US20040098090A1 - Polymeric endoprosthesis and method of manufacture - Google Patents

Polymeric endoprosthesis and method of manufacture Download PDF

Info

Publication number
US20040098090A1
US20040098090A1 US10342748 US34274803A US2004098090A1 US 20040098090 A1 US20040098090 A1 US 20040098090A1 US 10342748 US10342748 US 10342748 US 34274803 A US34274803 A US 34274803A US 2004098090 A1 US2004098090 A1 US 2004098090A1
Authority
US
Grant status
Application
Patent type
Prior art keywords
endoprosthesis
region
invention
material
comprises
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US10342748
Inventor
Michael Williams
Kevin Holbrook
Richard Glenn
Jeffrey Smith
Joseph DeSimone
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synecor LLC
Original Assignee
Synecor LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/91533Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other characterised by the phase between adjacent bands
    • A61F2002/91541Adjacent bands are arranged out of phase
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/9155Adjacent bands being connected to each other
    • A61F2002/91558Adjacent bands being connected to each other connected peak to peak
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/005Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements using adhesives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/0058Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements soldered or brazed or welded
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067Means for introducing or releasing pharmaceutical products into the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067Means for introducing or releasing pharmaceutical products into the body
    • A61F2250/0068Means for introducing or releasing pharmaceutical products into the body the pharmaceutical product being in a reservoir

Abstract

Improved polymeric endoprostheses and methods of making endoprostheses are disclosed. Said endoprostheses exhibit improved overall compliance, selective regional compliance, and selective radial strength without varying the geometries of selected regions. Numerous other physical characteristics of said endoprostheses may be selectively varied during manufacture. Some embodiments may comprise one or more erodible material. Some embodiments may comprise one or more therapeutics incorporated into said endoprosthesis via a solvent in a supercritical state.

