JP2013503621A5 - - Google Patents
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- Publication number
- JP2013503621A5 JP2013503621A5 JP2012527383A JP2012527383A JP2013503621A5 JP 2013503621 A5 JP2013503621 A5 JP 2013503621A5 JP 2012527383 A JP2012527383 A JP 2012527383A JP 2012527383 A JP2012527383 A JP 2012527383A JP 2013503621 A5 JP2013503621 A5 JP 2013503621A5
- Authority
- JP
- Japan
- Prior art keywords
- lrg1
- antagonist
- seq
- tumor
- interaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000005557 antagonist Substances 0.000 claims 33
- 230000003993 interaction Effects 0.000 claims 13
- 230000000694 effects Effects 0.000 claims 9
- 102100034136 Serine/threonine-protein kinase receptor R3 Human genes 0.000 claims 7
- 101710082813 Serine/threonine-protein kinase receptor R3 Proteins 0.000 claims 7
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 6
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 108010033276 Peptide Fragments Proteins 0.000 claims 5
- 102000007079 Peptide Fragments Human genes 0.000 claims 5
- 230000002792 vascular Effects 0.000 claims 5
- 108091005735 TGF-beta receptors Proteins 0.000 claims 4
- 102000016715 Transforming Growth Factor beta Receptors Human genes 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 230000002062 proliferating effect Effects 0.000 claims 4
- 108091023037 Aptamer Proteins 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 102000014172 Transforming Growth Factor-beta Type I Receptor Human genes 0.000 claims 3
- 108010011702 Transforming Growth Factor-beta Type I Receptor Proteins 0.000 claims 3
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 3
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 3
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims 2
- 108700011259 MicroRNAs Proteins 0.000 claims 2
- 108020004459 Small interfering RNA Proteins 0.000 claims 2
- 206010043189 Telangiectasia Diseases 0.000 claims 2
- 230000004913 activation Effects 0.000 claims 2
- 230000001772 anti-angiogenic effect Effects 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000002679 microRNA Substances 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 230000019491 signal transduction Effects 0.000 claims 2
- 239000004055 small Interfering RNA Substances 0.000 claims 2
- 208000009056 telangiectasis Diseases 0.000 claims 2
- 206010002329 Aneurysm Diseases 0.000 claims 1
- 208000018084 Bone neoplasm Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 208000005590 Choroidal Neovascularization Diseases 0.000 claims 1
- 206010060823 Choroidal neovascularisation Diseases 0.000 claims 1
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 1
- 206010061968 Gastric neoplasm Diseases 0.000 claims 1
- 206010019695 Hepatic neoplasm Diseases 0.000 claims 1
- 101000783723 Homo sapiens Leucine-rich alpha-2-glycoprotein Proteins 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 102100035987 Leucine-rich alpha-2-glycoprotein Human genes 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 206010029098 Neoplasm skin Diseases 0.000 claims 1
- 206010029113 Neovascularisation Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010038933 Retinopathy of prematurity Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 230000000903 blocking effect Effects 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 230000007850 degeneration Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 208000030533 eye disease Diseases 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
- 230000002163 immunogen Effects 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000037841 lung tumor Diseases 0.000 claims 1
