JP2013505030A - 抗炎症及び抗凝固活性を有するヘパリンコファクターｉｉ断片 - Google Patents

抗炎症及び抗凝固活性を有するヘパリンコファクターｉｉ断片 Download PDF

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JP2013505030A
JP2013505030A JP2012530325A JP2012530325A JP2013505030A JP 2013505030 A JP2013505030 A JP 2013505030A JP 2012530325 A JP2012530325 A JP 2012530325A JP 2012530325 A JP2012530325 A JP 2012530325A JP 2013505030 A JP2013505030 A JP 2013505030A
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polypeptide
inflammatory
peptide
polypeptide according
treatment
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マルティナ・カレ
ゴピニト・キャセティ
ニルス・マルティン・マルムステン
プラヴィーン・パパレディ
アルトゥル・シュミットチェン
ビョーム・ウーリック・ヴァルセ
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エクセルミューネ・アクチエボラーグ
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
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  • Tropical Medicine & Parasitology (AREA)
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JP2012530325A 2009-09-22 2010-09-21 抗炎症及び抗凝固活性を有するヘパリンコファクターｉｉ断片 Pending JP2013505030A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0916578.8 2009-09-22
GBGB0916578.8A GB0916578D0 (en) 2009-09-22 2009-09-22 Polypeptides and uses thereof
PCT/GB2010/001780 WO2011036444A1 (en) 2009-09-22 2010-09-21 Heparin cofactor ii fragments with anti-inflammatory and anti-coagulant activity

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JP2013505030A true JP2013505030A (ja) 2013-02-14
JP2013505030A5 JP2013505030A5 (https=) 2015-06-18

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JP2012530325A Pending JP2013505030A (ja) 2009-09-22 2010-09-21 抗炎症及び抗凝固活性を有するヘパリンコファクターｉｉ断片
JP2012530326A Abandoned JP2013505286A (ja) 2009-09-22 2010-09-22 ポリペプチド及びその使用

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US (2) US9169315B2 (https=)
EP (2) EP2480244A1 (https=)
JP (2) JP2013505030A (https=)
CN (2) CN102655874B (https=)
AU (2) AU2010299630A1 (https=)
BR (2) BR112012006502A2 (https=)
CA (2) CA2774288A1 (https=)
EA (1) EA201200515A1 (https=)
GB (1) GB0916578D0 (https=)
IN (2) IN2012DN02981A (https=)
MX (1) MX2012003425A (https=)
WO (2) WO2011036444A1 (https=)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140296146A1 (en) * 2011-08-23 2014-10-02 Synapse B.V. Thermostable Inhibitors of Activation of the Blood Clotting System Through Contact with Foreign Surfaces
RU2476231C1 (ru) * 2011-10-11 2013-02-27 Федеральное государственное бюджетное учреждение "Российский научный центр "Восстановительная травматология и ортопедия" имени академика Г.А. Илизарова" Министерства здравоохранения и социального развития Российской Федерации Способ купирования некроза краев кожи послеоперационной раны после эндопротезирования голеностопного сустава
GB2500184A (en) * 2012-03-12 2013-09-18 Ximmune Ab Polypeptide derived from helix A of heparin cofactor II
CN104292309B (zh) * 2014-09-29 2017-04-12 广西中医药大学 一种小分子多肽
JPWO2016104436A1 (ja) * 2014-12-22 2017-10-26 国立大学法人 岡山大学 サイトカインストーム抑制剤
RU2606836C2 (ru) * 2015-03-12 2017-01-10 Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Антикоагулянтный, антитромбоцитарный и фибриндеполимеризационный комплекс на основе гепарина, способ его получения и применение
RU2610433C1 (ru) * 2016-02-17 2017-02-10 Людмила Анисимовна Ляпина Антикоагулянт
CN107875372A (zh) * 2017-12-20 2018-04-06 辽宁师范大学 重组肽rLj‑112在制备协同肝素抗凝药物中的应用
CN108338163A (zh) * 2018-03-28 2018-07-31 陈太师 一种持效型杀菌灭藻剂的制备方法
CN112512545A (zh) * 2018-05-31 2021-03-16 国立大学法人冈山大学 活性氧的产生抑制剂和/或消除促进剂
WO2020003978A1 (ja) * 2018-06-28 2020-01-02 国立大学法人 岡山大学 好中球貪食能増強剤
BR112021002725A2 (pt) * 2018-08-16 2021-07-20 F. Hoffmann-La Roche Ag métodos para avaliar a fibrilação atrial, para prever o risco de acidente vascular cerebral, para avaliar a eficácia de uma terapia, para identificar um paciente, para monitorar a terapia de anticoagulação e para auxiliar na avaliação da fibrilação atrial, método implementado por computador, kit e uso in vitro
CN109432513B (zh) * 2018-12-12 2021-03-23 中国医科大学 一种具有抗血栓再形成功能的生物材料及其制备方法
US11904000B2 (en) 2019-05-06 2024-02-20 Brown University Compositions and methods to enhance cutaneous wound healing
WO2021240371A1 (en) * 2020-05-26 2021-12-02 Universitätsmedizin Der Johannes Gutenberg-Universität Mainz Methods and compositions for treatment of coronavirus infection and associated coagulopathy
CN114113601A (zh) * 2020-08-25 2022-03-01 张曼 尿液肝素辅因子ii及其多肽片段在烧伤中的应用
CN114292765B (zh) * 2021-09-24 2023-04-07 江西康之康中药科技有限公司 枯草芽孢杆菌纳豆亚种r3及其在发酵水蛭低温干燥品中的应用
CN114886116B (zh) * 2022-03-18 2023-11-21 广东丸美生物技术股份有限公司 一种调理育龄女性健康的组合物及其制备方法和饮料及应用
AU2023260921A1 (en) * 2022-04-29 2024-11-07 Serpin Pharma, Llc Serpin peptide derivatives and methods of using the same
CN116510074A (zh) * 2023-03-13 2023-08-01 西南交通大学 一种胆碱磷酸功能化可植入钛支架的制备方法
CN116836233B (zh) * 2023-08-31 2023-11-14 中国农业大学 抗炎活性多肽及其应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03139280A (ja) * 1989-10-20 1991-06-13 Washington Univ 修飾へパリンコファクター２
WO1992018139A1 (en) * 1991-04-09 1992-10-29 Brigham And Women's Hospital Chimeric molecule with plasminogen activator activity and affinity for atherosclerotic plaques
JPH09176040A (ja) * 1995-12-27 1997-07-08 Green Cross Corp:The ヘパリンコファクターｉｉの医薬用途
US5712247A (en) * 1995-02-21 1998-01-27 University Of North Carolina Use of lactoferrin to modulate and/or neutralize heparin activity
JPH10503375A (ja) * 1994-08-05 1998-03-31 カイロン コーポレイション 組織因子活性インヒビターｔｆｐｉおよびｔｆｐｉ−２のキメラタンパク質および変異体
WO1999043810A1 (en) * 1998-02-27 1999-09-02 The University Of North Carolina At Chapel Hill Mutant heparin cofactor ii