Description

    RELATED APPLICATIONS
  • [0001]
    This application is related to Provisional U.S. Patent Application Serial No. 60/426,898 entitled “Polymeric Endoprostheses and Methods of Manufacture”, to Williams, et al., Provisional U.S. Patent Application Serial No. 60/426,737 entitled “Improved Endoprostheses and Methods of Manufacture”, to Williams, et al., Provisional U.S. Patent Application Serial No. 60/426,734, entitled “Photocurable Endoprostheses and Methods of Manufacture”, to Williams et al., Provisional U.S. Patent Application Serial No. 60/426,126 entitled “Carbon Dioxide-Assisted Methods of Providing Biocompatible Intraluminal Prostheses”, to Williams, et al., and Provisional U.S. Patent Application Serial No. 60/426,125 entitled “Intraluminal Prostheses and Carbon Dioxide-Assisted Methods of Impregnating Same with Pharmacological Agents” to Williams, et al.”. The above applications are commonly owned. All of the above applications are hereby incorporated by reference, each in its entirety.
  • FIELD OF THE INVENTION
  • [0002]
    The invention herein relates generally to medical devices and the manufacture thereof, and to improved endoprostheses for use in the treatment of strictures in lumens of the body. More particularly, the invention is directed to polymeric endoprostheses and addresses the shortcomings of the prior art, especially, but not limited to, material limitations including radial strength and elastic recoil.
  • BACKGROUND OF THE INVENTION
  • [0003]
    Ischemic heart disease is the major cause of death in industrialized countries. Ischemic heart disease, which often results in myocardial infarction, is a consequence of coronary atherosclerosis. Atherosclerosis is a complex chronic inflammatory disease and involves focal accumulation of lipids and inflammatory cells, smooth muscle cell proliferation and migration, and the synthesis of extracellular matrix. Nature 1993;362:801-809. These complex cellular processes result in the formation of atheromatous plaque, which consists of a lipid-rich core covered with a collagen-rich fibrous cap, varying widely in thickness. Further, plaque disruption is associated with varying degrees of internal hemorrhage and luminal thrombosis because the lipid core and exposed collagen are thrombogenic. J. Am Coll Cardiol. 1994;23:1562-1569 Acute coronary syndrome usually occurs as a consequence of such disruption or ulceration of a so called “vulnerable plaque”. Arterioscler Thromb Vasc Biol. Volume 22, No. 6, June 2002, p. 1002.
  • [0004]
    In addition to coronary bypass surgery, a current treatment strategy to alleviate vascular occlusion includes percutaneous transluminal coronary angioplasty, expanding the internal lumen of the coronary artery with a balloon. Roughly 800,000 angioplasty procedures are performed in the U.S. each year (Arteriosclerosis, Thrombosis, and Vascular Biology Volume 22, No. 6, June 2002, p. 884). However, 30% to 50% of angioplasty patients soon develop significant restenosis, a narrowing of the artery through migration and growth of smooth muscle cells.
  • [0005]
    In response to the significant restenosis rate following angioplasty, percutaneously placed endoprostheses have been extensively developed to support the vessel wall and to maintain fluid flow through a diseased coronary artery. Such endoprostheses, or stents, which have been traditionally fabricated using metal alloys, include self-expanding or balloon-expanded devices that are “tracked” through the vasculature and deployed proximate one or more lesions. Stents considerably enhance the long-term benefits of angioplasty, but 10% to 50% of patients receiving stents still develop restenosis. (J Am Coll Cardiol. 2002; 39:183-193. Consequently, a significant portion of the relevant patient population undergoes continued monitoring and, in many cases, additional treatment.
  • [0006]
    Continued improvements in stent technology aim at producing easily tracked, easily visualized and readily deployed stents, which exhibit the requisite radial strength without sacrificing a small delivery profile and sufficient flexibility to traverse the diseased human vasculature. Further, numerous therapies directed to the cellular mechanisms of accumulation of inflammatory cells, smooth muscle cell proliferation and migration show tremendous promise for the successful long-term treatment of ischemic heart disease. Consequently, advances in coupling delivery of such therapies to the mechanical support of vascular endoprostheses, delivered proximate the site of disease, offer great hope to the numerous individuals suffering heart disease.
  • [0007]
    While advances in the understanding of ischemic heart disease as a complex chronic inflammatory process take place, traditional diagnostic techniques such as coronary angiography yield to next generation imaging modalities. In fact, coronary angiography may not be at all useful in identifying inflamed atherosclerotic plaques that are prone to producing clinical events. Imaging based upon temperature differences, for example, are undergoing examination for use in detecting coronary disease. Magnetic resonance imaging (MRI) is currently emerging as the state of the art diagnostic for arterial imaging, enhancing the detection, diagnosis and monitoring of the formation of vulnerable plaques. Transluminal intervention guided by MRI is expected to follow. However, metals produce distortion and artifacts in MR images, rendering use of the traditionally metallic stents in coronary, biliary, esophageal, ureteral, and other body lumens incompatible with the use of MRI.
  • [0008]
    Consequently, an emerging clinical need for interventional devices that are compatible with and complementary to new imaging modalities is evident. Further, devices that exhibit improved trackability to previously undetectable disease within remote regions of the body, especially the coronary vasculature are needed. And finally, devices that both exhibit improved mechanical support and are readily compatible with adjunct therapies in order to lower or eliminate the incidence of restenosis are needed.
  • SUMMARY OF THE INVENTION
  • [0009]
    An endoprosthesis is provided comprising one or more erodible materials, a first region and a second region, wherein said first region comprises a first degree of overall compliance and said second region comprises a second degree of overall compliance, wherein said first degree of overall compliance is greater than said second degree, whereby when said endoprosthesis is disposed within a body lumen comprising walls comprising irregular morphology, said first region is substantially compliant with said walls. In some embodiments, the greater compliance is proximate one or both ends of the endoprosthesis. Alternatively, the connecting members of an endoprosthesis may be more compliant according to the invention. The improved compliance can be attained without altering the cross section or geometry of the endoprosthesis. Radial conformability, axial flexibility, linear extensibility, outward radial force, density, crystallinity, permeability and diffusion coefficient can all be altered according to the invention. In some embodiments according to the invention, the endoprosthesis elements comprise a trapezoidal cross section, narrowed apices, a metal reinforcing element, one or more therapeutic agents. Some embodiments according to the invention comprise an expandable endoprosthesis comprising poly-lactic acid and polycaprolactone in a ratio of between 80:20 and 95:5. The endoprosthesis may further be is annealed at a temperature of between 50 and 200 degrees C. for a duration of between one half and 24 hours, and may additionally undergo strain induced crystallization upon expansion.
  • [0010]
    An endoprosthesis according to the invention may comprise and endoprosthesis element comprising a plurality of apices alternating with a plurality of straight sections wherein said endoprosthesis undergoes strain induced crystallization upon expansion proximate the apices. Methods of manufacturing endoprostheses according to the invention are also disclosed.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • [0011]
    [0011]FIG. 1 is a plan view of the distal end of a conventional balloon catheter having a stent according to the invention mounted thereon.
  • [0012]
    [0012]FIG. 2 shows the embodiment of FIG. 1 in its deployed configuration.
  • [0013]
    FIGS. 3A-C illustrate a method of manufacture according to the invention.
  • [0014]
    [0014]FIG. 4 is a plan view of a component used in a method according to the invention.
  • [0015]
    FIGS. 5A-C illustrate an alternative method according to the invention.
  • [0016]
    [0016]FIG. 6 depicts an alternative embodiment according to the invention.
  • [0017]
    [0017]FIG. 7 illustrates yet another embodiment according to the invention.
  • [0018]
    [0018]FIG. 8 illustrates an additional embodiment according to the invention.
  • [0019]
    [0019]FIG. 9 is a plan view of an embodiment according to the invention.
  • [0020]
    [0020]FIG. 10A is an end view of a cross section of an embodiment according to the invention.
  • [0021]
    [0021]FIG. 10B is an end view of a cross section of an endoprosthesis of the prior art.
  • [0022]
    [0022]FIG. 11 is a plan view of an alternative embodiment according to the invention.
  • [0023]
    [0023]FIG. 12 is a plan view of an alternative embodiment according to the invention.
  • [0024]
    [0024]FIG. 13A is a plan view of another alternative embodiment according to the invention. FIG. 13B is a plan view of a portion of the element of FIG. 13A illustrating the reconfiguration of the element when in its deployed configuration.
  • [0025]
    [0025]FIG. 14A is a plan view of yet another alternative embodiment according to the invention. FIG. 14B is a plan view of a portion of the element of FIG. 14A illustrating the reconfiguration of the element when in its deployed configuration.
  • [0026]
    [0026]FIG. 15 is an end view of a cross section of yet another embodiment according to the invention.
  • [0027]
    [0027]FIG. 16 is an end view of a cross section of yet another embodiment according to the invention.
  • [0028]
    [0028]FIG. 17 is an end view of a cross section of yet another embodiment according to the invention.
  • [0029]
    [0029]FIG. 18 is a graph illustrating the modulus of elasticity of prior art materials and materials according to the invention.
  • DETAILED DESCRIPTION OF THE INVENTION
  • [0030]
    Although the invention herein is not limited as such, some embodiments of the invention comprise materials that are bioerodible. “Erodible” refers to the ability of a material to maintain its structural integrity for a desired period of time, and thereafter gradually undergo any of numerous processes whereby the material substantially loses tensile strength and mass. Examples of such processes comprise hydrolysis, enzymatic and non-enzymatic degradation, oxidation, enzymatically-assisted oxidation, and others, thus including bioresorption, dissolution, and mechanical degradation upon interaction with a physiological environment into components that the patient's tissue can absorb, metabolize, respire, and/or excrete. Polymer chains are cleaved by hydrolysis and are eliminated from the body through the Krebs cycle, primarily as carbon dioxide and in urine. “Erodible” and “degradable” are intended to be used interchangeably herein.
  • [0031]
    The term “endoprosthesis” refers to any prosthetic device placed within a body lumen or duct to in order to therapeutically treat the body lumen or duct, including but not limited to the objective of restoring or enhancing flow of fluids through a body lumen or duct.
  • [0032]
    A “self-expanding” endoprosthesis has the ability to revert readily from a reduced profile configuration to a larger profile configuration in the absence of a restraint upon the device that maintains the device in the reduced profile configuration.
  • [0033]
    “Balloon expandable” refers to a device that comprises a reduced profile configuration and an expanded profile configuration, and undergoes a transition from the reduced configuration to the expanded configuration via the outward radial force of a balloon expanded by any suitable inflation medium.
  • [0034]
    The term “balloon assisted” refers to a self-expanding device the final deployment of which is facilitated by an expanded balloon.
  • [0035]
    The term “fiber” refers to any generally elongate member fabricated from any suitable material, whether polymeric, metal or metal alloy, natural or synthetic.
  • [0036]
    The phrase “points of intersection”, when used in relation to fiber(s), refers to any point at which a portion of a fiber or two or more fibers cross, overlap, wrap, pass tangentially, pass through one another, or come near to or in actual contact with one another.
  • [0037]
    As used herein, a device is “implanted” if it is placed within the body to remain for any length of time following the conclusion of the procedure to place the device within the body.
  • [0038]
    The term “diffusion coefficient” refers to the rate by which a substance elutes, or is released either passively or actively from a substrate.
  • [0039]
    As used herein, the term “braid” refers to any braid or mesh or similar woven structure produced from between 1 and several hundred longitudinal and/or transverse elongate elements woven, braided, knitted, helically wound, or intertwined by any manner, at angles between 0 and 180 degrees and usually between 45 and 105 degrees, depending upon the overall geometry and dimensions desired.
  • [0040]
    Unless specified, suitable means of attachment may include by thermal melt, chemical bond, adhesive, sintering, welding, or any means known in the art.
  • [0041]
    “Shape memory” refers to the ability of a material to undergo structural phase transformation such that the material may define a first configuration under particular physical and/or chemical conditions, and to revert to an alternate configuration upon a change in those conditions. Shape memory materials may be metal alloys including but not limited to nickel titanium, or may be polymeric. A polymer is a shape memory polymer if the original shape of the polymer is recovered by heating it above a shape recovering temperature (defined as the transition temperature of a soft segment) even if the original molded shape of the polymer is destroyed mechanically at a lower temperature than the shape recovering temperature, or if the memorized shape is recoverable by application of another stimulus. Such other stimulus may include but is not limited to pH, salinity, hydration, and others.
  • [0042]
    As used herein, the term “segment” refers to a block or sequence of polymer forming part of the shape memory polymer. The terms hard segment and soft segment are relative terms, relating to the transition temperature of the segments. Generally speaking, hard segments have a higher glass transition temperature than soft segments, but there are exceptions. Natural polymer segments or polymers include but are not limited to proteins such as casein, gelatin, gluten, zein, modified zein, serum albumin, and collagen, and polysaccharides such as alginate, chitin, celluloses, dextrans, pullulane, and polyhyaluronic acid; poly(3-hydroxyalkanoate)s, especially poly(.beta.-hydroxybutyrate), poly(3-hydroxyoctanoate) and poly(3-hydroxyfatty acids).
  • [0043]
    Representative natural erodible polymer segments or polymers include polysaccharides such as alginate, dextran, cellulose, collagen, and chemical derivatives thereof (substitutions, additions of chemical groups, for example, alkyl, alkylene, hydroxylations, oxidations, and other modifications routinely made by those skilled in the art), and proteins such as albumin, zein and copolymers and blends thereof, alone or in combination with synthetic polymers.
  • [0044]
    Suitable synthetic polymer blocks include polyphosphazenes, poly(vinyl alcohols), polyamides, polyester amides, poly(amino acid)s, synthetic poly(amino acids), polyanhydrides, polycarbonates, polyacrylates, polyalkylenes, polyacrylamides, polyalkylene glycols, polyalkylene oxides, polyalkylene terephthalates, polyortho esters, polyvinyl ethers, polyvinyl esters, polyvinyl halides, polyvinylpyrrolidone, polyesters, polylactides, polyglycolides, polysiloxanes, polyurethanes and copolymers thereof.
  • [0045]
    Examples of suitable polyacrylates include poly(methyl methacrylate), poly(ethyl methacrylate), poly(butyl methacrylate), poly(isobutyl methacrylate), poly(hexyl methacrylate), poly(isodecyl methacrylate), poly(lauryl methacrylate), poly(phenyl methacrylate), poly(methyl acrylate), poly(isopropyl acrylate), poly(isobutyl acrylate) and poly(octadecyl acrylate).
  • [0046]
    Synthetically modified natural polymers include cellulose derivatives such as alkyl celluloses, hydroxyalkyl celluloses, cellulose ethers, cellulose esters, nitrocelluloses, and chitosan. Examples of suitable cellulose derivatives include methyl cellulose, ethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, hydroxybutyl methyl cellulose, cellulose acetate, cellulose propionate, cellulose acetate butyrate, cellulose acetate phthalate, arboxymethyl cellulose, cellulose triacetate and cellulose sulfate sodium salt. These are collectively referred to herein as “celluloses”.
  • [0047]
    Examples of synthetic degradable polymer segments or polymers include polyhydroxy acids, polylactides, polyglycolides and copolymers thereof, poly(ethylene terephthalate), poly(hydroxybutyric acid), poly(hydroxyvaleric acid), poly[lactide-co-(epsilon-caprolactone)], poly[glycolide-co-(epsilon-caprolactone)], polycarbonates, poly-(epsilon caprolactone) poly(pseudo amino acids), poly(amino acids), poly(hydroxyalkanoate)s, polyanhydrides, polyortho esters, and blends and copolymers thereof.
  • [0048]
    The degree of crystallinity of the polymer or polymeric block(s) is between 3 and 80%, more often between 3 and 65%. The tensile modulus of the polymers below the transition temperature is typically between 50 MPa and 2 GPa (gigapascals), whereas the tensile modulus of the polymers above the transition temperature is typically between 1 and 500 MPa.
  • [0049]
    The melting point and glass transition temperature of the hard segment are generally at least 10 degrees C., and preferably 20 degrees C., higher than the transition temperature of the soft segment. The transition temperature of the hard segment is preferably between −60 and 270 degrees C., and more often between 30 and 150 degrees C. The ratio by weight of the hard segment to soft segments is between about 5:95 and 95:5, and most often between 20:80 and 80:20. The polymers contain at least one physical crosslink (physical interaction of the hard segment) or contain covalent crosslinks instead of a hard segment. Polymers can also be interpenetrating networks or semi-interpenetrating networks.
  • [0050]
    Rapidly erodible polymers such as poly(lactide-co-glycolide)s, polyanhydrides, and polyorthoesters, which have carboxylic groups exposed on the external surface as the smooth surface of the polymer erodes, also can be used. In addition, polymers containing labile bonds, such as polyanhydrides and polyesters, are well known for their hydrolytic reactivity. Their hydrolytic degradation rates can generally be altered by simple changes in the polymer backbone and their sequence structure.
  • [0051]
    Examples of suitable hydrophilic polymers include but are not limited to poly(ethylene oxide), polyvinyl pyrrolidone, polyvinyl alcohol, poly(ethylene glycol), polyacrylamide poly(hydroxy alkyl methacrylates), poly(hydroxy ethyl methacrylate), hydrophilic polyurethanes, HYPAN, oriented HYPAN, poly(hydroxy ethyl acrylate), hydroxy ethyl cellulose, hydroxy propyl cellulose, methoxylated pectin gels, agar, starches, modified starches, alginates, hydroxy ethyl carbohydrates and mixtures and copolymers thereof.
  • [0052]
    Hydrogels can be formed from polyethylene glycol polyethylene oxide, polyvinyl alcohol, polyvinyl pyrrolidone, polyacrylates, poly (ethylene terephthalate), poly(vinyl acetate), and copolymers and blends thereof. Several polymeric segments, for example, acrylic acid, are elastomeric only when the polymer is hydrated and hydrogels are formed. Other polymeric segments, for example, methacrylic acid, are crystalline and capable of melting even when the polymers are not hydrated. Either type of polymeric block can be used, depending on the desired application and conditions of use.
  • [0053]
    The use of polymeric materials in the fabrication of endoprostheses confers the advantages of improved flexibility, compliance and conformability, permitting treatment in body lumens not accessible by more conventional endoprostheses. Such advantages over a more conventional metal alloy are most readily apparent in an endoprosthesis comprising longitudinal connecting members, for example. Such connecting members, when fabricated from one or more polymeric materials, allow compression of the connecting member under compression loads, or, alternatively, stretching under tension, while maintaining axial stability. In addition, more connecting members at more points on the endoprosthesis can be utilized, stabilizing the device without rendering the device overly rigid.
  • [0054]
    Fabrication of an endoprosthesis according to the invention allows for the use of different materials in different regions of the prosthesis to achieve different physical properties as desired for a selected region. A material selected for its ability to allow elongation of longitudinal connecting members on the outer radius of a curve in a lumen, and compression on the inner radius of a curve in a vessel allows improved tracking of a device through a diseased lumen. A distinct material may be selected for support elements in order that the support elements exhibit sufficient radial strength. Further, the use of polymeric materials readily allows for the fabrication of endoprostheses comprising transitional end portions with greater compliance than the remainder of the prosthesis, thereby minimizing any compliance mismatch between the endoprosthesis and diseased lumen. Further, a polymeric material can uniformly be processed to fabricate a device exhibiting better overall compliance with a pulsating vessel, which, especially when diseased, typically has irregular and often rigid morphology. Trauma to the vasculature, for example, is thereby minimized, reducing the incidence of restenosis that commonly results from vessel trauma.
  • [0055]