- 208000025189 neoplasm of testis Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 239000000816 peptidomimetic Substances 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 208000023958 prostate neoplasm Diseases 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 208000004644 retinal vein occlusion Diseases 0.000 claims 1
- 230000011664 signaling Effects 0.000 claims 1
- 201000003120 testicular cancer Diseases 0.000 claims 1
- 210000003556 vascular endothelial cell Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0915515.1A GB0915515D0 (en) | 2009-09-04 | 2009-09-04 | Treatment of vasculoproliferative conditions |
| GB0915515.1 | 2009-09-04 | ||
| PCT/GB2010/001681 WO2011027129A1 (en) | 2009-09-04 | 2010-09-06 | Treatment of vasculoproliferative conditions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015241950A Division JP6242847B2 (ja) | 2009-09-04 | 2015-12-11 | 血管増殖性疾患の治療 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013503621A JP2013503621A (ja) | 2013-02-04 |
| JP2013503621A5 true JP2013503621A5 (https=) | 2013-10-24 |
Family
ID=41203240
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012527383A Pending JP2013503621A (ja) | 2009-09-04 | 2010-09-06 | 血管増殖性疾患の治療 |
| JP2015241950A Active JP6242847B2 (ja) | 2009-09-04 | 2015-12-11 | 血管増殖性疾患の治療 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015241950A Active JP6242847B2 (ja) | 2009-09-04 | 2015-12-11 | 血管増殖性疾患の治療 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US8790647B2 (https=) |
| EP (1) | EP2473526B1 (https=) |
| JP (2) | JP2013503621A (https=) |
| CN (1) | CN102596998B (https=) |
| AU (1) | AU2010290986B2 (https=) |
| CA (1) | CA2771965C (https=) |
| ES (1) | ES2647359T3 (https=) |
| GB (1) | GB0915515D0 (https=) |
| WO (1) | WO2011027129A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5717021B2 (ja) * | 2009-12-03 | 2015-05-13 | 独立行政法人医薬基盤研究所 | 血管新生誘導分子 |
| WO2013132267A1 (en) | 2012-03-09 | 2013-09-12 | Ucl Business Plc | Treatment of cancer |
| TWI498425B (zh) * | 2013-01-08 | 2015-09-01 | Nat Univ Tsing Hua | 層析濾紙型酵素連結免疫吸附分析法 |
| JP6226315B2 (ja) * | 2013-04-11 | 2017-11-08 | 国立大学法人高知大学 | 炎症性疾患の予防・治療剤、並びに炎症性疾患予防・治療薬のスクリーニング方法 |
| KR101947229B1 (ko) | 2013-06-08 | 2019-02-12 | 애플 인크. | 2개 이상의 디스플레이들을 동기화하기 위한 디바이스, 방법, 및 그래픽 사용자 인터페이스 |
| CN103926413A (zh) * | 2014-04-28 | 2014-07-16 | 刘红莉 | 一种用尿液进行癌症快速检测的试剂条的制备方法 |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| SG11201701725QA (en) * | 2014-09-17 | 2017-04-27 | Toshiba Kk | Semiconductor device |
| JP6675605B2 (ja) * | 2014-10-10 | 2020-04-01 | 国立大学法人高知大学 | 細胞遊走調節に関する疾患の予防・治療剤および肺間質の疾患の疾患活動性判定・予後評価 |
| WO2016110782A1 (en) | 2015-01-05 | 2016-07-14 | University Of Oslo | Prostate cancer markers and uses thereof |
| GB201503438D0 (en) * | 2015-02-27 | 2015-04-15 | Ucl Business Plc | Antibodies |
| KR102799807B1 (ko) | 2015-12-30 | 2025-04-24 | 코디악 사이언시스 인코포레이티드 | 항체 및 이의 접합체 |
| WO2018021778A1 (ko) * | 2016-07-28 | 2018-02-01 | 인하대학교 산학협력단 | Lrg1 당단백질을 포함하는 융합 단백질을 함유하는 발기부전, 허혈성 질환 또는 말초 신경질환의 예방 또는 치료용 조성물 |
| MX2020009152A (es) | 2018-03-02 | 2020-11-09 | Kodiak Sciences Inc | Anticuerpos de il-6 y constructos de fusion y conjugados de los mismos. |
| CA3157509A1 (en) | 2019-10-10 | 2021-04-15 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
| KR102661295B1 (ko) * | 2021-01-22 | 2024-04-30 | 기초과학연구원 | 탈당화된 lrg1 당단백질 및 lrg1 당단백질 변이체, 및 이의 용도 |
| US20250002588A1 (en) | 2023-04-07 | 2025-01-02 | Diagonal Therapeutics Inc. | Bispecific agonistic antibodies to activin a receptor like type 1 (alk1) |
| WO2025263529A1 (ja) * | 2024-06-19 | 2025-12-26 | 国立大学法人東京科学大学 | 血管新生を処置する方法、および当該方法において用いるための免疫原性組成物 |
