JP2013504459A - 生体吸収性ステントの結晶モルフォロジの制御 - Google Patents
生体吸収性ステントの結晶モルフォロジの制御 Download PDFInfo
- Publication number
- JP2013504459A JP2013504459A JP2012528900A JP2012528900A JP2013504459A JP 2013504459 A JP2013504459 A JP 2013504459A JP 2012528900 A JP2012528900 A JP 2012528900A JP 2012528900 A JP2012528900 A JP 2012528900A JP 2013504459 A JP2013504459 A JP 2013504459A
- Authority
- JP
- Japan
- Prior art keywords
- tube
- stent
- expansion
- mold
- radial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000013078 crystal Substances 0.000 title abstract description 6
- 238000000034 method Methods 0.000 claims abstract description 31
- 238000004519 manufacturing process Methods 0.000 claims abstract description 14
- 229920001432 poly(L-lactide) Polymers 0.000 claims description 28
- 238000001816 cooling Methods 0.000 claims description 9
- 238000010438 heat treatment Methods 0.000 claims description 9
- 238000013519 translation Methods 0.000 claims description 8
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 claims 5
- 229920000642 polymer Polymers 0.000 abstract description 75
- 230000035882 stress Effects 0.000 description 23
- 238000010586 diagram Methods 0.000 description 21
- 230000006870 function Effects 0.000 description 18
- 230000009477 glass transition Effects 0.000 description 18
- 239000000463 material Substances 0.000 description 18
- 238000012545 processing Methods 0.000 description 18
- 238000000113 differential scanning calorimetry Methods 0.000 description 12
- 229920002988 biodegradable polymer Polymers 0.000 description 8
- 239000004621 biodegradable polymer Substances 0.000 description 8
- 210000004204 blood vessel Anatomy 0.000 description 8
- 239000012530 fluid Substances 0.000 description 8
- 239000002243 precursor Substances 0.000 description 8
- 230000008569 process Effects 0.000 description 8
- 238000002788 crimping Methods 0.000 description 7
- 238000002425 crystallisation Methods 0.000 description 7
- 230000008025 crystallization Effects 0.000 description 7
- 230000033001 locomotion Effects 0.000 description 7
- 238000005452 bending Methods 0.000 description 6
- 230000003068 static effect Effects 0.000 description 6
- 230000004962 physiological condition Effects 0.000 description 5
- 229920006126 semicrystalline polymer Polymers 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 4
- 230000007423 decrease Effects 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 230000002792 vascular Effects 0.000 description 4
- 208000031481 Pathologic Constriction Diseases 0.000 description 3
- 239000003570 air Substances 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 230000000875 corresponding effect Effects 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 239000007943 implant Substances 0.000 description 3
- 238000002844 melting Methods 0.000 description 3
- 230000008018 melting Effects 0.000 description 3
- 239000002861 polymer material Substances 0.000 description 3
- 230000036262 stenosis Effects 0.000 description 3
- 208000037804 stenosis Diseases 0.000 description 3
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 238000007664 blowing Methods 0.000 description 2
- 230000036760 body temperature Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 238000012377 drug delivery Methods 0.000 description 2
- 238000002513 implantation Methods 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 238000011068 loading method Methods 0.000 description 2
- 230000006911 nucleation Effects 0.000 description 2
- 238000010899 nucleation Methods 0.000 description 2
- 230000000737 periodic effect Effects 0.000 description 2
- 208000037803 restenosis Diseases 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 241000446313 Lamella Species 0.000 description 1
- 206010063493 Premature ageing Diseases 0.000 description 1