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
SE459005B (sv) 1985-07-12 1989-05-29 Aake Rikard Lindahl Saett att framstaella sfaeriska polymerpartiklar
US5118793A (en) * 1989-10-20 1992-06-02 Washington University Modified heparin cofactor II
US5643872A (en) 1989-10-23 1997-07-01 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
US6008058A (en) 1993-06-18 1999-12-28 University Of Louisville Cyclic peptide mixtures via side chain or backbone attachment and solid phase synthesis
CA2192782C (en) 1995-12-15 2008-10-14 Nobuyuki Takechi Production of microspheres
US6946439B2 (en) * 1997-02-06 2005-09-20 Entre Med, Inc. Compositions and methods for inhibiting cellular proliferation comprising TFPI fragments
AU1410801A (en) * 1999-11-17 2001-05-30 Compugen Ltd. Variants of alternative splicing
JP2005504025A (ja) * 2001-07-20 2005-02-10 アイトゲネシシェ テクニシェ ホッヒシュル チューリッヒ（エーテーハーツェット） スルフォネート化またはスルフェート化アミノ酸から誘導された生物学的薬剤の使用法と組成物
GB0131112D0 (en) 2001-12-31 2002-02-13 Univ London Pharmacy Block copolymers
CA2487901A1 (en) * 2002-05-31 2003-12-11 University Of Utah Research Foundation Variants of antithrombin iii
CA2506526C (en) * 2002-11-22 2017-04-18 Mang Yu Broad spectrum anti-viral therapeutics and prophylaxis
GB0316294D0 (en) 2003-07-11 2003-08-13 Polytherics Ltd Conjugated biological molecules and their preparation
JP2007501605A (ja) 2003-08-08 2007-02-01 ジェノバ・リミテッド 心血管疾患に関連する分泌ポリペプチド種
EP1729791A2 (en) * 2004-03-17 2006-12-13 Chiron Corporation Treatment of severe community-acquired pneumonia by admistration of tissue factor pathway inhibitor (tfpi)
US20050261241A1 (en) * 2004-05-19 2005-11-24 Celsus Biopharmaceuticals, Inc. Use of dermatan sulfates and/or desulfated heparins to treat or prevent heparinoid-induced autoimmune responses
CA2607293A1 (en) * 2005-05-06 2006-11-16 Novartis Ag Use of tfpi to treat severe bacterial infections
JP2009502810A (ja) * 2005-07-22 2009-01-29 ノバルティス アクチエンゲゼルシャフト 補体系と相互作用する抗微生物剤
EP3088522B1 (en) * 2005-12-29 2017-11-29 The Regents of the University of California Methods and compositions related to mutant kunitz domain i of tfpi-2
PL1981519T3 (pl) * 2005-12-29 2018-07-31 Dyax Corp. Hamowanie proteaz
EP1987056B1 (en) * 2006-02-10 2012-07-25 Dermagen AB Novel antimicrobial peptides and use thereof
CA2683443A1 (en) * 2007-04-13 2008-10-23 Catalyst Biosciences, Inc. Modified factor vii polypeptides and uses thereof
AU2008279129A1 (en) * 2007-07-24 2009-01-29 Nexbio, Inc. Technology for the preparation of microparticles