    An additional advantage of polymers includes the ability to control and modify properties of the polymers through the use a variety of techniques. According to the invention, optimal ratios of combined polymers, and optimal processing have been found to achieve highly desired properties not typically found in polymers. Polymers such as poly-l-lactic acid and poly-caprolactone, combined in ratios of between 80:20 and 95:5 respectively, form materials exhibiting a desirable modulus of elasticity. Further, the annealing process (comprising heating of the materials according chosen parameters including time and temperature) increases polymer chain crystallization, thereby increasing the strength of the material. Consequently, according to the invention, the desired material properties can be achieved by using the appropriate ratio of materials and by annealing the materials.
  • [0056]
    Additionally, the properties of polymers can be enhanced and differentiated by controlling the degree to which the material crystallizes through strain-induced crystallization. Means for imparting strain-induced crystallization arc enhanced during deployment of an endoprosthesis according to the invention. Upon expansion of an endoprosthesis according to the invention, focal regions of plastic deformation undergo strain-induced crystallization, further enhancing the desired mechanical properties of the device, such as further increasing radial strength. The strength is optimized when the endoprosthesis is induced to bend preferentially at desired points, and the included angle of the endoprosthesis member is between 40 and 70 degrees.
  • [0057]
    Curable materials employed in the fabrication of some of the embodiments herein include any material capable of being able to transform from a fluent or soft material to a harder material, by cross-linking, polymerization, or other suitable process. Materials may be cured over time, thermally, chemically, or by exposure to radiation. For those materials that are cured by exposure to radiation, many types of radiation may be used, depending upon the material. Wavelengths in the spectral range of about 100-1300 nm may be used. The material should absorb fight within a wavelength range that is not readily absorbed by tissue, blood elements, physiological fluids, or water. Ultraviolet radiation having a wavelength ranging from about 100-400 nm may be used, as well as visible, infrared and thermal radiation. The following materials are examples of curable materials: urethanes, polyurethane oligomer mixtures, acrylate monomers, aliphatic urethane acrylate oligomers, acrylamides, UV polyanhydrides, UV curable epoxies, and other UV curable monomers. Alternatively, the curable material can be a material capable of being chemically cured, such as silicone based compounds which undergo room temperature vulcanization.
  • [0058]
    Some embodiments according to the invention comprise materials that are cured in a desired pattern. Such materials may be cured by any of the foregoing means. Further, for those materials that are photocurable, such a pattern may be created by coating the material in a negative image of the desired pattern with a masking material using standard photoresist technology. Absorption of both direct and incident radiation is thereby prevented in the masked regions, curing the device in the desired pattern. A variety of biocompatibly eroding coating materials may be used, including but not limited to gold, magnesium, aluminum, silver, copper, platinum, inconel, chrome, titanium indium, indium tin oxide. Projection optical photolithography systems that utilize the vacuum ultraviolet wavelengths of light below 240 nm provide benefits in terms of achieving smaller feature dimensions. Such systems that utilize ultraviolet wavelengths in the 193 nm region or 157 nm wavelength region have the potential of improving precision masking devices having smaller feature sizes.
  • [0059]
    An endoprosthesis comprising polymeric materials has the additional advantage of compatibility with magnetic resonance imaging, potentially a long term clinical benefit. Further, if the more conventional diagnostic tools employing angiography continue as the technique of choice for delivery and monitoring, radiopacity can be readily conferred upon polymeric materials.
  • [0060]
    Though not limited thereto, some embodiments according to the invention comprise one or more therapeutic substances that will elute from the surface or the structure or prosthesis independently or as the prosthesis erodes. The cross section of an endoprosthesis member may be modified according to the invention in order to maximize the surface area available for delivery of a therapeutic from the vascular surface of the device. A trapezoidal geometry will yield a 20% increase in surface area over a rectangular geometry of the same cross-sectional area. In addition, the diffusion coefficient and/or direction of diffusion of various regions of an endoprosthesis, surface, may be varied according to the desired diffusion coefficient of a particular surface. Permeability of the luminal surface, for example, may be minimized, and diffusion from the vascular surface maximized, for example, by altering the degree of crystallinity of the respective surfaces.
  • [0061]
    According to the invention, such surface treatment and/or incorporation of therapeutic substances may be performed utilizing one or more of numerous processes that utilize carbon dioxide fluid, e.g., carbon dioxide in a liquid or supercritical state. A supercritical fluid is a substance above its critical temperature and critical pressure (or “critical point”). Compressing a gas normally causes a phase separation and the appearance of a separate liquid phase. However, all gases have a critical temperature above which the gas cannot be liquefied by increasing pressure, and a critical pressure or pressure which is necessary to liquefy the gas at the critical temperature. For example, carbon dioxide in its supercritical state exists as a form of matter in which its liquid and gaseous states are indistinguishable from one another. For carbon dioxide, the critical temperature is about 31 degrees C. (88 degrees D) and the critical pressure is about 73 atmospheres or about 1070 psi.
  • [0062]
    The term “supercritical carbon dioxide” as used herein refers to carbon dioxide at a temperature greater than about 31 degrees C. and a pressure greater than about 1070 psi. Liquid carbon dioxide may be obtained at temperatures of from about −15 degrees C. to about 55 degrees C. and pressures of from about 77 psi to about 335 psi. One or more solvents and blends thereof may optionally be included in the carbon dioxide. Illustrative solvents include, but are not limited to, tetrafluoroisopropanol, chloroform, tetrahydrofuran, cyclohexane, and methylene chloride. Such solvents are typically included in an amount, by weight, of up to about 20%.
  • [0063]
    In general, carbon dioxide may be used to effectively lower the glass transition temperature of a polymeric material to facilitate the infusion of pharmacological agent(s) into the polymeric material. Such agents include but are not limited to hydrophobic agents, hydrophilic agents and agents in particulate form. For example, following fabrication, an endoprosthesis and a hydrophobic pharmacological agent may be immersed in supercritical carbon dioxide. The supercritical carbon dioxide “plasticizes” the polymeric material, that is, it allows the polymeric material to soften at a lower temperature, and facilitates the infusion of the pharmacological agent into the polymeric endoprosthesis or polymeric coating of a stent at a temperature that is less likely to alter and/or damage the pharmacological agent.
  • [0064]
    As an additional example, an endoprosthesis and a hydrophilic pharmacological agent can be immersed in water with an overlying carbon dioxide “blanket”. The hydrophilic pharmacological agent enters solution in the water, and the carbon dioxide “plasticizes” the polymeric material, as described above, and thereby facilitates the infusion of the pharmacological agent into a polymeric endoprosthesis or a polymeric coating of an endoprosthesis.
  • [0065]
    As yet another example, carbon dioxide may be used to “tackify”, or render more fluent and adherent a polymeric endoprosthesis or a polymeric coating on an endoprosthesis to facilitate the application of a pharmacological agent thereto in a dry, micronized form. A membrane-forming polymer, selected for its ability to allow the diffusion of the pharmacological agent therethrough, may then applied in a layer over the endoprosthesis. Following curing by suitable means, a membrane that permits diffusion of the pharmacological agent over a predetermined time period forms.
  • [0066]
    Objectives of therapeutics substances incorporated into materials forming or coating an endoprosthesis according to the invention include reducing the adhesion and aggregation of platelets at the site of arterial injury, block the expression of growth factors and their receptors; develop competitive antagonists of growth factors, interfere with the receptor signaling in the responsive cell, promote an inhibitor of smooth muscle proliferation. Anitplatelets, anticoagulants, antineoplastics, antifibrins, enzymes and enzyme inhibitors, antimitotics, antimetabolites, anti-inflammatories, antithrombins, antiproliferatives, antibiotics, and others may be suitable. More specific examples of the foregoing examples are set forth in related Provisional Patent Application Serial No. 60/426,125, and are incorporated herein.
  • [0067]
    Details of the invention can be better understood from the following descriptions of specific embodiments according to the invention. As an example, in FIG. 1, distal end 3 of standard delivery catheter 1 is shown, bearing endoprosthesis 10. Although an endoprosthesis according to the invention may be self-expanding, endoprosthesis 10 mounted on distal end 3 is balloon-expandable. Accordingly, endoprosthesis 10 is deployed via delivery catheter 1, which comprises balloon 5 at distal end 3. Endoprosthesis 10 may be fabricated from one or more of the foregoing conventional or shape memory materials, polymers, or other suitable materials selected for molecular weight, chemical composition and other properties, manufactured to achieve any desired geometries and processed to achieve sterilization, desired geometries and in vivo lifetime. Endoprosthesis 10 is “crimped” down upon balloon 5 into its low-profile delivery configuration. Endoprosthesis 10 can then be tracked to a lesion site within a lumen of the body where endoprosthesis 10 can be deployed. In order to deploy endoprosthesis 10, balloon 5 is inflated via inflation medium through catheter 1. The outward radial force of expanding balloon 5 expands endoprosthesis 10 to its deployed configuration, and permanently plastically deforms endoprosthesis 10 to exert an outward radial force upon the diseased lumen.
  • [0068]
    [0068]FIG. 2 illustrates endoprosthesis 10. Accordingly, endoprosthesis 10 may be between 0.5 mm and 10.0 mm at its deployed diameter, depending upon the size of the lumen of the patient (not pictured). Endoprosthesis 10 comprises support elements 12 and one or more connecting elements 14.
  • [0069]
    The manufacture of an endoprosthesis according to the invention can be better understood from a discussion of FIGS. 3A-C. FIG. 3A represents an end view of mold 20. As a first step in preparing an endoprosthesis according to the invention, a blend of poly-1-lactide and poly-caprolactone in a ratio of between 80:20 and 95:5 is attained. Raw material is placed onto mold 20, heated and pressurized to produce flat cast film 25. Flat cast film 25 is removed from mold 20, as shown in FIG. 3B, and rolled to form endoprosthesis 30, shown in a plan view in FIG. 3C. Endoprosthesis 30, which is balloon-expandable, comprises thin film portion 32 and one or more ribs 34. Alternatively, thin film portion 32 can be removed at all but portions left to connect ribs to one another. Also, in an alternative embodiment, one or more therapeutic agents can be added to polymer mixture such that the resulting endoprosthesis elutes one or more therapeutic agents in situ.
  • [0070]
    An alternative embodiment according to the invention may be described in relation to FIGS. 4A-C. FIG. 4A is a plan view depicting mold 40, etched onto flat plate 42. Mold 40 comprises relief for endoprosthesis elements 44, and connecting members 46. As a first step in fabricating an endoprosthesis using mold 40, polymers having desired properties are placed onto mold 40, heated and pressurized to form flat cast film 48, shown in FIG. 4B. Flat cast film 48 is removed from mold 40, trimmed of excess via laser technology known in the art, including but not limited to excimer laser at a wavelength between 150 nm and 250 nm, or carbon dioxide laser, and rolled to form endoprosthesis 50, shown in FIG. 4C. Although a self-expanding alternative is possible, endoprosthesis 50 is balloon expandable. An endoprosthesis according to the invention may alternatively be fabricated using injection molding, compression molding, or by laser cutting a tube, or chemically etching a tube.
  • [0071]
    Yet another alternative embodiment according to the invention is illustrated in FIGS. 5A-C. Mold 60 of FIG. 5A comprises relief for endoprosthesis elements 62 and connecting elements 64. In a first step, suitable “masking” material 65 is placed over etchings for connecting elements 64 before a desired selection of endoprosthesis materials, chosen to confer desired physical properties upon the resulting endoprosthesis elements, are placed onto mold 60, heated and pressurized, preventing the formation of connecting elements during the first step. Following the formation of endoprosthesis elements 62, masking material 65 is removed, leaving endoprosthesis elements 62 covered in a first-thin film 63, as shown in FIG. 5B. A second selection of desired endoprosthesis materials, chosen to confer desired physical properties to be conferred upon the resulting connecting elements, is then placed onto mold 60, heated and pressurized, to form composite flat film 68, shown in FIG. 5C. In the alternative, a masking material may be placed over endoprosthesis elements 62. Following forming, composite flat film 66 is removed from mold 60, trimmed of excess and rolled to form composite endoprosthesis 68, shown in FIG. 51).
  • [0072]
    Alternatively, other regions of the endoprosthesis, for example, the end regions, may be formed selectively from yet a third polymeric composition in order to confer desired physical properties on the resulting end regions. The luminal surface of the endoluminal prosthesis is another example of a region of an endoprosthesis may be selectively formed from a particular polymeric composition. Physical properties that can be controlled according to the invention include but are not limited to density, modulus of elasticity, degree of crystallinity, permeability and diffusion coefficient.
  • [0073]
    Turning now to FIG. 6, another embodiment according to the invention is provided. Endoprosthesis 70 comprises highly compliant tubular member 72 enveloping a rigid thin fiber 74. One or more plastically deformable bonds 76 is formed at the intersections of rigid thin fibers 74. Endoprosthesis 70 may be self-expanding, balloon assisted, or balloon expandable.
  • [0074]
    An additional embodiment is illustrated in FIG. 7. Endoprosthesis 80 comprises a generally tubular member 82 that further encapsulates cavity 84. Cavity 84 is filled with a suitable curable material 86. Following deployment by balloon expansion, curable material 86 cures to impart rigidity to endoprosthesis 80.
  • [0075]
    [0075]FIG. 8 illustrates an end view of alternative embodiment of the invention comprising layer 110 into which α-hydrophilic therapeutic agent has been incorporated. Following fabrication of endoprosthesis 115 according to any of the methods described herein from any of suitable material, endoprosthesis 115 is immersed in a solution of polymer, water and hydrophilic therapeutic agent, underlying a “blanket” of supercritical carbon dioxide. The carbon dioxide renders the polymer more receptive to the incorporation of therapeutic agent. The polymer comprising the therapeutic agent forms layer 110 on the surface of endoprosthesis 115 for elution in situ.
  • [0076]
    Turning now to FIG. 9, a portion of an element of an endoprosthesis according to the invention is illustrated as a flat section. Endoprosthesis elements 120 are generally serpentine, and between 0.008 and 0.010 inches wide. Two opposed connecting members 125 are disposed between endoprosthesis elements and are spaced spirally at 45 degrees. FIG. 10A represents an end view of a cross-section taken along the longitudinal axis of endoprosthesis 126 according to the invention. Endoprosthesis elements 127 comprise trapezoidal cross-sections, oriented such that the broadest side of the trapezoid is disposed at the outer diameter, or vascular surface of endoprosthesis 126. Such a cross section maximizes the vascular surface area of endoprosthesis 126 by over 20% as compared to an equivalent cross sectional area, while allowing endoprosthesis 126 to be crimped down to a minimal profile for tracking and delivery through the vasculature. Endoprosthesis 126 may be excimer laser cut from a cylinder, and endoprosthesis elements 127 can accordingly be cut to exhibit a trapezoidal cross-section. FIG. 10B illustrates an end view of a cross section of a prior art endoprosthesis comprising elements 128 having generally rectangular cross-sections.
  • [0077]
    In FIG. 11, endoprosthesis element 130 is generally elliptical or ovular in shape. Connecting members 135 adjoin each adjacent endoprosthesis element 130 generally at the midsections 131 and ends 132 of endoprosthesis elements 130. Endoprosthesis elements 130 may be fabricated from a first material exhibiting a high modulus of elasticity- and strength, while connecting members 135 may be fabricated from a second, more flexible material, such as an elastomer.
  • [0078]
    [0078]FIG. 12 depicts a portion of an element to be used in the fabrication of an alternative embodiment according to the invention in a partially expanded or deployed configuration. Endoprosthesis members 140 comprise a thinner cross-section at the inner apex 145 to allow for preferential bending at inner apex 145 upon expansion. Such preferential bending enhances uniform deployment of an endoprosthesis. Included angle 146 is between 40 and 65 degrees. Upon expansion, strain induced crystallization is induced in the polymer at the bending site, increasing the degree of crystallization, and consequently the strength of the material, at the bending site.
  • [0079]
    [0079]FIG. 13A illustrates a portion of an alternative embodiment according to the invention wherein generally serpentine endoprosthesis elements 150 comprise deployment stops 151 at one or more apex 152. As illustrated in FIG. 13B, once expansion of the endoprosthesis reaches a certain point, the edges of deployment stops 151 touch one another and prevent further expansion of that element and force expansion of the next element, thus ensuring uniform expansion.
  • [0080]
    [0080]FIG. 14A illustrates yet another embodiment according to the invention prior to expansion. FIG. 14B illustrates a portion of the embodiment of FIG. 14A after expansion. Endoprosthesis elements 155 comprise deployment stops 156 inside each crown element 157. Upon reaching a linear shape as shown in FIG. 14B, deployment stops 156 prevent further expansion of that element and force expansion of the next element, thus ensuring uniform expansion.
  • [0081]
    An alternative embodiment according to the invention is illustrated in a cross section of an endoprosthesis 160 shown in FIG. 15. Endoprosthesis elements 165, of a trapezoidal shape, comprise metal reinforcement elements 166. Metal reinforcement element 166 may be fabricated from any suitable biocompatibly corrosive metal, such as, for example, Magnesium. This composite can greatly enhance the mechanical performance of the device.
  • [0082]
    [0082]FIG. 16 depicts a cross section of endoprosthesis 170. Endoprosthesis elements 175 comprise metal reinforcement layer 176 disposed on luminal surface 177 of endoprosthesis 170. Similar to the metal reinforcement elements 166 depicted in FIG. 15, metal reinforcement layer 176 may comprise any suitable biocompatibly corrosive metal. FIG. 17 illustrates a cross section of endoprosthesis 180. Endoprosthesis elements 181 are encapsulated by metal reinforcement layer 182, which may comprise any suitable biocompatibly corrosive metal. This encapsulation may be spray-coated, dipped, electrostatically coated, ion beam deposited or coated by any means known by those skilled in the art.
  • [0083]
    Turning now to FIG. 18, the stress-strain curve exhibited by materials according to the invention is curve A. The engineering tensile stress strain curve was obtained by static loading of the material, that is, by applying the load slowly enough that all parts of the material are in equilibrium at any instant. For most engineering materials, the curve will have an initial linear region in which deformation is reversible and time independent. The slope in this region is Young's modulus. The proportional elastic limit is the point where the curve starts to deviate from a straight line. The elastic limit is the point on the curve beyond which plastic deformation is present after release of the load. If the stress is increased further, the stress strain curve departs more and more from the straight line. In FIG. 18, the curve for a brittle material is indicated at B. A typical copolymer trend is expressed in curve C, and for a low modulus material in curve D. Curve A closely resembles the stress-strain curve of a stainless steel alloy, radically surpassing the performance of know polymers under stress.
  • [0084]
    According to the invention, a poly-l-lactide blend with poly-caprolactone in a ratio of between 80:20 and 95:5 is preferred. A material prepared comprising the foregoing ratio of polymers consistently achieves the modulus of elasticity illustrated as curve A in FIG. 18. The shape of this curve mirrors that obtained by biometals such as 316L, stainless steel, a material commonly used in vascular stents. Further, if the mixture is annealed at roughly 100 degrees C. in an inert, moisture-free environment for between 1 and 24 hours, and most desirably between 1 and 3 hours, polymer chain crystallization is enhanced, and consequently the point at which plastic deformation occurs is increased. Still further, upon deployment, strain induced crystallization is initiated, further raising the point on the curve at which plastic deformation occurs.
  • [0085]
    While particular forms of the invention have been illustrated and described above, the foregoing descriptions are intended as examples, and to one skilled in the art will it will be apparent that various modifications can be made without departing from the spirit and scope of the invention.

