JP2013189450A5 - - Google Patents
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- Publication number
- JP2013189450A5 JP2013189450A5 JP2013104771A JP2013104771A JP2013189450A5 JP 2013189450 A5 JP2013189450 A5 JP 2013189450A5 JP 2013104771 A JP2013104771 A JP 2013104771A JP 2013104771 A JP2013104771 A JP 2013104771A JP 2013189450 A5 JP2013189450 A5 JP 2013189450A5
- Authority
- JP
- Japan
- Prior art keywords
- solution composition
- ophthalmic solution
- composition according
- latanoprost
- component
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 14
- 229940054534 ophthalmic solution Drugs 0.000 claims 14
- 239000002997 ophthalmic solution Substances 0.000 claims 14
- -1 polypropylene Polymers 0.000 claims 8
- GGXICVAJURFBLW-CEYXHVGTSA-N latanoprost Chemical compound CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCC1=CC=CC=C1 GGXICVAJURFBLW-CEYXHVGTSA-N 0.000 claims 5
- 229960001160 latanoprost Drugs 0.000 claims 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 4
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 4
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 3
- 239000004698 Polyethylene Substances 0.000 claims 3
- 239000004743 Polypropylene Substances 0.000 claims 3
- 229920000573 polyethylene Polymers 0.000 claims 3
- 229920001155 polypropylene Polymers 0.000 claims 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- 150000001720 carbohydrates Chemical class 0.000 claims 2
- 235000011187 glycerol Nutrition 0.000 claims 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 2
- 229960003943 hypromellose Drugs 0.000 claims 2
- 235000010355 mannitol Nutrition 0.000 claims 2
- 239000002736 nonionic surfactant Substances 0.000 claims 2
- 235000011007 phosphoric acid Nutrition 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000002562 thickening agent Substances 0.000 claims 2
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims 2
- 229960000281 trometamol Drugs 0.000 claims 2
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 claims 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 1
- 229920002307 Dextran Polymers 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 229920002675 Polyoxyl Polymers 0.000 claims 1
- 229920001214 Polysorbate 60 Polymers 0.000 claims 1
- 150000001298 alcohols Chemical class 0.000 claims 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 1
- 229960000686 benzalkonium chloride Drugs 0.000 claims 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 1
- 235000010338 boric acid Nutrition 0.000 claims 1
- 125000005619 boric acid group Chemical class 0.000 claims 1
- 239000004359 castor oil Substances 0.000 claims 1
- 235000019438 castor oil Nutrition 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims 1
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims 1
- 235000019799 monosodium phosphate Nutrition 0.000 claims 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 1
- 150000003016 phosphoric acids Chemical class 0.000 claims 1
- 239000004033 plastic Substances 0.000 claims 1
- 229920003023 plastic Polymers 0.000 claims 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 1
- 229920000053 polysorbate 80 Polymers 0.000 claims 1
- 229940068968 polysorbate 80 Drugs 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims 1
- 239000000600 sorbitol Substances 0.000 claims 1