- 208000032038 Premature aging Diseases 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 230000009102 absorption Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 229920006125 amorphous polymer Polymers 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 238000002399 angioplasty Methods 0.000 description 1
- 238000000137 annealing Methods 0.000 description 1
- 210000000709 aorta Anatomy 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- 230000003143 atherosclerotic effect Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 238000010009 beating Methods 0.000 description 1
- 210000000013 bile duct Anatomy 0.000 description 1
- 239000012867 bioactive agent Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000002144 chemical decomposition reaction Methods 0.000 description 1
- 238000003486 chemical etching Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000005336 cracking Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000006355 external stress Effects 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000012447 hatching Effects 0.000 description 1
- 210000003709 heart valve Anatomy 0.000 description 1
- 230000017525 heat dissipation Effects 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 238000003698 laser cutting Methods 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 238000000059 patterning Methods 0.000 description 1
- 229920002643 polyglutamic acid Polymers 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000001635 urinary tract Anatomy 0.000 description 1
- 230000004865 vascular response Effects 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
- 238000004804 winding Methods 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C49/00—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor
- B29C49/08—Biaxial stretching during blow-moulding
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
- B29D22/00—Producing hollow articles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C49/00—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor
- B29C49/02—Combined blow-moulding and manufacture of the preform or the parison
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C55/00—Shaping by stretching, e.g. drawing through a die; Apparatus therefor
- B29C55/22—Shaping by stretching, e.g. drawing through a die; Apparatus therefor of tubes
- B29C55/26—Shaping by stretching, e.g. drawing through a die; Apparatus therefor of tubes biaxial
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C49/00—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor
- B29C49/42—Component parts, details or accessories; Auxiliary operations
- B29C49/78—Measuring, controlling or regulating
- B29C49/783—Measuring, controlling or regulating blowing pressure
- B29C2049/7831—Measuring, controlling or regulating blowing pressure characterised by pressure values or ranges
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C49/00—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor
- B29C49/42—Component parts, details or accessories; Auxiliary operations
- B29C49/78—Measuring, controlling or regulating
- B29C49/786—Temperature
- B29C2049/7861—Temperature of the preform
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C49/00—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor
- B29C49/42—Component parts, details or accessories; Auxiliary operations
- B29C49/78—Measuring, controlling or regulating
- B29C49/786—Temperature
- B29C2049/7864—Temperature of the mould
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C49/00—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor
- B29C49/42—Component parts, details or accessories; Auxiliary operations
- B29C49/78—Measuring, controlling or regulating
- B29C2049/7879—Stretching, e.g. stretch rod
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C2793/00—Shaping techniques involving a cutting or machining operation
- B29C2793/009—Shaping techniques involving a cutting or machining operation after shaping
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C49/00—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor
- B29C49/0005—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor characterised by the material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C49/00—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor
- B29C49/02—Combined blow-moulding and manufacture of the preform or the parison
- B29C49/04—Extrusion blow-moulding
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C49/00—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor
- B29C49/08—Biaxial stretching during blow-moulding
- B29C49/087—Means for providing controlled or limited stretch ratio
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C49/00—Blow-moulding, i.e. blowing a preform or parison to a desired shape within a mould; Apparatus therefor
- B29C49/42—Component parts, details or accessories; Auxiliary operations
- B29C49/78—Measuring, controlling or regulating
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2995/00—Properties of moulding materials, reinforcements, fillers, preformed parts or moulds
- B29K2995/0037—Other properties
- B29K2995/004—Semi-crystalline
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2995/00—Properties of moulding materials, reinforcements, fillers, preformed parts or moulds
- B29K2995/0037—Other properties
- B29K2995/0041—Crystalline
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2995/00—Properties of moulding materials, reinforcements, fillers, preformed parts or moulds
- B29K2995/0037—Other properties
- B29K2995/0046—Elastic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2995/00—Properties of moulding materials, reinforcements, fillers, preformed parts or moulds
- B29K2995/0037—Other properties
- B29K2995/0056—Biocompatible, e.g. biopolymers or bioelastomers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2995/00—Properties of moulding materials, reinforcements, fillers, preformed parts or moulds
- B29K2995/0037—Other properties
- B29K2995/0059—Degradable
- B29K2995/006—Bio-degradable, e.g. bioabsorbable, bioresorbable or bioerodible
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2995/00—Properties of moulding materials, reinforcements, fillers, preformed parts or moulds
- B29K2995/0037—Other properties
- B29K2995/0077—Yield strength; Tensile strength
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2995/00—Properties of moulding materials, reinforcements, fillers, preformed parts or moulds
- B29K2995/0037—Other properties
- B29K2995/0089—Impact strength or toughness
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
- B29L2031/00—Other particular articles
- B29L2031/753—Medical equipment; Accessories therefor
- B29L2031/7542—Catheters
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Manufacturing & Machinery (AREA)
- Materials For Medical Uses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Blow-Moulding Or Thermoforming Of Plastics Or The Like (AREA)
Abstract
Description
圧力:110乃至140psi
加熱ノズル速度:0.32乃至1.0mm/秒
引張速度:0.58乃至3.8mm/秒
予備加熱時間(予備加熱は各グループに示す温度で行った):4乃至32秒
結晶化度は、示差走査熱量測定法(DSC)を用いて測定された。
Tg又はガラス転移の開始は、示差走査熱量測定法(DSC)を用いて測定された。
終局強度(破壊強度)及び破断時の伸びは、フープ方向及び軸線方向で、変形されたチューブについて測定された。フープ特性は、変形されたチューブの端部からフープ又はリングを切り離すステップと、チューブ内のノッチを切断するステップと、及びチューブが破断するまで、チューブに挿入されたピンで反対方向にチューブを引くステップとによって測定された。軸線方向の特性はその円筒軸線に沿ってチューブを引くステップによって測定された。破断時の伸びは、破断に至るまでの降伏点から生じる伸びの量である。
変形されたチューブの半径方向及び軸線方向の弾性率は動的機械分析(DMA)により測定された。
半径方向の強度及び半径方向の剛性は、アリゾナ州フラッグスタッフのMachine Solutions Inc.が製造したMSI RX650半径方向拡張力測定装置により測定された。
リコイル(スプリングバック)はNikon(登録商標)製のカメラ装置により測定された。
破壊に至る展開(拡張)の直径は、最初に1.3mmまでステントを圧着し、次にストラットの破壊(破断)が観察されるまでステントを展開させるステップによって測定された。
3mmの展開時のクラックの計数は、最初に1.3mmにステントを圧着し、次に3mmに展開するステップによって測定された。クラックの計数は同一のステントを3.5mmに展開(拡張)することによって、3.5mmで測定された。
(1)T及びX
(2)X、B、G及びP
(3)F
弾性率と%RE及び%AEとの間に相関性は観察されなかった。
110 ストラット
160 円筒軸線
200 チューブ
205 外径
210 内径
215 外側表面
220 円筒軸線
300 システム
301 ポリマーチューブ
305 外径(ポリマーチューブ拡張及び伸長前)
310 モールド型
315 外径(ポリマーチューブ拡張及び伸長後)
320 遠位端部(ポリマーチューブ)
321 近位端部(ポリマーチューブ)
325 矢印(気体の送り方向)
335 矢印(加熱した流体の吹付け方向)
340 矢印(加熱した流体の吹付け方向)
330 ノズル
360 構造部材(ノズル)
365 矢印(ノズルの平行移動方向)
367 矢印(ノズルの平行移動方向)
370 拡張されたセクション(ポリマーチューブ)