Claims (60)

    We claim:
  1. 1. An endoprosthesis comprising one or more erodible materials, a first region and a second region, wherein said first region comprises a first degree of overall compliance and said second region comprises a second degree of overall compliance, wherein said first degree of overall compliance is greater than said second degree, whereby when said endoprosthesis is disposed within a body lumen comprising walls comprising irregular morphology, said first region is substantially compliant with said walls.
  2. 2. The endoprosthesis of claim 1 wherein said endoprosthesis comprises a first end and a second end, and wherein said first region is proximate said first end.
  3. 3. The endoprosthesis of claim 1, wherein said endoprosthesis comprises an endoprosthesis element and a lumen defined therethrough, wherein said endoprosthesis element comprises a cross section in said first region and in said second region, and wherein said cross section in said first region is substantially similar to said cross section in said second region.
  4. 4. The endoprosthesis of claim 1 wherein said endoprosthesis comprises a plurality of endoprosthesis elements and a lumen defined therethrough, wherein said endoprosthesis elements comprise linear dimensions in said first region and in said second region, and wherein said linear dimensions of said first region are substantially similar to said linear dimensions of said second region.
  5. 5. An endoprosthesis comprising one or more erodible materials, a first region and a second region, wherein said first region comprises a first degree of radial conformability and said second region comprises a second degree of radial conformability, wherein said first degree of radial conformability is greater than said second degree of radial conformability.
  6. 6. The endoprosthesis of claim 5 wherein said endoprosthesis comprises a first end and a second end, and wherein said first region is proximate said first end.
  7. 7. The endoprosthesis of claim 5 wherein said endoprosthesis comprises an endoprosthesis element and a lumen defined therethrough, wherein said endoprosthesis element comprises a cross section in said first region and in said second region, and wherein said cross section in said first region is substantially similar to said cross section in said second region.
  8. 8. The endoprosthesis of claim 5 wherein said endoprosthesis comprises a plurality of endoprosthesis elements and a lumen defined therethrough, wherein said endoprosthesis elements comprise linear dimensions in said first region and in said second region, and wherein said linear dimensions of said first region are substantially similar to said linear dimensions of said second region.
  9. 9. The endoprosthesis of claim 5 wherein said endoprosthesis further comprises one or more connecting members, and said first region is proximate said one or more connecting members.
  10. 10. An endoprosthesis comprising one or more erodible materials, a first region and a second region, wherein said first region comprises a first outward radial force and said second region comprises a second outward radial force, wherein said second outward radial is greater than said first outward radial force.
  11. 11. The endoprosthesis of claim 10 wherein said endoprosthesis comprises a first end and a second end, and wherein said first region is proximate said first end.
  12. 12. The endoprosthesis of claim 10 wherein said endoprosthesis comprises an endoprosthesis element and a lumen defined therethrough, wherein said endoprosthesis element comprises a cross section in said first region and in said second region, and wherein said cross section in said first region is substantially similar to said cross section in said second region.
  13. 13. The endoprosthesis of claim 10 wherein said endoprosthesis comprises a plurality of endoprosthesis elements and a lumen defined theretbrough, wherein said endoprosthesis elements comprise linear dimensions in said first region and in said second region, and wherein said linear dimensions of said first region are substantially similar to said linear dimensions of said second region.
  14. 14. The endoprosthesis of claim 10 wherein said endoprosthesis further comprises one or more connecting members, and said first region is proximate said one or more connecting members.
  15. 15. An endoprosthesis comprising one or more erodible materials, a first region and a second region, wherein said first region comprises a first axial flexibility and said second region comprises a second axial flexibility, wherein said first axial flexibility is greater than said second axial flexibility.
  16. 16. The endoprosthesis of claim 15 wherein said endoprosthesis comprises a first end and a second end, and wherein said first region is proximate said first end.
  17. 17. The endoprosthesis of claim 15 wherein said endoprosthesis comprises an endoprosthesis member and a lumen defined therethrough, wherein said endoprosthesis member comprises a cross section in said first region and in said second region, and wherein said cross section in said first region is substantially similar to said cross section in said second region.
  18. 18. The endoprosthesis of claim 15 wherein said endoprosthesis comprises a plurality of endoprosthesis elements and a lumen therethrough, wherein said endoprosthesis elements comprise linear dimensions in said first region and in said second region, and wherein said linear dimensions of said first region are substantially similar to said linear dimensions of said second region.
  19. 19. An endoprosthesis comprising at least one erodible polymer, a first region and a second region, wherein said at least one erodible polymer comprises a first density in said first region and a second density in said second region that is greater than said first density.
  20. 20. The endoprosthesis of claim 19 wherein said endoprosthesis comprises a first end and a second end, and wherein said first region is proximate said first end.
  21. 21. The endoprosthesis of claim 19 wherein said endoprosthesis further comprises one or more connecting members, and said first region is proximate said one or more connecting members.
  22. 22. An endoprosthesis comprising a first region and a second region, wherein said first region comprises a first diffusion coefficient and said second region comprises a second diffusion coefficient that is greater than said first diffusion coefficient.
  23. 23. The endoprosthesis of claim 22 wherein said endoprosthesis comprises a luminal surface and a vascular surface, and said first region is disposed on said luminal surface, and said second region is disposed on said vascular surface.
  24. 24. An endoprosthesis comprising one or more polymeric materials, a first and a second region, wherein said one or more polymeric materials comprise a first degree of crystallinity in said first region and a second degree of crystallinity in said second region that is greater than the first degree of crystallinity.
  25. 25. The endoprosthesis of claim 24 wherein said endoprosthesis further comprises one or more connecting members, and said first region is proximate said one or more connecting members.
  26. 26. An endoprosthesis comprising one or more erodible materials and one or more endoprosthesis elements, wherein said one or more endoprosthesis elements comprises a trapezoidal cross-section.
  27. 27. The endoprosthesis of claim 26 wherein said endoprosthesis comprises a vascular surface area, and said surface area is 10% or more greater than the surface area of an endoprosthesis comprising equivalent non-trapezoidal endoprosthesis elements.
  28. 28. An expandable endoprosthesis comprising one or more endoprosthesis elements, said endoprosthesis elements comprising a plurality of apices alternating with a plurality of straight sections, said apices comprising a first width and said straight sections comprising a second width, wherein the second width is greater than said first width.
  29. 29. The endoprosthesis of claim 28 wherein upon expansion, said endoprosthesis elements bend preferentially at said apices.
  30. 30. The endoprosthesis of claim 29 wherein following expansion, said apices comprise an angle of between 40 and 65 degrees.
  31. 31. The endoprosthesis of claim 30 wherein said endoprosthesis comprises a first material, wherein said first material undergoes strain induced crystallization upon expansion.
  32. 32. An expandable endoprosthesis comprising means for limiting expansion of said endoprosthesis.
  33. 33. The endoprosthesis of claim 32 wherein said endoprosthesis comprises an endoprosthesis element comprising a plurality of apices, said apices comprising one or more stop portions, wherein said stop portions are separate from one another prior to expansion, and abut one another upon expansion of said endoprosthesis.
  34. 34. The endoprosthesis of claim 32 comprising one or more stop elements, wherein said one or more stop elements comprise a curved configuration prior to expansion and a linear configuration following expansion, wherein said linear configuration prevents the further expansion of said endoprosthesis.
  35. 35. An endoprosthesis comprising one or more erodible materials, wherein said endoprosthesis comprises one or more endoprosthesis elements and one or more reinforcing elements.
  36. 36. The endoprosthesis of claim 35 wherein said reinforcing elements comprise a biocompatibly corrosive metal.
  37. 37. The endoprosthesis of claim 35 wherein said reinforcing element is encapsulated by said one or more endoprosthesis elements.
  38. 38. The endoprosthesis of claim 35 wherein said endoprosthesis comprises a luminal surface and a vascular surface, and wherein said reinforcing element is disposed on said luminal surface.
  39. 39. The endoprosthesis of claim 35 wherein said reinforcing element encapsulates said one or more endoprosthesis elements.
  40. 40. An expandable endoprosthesis comprising poly-lactic acid and polycaprolactone in a ratio of between 80:20 and 95:5.
  41. 41. The endoprosthesis of claim 40 wherein said endoprosthesis is annealed at a temperature of between 50 and 200 degrees C. for a duration of between one half and 24 hours.
  42. 42. The endoprosthesis of claim 41 wherein said endoprosthesis undergoes strain induced crystallization upon expansion.
  43. 43. The endoprosthesis of claim 42 wherein said endoprosthesis comprises an endoprosthesis element comprising a plurality of apices alternating with a plurality of straight sections wherein said endoprosthesis undergoes strain induced crystallization upon expansion proximate the apices.
  44. 44. The endoprosthesis of claim 43 wherein said apices define an included angle between straight sections comprise of between 40 and 90 degrees following expansion of the endoprosthesis.
  45. 45. An endoprosthesis comprising one or more polymeric materials that undergo plastic deformation between 3 and 20 ksi.
  46. 46. The endoprosthesis according to claim 45 wherein said one or more polymeric materials continues to strengthen following plastic deformation until the point of material failure.
  47. 47. The endoprosthesis of claim 1 further comprising one or more therapeutic substances incorporated into the endoprosthesis using a solvent in a supercritical state.
  48. 48. The endoprosthesis of claim 47 wherein said endoprosthesis is formed from one or more curable materials using a first set of first set of parameters to achieve said first set of physical properties and using a second set of parameters to achieve said second set of physical properties.
  49. 49. A method of manufacture of an endoprosthesis comprising:
    providing a mold;
    placing a first material into said mold;
    placing a second material into said mold;
    apply heat and pressure to mold to form film;
    removing said film from said mold; and
    forming a cylinder from said film to define said endoprosthesis.
  50. 50. The method of claim 49 wherein said mold comprises a first region and a second region, and wherein said first material is placed in said first region and said second material is placed in said second region.
  51. 51. The method of claim 50 wherein said first material comprises a first set of properties and said second material comprises a second set of properties.
  52. 52. The method of claim 51 wherein said properties comprise material density, modulus of elasticity, rate of erosion, extensibility, compressibility, mechanical strength, tensile strength, degree of crystallinity, diffusion coefficient, and permeability.
  53. 53. A method of manufacture of an endoprosthesis comprising the steps of:
    coextruding a first material and a second material to form a generally tubular structure; and
    selectively removing portions of said first material from said tube.
  54. 54. The method of claim 53 comprising the additional step of selectively removing portions of said second material.
  55. 55. The method of claim 54 wherein said first material comprises a first set of properties and said second material comprises a second set of properties.
  56. 56. The method of claim 55 wherein said properties comprise material density, modulus of elasticity, rate of erosion, extensibility, compressibility, mechanical strength, tensile strength, degree of crystallinity, diffusion coefficient, and permeability.
  57. 57. The method of claim 49 wherein the method further comprises the step of immersing said endoprosthesis and a hydrophilic therapeutic agent in water beneath a blanket of carbon dioxide in its supercritical state, whereby said hydrophilic therapeutic agent is incorporated into said endoprosthesis.
  58. 58. The method of claim 49 wherein the method further comprises the step of immersing said endoprosthesis and a hydrophobic therapeutic agent in carbon dioxide in its supercritical state, whereby said hydrophobic therapeutic agent is incorporated into said endoprosthesis.
  59. 59. The method of claim 53 wherein the method further comprises the step of immersing said endoprosthesis and a hydrophilic therapeutic agent in water beneath a blanket of carbon dioxide in its supercritical state, whereby said hydrophilic therapeutic agent is incorporated into said endoprosthesis.
  60. 60. The method of claim 53 wherein the method further comprises the step of immersing said endoprosthesis and a hydrophobic therapeutic agent in carbon dioxide in its supercritical state, whereby said hydrophobic therapeutic agent is incorporated into said endoprosthesis.
US10342748 2002-11-14 2003-01-15 Polymeric endoprosthesis and method of manufacture Abandoned US20040098090A1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
US42612602 true 2002-11-14 2002-11-14
US42612502 true 2002-11-14 2002-11-14
US42673402 true 2002-11-15 2002-11-15
US42673702 true 2002-11-15 2002-11-15
US42689802 true 2002-11-15 2002-11-15
US10342748 US20040098090A1 (en) 2002-11-14 2003-01-15 Polymeric endoprosthesis and method of manufacture

