JP2013508458A5 - - Google Patents

Info

Publication number

JP2013508458A5

JP2013508458A5 JP2012536940A JP2012536940A JP2013508458A5 JP 2013508458 A5 JP2013508458 A5 JP 2013508458A5 JP 2012536940 A JP2012536940 A JP 2012536940A JP 2012536940 A JP2012536940 A JP 2012536940A JP 2013508458 A5 JP2013508458 A5 JP 2013508458A5

Authority

JP

Japan

Prior art keywords

cancer

fts

combination

use according

active agents

Prior art date

2010-10-26

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 239000013543 active substance Substances 0.000 claims 12
• 206010028980 Neoplasm Diseases 0.000 claims 11
• 239000005557 antagonist Substances 0.000 claims 11
• 201000011510 cancer Diseases 0.000 claims 11
• 229940121372 histone deacetylase inhibitor Drugs 0.000 claims 11
• 239000003276 histone deacetylase inhibitor Substances 0.000 claims 11
• 239000000203 mixture Substances 0.000 claims 11
• 125000000217 alkyl group Chemical group 0.000 claims 8
• 102000003964 Histone deacetylase Human genes 0.000 claims 4
• 108090000353 Histone deacetylase Proteins 0.000 claims 4
• NIJJYAXOARWZEE-UHFFFAOYSA-N Valproic acid Chemical group CCCC(C(O)=O)CCC NIJJYAXOARWZEE-UHFFFAOYSA-N 0.000 claims 4
• 125000003342 alkenyl group Chemical group 0.000 claims 4
• 239000002552 dosage form Substances 0.000 claims 4
• 229910052739 hydrogen Inorganic materials 0.000 claims 4
• 239000001257 hydrogen Substances 0.000 claims 4
• 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 4
• 239000003937 drug carrier Substances 0.000 claims 3
• 208000003174 Brain Neoplasms Diseases 0.000 claims 2
• 201000009030 Carcinoma Diseases 0.000 claims 2
• 206010009944 Colon cancer Diseases 0.000 claims 2
• GZTMFRUGZMZCRD-CFBAGHHKSA-N Farnesyl Thiosalicylic Acid Amide Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\CSC1=CC=CC=C1C(N)=O GZTMFRUGZMZCRD-CFBAGHHKSA-N 0.000 claims 2
• 208000000453 Skin Neoplasms Diseases 0.000 claims 2
• 208000024770 Thyroid neoplasm Diseases 0.000 claims 2
• 125000003545 alkoxy group Chemical group 0.000 claims 2
• 125000004414 alkyl thio group Chemical group 0.000 claims 2
• 238000011260 co-administration Methods 0.000 claims 2
• INVTYAOGFAGBOE-UHFFFAOYSA-N entinostat Chemical group NC1=CC=CC=C1NC(=O)C(C=C1)=CC=C1CNC(=O)OCC1=CC=CN=C1 INVTYAOGFAGBOE-UHFFFAOYSA-N 0.000 claims 2
• DORNPDMJRCKEOM-UHFFFAOYSA-N ethoxymethyl 2-(3,7,11-trimethyldodeca-2,6,10-trienylsulfanyl)benzoate Chemical compound CCOCOC(=O)C1=CC=CC=C1SCC=C(C)CCC=C(C)CCC=C(C)C DORNPDMJRCKEOM-UHFFFAOYSA-N 0.000 claims 2
• 125000004030 farnesyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
• 125000002686 geranylgeranyl group Chemical group [H]C([*])([H])/C([H])=C(C([H])([H])[H])/C([H])([H])C([H])([H])/C([H])=C(C([H])([H])[H])/C([H])([H])C([H])([H])/C([H])=C(C([H])([H])[H])/C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
• 125000001475 halogen functional group Chemical group 0.000 claims 2
• 239000003112 inhibitor Substances 0.000 claims 2
• DFJYJOZSAORDLT-UHFFFAOYSA-N methoxymethyl 5-fluoro-2-(3,7,11-trimethyldodeca-2,6,10-trienylsulfanyl)benzoate Chemical compound COCOC(=O)C1=CC(F)=CC=C1SCC=C(C)CCC=C(C)CCC=C(C)C DFJYJOZSAORDLT-UHFFFAOYSA-N 0.000 claims 2
• 201000000849 skin cancer Diseases 0.000 claims 2
• 201000002510 thyroid cancer Diseases 0.000 claims 2
• 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 2
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
• 229960000604 valproic acid Drugs 0.000 claims 2
• WAEXFXRVDQXREF-UHFFFAOYSA-N vorinostat Chemical group ONC(=O)CCCCCCC(=O)NC1=CC=CC=C1 WAEXFXRVDQXREF-UHFFFAOYSA-N 0.000 claims 2
• 229960000237 vorinostat Drugs 0.000 claims 2
• 206010006187 Breast cancer Diseases 0.000 claims 1
• 208000026310 Breast neoplasm Diseases 0.000 claims 1
• 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
• 206010014733 Endometrial cancer Diseases 0.000 claims 1
• 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
• 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
• 206010025323 Lymphomas Diseases 0.000 claims 1
• 206010059282 Metastases to central nervous system Diseases 0.000 claims 1
• 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 1
• 206010033128 Ovarian cancer Diseases 0.000 claims 1
• 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
• 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
• 206010060862 Prostate cancer Diseases 0.000 claims 1
• 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
• 206010038389 Renal cancer Diseases 0.000 claims 1
• 201000010208 Seminoma Diseases 0.000 claims 1
• 239000002775 capsule Substances 0.000 claims 1
• 208000029742 colonic neoplasm Diseases 0.000 claims 1
• 201000010536 head and neck cancer Diseases 0.000 claims 1
• 208000014829 head and neck neoplasm Diseases 0.000 claims 1
• 201000010982 kidney cancer Diseases 0.000 claims 1
• 208000032839 leukemia Diseases 0.000 claims 1
• 239000007788 liquid Substances 0.000 claims 1
• 201000007270 liver cancer Diseases 0.000 claims 1
• 208000014018 liver neoplasm Diseases 0.000 claims 1
• 201000005202 lung cancer Diseases 0.000 claims 1
• 208000020816 lung neoplasm Diseases 0.000 claims 1
• 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
• 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
• 201000002528 pancreatic cancer Diseases 0.000 claims 1
• 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
• 239000007787 solid Substances 0.000 claims 1
• 230000002485 urinary effect Effects 0.000 claims 1
• 0 **c1c(*)c(*)c(*)c(S)c1* Chemical compound **c1c(*)c(*)c(*)c(S)c1* 0.000 description 2