372 拡張しているセクション(ポリマーチューブ)
380 矢印(半径方向の拡張成分)
382 矢印(軸線方向の伸長成分)
385 矢印(引張力の負荷方向)
700 ステントパターン
702 ストラット
703 ギャップ
704 セル
706 ストラット
707 クレスト(山部)
708 下縁部
709 トラフ(谷部)
710 上縁部
712 リング
713 連結部
Claims (18)
- PLLAのチューブを半径方向に拡張するステップと;
前記半径方向に拡張するステップの間に前記PLLAのチューブを軸線方向に伸長するステップであって、前記半径方向への拡張の拡張率は300乃至500%であり、前記軸線方向への伸長の伸長率は100乃至200%である、前記PLLAのチューブを軸線方向に伸長させるステップと;
前記軸線方向に伸長され、前記半径方向に拡張されたチューブにステントパターンを形成するステップとを備える;
ステントを製造する方法。 - 前記半径方向に拡張するステップ及び前記軸線方向に伸長するステップの間に、結晶化度が45乃至50%まで増大する、請求項1に記載の方法。
- 前記チューブは、摂氏80乃至100度の間の温度で前記半径方向に拡張され、前記軸線方向に伸長される、請求項1に記載の方法。
- 前記チューブは、摂氏115度乃至120度の間の温度で前記半径方向に拡張され、前記軸線方向に伸長される、請求項1に記載の方法。
- 前記チューブを前記半径方向に拡張させ、前記軸線方向に伸長させるときの温度を調節することにより、変形した前記チューブの内面と外面との間の深さの関数としての弾性率の不均衡を解消する、請求項1に記載の方法。
- 円筒状のモールド型の内部に配置されたPLLAのチューブを提供するステップと;
前記モールド型及び前記チューブを前記モールド型及び前記チューブの円筒軸線に沿って平行移動する熱源で前記チューブの変形温度まで加熱するステップと;
前記チューブの内部の圧力を増大させるステップと;
前記チューブの内部の前記増大された圧力が前記チューブを前記モールド型の内面に対して半径方向に拡張することを許容するステップであって、前記モールド型の円筒軸線に沿って前記熱源が平行移動して加熱する際、前記モールド型の円筒軸線に沿って前記半径方向の拡張が伝搬する、前記チューブを半径方向に拡張することを許容するステップと;
前記半径方向の拡張の間に前記円筒軸線に沿って前記チューブに引張力を負荷して前記半径方向の拡張の間に前記チューブを軸線方向に伸長するステップであって、前記半径方向の拡張率は300乃至500%であり、前記軸線方向の伸長率は100乃至200%である、前記チューブを軸線方向に伸長するステップと;
前記半径方向に拡張され、軸線方向に伸長されたチューブにステントパターンを形成するステップとを備える;
ステントを製造する方法。 - 前記半径方向の拡張と前記軸線方向の伸長とは同時に始まり同時に終了する、請求項6に記載の方法。
- 前記チューブの変形温度は、前記チューブが前記モールド型の内面に対して半径方向に拡張することを許容する最低温度である、請求項6に記載の方法。
- 前記チューブの変形温度は、前記拡張及び前記伸長されたチューブの内面と外面との間の深さの関数としての弾性率の不均衡が生じないように調整される、請求項6に記載の方法。
- 前記半径方向に拡張するステップ及び前記軸線方向に伸長するステップの間に、結晶化度が45乃至50%まで増大する、請求項6に記載の方法。
- 前記チューブは、摂氏80乃至100度の間の温度で前記半径方向に拡張され、前記軸線方向に伸長される、請求項6に記載の方法。
- 前記チューブは、摂氏115度乃至120度の間の温度で前記半径方向に拡張され、前記軸線方向に伸長される、請求項6に記載の方法。
- 前記チューブが拡張するときの前記チューブの内部の圧力は、110乃至140psiである、請求項6に記載の方法。
- 前記熱源の平行移動速度は、前記半径方向の拡張及び前記軸線方向の伸長の全体の期間にわたって一定である、請求項6に記載の方法。
- 前記引張力は前記チューブを一定速度で引くステップによって引き起こされて一定の前記伸長率を提供する、請求項6に記載の方法。
- 前記半径方向の拡張の圧力は、110乃至140psiである、請求項6に記載の方法。
- 前記チューブが前記モールド型の内面に対して拡張するために十分に加熱されることを許容するように前記熱源の平行移動速度が十分に遅く調整され、前記熱源の平行移動速度は0.2乃至1.2mm/秒の間である、請求項6に記載の方法。
- 円筒状のモールド型の内部に配置されたPLLAのチューブを提供するステップと;
前記モールド型及び前記チューブを前記モールド型及び前記チューブの全体を一時に加熱する熱源で前記チューブの変形温度まで加熱するステップと;
前記チューブの内部の圧力を増大させるステップと;
前記チューブ内の前記増大された圧力が前記チューブを前記モールド型の内面に対して半径方向に拡張することを許容するステップと、続いて前記モールド型と前記チューブの全体を一時に冷却源で冷却するステップとを備える;
ステントを製造する方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/559,400 | 2009-09-14 | ||
US12/559,400 US8501079B2 (en) | 2009-09-14 | 2009-09-14 | Controlling crystalline morphology of a bioabsorbable stent |
PCT/US2010/048287 WO2011031872A2 (en) | 2009-09-14 | 2010-09-09 | Controlling crystalline morphology of a bioabsorbable stent |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2013504459A true JP2013504459A (ja) | 2013-02-07 |
JP2013504459A5 JP2013504459A5 (ja) | 2013-10-31 |
JP5718923B2 JP5718923B2 (ja) | 2015-05-13 |
Family
ID=43567942
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012528900A Active JP5718923B2 (ja) | 2009-09-14 | 2010-09-09 | 生体吸収性ステントの結晶モルフォロジの制御 |
Country Status (5)
Country | Link |
---|---|
US (2) | US8501079B2 (ja) |
EP (1) | EP2477797B1 (ja) |
JP (1) | JP5718923B2 (ja) |
CN (1) | CN102497970B (ja) |
WO (1) | WO2011031872A2 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2016514007A (ja) * | 2013-03-15 | 2016-05-19 | アボット カルディオバスキュラー システムズ インコーポレーテッドAbbott Cardiovascular Systems Inc. | 強化された軸線方向疲労特性を有するポリマースキャフォールド |
JP2017522160A (ja) * | 2014-07-07 | 2017-08-10 | メリル ライフ サイエンシズ ピーブィティ.エルティディ | 高い疲労強度および半径方向強さを有する生体吸収性ポリマー由来の薄型ストラットステント、並びに、その製造方法 |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8814930B2 (en) | 2007-01-19 | 2014-08-26 | Elixir Medical Corporation | Biodegradable endoprosthesis and methods for their fabrication |
US8370120B2 (en) * | 2010-04-30 | 2013-02-05 | Abbott Cardiovascular Systems Inc. | Polymeric stents and method of manufacturing same |
TW201311226A (zh) * | 2011-05-06 | 2013-03-16 | Ind Tech Res Inst | 生物可吸收血管支架之製造方法 |
US8747728B2 (en) * | 2011-05-24 | 2014-06-10 | Abbott Cardiovascular Systems Inc. | Method and system for manufacturing a polymer endoprosthesis by injection molding and blow molding |