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US10342748 US20040098090A1 (en) 2002-11-14 2003-01-15 Polymeric endoprosthesis and method of manufacture
CA 2506655 CA2506655A1 (en) 2002-11-15 2003-11-12 Polymeric endoprosthesis and method of manufacture
JP2004570377A JP2006506208A (en) 2002-11-15 2003-11-12 Polymer manufactured by the body prosthesis and a method for manufacturing
PCT/US2003/035805 WO2004045653A3 (en) 2002-11-15 2003-11-12 Polymeric endoprosthesis and method of manufacture
EP20030783280 EP1567089B1 (en) 2002-11-15 2003-11-12 Polymeric endoprosthesis
US11541195 US20070023951A1 (en) 2002-11-15 2006-09-30 Polymeric endoprosthesis and method of manufacture
US11541172 US20070027527A1 (en) 2002-11-15 2006-09-30 Polymeric endoprosthesis and method of manufacture
US12215493 US8152843B2 (en) 2002-11-14 2008-06-26 Polymeric endoprosthesis and method of manufacture

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US11541172 Division US20070027527A1 (en) 2002-11-14 2006-09-30 Polymeric endoprosthesis and method of manufacture
US11541195 Division US20070023951A1 (en) 2002-11-14 2006-09-30 Polymeric endoprosthesis and method of manufacture
US12215493 Division US8152843B2 (en) 2002-11-14 2008-06-26 Polymeric endoprosthesis and method of manufacture

Publications (1)

Publication Number Publication Date
US20040098090A1 true true US20040098090A1 (en) 2004-05-20

Family

ID=32303864

Family Applications (2)

Application Number Title Priority Date Filing Date
US10342748 Abandoned US20040098090A1 (en) 2002-11-14 2003-01-15 Polymeric endoprosthesis and method of manufacture
US12215493 Expired - Fee Related US8152843B2 (en) 2002-11-14 2008-06-26 Polymeric endoprosthesis and method of manufacture

Family Applications After (1)

Application Number Title Priority Date Filing Date
US12215493 Expired - Fee Related US8152843B2 (en) 2002-11-14 2008-06-26 Polymeric endoprosthesis and method of manufacture

Country Status (1)

Country Link
US (2) US20040098090A1 (en)

Cited By (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040260386A1 (en) * 2003-01-31 2004-12-23 Shalaby Shalaby W. Absorbable / biodegradable tubular stent and methods of making the same
US20060076708A1 (en) * 2004-09-30 2006-04-13 Bin Huang Method of fabricating a biaxially oriented implantable medical device
US20060121087A1 (en) * 2004-12-06 2006-06-08 Williams Michael S Polymeric endoprostheses with modified erosion rates and methods of manufacture
US20070150047A1 (en) * 1995-06-07 2007-06-28 Med Institute, Inc. Implantable medical device with bioabsorbable coating
US20070156231A1 (en) * 2006-01-05 2007-07-05 Jan Weber Bioerodible endoprostheses and methods of making the same
US20070196423A1 (en) * 2005-11-21 2007-08-23 Med Institute, Inc. Implantable medical device coatings with biodegradable elastomer and releasable therapeutic agent
US20080097575A1 (en) * 2006-10-20 2008-04-24 Orbusneich Medical, Inc. Bioabsorbable Medical Device with Coating
US20080103594A1 (en) * 2005-01-20 2008-05-01 Biotronik Vi Patent Ag Absorbable Medical Implant Made of Fiber-Reinforced Magnesium or Fiber-Reinforced Magnesium Alloys
US20080177373A1 (en) * 2007-01-19 2008-07-24 Elixir Medical Corporation Endoprosthesis structures having supporting features
US20080206440A1 (en) * 2006-10-20 2008-08-28 Orbusneich Medical, Inc. Bioabsorbable Polymeric Composition and Medical Device Background
US20080319540A1 (en) * 2007-06-13 2008-12-25 Boston Scientific Scimed, Inc. Anti-migration features and geometry for a shape memory polymer stent
US20090001633A1 (en) * 2007-06-29 2009-01-01 Limon Timothy A Method Of Manufacturing A Stent From A Polymer Tube
US20090005854A1 (en) * 2007-06-29 2009-01-01 Bin Huang Stent having circumferentially deformable struts
US20090146348A1 (en) * 2007-12-11 2009-06-11 Bin Huang Method of fabrication a stent from blow molded tubing
US20100025894A1 (en) * 2008-08-04 2010-02-04 Abbott Cardiovascular Inc. Tube expansion process for semicrystalline polymers to maximize fracture toughness
US20100049296A1 (en) * 2008-08-22 2010-02-25 Med Institute, Inc. Implantable medical device coatings with biodegradable elastomer and releasable taxane agent
US20100094405A1 (en) * 2008-10-10 2010-04-15 Orbusneich Medical, Inc. Bioabsorbable Polymeric Medical Device
US20100093946A1 (en) * 2008-10-11 2010-04-15 Orbusneich Medical, Inc. Bioabsorbable Polymeric Compositions and Medical Devices
US7731890B2 (en) 2006-06-15 2010-06-08 Advanced Cardiovascular Systems, Inc. Methods of fabricating stents with enhanced fracture toughness
US7740791B2 (en) 2006-06-30 2010-06-22 Advanced Cardiovascular Systems, Inc. Method of fabricating a stent with features by blow molding
US20100244304A1 (en) * 2009-03-31 2010-09-30 Yunbing Wang Stents fabricated from a sheet with increased strength, modulus and fracture toughness
US7823263B2 (en) 2006-07-11 2010-11-02 Abbott Cardiovascular Systems Inc. Method of removing stent islands from a stent
US20100318175A1 (en) * 2007-12-31 2010-12-16 C.R. Bard, Inc. Vascular graft prosthesis with selective flow reduction
US7901452B2 (en) 2007-06-27 2011-03-08 Abbott Cardiovascular Systems Inc. Method to fabricate a stent having selected morphology to reduce restenosis
US20110062638A1 (en) * 2009-09-14 2011-03-17 Thierry Glauser Controlling Crystalline Morphology Of A Bioabsorbable Stent
US20110066222A1 (en) * 2009-09-11 2011-03-17 Yunbing Wang Polymeric Stent and Method of Making Same
US20110130822A1 (en) * 2007-07-20 2011-06-02 Orbusneich Medical, Inc. Bioabsorbable Polymeric Compositions and Medical Devices
US7955381B1 (en) 2007-06-29 2011-06-07 Advanced Cardiovascular Systems, Inc. Polymer-bioceramic composite implantable medical device with different types of bioceramic particles
US8043553B1 (en) 2004-09-30 2011-10-25 Advanced Cardiovascular Systems, Inc. Controlled deformation of a polymer tube with a restraining surface in fabricating a medical article
US8128688B2 (en) 2006-06-27 2012-03-06 Abbott Cardiovascular Systems Inc. Carbon coating on an implantable device
US8173062B1 (en) 2004-09-30 2012-05-08 Advanced Cardiovascular Systems, Inc. Controlled deformation of a polymer tube in fabricating a medical article
US8192678B2 (en) 2004-07-26 2012-06-05 Advanced Cardiovascular Systems, Inc. Method of fabricating an implantable medical device with biaxially oriented polymers
US8370120B2 (en) 2010-04-30 2013-02-05 Abbott Cardiovascular Systems Inc. Polymeric stents and method of manufacturing same
US20130096668A1 (en) * 2010-04-22 2013-04-18 Abbott Cardiovascular Systems Inc. Optimal ratio of polar and bending moment of inertia for stent strut design
US8535372B1 (en) 2006-06-16 2013-09-17 Abbott Cardiovascular Systems Inc. Bioabsorbable stent with prohealing layer
FR2993451A1 (en) * 2012-07-17 2014-01-24 St George Medical Inc endoluminal vascular prosthesis for small vessels
US8709071B1 (en) 2007-09-28 2014-04-29 Abbott Cardiovascular Systems Inc. Stent with preferential coating
US8752267B2 (en) 2006-05-26 2014-06-17 Abbott Cardiovascular Systems Inc. Method of making stents with radiopaque markers
US8778256B1 (en) 2004-09-30 2014-07-15 Advanced Cardiovascular Systems, Inc. Deformation of a polymer tube in the fabrication of a medical article
US9173973B2 (en) 2006-07-20 2015-11-03 G. Lawrence Thatcher Bioabsorbable polymeric composition for a medical device
US9198785B2 (en) 2010-01-30 2015-12-01 Abbott Cardiovascular Systems Inc. Crush recoverable polymer scaffolds
US9198782B2 (en) 2006-05-30 2015-12-01 Abbott Cardiovascular Systems Inc. Manufacturing process for polymeric stents
US9216238B2 (en) 2006-04-28 2015-12-22 Abbott Cardiovascular Systems Inc. Implantable medical device having reduced chance of late inflammatory response
US9364588B2 (en) 2014-02-04 2016-06-14 Abbott Cardiovascular Systems Inc. Drug delivery scaffold or stent with a novolimus and lactide based coating such that novolimus has a minimum amount of bonding to the coating
US9517149B2 (en) 2004-07-26 2016-12-13 Abbott Cardiovascular Systems Inc. Biodegradable stent with enhanced fracture toughness
US9532888B2 (en) 2006-01-04 2017-01-03 Abbott Cardiovascular Systems Inc. Stents with radiopaque markers
US9827119B2 (en) 2010-01-30 2017-11-28 Abbott Cardiovascular Systems Inc. Polymer scaffolds having a low crossing profile
US9878150B2 (en) 2005-09-12 2018-01-30 The Cleveland Clinic Foundation Methods and systems for increasing heart contractility by neuromodulation
US9999527B2 (en) 2015-02-11 2018-06-19 Abbott Cardiovascular Systems Inc. Scaffolds having radiopaque markers

