013-02-19 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8362020B2 (en) | 2009-12-30 | 2013-01-29 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8933110B2 (en) | 2010-01-25 | 2015-01-13 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| MA34013B1 (fr) | 2010-01-25 | 2013-02-01 | Enanta Pharm Inc | Inhibiteurs du virus de l'hépatite c |
| WO2011119858A1 (en) * | 2010-03-24 | 2011-09-29 | Vertex Pharmaceuticals Incorporated | Analogues for the treatment or prevention of flavivirus infections |
| CA2794145A1 (en) | 2010-03-24 | 2011-09-29 | Vertex Pharmaceuticals Incorporated | Analogues for the treatment or prevention of flavivirus infections |
| EP2555622A4 (en) | 2010-04-09 | 2013-09-18 | Enanta Pharm Inc | HEPATITIS C-VIRUS HEMMER |
| US9096590B2 (en) * | 2010-05-24 | 2015-08-04 | Intellikine Llc | Substituted benzoxazoles as PI3 kinase inhibitors |
| EP2575819A4 (en) | 2010-06-04 | 2013-11-27 | Enanta Pharm Inc | INHIBITORS OF HEPATITIS C VIRUS |
| NZ605440A (en) | 2010-06-10 | 2014-05-30 | Abbvie Bahamas Ltd | Solid compositions comprising an hcv inhibitor |
| MA34392B1 (fr) | 2010-06-24 | 2013-07-03 | Gilead Sciences Inc | Pyrimidines en tant qu'agents antiviraux |
| EP2603080A4 (en) | 2010-08-12 | 2014-01-22 | Enanta Pharm Inc | HEPATITIS C-VIRUS HEMMER |
| US20120195857A1 (en) | 2010-08-12 | 2012-08-02 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| US8552047B2 (en) * | 2011-02-07 | 2013-10-08 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US9546160B2 (en) | 2011-05-12 | 2017-01-17 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
| EP2729448B1 (en) | 2011-07-06 | 2015-09-09 | Gilead Sciences, Inc. | Compounds for the treatment of hiv |
| US9303061B2 (en) | 2011-07-09 | 2016-04-05 | Sunshine Luke Pharma Co., Ltd. | Spiro compounds as Hepatitis C virus inhibitors |
| WO2013025975A1 (en) * | 2011-08-17 | 2013-02-21 | Glaxosmithkline Llc | Combination treatments for hepatitis c |
| WO2013030750A1 (en) | 2011-09-01 | 2013-03-07 | Lupin Limited | Antiviral compounds |
| PL2709613T5 (pl) | 2011-09-16 | 2020-12-14 | Gilead Pharmasset Llc | Metody leczenia hcv |
| CN103946220B (zh) | 2011-11-03 | 2017-12-22 | 施万生物制药研发Ip有限责任公司 | 含有片段{2‑[4‑(联苯‑4‑基)‑1h‑咪唑‑2‑基]吡咯烷‑1‑羰基甲基}胺的杆状丙型肝炎病毒抑制剂 |
| CA2858096C (en) | 2011-12-22 | 2020-06-23 | Gilead Sciences, Inc. | Pyrazolo[1,5-a]pyrimidines as antiviral agents |
| US9034832B2 (en) | 2011-12-29 | 2015-05-19 | Abbvie Inc. | Solid compositions |
| US9326973B2 (en) | 2012-01-13 | 2016-05-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| CA2862755A1 (en) | 2012-02-10 | 2013-08-15 | Lupin Limited | Antiviral compounds with a dibenzooxaheterocycle moiety |
| CN106986869A (zh) | 2012-04-17 | 2017-07-28 | 吉利德科学公司 | 用于抗病毒治疗的化合物和方法 |
| HUE032173T2 (en) | 2012-04-25 | 2017-09-28 | Theravance Biopharma R&D Ip Llc | Piperazine piperidine compounds as inhibitors of hepatitis C virus |
| JP6006008B2 (ja) * | 2012-06-14 | 2016-10-12 | ユー・ディー・シー アイルランド リミテッド | 化合物、有機電界発光素子並びに該有機電界発光素子を用いた発光装置、表示装置及び照明装置 |
| TWI610916B (zh) | 2012-08-03 | 2018-01-11 | 廣東東陽光藥業有限公司 | 作爲丙型肝炎抑制劑的橋環化合物及其在藥物中的應用 |