CN102429749A (zh) * | 2011-07-27 | 2012-05-02 | 微创医疗器械(上海)有限公司 | 一种新的生物可降解支架的加工方法 |
WO2013019762A2 (en) * | 2011-07-31 | 2013-02-07 | SCANLON, John, James | Filamentous bioresorbable stent |
CN102499999B (zh) * | 2011-11-22 | 2014-06-18 | 深圳市信立泰生物医疗工程有限公司 | 一种形变后的聚合物管材和由其制备的完全可生物降解聚合物支架 |
GB2512016A (en) * | 2012-09-24 | 2014-09-24 | Arterius Ltd | Methods |
CN106618820A (zh) * | 2012-12-21 | 2017-05-10 | 上海微创医疗器械(集团)有限公司 | 一种生物可降解聚合物支架的制备方法 |
EP2883554A1 (de) | 2013-12-16 | 2015-06-17 | MeKo Laserstrahl-Materialbearbeitungen e.K. | Herstellung von resorbierbaren Polymerrohren aus Fäden |
US10207449B2 (en) | 2014-06-24 | 2019-02-19 | Cook Medical Technologies Llc | Sequential biaxial strain of semi-crystalline tubes |
US10603833B2 (en) | 2014-07-07 | 2020-03-31 | Meril Life Sciences Pvt. Ltd. | Method to manufacture thin strut stent from bioabsorbable polymer |
US10675387B2 (en) | 2014-07-07 | 2020-06-09 | Meril Life Sciences Pvt. Ltd. | Multi stage radial deformation for manufacturing thin strut stent from bioabsorbable polymer |
US10518003B2 (en) | 2014-07-07 | 2019-12-31 | Meril Life Sciences Pvt. Ltd. | Method to manufacture thin strut stent from bioabsorbable polymer with high fatigue and radial strength |
US10022906B2 (en) | 2014-07-30 | 2018-07-17 | Abbott Cardiovascular Systems Inc. | Methods for solid phase processing of tubes and medical devices made from the processed tubes |
US9480588B2 (en) | 2014-08-15 | 2016-11-01 | Elixir Medical Corporation | Biodegradable endoprostheses and methods of their fabrication |
US9259339B1 (en) | 2014-08-15 | 2016-02-16 | Elixir Medical Corporation | Biodegradable endoprostheses and methods of their fabrication |
US9730819B2 (en) | 2014-08-15 | 2017-08-15 | Elixir Medical Corporation | Biodegradable endoprostheses and methods of their fabrication |
US9855156B2 (en) * | 2014-08-15 | 2018-01-02 | Elixir Medical Corporation | Biodegradable endoprostheses and methods of their fabrication |
WO2016044788A2 (en) | 2014-09-18 | 2016-03-24 | Abbott Cardiovascular Systems Inc. | Thermal processing of polymer scaffolds |
WO2016197351A1 (en) * | 2015-06-11 | 2016-12-15 | Beijing Advanced Medical Technologies, Inc. | A close-cell structured stent, a preparation method and use thereof |
EP3457985B1 (en) | 2016-05-16 | 2021-02-17 | Elixir Medical Corporation | Uncaging stent |
US11622872B2 (en) | 2016-05-16 | 2023-04-11 | Elixir Medical Corporation | Uncaging stent |
CN106267382A (zh) * | 2016-10-21 | 2017-01-04 | 上海脉全医疗器械有限公司 | 一种可降解的药物洗脱支架及其制备方法 |
CN108261275A (zh) | 2016-12-31 | 2018-07-10 | 先健科技(深圳)有限公司 | 可吸收支架 |
WO2023168256A1 (en) * | 2022-03-01 | 2023-09-07 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Methods and materials for modulating construct wear due to cyclic loading |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007143030A2 (en) * | 2006-05-31 | 2007-12-13 | Abbott Cardiovascular Systems Inc. | Method of fabricating an implantable medical device to reduce chance of late inflammatory response |
WO2007142736A2 (en) * | 2006-05-30 | 2007-12-13 | Abbott Cardiovascular Systems Inc. | Manufacturing process for polymeric stents |
JP2007325923A (ja) * | 2006-05-25 | 2007-12-20 | Cordis Corp | フープと可撓性コネクターの選定された部分との両方に、改変された分子構造を有するポリマーステント |
WO2007149457A1 (en) * | 2006-06-19 | 2007-12-27 | Abbott Cardiovascular Systems Inc. | Fabricating a stent with selected properties in the radial and axial directions |
Family Cites Families (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE758156R (fr) | 1970-05-13 | 1971-04-28 | Ethicon Inc | Element de suture absorbable et sa |
GB2089276B (en) | 1980-11-19 | 1984-09-05 | Metal Box Co Ltd | Thermoplastics tubular articles |
FR2510411B1 (fr) | 1981-07-30 | 1986-09-12 | Ethicon Inc | Appareil chirurgical en polydioxanone reticulee et procede pour sa production |
FR2554386B1 (fr) | 1983-11-07 | 1986-02-07 | Plastic Omnium Cie | Procede de fabrication de tubes profiles en matiere plastique, dispositif pour la mise en oeuvre de ce procede, et tubes profiles obtenus |