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9592136B2 (en) 2005-07-25 2017-03-14 Vascular Dynamics, Inc. Devices and methods for control of blood pressure
US9642726B2 (en) 2005-07-25 2017-05-09 Vascular Dynamics, Inc. Devices and methods for control of blood pressure
US8923972B2 (en) * 2005-07-25 2014-12-30 Vascular Dynamics, Inc. Elliptical element for blood pressure reduction
US9125732B2 (en) * 2005-07-25 2015-09-08 Vascular Dynamics, Inc. Devices and methods for control of blood pressure
EP2346405A4 (en) 2008-09-26 2017-08-23 Vascular Dynamics Inc Devices and methods for control of blood pressure
US8888840B2 (en) * 2009-05-20 2014-11-18 Boston Scientific Scimed, Inc. Drug eluting medical implant
US9309347B2 (en) 2009-05-20 2016-04-12 Biomedical, Inc. Bioresorbable thermoset polyester/urethane elastomers
US8992601B2 (en) 2009-05-20 2015-03-31 480 Biomedical, Inc. Medical implants
US20110319987A1 (en) 2009-05-20 2011-12-29 Arsenal Medical Medical implant
JP5820370B2 (en) 2009-05-20 2015-11-24 アーセナル メディカル, インコーポレイテッド Medical implants
US8372133B2 (en) 2009-10-05 2013-02-12 480 Biomedical, Inc. Polymeric implant delivery system

Citations (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6179869B2 (en) *
US5059211A (en) * 1987-06-25 1991-10-22 Duke University Absorbable vascular stent
US5085629A (en) * 1988-10-06 1992-02-04 Medical Engineering Corporation Biodegradable stent
US5423885A (en) * 1992-01-31 1995-06-13 Advanced Cardiovascular Systems, Inc. Stent capable of attachment within a body lumen
US5443498A (en) * 1991-10-01 1995-08-22 Cook Incorporated Vascular stent and method of making and implanting a vacsular stent
US5443458A (en) * 1992-12-22 1995-08-22 Advanced Cardiovascular Systems, Inc. Multilayered biodegradable stent and method of manufacture
US5443500A (en) * 1989-01-26 1995-08-22 Advanced Cardiovascular Systems, Inc. Intravascular stent
US5449382A (en) * 1992-11-04 1995-09-12 Dayton; Michael P. Minimally invasive bioactivated endoprosthesis for vessel repair
US5456917A (en) * 1993-04-12 1995-10-10 Cambridge Scientific, Inc. Method for making a bioerodible material for the sustained release of a medicament and the material made from the method
US5500013A (en) * 1991-10-04 1996-03-19 Scimed Life Systems, Inc. Biodegradable drug delivery vascular stent
US5527337A (en) * 1987-06-25 1996-06-18 Duke University Bioabsorbable stent and method of making the same
US5545208A (en) * 1990-02-28 1996-08-13 Medtronic, Inc. Intralumenal drug eluting prosthesis
US5551954A (en) * 1991-10-04 1996-09-03 Scimed Life Systems, Inc. Biodegradable drug delivery vascular stent
US5591199A (en) * 1995-06-07 1997-01-07 Porter; Christopher H. Curable fiber composite stent and delivery system
US5591224A (en) * 1992-03-19 1997-01-07 Medtronic, Inc. Bioelastomeric stent
US5591227A (en) * 1992-03-19 1997-01-07 Medtronic, Inc. Drug eluting stent
US5607467A (en) * 1990-09-14 1997-03-04 Froix; Michael Expandable polymeric stent with memory and delivery apparatus and method
US5618299A (en) * 1993-04-23 1997-04-08 Advanced Cardiovascular Systems, Inc. Ratcheting stent
US5629077A (en) * 1994-06-27 1997-05-13 Advanced Cardiovascular Systems, Inc. Biodegradable mesh and film stent
US5649952A (en) * 1993-12-28 1997-07-22 Advanced Cardiovascular Systems, Inc. Expandable stents and method for making same
US5670161A (en) * 1996-05-28 1997-09-23 Healy; Kevin E. Biodegradable stent
US5674192A (en) * 1990-12-28 1997-10-07 Boston Scientific Corporation Drug delivery
US5733330A (en) * 1997-01-13 1998-03-31 Advanced Cardiovascular Systems, Inc. Balloon-expandable, crush-resistant locking stent
US5733327A (en) * 1994-10-17 1998-03-31 Igaki; Keiji Stent for liberating drug
US5741323A (en) * 1993-04-28 1998-04-21 Focal, Inc. Polymeric article for intraluminal photothermoforming
US5749922A (en) * 1988-08-24 1998-05-12 Endoluminal Therapeutics, Inc. Biodegradable polymeric endoluminal sealing process, apparatus and polymeric products for use therein
US5762625A (en) * 1992-09-08 1998-06-09 Kabushikikaisha Igaki Iryo Sekkei Luminal stent and device for inserting luminal stent
US5800507A (en) * 1992-03-19 1998-09-01 Medtronic, Inc. Intraluminal stent
US5916585A (en) * 1996-06-03 1999-06-29 Gore Enterprise Holdings, Inc. Materials and method for the immobilization of bioactive species onto biodegradable polymers
US5957975A (en) * 1997-12-15 1999-09-28 The Cleveland Clinic Foundation Stent having a programmed pattern of in vivo degradation
USRE36370E (en) * 1992-01-13 1999-11-02 Li; Shu-Tung Resorbable vascular wound dressings
US5980564A (en) * 1997-08-01 1999-11-09 Schneider (Usa) Inc. Bioabsorbable implantable endoprosthesis with reservoir
US5984963A (en) * 1993-03-18 1999-11-16 Medtronic Ave, Inc. Endovascular stents
US6004346A (en) * 1990-02-28 1999-12-21 Medtronic, Inc. Intralumenal drug eluting prosthesis
US6045568A (en) * 1991-03-08 2000-04-04 Igaki; Keiji Luminal stent, holding structure therefor and device for attaching luminal stent
US6113628A (en) * 1995-06-08 2000-09-05 Ave Galway Limited Endovascular stent with support wire
US6156062A (en) * 1997-12-03 2000-12-05 Ave Connaught Helically wrapped interlocking stent
US6179869B1 (en) * 1996-07-11 2001-01-30 Tricumed Medizintechnik Gmbh Artificial heart valve
US6224626B1 (en) * 1998-02-17 2001-05-01 Md3, Inc. Ultra-thin expandable stent
US6245103B1 (en) * 1997-08-01 2001-06-12 Schneider (Usa) Inc Bioabsorbable self-expanding stent
US6251136B1 (en) * 1999-12-08 2001-06-26 Advanced Cardiovascular Systems, Inc. Method of layering a three-coated stent using pharmacological and polymeric agents
US20010029398A1 (en) * 1999-06-03 2001-10-11 Jadhav Balkrishna S. Bioresorbable stent
US6312457B1 (en) * 1999-04-01 2001-11-06 Boston Scientific Corporation Intraluminal lining
US6338739B1 (en) * 1999-12-22 2002-01-15 Ethicon, Inc. Biodegradable stent
US6413272B1 (en) * 1997-03-31 2002-07-02 Kabushikikaisha Igaki Iryo Sekkei Stent for vessel
US6451373B1 (en) * 2000-08-04 2002-09-17 Advanced Cardiovascular Systems, Inc. Method of forming a therapeutic coating onto a surface of an implantable prosthesis
US20020188342A1 (en) * 2001-06-01 2002-12-12 Rykhus Robert L. Short-term bioresorbable stents
US20030044514A1 (en) * 2001-06-13 2003-03-06 Richard Robert E. Using supercritical fluids to infuse therapeutic on a medical device
US20030074049A1 (en) * 2000-08-25 2003-04-17 Kensey Nash Corporation Covered stents and systems for deploying covered stents
US20030104030A1 (en) * 2000-11-30 2003-06-05 Keiji Igaki Stent for blood vessel and material for stent for blood vessel

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5662701A (en) * 1989-08-18 1997-09-02 Endovascular Instruments, Inc. Anti-stenotic method and product for occluded and partially occluded arteries
CA2178541C (en) * 1995-06-07 2009-11-24 Neal E. Fearnot Implantable medical device
DE19731021A1 (en) * 1997-07-18 1999-01-21 Meyer Joerg In vivo degradable metallic implant
US20020099438A1 (en) * 1998-04-15 2002-07-25 Furst Joseph G. Irradiated stent coating
EP0966979B1 (en) * 1998-06-25 2006-03-08 Biotronik AG Implantable bioresorbable support for the vascular walls, in particular coronary stent
EP1148839B1 (en) 1999-02-01 2008-09-10 The Board Of Regents The University Of Texas System Woven bifurcated and trifurcated stents and methods for making the same
DE10105592A1 (en) 2001-02-06 2002-08-08 Achim Goepferich Placeholder for drug release in the frontal sinus
US6752826B2 (en) * 2001-12-14 2004-06-22 Thoratec Corporation Layered stent-graft and methods of making the same