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03139280A (ja) * 1989-10-20 1991-06-13 Washington Univ 修飾へパリンコファクター２
WO1992018139A1 (en) * 1991-04-09 1992-10-29 Brigham And Women's Hospital Chimeric molecule with plasminogen activator activity and affinity for atherosclerotic plaques
JPH10503375A (ja) * 1994-08-05 1998-03-31 カイロン コーポレイション 組織因子活性インヒビターｔｆｐｉおよびｔｆｐｉ−２のキメラタンパク質および変異体
US6174721B1 (en) * 1994-08-05 2001-01-16 Chiron Corporation Chimeric proteins
US5712247A (en) * 1995-02-21 1998-01-27 University Of North Carolina Use of lactoferrin to modulate and/or neutralize heparin activity
JPH09176040A (ja) * 1995-12-27 1997-07-08 Green Cross Corp:The ヘパリンコファクターｉｉの医薬用途
WO1999043810A1 (en) * 1998-02-27 1999-09-02 The University Of North Carolina At Chapel Hill Mutant heparin cofactor ii

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
JPN6014044870; ＣＨＵＲＣＨ，　Ｆ．Ｃ．　ｅｔ　ａｌ．: Ｊ．　Ｂｉｏｌ．　Ｃｈｅｍ． Ｖｏｌ．２６６，　Ｎｏ．２, 1991, ｐｐ．７０４-７０９ *
JPN6014044872; ＢＡＵＭＡＮ，　Ｓ．Ｊ．　ａｎｄ　ＣＨＵＲＣＨ，　Ｆ．Ｃ．: Ｊ．　Ｂｉｏｌ．　Ｃｈｅｍ． Ｖｏｌ．２７４, 1999, ｐｐ．３４５５６-３４５６５ *
JPN6014044875; ＭＡＥＫＡＷＡ，　Ｈ．　ｅｔ　ａｌ．: Ｔｈｒｏｍｂ．　Ｒｅｓ． Ｖｏｌ．１００, 2000, ｐｐ．４４３-４５１ *
JPN6014044877; ＫＡＬＬＥ，　Ｍ．　ｅｔ　ａｌ．: Ｊ．　Ｉｍｍｕｎｏｌ． Ｖｏｌ．１９０, 2013, ｐｐ．６３０３-６３１０ *
JPN6014044879; ＢＡＧＬＩＮ，　Ｔ．Ｐ．　ｅｔ　ａｌ．: Ｐｒｏｃ．　Ｎａｔｌ．　Ａｃａｄ．　Ｓｃｉ．　ＵＳＡ Ｖｏｌ．９９，　Ｎｏ．１７, 2002, ｐｐ．１１０７９-１１０８４ *
JPN6014044881; ＴＯＬＬＥＦＳＥＮ，　Ｄ．Ｍ．: Ａｄｖ．　Ｅｘｐ．　Ｍｅｄ．　Ｂｉｏｌ． Ｖｏｌ．４２５, 1997, ｐｐ．３５-４４ *
JPN6014044884; ＳＨＥＦＦＩＥＬＤ，　Ｗ．Ｐ．　ａｎｄ　ＢＬＡＪＣＨＭＡＮ，　Ｍ．Ａ．: ＦＥＢＳ　Ｌｅｔｔ． Ｖｏｌ．３６５, 1995, ｐｐ．１８９-１９２ *
JPN6015040934; ＷＨＩＮＮＡ，　Ｈ．Ｃ．　ｅｔ　ａｌ．: Ｊ．　Ｂｉｏｌ．　Ｃｈｅｍ． Ｖｏｌ．２６６，　Ｎｏ．１３, 1991, ｐｐ．８１２９-８１３５ *

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