EP0213807B1 (en) | 1985-08-12 | 1991-01-02 | Mitsui Petrochemical Industries, Ltd. | Inflation film and production method and apparatus thereof |
US4698196A (en) | 1985-12-24 | 1987-10-06 | Xerox Corporation | Method and apparatus for extruding creaseless thin walled tubes |
US4702884A (en) | 1986-07-03 | 1987-10-27 | The United States Of America As Represented By The Secretary Of The Navy | Glass-lined pipes |
US6500146B1 (en) | 1988-10-04 | 2002-12-31 | Cordis Corporation | Balloons for medical devices and fabrication thereof |
US5147302A (en) | 1989-04-21 | 1992-09-15 | Scimed Life Systems, Inc. | Method of shaping a balloon of a balloon catheter |
US5087394A (en) | 1989-11-09 | 1992-02-11 | Scimed Life Systems, Inc. | Method for forming an inflatable balloon for use in a catheter |
US5108416A (en) | 1990-02-13 | 1992-04-28 | C. R. Bard, Inc. | Stent introducer system |
US5116365A (en) | 1991-02-22 | 1992-05-26 | Cordis Corporation | Stent apparatus and method for making |
US5500013A (en) | 1991-10-04 | 1996-03-19 | Scimed Life Systems, Inc. | Biodegradable drug delivery vascular stent |
AU664913B2 (en) | 1992-08-13 | 1995-12-07 | Implico B.V. | A hydrogel composition and methods of making it |
US5857998A (en) | 1994-06-30 | 1999-01-12 | Boston Scientific Corporation | Stent and therapeutic delivery system |
US5628786A (en) | 1995-05-12 | 1997-05-13 | Impra, Inc. | Radially expandable vascular graft with resistance to longitudinal compression and method of making same |
KR100455975B1 (ko) | 1996-03-07 | 2005-06-17 | 메드 인스티튜트, 인코포레이티드 | 팽창 가능한 스텐트 |
US5670161A (en) | 1996-05-28 | 1997-09-23 | Healy; Kevin E. | Biodegradable stent |
US5891386A (en) | 1997-04-25 | 1999-04-06 | Medtronic, Inc. | Method for making catheter balloons |
CA2232250C (en) | 1997-05-14 | 2007-06-26 | Navius Corporation | Balloon for a dilation catheter and method for manufacturing a balloon |
US6626939B1 (en) | 1997-12-18 | 2003-09-30 | Boston Scientific Scimed, Inc. | Stent-graft with bioabsorbable structural support |
US6015433A (en) | 1998-05-29 | 2000-01-18 | Micro Therapeutics, Inc. | Rolled stent with waveform perforation pattern |
EP1119379A1 (en) | 1998-09-02 | 2001-08-01 | Boston Scientific Limited | Drug delivery device for stent |
CA2308434C (en) | 1998-09-08 | 2008-02-05 | Kabushikikaisha Igaki Iryo Sekkei | Stent for vessels |
US20010014821A1 (en) | 1998-11-16 | 2001-08-16 | Mohamad Ike Juman | Balloon catheter and stent delivery system having enhanced stent retention |
DE60041725D1 (de) | 1999-09-01 | 2009-04-16 | Boston Scient Scimed Inc | Röhrenförmige Stent-Graft-Kompositvorrichtung und Verfahren zu ihrer Herstellung |
US6360577B2 (en) | 1999-09-22 | 2002-03-26 | Scimed Life Systems, Inc. | Apparatus for contracting, or crimping stents |
US7226475B2 (en) | 1999-11-09 | 2007-06-05 | Boston Scientific Scimed, Inc. | Stent with variable properties |
US6936066B2 (en) | 1999-11-19 | 2005-08-30 | Advanced Bio Prosthetic Surfaces, Ltd. | Complaint implantable medical devices and methods of making same |
US6572813B1 (en) | 2000-01-13 | 2003-06-03 | Advanced Cardiovascular Systems, Inc. | Balloon forming process |
ES2392798T3 (es) | 2000-03-13 | 2012-12-13 | Kabushiki Kaisha Kyoto Iryo Sekkei | Material líneal para endoprótesis intravascular y endoprótesis intravascular que utiliza el mismo |
US6878790B2 (en) | 2000-11-30 | 2005-04-12 | The Procter & Gamble Company | High molecular weight polyolefin and catalyst and process for polymerizing said polyolefin |
US6563080B2 (en) | 2001-02-15 | 2003-05-13 | Scimed Life Systems, Inc. | Laser cutting of stents and other medical devices |
US8182527B2 (en) | 2001-05-07 | 2012-05-22 | Cordis Corporation | Heparin barrier coating for controlled drug release |
US6926733B2 (en) | 2001-08-02 | 2005-08-09 | Boston Scientific Scimed, Inc. | Method for enhancing sheet or tubing metal stent radiopacity |