Patent Citations (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6179869B2 (en) *
US5059211A (en) * 1987-06-25 1991-10-22 Duke University Absorbable vascular stent
US5306286A (en) * 1987-06-25 1994-04-26 Duke University Absorbable stent
US5527337A (en) * 1987-06-25 1996-06-18 Duke University Bioabsorbable stent and method of making the same
US5749922A (en) * 1988-08-24 1998-05-12 Endoluminal Therapeutics, Inc. Biodegradable polymeric endoluminal sealing process, apparatus and polymeric products for use therein
US5085629A (en) * 1988-10-06 1992-02-04 Medical Engineering Corporation Biodegradable stent
US5443500A (en) * 1989-01-26 1995-08-22 Advanced Cardiovascular Systems, Inc. Intravascular stent
US5545208A (en) * 1990-02-28 1996-08-13 Medtronic, Inc. Intralumenal drug eluting prosthesis
US6004346A (en) * 1990-02-28 1999-12-21 Medtronic, Inc. Intralumenal drug eluting prosthesis
US5851217A (en) * 1990-02-28 1998-12-22 Medtronic, Inc. Intralumenal drug eluting prosthesis
US5607467A (en) * 1990-09-14 1997-03-04 Froix; Michael Expandable polymeric stent with memory and delivery apparatus and method
US5674192A (en) * 1990-12-28 1997-10-07 Boston Scientific Corporation Drug delivery
US6045568A (en) * 1991-03-08 2000-04-04 Igaki; Keiji Luminal stent, holding structure therefor and device for attaching luminal stent
US6080177A (en) * 1991-03-08 2000-06-27 Igaki; Keiji Luminal stent, holding structure therefor and device for attaching luminal stent
US5443498A (en) * 1991-10-01 1995-08-22 Cook Incorporated Vascular stent and method of making and implanting a vacsular stent
US6387124B1 (en) * 1991-10-04 2002-05-14 Scimed Life Systems, Inc. Biodegradable drug delivery vascular stent
US5551954A (en) * 1991-10-04 1996-09-03 Scimed Life Systems, Inc. Biodegradable drug delivery vascular stent
US5500013A (en) * 1991-10-04 1996-03-19 Scimed Life Systems, Inc. Biodegradable drug delivery vascular stent
US5769883A (en) * 1991-10-04 1998-06-23 Scimed Life Systems, Inc. Biodegradable drug delivery vascular stent
USRE36370E (en) * 1992-01-13 1999-11-02 Li; Shu-Tung Resorbable vascular wound dressings
US5423885A (en) * 1992-01-31 1995-06-13 Advanced Cardiovascular Systems, Inc. Stent capable of attachment within a body lumen
US6080190A (en) * 1992-03-19 2000-06-27 Medtronic, Inc. Intraluminal stent
US5591227A (en) * 1992-03-19 1997-01-07 Medtronic, Inc. Drug eluting stent
US5957971A (en) * 1992-03-19 1999-09-28 Medtronic, Inc. Intraluminal stent
US5800507A (en) * 1992-03-19 1998-09-01 Medtronic, Inc. Intraluminal stent
US5591224A (en) * 1992-03-19 1997-01-07 Medtronic, Inc. Bioelastomeric stent
US5762625A (en) * 1992-09-08 1998-06-09 Kabushikikaisha Igaki Iryo Sekkei Luminal stent and device for inserting luminal stent
US5449382A (en) * 1992-11-04 1995-09-12 Dayton; Michael P. Minimally invasive bioactivated endoprosthesis for vessel repair
US5443458A (en) * 1992-12-22 1995-08-22 Advanced Cardiovascular Systems, Inc. Multilayered biodegradable stent and method of manufacture
US5984963A (en) * 1993-03-18 1999-11-16 Medtronic Ave, Inc. Endovascular stents
US5456917A (en) * 1993-04-12 1995-10-10 Cambridge Scientific, Inc. Method for making a bioerodible material for the sustained release of a medicament and the material made from the method
US5618299A (en) * 1993-04-23 1997-04-08 Advanced Cardiovascular Systems, Inc. Ratcheting stent
US6176871B1 (en) * 1993-04-28 2001-01-23 Focal, Inc. Apparatus and methods for intraluminal photothermoforming
US5741323A (en) * 1993-04-28 1998-04-21 Focal, Inc. Polymeric article for intraluminal photothermoforming
US5649952A (en) * 1993-12-28 1997-07-22 Advanced Cardiovascular Systems, Inc. Expandable stents and method for making same
US5629077A (en) * 1994-06-27 1997-05-13 Advanced Cardiovascular Systems, Inc. Biodegradable mesh and film stent
US5766710A (en) * 1994-06-27 1998-06-16 Advanced Cardiovascular Systems, Inc. Biodegradable mesh and film stent
US5733327A (en) * 1994-10-17 1998-03-31 Igaki; Keiji Stent for liberating drug
US5591199A (en) * 1995-06-07 1997-01-07 Porter; Christopher H. Curable fiber composite stent and delivery system
US5766204A (en) * 1995-06-07 1998-06-16 Metastent Incorporated Curable fiber composite stent and delivery system
US6113628A (en) * 1995-06-08 2000-09-05 Ave Galway Limited Endovascular stent with support wire
US5670161A (en) * 1996-05-28 1997-09-23 Healy; Kevin E. Biodegradable stent
US5916585A (en) * 1996-06-03 1999-06-29 Gore Enterprise Holdings, Inc. Materials and method for the immobilization of bioactive species onto biodegradable polymers
US6179869B1 (en) * 1996-07-11 2001-01-30 Tricumed Medizintechnik Gmbh Artificial heart valve
US5733330A (en) * 1997-01-13 1998-03-31 Advanced Cardiovascular Systems, Inc. Balloon-expandable, crush-resistant locking stent
US6413272B1 (en) * 1997-03-31 2002-07-02 Kabushikikaisha Igaki Iryo Sekkei Stent for vessel
US20010021871A1 (en) * 1997-08-01 2001-09-13 Stinson Jonathan S. Process for making bioabsorbable self-expanding stent
US5980564A (en) * 1997-08-01 1999-11-09 Schneider (Usa) Inc. Bioabsorbable implantable endoprosthesis with reservoir
US6245103B1 (en) * 1997-08-01 2001-06-12 Schneider (Usa) Inc Bioabsorbable self-expanding stent
US6156062A (en) * 1997-12-03 2000-12-05 Ave Connaught Helically wrapped interlocking stent
US5957975A (en) * 1997-12-15 1999-09-28 The Cleveland Clinic Foundation Stent having a programmed pattern of in vivo degradation
US6224626B1 (en) * 1998-02-17 2001-05-01 Md3, Inc. Ultra-thin expandable stent
US6312457B1 (en) * 1999-04-01 2001-11-06 Boston Scientific Corporation Intraluminal lining
US20010029398A1 (en) * 1999-06-03 2001-10-11 Jadhav Balkrishna S. Bioresorbable stent
US6368346B1 (en) * 1999-06-03 2002-04-09 American Medical Systems, Inc. Bioresorbable stent
US6251136B1 (en) * 1999-12-08 2001-06-26 Advanced Cardiovascular Systems, Inc. Method of layering a three-coated stent using pharmacological and polymeric agents
US6338739B1 (en) * 1999-12-22 2002-01-15 Ethicon, Inc. Biodegradable stent
US6451373B1 (en) * 2000-08-04 2002-09-17 Advanced Cardiovascular Systems, Inc. Method of forming a therapeutic coating onto a surface of an implantable prosthesis
US20030074049A1 (en) * 2000-08-25 2003-04-17 Kensey Nash Corporation Covered stents and systems for deploying covered stents
US20030104030A1 (en) * 2000-11-30 2003-06-05 Keiji Igaki Stent for blood vessel and material for stent for blood vessel
US20020188342A1 (en) * 2001-06-01 2002-12-12 Rykhus Robert L. Short-term bioresorbable stents
US20030044514A1 (en) * 2001-06-13 2003-03-06 Richard Robert E. Using supercritical fluids to infuse therapeutic on a medical device