- 239000012929 tonicity agent Substances 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013104771A JP2013189450A (ja) | 2007-02-07 | 2013-05-17 | ラタノプロスト含有点眼液組成物 |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007028498 | 2007-02-07 | ||
| JP2007028498 | 2007-02-07 | ||
| JP2007166788 | 2007-06-25 | ||
| JP2007166788 | 2007-06-25 | ||
| JP2007245937 | 2007-09-21 | ||
| JP2007245937 | 2007-09-21 | ||
| JP2007338661 | 2007-12-28 | ||
| JP2007338661 | 2007-12-28 | ||
| JP2013104771A JP2013189450A (ja) | 2007-02-07 | 2013-05-17 | ラタノプロスト含有点眼液組成物 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008557147A Division JPWO2008096804A1 (ja) | 2007-02-07 | 2008-02-07 | ラタノプロスト含有点眼剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013189450A JP2013189450A (ja) | 2013-09-26 |
| JP2013189450A5 true JP2013189450A5 (https=) | 2013-11-07 |
Family
ID=39681708
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008557147A Pending JPWO2008096804A1 (ja) | 2007-02-07 | 2008-02-07 | ラタノプロスト含有点眼剤 |
| JP2013104771A Pending JP2013189450A (ja) | 2007-02-07 | 2013-05-17 | ラタノプロスト含有点眼液組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008557147A Pending JPWO2008096804A1 (ja) | 2007-02-07 | 2008-02-07 | ラタノプロスト含有点眼剤 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US20100120908A1 (https=) |
| EP (1) | EP2123278B1 (https=) |
| JP (2) | JPWO2008096804A1 (https=) |
| WO (1) | WO2008096804A1 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009040727A (ja) * | 2007-08-09 | 2009-02-26 | Towa Yakuhin Kk | ラタノプロストを有効成分とする安定な点眼液剤 |
| JP5253775B2 (ja) * | 2007-08-10 | 2013-07-31 | 科研製薬株式会社 | ラタノプロスト点眼剤 |
| TWI544927B (zh) | 2008-03-17 | 2016-08-11 | 愛爾康研究有限公司 | 具有低濃度的表面活性劑以促進治療劑之生物可利用性的藥學組成物 |
| US20100087540A1 (en) * | 2008-10-07 | 2010-04-08 | R-Tech Ueno, Ltd. | Pharmaceutical composition |
| US20130213393A1 (en) | 2009-12-22 | 2013-08-22 | Evoke Pharma, Inc. | Nasal formulations of metoclopramide |
| DK2376075T3 (en) | 2008-12-22 | 2015-05-26 | Evoke Pharma Inc | Nasal formulations of metoclopramide |
| DE102009021372A1 (de) * | 2009-05-14 | 2010-11-18 | Ursapharm Arzneimittel Gmbh | Phosphatfreie pharmazeutische Zusammensetzung zur Glaukombehandlung |
| JP2010275259A (ja) * | 2009-05-29 | 2010-12-09 | Toa Yakuhin Kk | 均一、かつ安定なラタノプロスト点眼液剤組成物 |
| US20120108672A1 (en) * | 2009-06-25 | 2012-05-03 | Hazuki Tsutsui | Ophthalmic composition and method for prevention of cloudiness/precipitation |
| JP5673531B2 (ja) * | 2009-06-30 | 2015-02-18 | ライオン株式会社 | 眼科用組成物 |
| EP2269575A1 (en) * | 2009-06-30 | 2011-01-05 | Santen Pharmaceutical Co., Ltd | Method for improving bioavailability of latanoprost |
| TW201113022A (en) * | 2009-09-01 | 2011-04-16 | R Tech Ueno Ltd | Composition for ocular local-administration for treating ocular hypertension and glaucoma |
| WO2011034192A1 (ja) | 2009-09-17 | 2011-03-24 | 千寿製薬株式会社 | ラタノプロストを含有する水性点眼剤、並びにラタノプロストの樹脂への吸着の抑制方法 |
| US20110136872A1 (en) * | 2009-12-09 | 2011-06-09 | Burk Robert M | Stable aqueous compositions of prostglandin agonist prodrugs and methods for use thereof |
| EP2603232B1 (en) * | 2010-08-11 | 2019-09-25 | Ironwood Pharmaceuticals, Inc. | Stable formulations of linaclotide |
| EP2452669A1 (en) | 2010-10-29 | 2012-05-16 | Omnivision GmbH | Ophthalmic composition |