US7083639B2 (en) | 2001-09-26 | 2006-08-01 | Medtronic Vascular, Inc. | Stent delivery catheter with grooved balloon and methods of making same |
US7572287B2 (en) | 2001-10-25 | 2009-08-11 | Boston Scientific Scimed, Inc. | Balloon expandable polymer stent with reduced elastic recoil |
US7163655B2 (en) | 2002-03-28 | 2007-01-16 | Scimed Life Systems, Inc. | Method and apparatus for extruding polymers employing microwave energy |
US6948223B2 (en) | 2002-05-03 | 2005-09-27 | Medtronic Vascular, Inc. | Apparatus for mounting a stent onto a stent delivery system |
US6780261B2 (en) | 2002-06-27 | 2004-08-24 | Scimed Life Systems, Inc. | Method of manufacturing an implantable stent having improved mechanical properties |
US20040098090A1 (en) | 2002-11-14 | 2004-05-20 | Williams Michael S. | Polymeric endoprosthesis and method of manufacture |
US20050187615A1 (en) | 2004-02-23 | 2005-08-25 | Williams Michael S. | Polymeric endoprostheses with enhanced strength and flexibility and methods of manufacture |
US7128868B2 (en) | 2003-01-10 | 2006-10-31 | Boston Scientific Scimed, Inc. | Balloon wing forming apparatus and method |
US20050137678A1 (en) | 2003-12-22 | 2005-06-23 | Medtronic Vascular, Inc. | Low profile resorbable stent |
US20050196485A1 (en) | 2004-01-13 | 2005-09-08 | Martin Cass | Heat transfer system for a mold |
US20050177130A1 (en) | 2004-02-10 | 2005-08-11 | Angioscore, Inc. | Balloon catheter with spiral folds |
JP4451268B2 (ja) * | 2004-03-04 | 2010-04-14 | 株式会社リコー | 光学素子及びその製造方法と、これを用いた光学製品、光ピックアップ及び光情報処理装置 |
US20090012598A1 (en) | 2004-06-29 | 2009-01-08 | Abbate Anthony J | Method of fabricating an implantable medical device by deformation of a tube or a sheet |
US8268228B2 (en) | 2007-12-11 | 2012-09-18 | Abbott Cardiovascular Systems Inc. | Method of fabricating stents from blow molded tubing |
US7731890B2 (en) | 2006-06-15 | 2010-06-08 | Advanced Cardiovascular Systems, Inc. | Methods of fabricating stents with enhanced fracture toughness |
US20060020330A1 (en) | 2004-07-26 | 2006-01-26 | Bin Huang | Method of fabricating an implantable medical device with biaxially oriented polymers |
US8747878B2 (en) | 2006-04-28 | 2014-06-10 | Advanced Cardiovascular Systems, Inc. | Method of fabricating an implantable medical device by controlling crystalline structure |
US20110066222A1 (en) * | 2009-09-11 | 2011-03-17 | Yunbing Wang | Polymeric Stent and Method of Making Same |
US7875233B2 (en) * | 2004-09-30 | 2011-01-25 | Advanced Cardiovascular Systems, Inc. | Method of fabricating a biaxially oriented implantable medical device |
AU2006227766B2 (en) | 2005-03-18 | 2012-04-05 | Wilson-Cook Medical, Inc. | Wire guides having novel outer surface areas and reservoirs for enhancing hydrophilic properties and delivering therapeutic agents |
US20060224226A1 (en) | 2005-03-31 | 2006-10-05 | Bin Huang | In-vivo radial orientation of a polymeric implantable medical device |
US20070135898A1 (en) * | 2005-12-13 | 2007-06-14 | Robert Burgermeister | Polymeric stent having modified molecular structures in the flexible connectors and the radial arcs of the hoops |
US20070134294A1 (en) | 2005-12-13 | 2007-06-14 | Robert Burgermeister | Polymeric stent having modified molecular structures in selected regions of the flexible connectors |
US20070282433A1 (en) | 2006-06-01 | 2007-12-06 | Limon Timothy A | Stent with retention protrusions formed during crimping |
US7740791B2 (en) | 2006-06-30 | 2010-06-22 | Advanced Cardiovascular Systems, Inc. | Method of fabricating a stent with features by blow molding |
US8099849B2 (en) * | 2006-12-13 | 2012-01-24 | Abbott Cardiovascular Systems Inc. | Optimizing fracture toughness of polymeric stent |
US8002817B2 (en) * | 2007-05-04 | 2011-08-23 | Abbott Cardiovascular Systems Inc. | Stents with high radial strength and methods of manufacturing same |
US7901452B2 (en) | 2007-06-27 | 2011-03-08 | Abbott Cardiovascular Systems Inc. | Method to fabricate a stent having selected morphology to reduce restenosis |