Cited By (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8313521B2 (en) 1995-06-07 2012-11-20 Cook Medical Technologies Llc Method of delivering an implantable medical device with a bioabsorbable coating
US20070150047A1 (en) * 1995-06-07 2007-06-28 Med Institute, Inc. Implantable medical device with bioabsorbable coating
US20090299465A1 (en) * 2003-01-31 2009-12-03 Shalaby Shalaby W Absorbable / biodegradable tubular stent and methods of making the same
US20040260386A1 (en) * 2003-01-31 2004-12-23 Shalaby Shalaby W. Absorbable / biodegradable tubular stent and methods of making the same
US8192678B2 (en) 2004-07-26 2012-06-05 Advanced Cardiovascular Systems, Inc. Method of fabricating an implantable medical device with biaxially oriented polymers
US9517149B2 (en) 2004-07-26 2016-12-13 Abbott Cardiovascular Systems Inc. Biodegradable stent with enhanced fracture toughness
US8715564B2 (en) 2004-07-26 2014-05-06 Advanced Cardiovascular Systems, Inc. Method of fabricating an implantable medical device with biaxially oriented polymers
US8778256B1 (en) 2004-09-30 2014-07-15 Advanced Cardiovascular Systems, Inc. Deformation of a polymer tube in the fabrication of a medical article
US8173062B1 (en) 2004-09-30 2012-05-08 Advanced Cardiovascular Systems, Inc. Controlled deformation of a polymer tube in fabricating a medical article
US20060076708A1 (en) * 2004-09-30 2006-04-13 Bin Huang Method of fabricating a biaxially oriented implantable medical device
US8043553B1 (en) 2004-09-30 2011-10-25 Advanced Cardiovascular Systems, Inc. Controlled deformation of a polymer tube with a restraining surface in fabricating a medical article
US7875233B2 (en) 2004-09-30 2011-01-25 Advanced Cardiovascular Systems, Inc. Method of fabricating a biaxially oriented implantable medical device
US20060121087A1 (en) * 2004-12-06 2006-06-08 Williams Michael S Polymeric endoprostheses with modified erosion rates and methods of manufacture
US20110038913A1 (en) * 2004-12-06 2011-02-17 Williams Michael S Polymeric endoprostheses with modified erosion rates and methods of manufacture
US9700652B2 (en) * 2005-01-20 2017-07-11 Biotronik Vi Patent Ag Absorbable medical implant made of fiber-reinforced magnesium or fiber-reinforced magnesium alloys
US20080103594A1 (en) * 2005-01-20 2008-05-01 Biotronik Vi Patent Ag Absorbable Medical Implant Made of Fiber-Reinforced Magnesium or Fiber-Reinforced Magnesium Alloys
US9878150B2 (en) 2005-09-12 2018-01-30 The Cleveland Clinic Foundation Methods and systems for increasing heart contractility by neuromodulation
US20070196423A1 (en) * 2005-11-21 2007-08-23 Med Institute, Inc. Implantable medical device coatings with biodegradable elastomer and releasable therapeutic agent
US9532888B2 (en) 2006-01-04 2017-01-03 Abbott Cardiovascular Systems Inc. Stents with radiopaque markers
US8840660B2 (en) * 2006-01-05 2014-09-23 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
US20070156231A1 (en) * 2006-01-05 2007-07-05 Jan Weber Bioerodible endoprostheses and methods of making the same
US9216238B2 (en) 2006-04-28 2015-12-22 Abbott Cardiovascular Systems Inc. Implantable medical device having reduced chance of late inflammatory response
US8752268B2 (en) 2006-05-26 2014-06-17 Abbott Cardiovascular Systems Inc. Method of making stents with radiopaque markers
US8752267B2 (en) 2006-05-26 2014-06-17 Abbott Cardiovascular Systems Inc. Method of making stents with radiopaque markers
US9038260B2 (en) 2006-05-26 2015-05-26 Abbott Cardiovascular Systems Inc. Stent with radiopaque markers
US9694116B2 (en) 2006-05-26 2017-07-04 Abbott Cardiovascular Systems Inc. Stents with radiopaque markers
US9358325B2 (en) 2006-05-26 2016-06-07 Abbott Cardiovascular Systems Inc. Stents with radiopaque markers
US9554925B2 (en) 2006-05-30 2017-01-31 Abbott Cardiovascular Systems Inc. Biodegradable polymeric stents
US9198782B2 (en) 2006-05-30 2015-12-01 Abbott Cardiovascular Systems Inc. Manufacturing process for polymeric stents
US9522503B2 (en) 2006-06-15 2016-12-20 Abbott Cardiovascular Systems Inc. Methods of treatment with stents with enhanced fracture toughness
US7731890B2 (en) 2006-06-15 2010-06-08 Advanced Cardiovascular Systems, Inc. Methods of fabricating stents with enhanced fracture toughness
US8323329B2 (en) 2006-06-15 2012-12-04 Advanced Cardiovascular Systems, Inc. Stents with enhanced fracture toughness
US20100289191A1 (en) * 2006-06-15 2010-11-18 Advanced Cardiovascular Systems, Inc. Methods of fabricating stents with enhanced fracture toughness
US20110112627A1 (en) * 2006-06-15 2011-05-12 Advanced Cardiovascular Systems, Inc. Stents with Enhanced Fracture Toughness
US8658081B2 (en) 2006-06-15 2014-02-25 Advanced Cardiovascular Systems, Inc. Methods of fabricating stents with enhanced fracture toughness
US8535372B1 (en) 2006-06-16 2013-09-17 Abbott Cardiovascular Systems Inc. Bioabsorbable stent with prohealing layer
US8128688B2 (en) 2006-06-27 2012-03-06 Abbott Cardiovascular Systems Inc. Carbon coating on an implantable device
US7740791B2 (en) 2006-06-30 2010-06-22 Advanced Cardiovascular Systems, Inc. Method of fabricating a stent with features by blow molding
US20100256742A1 (en) * 2006-06-30 2010-10-07 Klaus Kleine Tapered Polymeric Stent And Method Of Fabricating Same
US7823263B2 (en) 2006-07-11 2010-11-02 Abbott Cardiovascular Systems Inc. Method of removing stent islands from a stent
US9173973B2 (en) 2006-07-20 2015-11-03 G. Lawrence Thatcher Bioabsorbable polymeric composition for a medical device
US9724864B2 (en) 2006-10-20 2017-08-08 Orbusneich Medical, Inc. Bioabsorbable polymeric composition and medical device
US20080097575A1 (en) * 2006-10-20 2008-04-24 Orbusneich Medical, Inc. Bioabsorbable Medical Device with Coating
US20080206440A1 (en) * 2006-10-20 2008-08-28 Orbusneich Medical, Inc. Bioabsorbable Polymeric Composition and Medical Device Background
US8691321B2 (en) * 2006-10-20 2014-04-08 Orbusneich Medical, Inc. Bioabsorbable polymeric composition and medical device background
US7959942B2 (en) 2006-10-20 2011-06-14 Orbusneich Medical, Inc. Bioabsorbable medical device with coating
US20080177373A1 (en) * 2007-01-19 2008-07-24 Elixir Medical Corporation Endoprosthesis structures having supporting features
WO2008157362A3 (en) * 2007-06-13 2010-01-28 Boston Scientific Scimed, Inc. Anti-migration features and geometry for a shape memory polymer stent
US8435283B2 (en) 2007-06-13 2013-05-07 Boston Scientific Scimed, Inc. Anti-migration features and geometry for a shape memory polymer stent
US20080319540A1 (en) * 2007-06-13 2008-12-25 Boston Scientific Scimed, Inc. Anti-migration features and geometry for a shape memory polymer stent
US7901452B2 (en) 2007-06-27 2011-03-08 Abbott Cardiovascular Systems Inc. Method to fabricate a stent having selected morphology to reduce restenosis
US8940037B2 (en) 2007-06-29 2015-01-27 Abbott Cardiovascular Systems Inc. Stent having circumferentially deformable struts
US20090001633A1 (en) * 2007-06-29 2009-01-01 Limon Timothy A Method Of Manufacturing A Stent From A Polymer Tube
US7666342B2 (en) 2007-06-29 2010-02-23 Abbott Cardiovascular Systems Inc. Method of manufacturing a stent from a polymer tube
US20090005854A1 (en) * 2007-06-29 2009-01-01 Bin Huang Stent having circumferentially deformable struts
US7955381B1 (en) 2007-06-29 2011-06-07 Advanced Cardiovascular Systems, Inc. Polymer-bioceramic composite implantable medical device with different types of bioceramic particles
US8057531B2 (en) 2007-06-29 2011-11-15 Abbott Cardiovascular Systems Inc. Stent having circumferentially deformable struts
US20110130822A1 (en) * 2007-07-20 2011-06-02 Orbusneich Medical, Inc. Bioabsorbable Polymeric Compositions and Medical Devices
US8709071B1 (en) 2007-09-28 2014-04-29 Abbott Cardiovascular Systems Inc. Stent with preferential coating
US8658082B2 (en) 2007-12-11 2014-02-25 Abbott Cardiovascular Systems Inc. Method of fabricating stents from blow molded tubing
US8268228B2 (en) 2007-12-11 2012-09-18 Abbott Cardiovascular Systems Inc. Method of fabricating stents from blow molded tubing
US20090146348A1 (en) * 2007-12-11 2009-06-11 Bin Huang Method of fabrication a stent from blow molded tubing
US20100318175A1 (en) * 2007-12-31 2010-12-16 C.R. Bard, Inc. Vascular graft prosthesis with selective flow reduction
US8828305B2 (en) 2008-08-04 2014-09-09 Abbott Cardiovascular Systems Inc. Tube expansion processes for semicrystalline polymers to maximize fracture toughness
US8012402B2 (en) 2008-08-04 2011-09-06 Abbott Cardiovascular Systems Inc. Tube expansion process for semicrystalline polymers to maximize fracture toughness
US8303296B2 (en) 2008-08-04 2012-11-06 Abbott Cardiovascular Systems Inc. Polymer tube expansion apparatus to maximize fracture toughness
US20100025894A1 (en) * 2008-08-04 2010-02-04 Abbott Cardiovascular Inc. Tube expansion process for semicrystalline polymers to maximize fracture toughness
US20100049296A1 (en) * 2008-08-22 2010-02-25 Med Institute, Inc. Implantable medical device coatings with biodegradable elastomer and releasable taxane agent
US8642063B2 (en) 2008-08-22 2014-02-04 Cook Medical Technologies Llc Implantable medical device coatings with biodegradable elastomer and releasable taxane agent
US20100094405A1 (en) * 2008-10-10 2010-04-15 Orbusneich Medical, Inc. Bioabsorbable Polymeric Medical Device
US20100093946A1 (en) * 2008-10-11 2010-04-15 Orbusneich Medical, Inc. Bioabsorbable Polymeric Compositions and Medical Devices
US20100244304A1 (en) * 2009-03-31 2010-09-30 Yunbing Wang Stents fabricated from a sheet with increased strength, modulus and fracture toughness
US20110066222A1 (en) * 2009-09-11 2011-03-17 Yunbing Wang Polymeric Stent and Method of Making Same
US20110062638A1 (en) * 2009-09-14 2011-03-17 Thierry Glauser Controlling Crystalline Morphology Of A Bioabsorbable Stent
US9211682B2 (en) 2009-09-14 2015-12-15 Abbott Cardiovascular Systems Inc. Controlling crystalline morphology of a bioabsorbable stent
US8501079B2 (en) 2009-09-14 2013-08-06 Abbott Cardiovascular Systems Inc. Controlling crystalline morphology of a bioabsorbable stent
US9770351B2 (en) 2010-01-30 2017-09-26 Abbott Cardiovascular Systems Inc. Crush recoverable polymer scaffolds
US9763818B2 (en) 2010-01-30 2017-09-19 Abbott Cardiovascular Systems Inc. Method of crimping stent on catheter delivery assembly
US9867728B2 (en) 2010-01-30 2018-01-16 Abbott Cardiovascular Systems Inc. Method of making a stent
US9827119B2 (en) 2010-01-30 2017-11-28 Abbott Cardiovascular Systems Inc. Polymer scaffolds having a low crossing profile
US9198785B2 (en) 2010-01-30 2015-12-01 Abbott Cardiovascular Systems Inc. Crush recoverable polymer scaffolds
US9782280B2 (en) 2010-04-22 2017-10-10 Abbott Cardiovascular Systems Inc. Optimal ratio of polar and bending moment of inertia for stent strut design
US20130096668A1 (en) * 2010-04-22 2013-04-18 Abbott Cardiovascular Systems Inc. Optimal ratio of polar and bending moment of inertia for stent strut design
US9241814B2 (en) * 2010-04-22 2016-01-26 Abbott Cardiovascular Systems Inc. Optimal ratio of polar and bending moment of inertia for stent strut design
US8370120B2 (en) 2010-04-30 2013-02-05 Abbott Cardiovascular Systems Inc. Polymeric stents and method of manufacturing same
FR2993451A1 (en) * 2012-07-17 2014-01-24 St George Medical Inc endoluminal vascular prosthesis for small vessels
WO2014013444A3 (en) * 2012-07-17 2014-03-13 St George Medical Inc Endoluminal vascular prostheses for small vessels
US9364588B2 (en) 2014-02-04 2016-06-14 Abbott Cardiovascular Systems Inc. Drug delivery scaffold or stent with a novolimus and lactide based coating such that novolimus has a minimum amount of bonding to the coating
US9999527B2 (en) 2015-02-11 2018-06-19 Abbott Cardiovascular Systems Inc. Scaffolds having radiopaque markers

Also Published As

Publication number Publication date Type
US20080275539A1 (en) 2008-11-06 application
US8152843B2 (en) 2012-04-10 grant

Similar Documents

Publication Publication Date Title
US7468071B2 (en) Diametrically adaptable encapsulated stent and methods for deployment thereof
US6485510B1 (en) Multi-section stent
US5674287A (en) Biodegradable polymeric endoluminal sealing process, apparatus and polymeric product for use therein
US6364904B1 (en) Helically formed stent/graft assembly
US6936066B2 (en) Complaint implantable medical devices and methods of making same
US6053943A (en) Endoluminal graft with integral structural support and method for making same
US20060036311A1 (en) Stent and process for producing the same
US20020065549A1 (en) Non-foreshortening intraluminal prosthesis
US20010044652A1 (en) Stents with multi-layered struts
US20070253999A1 (en) Method of fabricating an implantable medical device to reduce chance of late inflammatory response
US20060241739A1 (en) Device comprising biodegradable bistable or multistable cells and methods of use
US5527354A (en) Stent formed of half-round wire
US5871538A (en) Luminal graft endoprotheses and manufacture thereof
US6673105B1 (en) Metal prosthesis coated with expandable ePTFE
US20070253996A1 (en) Method of fabricating an implantable medical device by controlling crystalline structure
US20070250156A1 (en) Self-supporting metallic implantable grafts, compliant implantable medical devices and methods of making same
US6500204B1 (en) Stent for vessels
US7128755B2 (en) Expandable biodegradable polymeric stents for combined mechanical support and pharmacological or radiation therapy
US20060155369A1 (en) Selective adherence of stent-graft coverings
US7097658B2 (en) Flexible MEMS actuated controlled expansion stent
US20020143384A1 (en) Stent cover and stent
US20070282433A1 (en) Stent with retention protrusions formed during crimping
US8303644B2 (en) Stents with high radial strength and methods of manufacturing same
US8002817B2 (en) Stents with high radial strength and methods of manufacturing same
US8523936B2 (en) Expandable slide and lock stent

Legal Events

Date Code Title Description
AS Assignment

Owner name: SYNECOR LLC, NORTH CAROLINA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:WILLIAMS, MICHAEL S.;HOLBROOK, KEVIN D.;GLENN, RICHARD A.;AND OTHERS;REEL/FRAME:013941/0691

Effective date: 20030328