| CA2903114A1 (en) * | 2013-03-15 | 2014-09-25 | Inotek Pharmaceuticals Corporation | Ophthalmic formulations |
| US9421199B2 (en) * | 2014-06-24 | 2016-08-23 | Sydnexis, Inc. | Ophthalmic composition |
| WO2016013993A1 (en) | 2014-07-25 | 2016-01-28 | Imuneks Farma Llac Sanayi Ve Ticaret A.Ş. | Stable preservative free ophthalmic formulations of opioid antagonists |
| PL3199161T3 (pl) * | 2014-09-25 | 2022-04-11 | Kowa Company, Ltd. | Preparat farmaceutyczny |
| KR101770324B1 (ko) * | 2016-11-09 | 2017-08-22 | 주식회사태준제약 | 안압 강하용 점안 조성물 |
| WO2018112061A1 (en) | 2016-12-15 | 2018-06-21 | Evoke Pharma, Inc. | Treatment of moderate and severe gastroparesis |
| JP7080504B2 (ja) * | 2020-05-08 | 2022-06-06 | 株式会社セラバリューズ | クルクミン含有経口摂取用固形製剤 |
| WO2022080397A1 (ja) * | 2020-10-14 | 2022-04-21 | 参天製薬株式会社 | 安定な医薬組成物 |
| US20240148755A1 (en) * | 2021-02-15 | 2024-05-09 | Santen Pharmaceuticalco., Ltd. | Water-based pharmaceutical composition containing ursodeoxycholic acid or salt thereof |
| CN118526450A (zh) * | 2024-05-24 | 2024-08-23 | 兆科（广州）眼科药物有限公司 | 一种拉坦前列素眼用凝胶剂及其制备方法与用途 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990002553A1 (en) | 1988-09-06 | 1990-03-22 | Pharmacia Ab | Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension |
| US5631287A (en) | 1994-12-22 | 1997-05-20 | Alcon Laboratories, Inc. | Storage-stable prostaglandin compositions |
| AR002194A1 (es) * | 1997-03-17 | 1998-01-07 | Sanchez Reynaldo Alemany | Instrumento computarizado para el analisis del movimiento. |
| US6646001B2 (en) * | 1997-12-19 | 2003-11-11 | Alcon Manufacturing, Ltd. | Use of non-steroidal anti-inflammatory agents in combination with prostaglandin FP receptor agonists to treat glaucoma and ocular hypertension |
| BR9906597A (pt) * | 1998-07-14 | 2000-07-18 | Alcon Lab Inc | Produto de prostaglandina |
| JP3876355B2 (ja) * | 2000-09-13 | 2007-01-31 | 参天製薬株式会社 | 点眼液 |
| JP2003206241A (ja) * | 2002-01-11 | 2003-07-22 | Teika Seiyaku Kk | 眼科用剤 |
| JP4314429B2 (ja) | 2002-08-23 | 2009-08-19 | 参天製薬株式会社 | ラタノプロストを有効成分とする安定な点眼液 |
| CA2707068A1 (en) * | 2002-09-09 | 2004-03-18 | Santen Pharmaceutical Co., Ltd. | Clear ophthalmic solution comprising latanoprost as active ingredient |
| JP2004123729A (ja) * | 2002-09-09 | 2004-04-22 | Santen Pharmaceut Co Ltd | ラタノプロストを有効成分とする澄明な点眼液 |
| US7074827B2 (en) * | 2002-10-24 | 2006-07-11 | Sucampo Ag (Usa) Inc. | Method for treating ocular hypertension and glaucoma |
| CN100484528C (zh) | 2003-11-07 | 2009-05-06 | 千寿制药株式会社 | 含有前列腺素的药物组合物 |
| GB0501192D0 (en) * | 2005-01-20 | 2005-03-02 | Resolution Chemicals Ltd | Stable prostaglandin-containing compositions |
| WO2007015510A1 (ja) * | 2005-08-02 | 2007-02-08 | Santen Pharmaceutical Co., Ltd. | 熱的に不安定な薬物の分解抑制方法 |
| JP5252787B2 (ja) | 2005-08-02 | 2013-07-31 | 参天製薬株式会社 | 熱的に不安定な薬物の分解抑制方法 |
-
2008
- 2008-02-07 WO PCT/JP2008/052005 patent/WO2008096804A1/ja not_active Ceased
- 2008-02-07 US US12/526,349 patent/US20100120908A1/en not_active Abandoned
- 2008-02-07 EP EP08704514A patent/EP2123278B1/en not_active Not-in-force
- 2008-02-07 JP JP2008557147A patent/JPWO2008096804A1/ja active Pending
-
2013
- 2013-05-17 JP JP2013104771A patent/JP2013189450A/ja active Pending
- 2013-06-20 US US13/922,837 patent/US20130281529A1/en not_active Abandoned
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