US7666342B2 (en) | 2007-06-29 | 2010-02-23 | Abbott Cardiovascular Systems Inc. | Method of manufacturing a stent from a polymer tube |
US20090319036A1 (en) * | 2008-06-19 | 2009-12-24 | Yunbing Wang | Medical Devices Made From Polymers With End Group Modification For Improved Thermal Stability |
-
2009
- 2009-09-14 US US12/559,400 patent/US8501079B2/en active Active
-
2010
- 2010-09-09 JP JP2012528900A patent/JP5718923B2/ja active Active
- 2010-09-09 CN CN201080040804.4A patent/CN102497970B/zh active Active
- 2010-09-09 WO PCT/US2010/048287 patent/WO2011031872A2/en active Application Filing
- 2010-09-09 EP EP10766384.1A patent/EP2477797B1/en not_active Not-in-force
-
2013
- 2013-01-04 US US13/734,879 patent/US9211682B2/en active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007325923A (ja) * | 2006-05-25 | 2007-12-20 | Cordis Corp | フープと可撓性コネクターの選定された部分との両方に、改変された分子構造を有するポリマーステント |
WO2007142736A2 (en) * | 2006-05-30 | 2007-12-13 | Abbott Cardiovascular Systems Inc. | Manufacturing process for polymeric stents |
WO2007143030A2 (en) * | 2006-05-31 | 2007-12-13 | Abbott Cardiovascular Systems Inc. | Method of fabricating an implantable medical device to reduce chance of late inflammatory response |
WO2007149457A1 (en) * | 2006-06-19 | 2007-12-27 | Abbott Cardiovascular Systems Inc. | Fabricating a stent with selected properties in the radial and axial directions |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2016514007A (ja) * | 2013-03-15 | 2016-05-19 | アボット カルディオバスキュラー システムズ インコーポレーテッドAbbott Cardiovascular Systems Inc. | 強化された軸線方向疲労特性を有するポリマースキャフォールド |
JP2017522160A (ja) * | 2014-07-07 | 2017-08-10 | メリル ライフ サイエンシズ ピーブィティ.エルティディ | 高い疲労強度および半径方向強さを有する生体吸収性ポリマー由来の薄型ストラットステント、並びに、その製造方法 |
Also Published As
Publication number | Publication date |
---|---|
WO2011031872A3 (en) | 2011-07-28 |
US9211682B2 (en) | 2015-12-15 |
US20110062638A1 (en) | 2011-03-17 |
WO2011031872A2 (en) | 2011-03-17 |
CN102497970A (zh) | 2012-06-13 |
EP2477797A2 (en) | 2012-07-25 |
US20130187313A1 (en) | 2013-07-25 |
US8501079B2 (en) | 2013-08-06 |
CN102497970B (zh) | 2016-01-06 |
JP5718923B2 (ja) | 2015-05-13 |
EP2477797B1 (en) | 2014-01-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5718923B2 (ja) | 生体吸収性ステントの結晶モルフォロジの制御 | |
US9668896B2 (en) | Method of fabricating stents from blow molded tubing | |
US9662231B2 (en) | Polymer scaffolds having enhanced axial fatigue properties | |
US7875233B2 (en) | Method of fabricating a biaxially oriented implantable medical device | |
EP2046411B1 (en) | Fabricating a stent with selected properties in the radial and axial directions | |
US9522503B2 (en) | Methods of treatment with stents with enhanced fracture toughness | |
US20110066222A1 (en) | Polymeric Stent and Method of Making Same | |
US8747878B2 (en) | Method of fabricating an implantable medical device by controlling crystalline structure | |
US20120280432A1 (en) | Method for manufacturing bioabsorbable stents | |
JP5575660B2 (ja) | ブローモールド成形チューブからステントを製作する方法 | |
US20110260352A1 (en) | Stabilizing Semi-Crystalline Polymers To Improve Storage Performance Of Medical Devices | |
JP6267196B2 (ja) | 末梢血管のための高分子スキャフォールド | |
WO2008137821A1 (en) | Stents with high radial strength and methods of manufacturing same |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20130909 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20130909 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20140826 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20141126 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20141203 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20141226 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20150126 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20150217 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20150319 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 5718923 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |