JP2013501058A5 - - Google Patents
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- Publication number
- JP2013501058A5 JP2013501058A5 JP2012523701A JP2012523701A JP2013501058A5 JP 2013501058 A5 JP2013501058 A5 JP 2013501058A5 JP 2012523701 A JP2012523701 A JP 2012523701A JP 2012523701 A JP2012523701 A JP 2012523701A JP 2013501058 A5 JP2013501058 A5 JP 2013501058A5
- Authority
- JP
- Japan
- Prior art keywords
- formulation
- antibody
- dma
- dmso
- preparation according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000009472 formulation Methods 0.000 claims 44
- 239000000203 mixture Substances 0.000 claims 44
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 26
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 claims 13
- 238000004519 manufacturing process Methods 0.000 claims 6
- 239000012634 fragment Substances 0.000 claims 4
- 238000001802 infusion Methods 0.000 claims 3
- 238000010254 subcutaneous injection Methods 0.000 claims 3
- 239000007929 subcutaneous injection Substances 0.000 claims 3
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 229960003589 arginine hydrochloride Drugs 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 2
- 238000002347 injection Methods 0.000 claims 2
- 239000007924 injection Substances 0.000 claims 2
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 229940024606 amino acid Drugs 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 239000012669 liquid formulation Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23114009P | 2009-08-04 | 2009-08-04 | |
| US61/231,140 | 2009-08-04 | ||
| PCT/US2010/044258 WO2011017330A1 (en) | 2009-08-04 | 2010-08-03 | Concentrated polypeptide formulations with reduced viscosity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013501058A JP2013501058A (ja) | 2013-01-10 |
| JP2013501058A5 true JP2013501058A5 (cg-RX-API-DMAC10.html) | 2013-09-12 |
Family
ID=43544629
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012523701A Pending JP2013501058A (ja) | 2009-08-04 | 2010-08-03 | 低減された粘性を有する濃縮ポリペプチド製剤 |
Country Status (15)
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9345661B2 (en) | 2009-07-31 | 2016-05-24 | Genentech, Inc. | Subcutaneous anti-HER2 antibody formulations and uses thereof |
| AR078161A1 (es) | 2009-09-11 | 2011-10-19 | Hoffmann La Roche | Formulaciones farmaceuticas muy concentradas de un anticuerpo anti cd20. uso de la formulacion. metodo de tratamiento. |
| CN107837395A (zh) | 2011-02-09 | 2018-03-27 | 葛兰素史密斯克莱有限责任公司 | 冻干制剂 |
| FR2994390B1 (fr) | 2012-08-10 | 2014-08-15 | Adocia | Procede d'abaissement de la viscosite de solutions de proteines a concentration elevee |
| IL312865B2 (en) * | 2013-09-11 | 2025-06-01 | Eagle Biologics Inc | Liquid protein formulations containing viscosity-lowering agents |
| CN111402950B (zh) * | 2013-11-29 | 2024-03-19 | 豪夫迈·罗氏有限公司 | 抗体选择装置和方法 |
| WO2016019969A1 (en) | 2014-08-08 | 2016-02-11 | Ludwig-Maximilians-Universität München | Subcutaneously administered bispecific antibodies for use in the treatment of cancer |
| SG11201702614SA (en) | 2014-10-01 | 2017-04-27 | Eagle Biolog Inc | Polysaccharide and nucleic acid formulations containing viscosity-lowering agents |
| IL307684B2 (en) | 2016-09-29 | 2025-04-01 | Amgen Inc | Low viscosity antigen binding proteins and methods for preparing them |
| RS67656B1 (sr) | 2018-05-10 | 2026-02-27 | Regeneron Pharma | Formulacije koje sadrže visoke koncentracije fuzionog proteina vegf receptora |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR013202A1 (es) * | 1997-07-10 | 2000-12-13 | Biotech Australia Pty Ltd | Vacunas no acuosas |
| DE60139944D1 (de) * | 2000-10-12 | 2009-10-29 | Genentech Inc | Niederviskose konzentrierte proteinformulierungen |
| GB0113179D0 (en) * | 2001-05-31 | 2001-07-25 | Novartis Ag | Organic compounds |
| AU2003251592A1 (en) * | 2002-06-21 | 2004-01-06 | Biogen Idec Inc. | Buffered formulations for concentrating antibodies and methods of use thereof |
| US20050158303A1 (en) * | 2003-04-04 | 2005-07-21 | Genentech, Inc. | Methods of treating IgE-mediated disorders comprising the administration of high concentration anti-IgE antibody formulations |
| GB0412530D0 (en) * | 2004-06-04 | 2004-07-07 | Camurus Ab | Formulation |
| PL1768650T3 (pl) * | 2004-06-04 | 2009-01-30 | Camurus Ab | Ciekłe formulacje depot |
| CA2560007A1 (en) * | 2004-06-14 | 2005-12-22 | Usv Limited | Process for the preparation of peptides |
| EP1909824B1 (en) * | 2005-04-08 | 2011-05-18 | Amylin Pharmaceuticals, Inc. | Pharmaceutical formulations comprising incretin peptide and aprotic polar solvent |
| JP5405122B2 (ja) * | 2005-12-21 | 2014-02-05 | ワイス・エルエルシー | 低粘度のタンパク質製剤およびその用途 |
-
2010
- 2010-08-03 WO PCT/US2010/044258 patent/WO2011017330A1/en not_active Ceased
- 2010-08-03 KR KR1020127005604A patent/KR20120047995A/ko not_active Withdrawn
- 2010-08-03 CA CA2769221A patent/CA2769221A1/en not_active Abandoned
- 2010-08-03 NZ NZ598518A patent/NZ598518A/en not_active IP Right Cessation
- 2010-08-03 AU AU2010279569A patent/AU2010279569A1/en not_active Abandoned
- 2010-08-03 CN CN2010800445005A patent/CN102573459A/zh active Pending
- 2010-08-03 JP JP2012523701A patent/JP2013501058A/ja active Pending
- 2010-08-03 SG SG2012007399A patent/SG178226A1/en unknown
- 2010-08-03 MX MX2012001560A patent/MX2012001560A/es not_active Application Discontinuation
- 2010-08-03 EP EP10807032.7A patent/EP2461677A4/en not_active Withdrawn
- 2010-08-03 BR BR112012002596A patent/BR112012002596A2/pt not_active IP Right Cessation
- 2010-08-03 US US13/388,962 patent/US20130236448A1/en not_active Abandoned
- 2010-08-03 RU RU2012108108/15A patent/RU2012108108A/ru not_active Application Discontinuation
-
2012
- 2012-01-31 ZA ZA2012/00760A patent/ZA201200760B/en unknown
- 2012-02-02 IL IL217887A patent/IL217887A0/en unknown
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