| WO2026068571A1 (en) * | 2024-09-25 | 2026-04-02 | Singapore Health Services Pte. Ltd. | Lrg1 antigen-binding molecules |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5567588A (en) | 1990-06-11 | 1996-10-22 | University Research Corporation | Systematic evolution of ligands by exponential enrichment: Solution SELEX |
| US5654151A (en) | 1990-06-11 | 1997-08-05 | Nexstar Pharmaceuticals, Inc. | High affinity HIV Nucleocapsid nucleic acid ligands |
| US5503978A (en) | 1990-06-11 | 1996-04-02 | University Research Corporation | Method for identification of high affinity DNA ligands of HIV-1 reverse transcriptase |
| AU732820B2 (en) | 1995-06-02 | 2001-05-03 | Nexstar Pharmaceuticals, Inc. | High-affinity oligonucleotide ligands to growth factors |
| AU5087799A (en) * | 1998-07-06 | 2000-01-24 | Beth Israel Deaconess Medical Center | Methods of inhibiting proliferative diseases by inhibiting tgf-beta mediated angiogenesis |
| US20050064516A1 (en) | 2003-09-18 | 2005-03-24 | Kantor Aaron B. | Biological markers for diagnosing multiple sclerosis |
| CA2621371C (en) * | 2005-09-07 | 2018-05-15 | Amgen Fremont Inc. | Human monoclonal antibodies to activin receptor-like kinase-1 |
| US7416850B2 (en) | 2006-01-25 | 2008-08-26 | Jemmerson Ronald R | Cytochrome c and leucine-rich alpha-2-glycoprotein-1 assays, methods and antibodies |
| EP2076599A2 (en) * | 2006-09-19 | 2009-07-08 | Asuragen, Inc. | Mir-200 regulated genes and pathways as targets for therapeutic intervention |
| AU2007301599B2 (en) * | 2006-09-28 | 2013-01-10 | Merck Serono S.A. | Junctional Adhesion Molecule-C (JAM-C) binding compounds and methods of their use |
| EP2104734A2 (en) * | 2006-12-08 | 2009-09-30 | Asuragen, INC. | Mir-20 regulated genes and pathways as targets for therapeutic intervention |
| CA2671270A1 (en) * | 2006-12-29 | 2008-07-17 | Asuragen, Inc. | Mir-16 regulated genes and pathways as targets for therapeutic intervention |
| WO2008092214A1 (en) | 2007-02-02 | 2008-08-07 | Minomic International Limited | Biomarkers for diabetes |
| JP2010529966A (ja) * | 2007-06-08 | 2010-09-02 | アシュラジェン インコーポレイテッド | 治療的介入の標的としてｍｉＲ−３４によって調節される遺伝子および経路 |
| JP5461402B2 (ja) * | 2007-09-14 | 2014-04-02 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 置換三環式化合物およびその使用方法 |
| KR20100090683A (ko) * | 2007-11-09 | 2010-08-16 | 제넨테크, 인크. | 액티빈 수용체-유사 키나제-ｉ 길항제 조성물 및 사용 방법 |
| US8071562B2 (en) * | 2007-12-01 | 2011-12-06 | Mirna Therapeutics, Inc. | MiR-124 regulated genes and pathways as targets for therapeutic intervention |
| US20090208495A1 (en) * | 2008-02-14 | 2009-08-20 | Bayer Schering Pharma Ag | Anti-tumor effective paramyxovirus |
| CA2769406A1 (en) | 2009-08-04 | 2011-02-10 | Biosystems International Sas | Lung cancer biomarkers |
-
2009
- 2009-09-04 GB GBGB0915515.1A patent/GB0915515D0/en not_active Ceased
-
2010
- 2010-09-06 EP EP10754361.3A patent/EP2473526B1/en active Active
- 2010-09-06 CA CA2771965A patent/CA2771965C/en active Active
- 2010-09-06 US US13/393,531 patent/US8790647B2/en active Active
- 2010-09-06 WO PCT/GB2010/001681 patent/WO2011027129A1/en not_active Ceased
- 2010-09-06 AU AU2010290986A patent/AU2010290986B2/en active Active
- 2010-09-06 CN CN201080039413.0A patent/CN102596998B/zh active Active
- 2010-09-06 JP JP2012527383A patent/JP2013503621A/ja active Pending
- 2010-09-06 ES ES10754361.3T patent/ES2647359T3/es active Active
-
2014
- 2014-06-23 US US14/312,593 patent/US9708397B2/en active Active
-
2015
- 2015-12-11 JP JP2015241950A patent/JP6242847B2/ja active Active
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