JP2013504610A5 - - Google Patents
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- Publication number
- JP2013504610A5 JP2013504610A5 JP2012529270A JP2012529270A JP2013504610A5 JP 2013504610 A5 JP2013504610 A5 JP 2013504610A5 JP 2012529270 A JP2012529270 A JP 2012529270A JP 2012529270 A JP2012529270 A JP 2012529270A JP 2013504610 A5 JP2013504610 A5 JP 2013504610A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- aqueous liquid
- liquid pharmaceutical
- surfactant
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 239000008194 pharmaceutical composition Substances 0.000 claims 20
- 239000007788 liquid Substances 0.000 claims 15
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 11
- 150000002632 lipids Chemical class 0.000 claims 10
- 239000004094 surface-active agent Substances 0.000 claims 9
- 239000006184 cosolvent Substances 0.000 claims 8
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical group CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 6
- 239000002516 radical scavenger Substances 0.000 claims 6
- 102000004877 Insulin Human genes 0.000 claims 5
- 108090001061 Insulin Proteins 0.000 claims 5
- 229940125396 insulin Drugs 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 4
- 230000000269 nucleophilic effect Effects 0.000 claims 4
- 229920001213 Polysorbate 20 Polymers 0.000 claims 3
- 239000011159 matrix material Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims 3
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims 3
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 3
- 229920000053 polysorbate 80 Polymers 0.000 claims 3
- -1 Rylo MG08 Pharma) Chemical compound 0.000 claims 2
- 150000001299 aldehydes Chemical class 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- GHBFNMLVSPCDGN-UHFFFAOYSA-N rac-1-monooctanoylglycerol Chemical compound CCCCCCCC(=O)OCC(O)CO GHBFNMLVSPCDGN-UHFFFAOYSA-N 0.000 claims 2
- LKUNXBRZDFMZOK-GFCCVEGCSA-N Capric acid monoglyceride Natural products CCCCCCCCCC(=O)OC[C@H](O)CO LKUNXBRZDFMZOK-GFCCVEGCSA-N 0.000 claims 1
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 claims 1
- NPTLAYTZMHJJDP-KTKRTIGZSA-N [3-[3-[3-[3-[3-[3-[3-[3-[3-(2,3-dihydroxypropoxy)-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropyl] (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(O)COCC(O)COCC(O)COCC(O)COCC(O)COCC(O)COCC(O)COCC(O)COCC(O)COCC(O)CO NPTLAYTZMHJJDP-KTKRTIGZSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 230000003796 beauty Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 claims 1
- 125000003916 ethylene diamine group Chemical group 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 150000002576 ketones Chemical class 0.000 claims 1
- 239000002736 nonionic surfactant Substances 0.000 claims 1
- 229920000223 polyglycerol Polymers 0.000 claims 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 1
- 229940068977 polysorbate 20 Drugs 0.000 claims 1
- 229940068968 polysorbate 80 Drugs 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- LKUNXBRZDFMZOK-UHFFFAOYSA-N rac-1-monodecanoylglycerol Chemical compound CCCCCCCCCC(=O)OCC(O)CO LKUNXBRZDFMZOK-UHFFFAOYSA-N 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09170389 | 2009-09-16 | ||
| EP09170389.2 | 2009-09-16 | ||
| PCT/EP2010/063610 WO2011033019A1 (en) | 2009-09-16 | 2010-09-16 | Stable non-aqueous liquid pharmaceutical compositions comprising an insulin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013504610A JP2013504610A (ja) | 2013-02-07 |
| JP2013504610A5 true JP2013504610A5 (enExample) | 2013-10-31 |
Family
ID=41622804
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012529270A Withdrawn JP2013504610A (ja) | 2009-09-16 | 2010-09-16 | インスリンを含む安定な非水性液体医薬組成物 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20120196800A1 (enExample) |
| EP (1) | EP2477644A1 (enExample) |
| JP (1) | JP2013504610A (enExample) |
| CN (1) | CN102481343A (enExample) |
| WO (1) | WO2011033019A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2910571B1 (en) | 2008-03-18 | 2016-10-05 | Novo Nordisk A/S | Protease stabilized, acylated insulin analogues |
| BR112012016853A2 (pt) * | 2010-01-12 | 2017-10-17 | Novo Nordisk As | "composições farmacêuticas para administração oral de peptídeos de insulina". |
| JP6199956B2 (ja) | 2012-04-11 | 2017-09-20 | ノヴォ ノルディスク アー／エス | インスリン製剤 |
| US10130288B2 (en) | 2013-03-14 | 2018-11-20 | Cell and Molecular Tissue Engineering, LLC | Coated sensors, and corresponding systems and methods |
| US10405961B2 (en) | 2013-03-14 | 2019-09-10 | Cell and Molecular Tissue Engineering, LLC | Coated surgical mesh, and corresponding systems and methods |
| PE20210857A1 (es) | 2016-12-16 | 2021-05-18 | Novo Nordisk As | Composiciones farmaceuticas que contienen insulina |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992004893A1 (en) * | 1990-09-13 | 1992-04-02 | Smithkline Beecham Corporation | Non-aqueous liquid oral suspensions |
| CN1160122C (zh) * | 2001-04-20 | 2004-08-04 | 清华大学 | 一种制备口服胰岛素油相制剂的方法 |
| AU2003272347A1 (en) * | 2002-09-17 | 2004-04-08 | Merck And Co., Inc. | Removal of aldehyde impurity by reactive polystyrene resin |
| EP2292653B1 (en) * | 2005-02-02 | 2014-05-21 | Novo Nordisk A/S | Novel insulin derivatives |
| CN101180081B (zh) | 2005-05-25 | 2015-08-26 | 诺沃-诺迪斯克有限公司 | 稳定的多肽制剂 |
| ES2601839T3 (es) | 2006-09-22 | 2017-02-16 | Novo Nordisk A/S | Análogos de insulina resistentes a proteasas |
| WO2008145732A1 (en) * | 2007-06-01 | 2008-12-04 | Novo Nordisk A/S | Stable non-aqueous pharmaceutical compositions |
| JP2011504871A (ja) * | 2007-06-01 | 2011-02-17 | ノボ・ノルデイスク・エー／エス | 固体又は半固体担体中にペプチド薬剤を含む自然に分散可能なプレコンセントレイト |
| EP2910571B1 (en) | 2008-03-18 | 2016-10-05 | Novo Nordisk A/S | Protease stabilized, acylated insulin analogues |
-
2010
- 2010-09-16 CN CN2010800409259A patent/CN102481343A/zh active Pending
- 2010-09-16 EP EP10754334A patent/EP2477644A1/en not_active Withdrawn
- 2010-09-16 WO PCT/EP2010/063610 patent/WO2011033019A1/en not_active Ceased
- 2010-09-16 JP JP2012529270A patent/JP2013504610A/ja not_active Withdrawn
- 2010-09-16 US US13/496,529 patent/US20120196800A1/en not_active Abandoned
-
2014
- 2014-07-17 US US14/333,793 patent/US20140329744A1/en not_active Abandoned
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