| US9416139B2 (en) | 2012-11-29 | 2016-08-16 | Sunshine Lake Pharma Co., Ltd. | Spiro ring compound as hepatitis C virus (HCV) inhibitor and uses thereof |
| US9802949B2 (en) | 2012-11-29 | 2017-10-31 | Sunshine Lake Pharma Co., Ltd. | Fused ring compounds as hepatitis C virus inhibitors, pharmaceutical compositions and uses thereof |
| PT2950786T (pt) | 2013-01-31 | 2020-03-03 | Gilead Pharmasset Llc | Formulação de combinação de dois compostos antivirais |
| US11484534B2 (en) | 2013-03-14 | 2022-11-01 | Abbvie Inc. | Methods for treating HCV |
| US20150023913A1 (en) | 2013-07-02 | 2015-01-22 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| US9717712B2 (en) | 2013-07-02 | 2017-08-01 | Bristol-Myers Squibb Company | Combinations comprising tricyclohexadecahexaene derivatives for use in the treatment of hepatitis C virus |
| US9775831B2 (en) | 2013-07-17 | 2017-10-03 | Bristol-Myers Squibb Company | Combinations comprising biphenyl derivatives for use in the treatment of HCV |
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2010
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- 2010-11-05 CN CN201080061186.1A patent/CN102712623B/zh not_active Expired - Fee Related
- 2010-11-05 MX MX2012005190A patent/MX2012005190A/es not_active Application Discontinuation
- 2010-11-05 BR BR112012011100A patent/BR112012011100A2/pt not_active IP Right Cessation
- 2010-11-05 ES ES10779605.4T patent/ES2690660T3/es active Active
- 2010-11-05 WO PCT/US2010/055565 patent/WO2011059887A1/en not_active Ceased
- 2010-11-05 EA EA201270622A patent/EA201270622A1/ru unknown
- 2010-11-05 KR KR1020127014909A patent/KR20130036173A/ko not_active Withdrawn
- 2010-11-05 PE PE2012000637A patent/PE20121354A1/es not_active Application Discontinuation
- 2010-11-05 CA CA2780812A patent/CA2780812A1/en not_active Abandoned
- 2010-11-05 AU AU2010319801A patent/AU2010319801A1/en not_active Abandoned
- 2010-11-05 JP JP2012538863A patent/JP2013510853A/ja active Pending
- 2010-11-05 NZ NZ600505A patent/NZ600505A/en not_active IP Right Cessation
- 2010-11-05 PH PH1/2012/500922A patent/PH12012500922A1/en unknown
- 2010-11-11 AR ARP100104186A patent/AR078976A1/es unknown
- 2010-11-11 TW TW099138879A patent/TWI475019B/zh not_active IP Right Cessation
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2012
- 2012-05-01 IL IL219516A patent/IL219516A/en not_active IP Right Cessation
- 2012-05-07 MA MA34842A patent/MA33731B1/fr unknown
- 2012-05-10 CL CL2012001230A patent/CL2012001230A1/es unknown
- 2012-05-11 TN TNP2012000214A patent/TN2012000214A1/en unknown
- 2012-11-08 US US13/672,266 patent/US20130115193A1/en not_active Abandoned
-
2015
- 2015-03-25 US US14/668,090 patent/US20150197499A1/en not_active Abandoned
- 2015-07-23 US US14/807,084 patent/US9776981B2/en active Active
- 2015-07-23 US US14/806,964 patent/US9303007B2/en active Active
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2017
- 2017-08-29 US US15/689,286 patent/US20170355689A1/en not_active Abandoned
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