JP2013177430A - GM−CSF及びインターフェロンαを用いて生成され、且つ熱処理され死滅したがん細胞を取り込んだ樹状細胞 - Google Patents
GM−CSF及びインターフェロンαを用いて生成され、且つ熱処理され死滅したがん細胞を取り込んだ樹状細胞 Download PDFInfo
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- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
【解決手段】熱ショックを与えその後死滅させた1つ又は複数のがん細胞の存在下において、GM−CSF及びインターフェロンαで活性化した1つ又は複数の抗原提示細胞をインキュベートすることにより、1つ又は複数のがん抗原を提示しT細胞の活性化を誘発する、1つ又は複数の抗原提示細胞を活性化するステップを含む、がんを治療するための組成物を作製する方法。
【選択図】なし
Description
発明者の参考文献
Banchereau, J., Palucka, A.K., Dhodapkar, M., Burkeholder, S., Taquet, N., Alexandre, R., Taquet, S., Coquery, S., Wittkowski, K., Bhardwaj, N., Pineiro, L., Steinman, R., and Fay, J. (2001). Immune and clinical responses in patients with metastatic melanoma to CD34+ progenitor-derived dendritic cell vaccine. Cancer Research. 61:6451-6458.
Blanco, P., Palucka, A.K., Gill, M., Pascual, V., and Banchereau, J. (2001). Interferon alpha and dendritic cells in SLE. Science. 294:1540-1543.
Mohamadzadeh, M., Berard, F., Essert, G., Chalouni, C., Pulendran, B., Davoust, J., Bridges, G., Palucka, A.K., and Banchereau, J. (2001). Interleukin 15 skews monocyte differentiation into dendritic cells with features of Langerhans cells. J.Exp.Med. 194:1013-20.
Chomarat, P., Dantin, C., Bennett, L., Banchereau, J., and Palucka, A.K. (2003) TNF skews monocyte differentiation from macrophages to dendritic cells. J. Immunol. 171:2262-9
Palucka, A.K., Dhodapkar, M., Burkeholder, S., Wittkowski, K., Steinman, R., Fay, J., and Banchereau, J. (2003). CD34+ progenitor-derived dendritic cell vaccine permits rapid induction of T cell immunity in patients with metastatic melanoma J. Immunotherapy. 26(5):432-9.
Neihardt-Berard, E-M., Berard, F., Banchereau, J. and Palucka, A.K. (2004) Dendritic cells loaded with killed breast cancer cells induce differentiation of tumor-specific cytotoxic T lymphocytes. Breast Cancer Res 2004, 6:R322-R328.
Paczesny, S., Banchereau, J., Fay, J., and Palucka, A.K. (2004) Expansion of melanoma-specific cytolytic CD8+ T cell precursors in patients with metastatic melanoma vaccinated with CD34+ progenitor-derived dendritic cells. J Exp Med 199(11):1503-11
Paczesny, S., Shi, H., Saito, H., Mannoni, P., Fay, J., Banchereau, J and Palucka, AK. (2005) Measuring Melanoma-specific CTLs Elicited by Dendritic Cell Vaccines with a Tumor Inhibition Assay in vitro. J. Immunotherapy 28(2):148-157
Palucka, AK., Dhodapkar, M., Paczesny, S., Ueno, H., Fay, J., and Banchereau, J. (2005) Boosting vaccinations with peptide-pulsed CD34+ progenitor derived dendritic cells can expand long-lived melanoma-specific CD8+ T cell immunity in patients with metastatic melanoma. J. Immunotherapy 28(2):158-168
Shi, H., Palucka, AK. Chapel, S., Bagnis, C., Mannoni, P., Davoust, J., and Banchereau, J. (2005) Enhanced cross-priming of melanoma-specific CTLs by dendritic cells loaded with killed allogeneic melanoma cells that were treated with hyperthermia. J Immunol (in revision)
Fay, J., Palucka, A.K., Paczesny, S., Ueno, H., Dhodapkar, M., Burkeholder, S., Steinman, R., and Banchereau, J. (2005) Long-term outcomes in patients with metastatic melanoma vaccinated with peptide-pulsed CD34-DCs. Cancer Immunol Immunother
Banchereau, J., Ueno, H., Dhodapkar, M., Connolly, J.E., Finholt-Perry, J., Klechevsky, E., Blanck, J-P., Johnston, DA., Steinman, R., Palucka, AK., Fay, J. (2005) Immune and clinical outcomes in patients with stage IV melanoma vaccinated with peptide-pulsed dendritic cells derived from CD34+ progenitors and activated with type I interferon. J Immunother.
Dubsky, P., Saito, H., Dantin, C., Connolly, J., Banchereau, J. and Palucka, AK. (2005) IL-15-induced human dendritic cells efficiently prime low frequency melanoma-specific naive CD8+T cells to differentiate into cytotoxic T cells. Submitted
Saito, H., Dubsky, P., Dantin, C., Finn, OJ., Banchereau, J. and Palucka, AK. Cross-priming of Cyclin B1, MUC-1 and survivin peptide-specific CD8+T cells by dendritic cells loaded with killed allogeneic breast cancer cells. Submitted.
Ueno, H., Connolly, JE., Vence, L., Palucka, AK., and Banchereau, J. (2005) Global assessment of tumor-antigen specific human T cell repertoire. In preparation
Palucka, AK., Ueno, H., Connolly, J., Kerneis-Norvell, F., Blanck, J-P., Johnston, DA., Fay, J., and Banchereau, J. (2005) Immune and clinical responses in patients with stage IV melanoma vaccinated with dendritic cells loaded with killed allogeneic melanoma cells. In revision
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Claims (1)
- がんを治療するための組成物を作製する方法であって、
熱ショックを与えその後死滅させた1つ又は複数のがん細胞の存在下において、GM−CSF及びインターフェロンαで活性化した1つ又は複数の抗原提示細胞をインキュベートすることにより、1つ又は複数のがん抗原を提示しT細胞の活性化を誘発する、1つ又は複数の抗原提示細胞を活性化するステップ
を含む方法。
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MX2010013265A (es) * | 2008-06-06 | 2011-02-24 | Baylor Res Inst | Anticuerpos anti-cd8 bloquean cebado de efectores citotoxicos y conducen a generacion de celulas t cd8+ reguladoras. |
WO2009155332A1 (en) * | 2008-06-17 | 2009-12-23 | Cedars-Sinai Medical Center | Use of toll-like receptor ligands as adjuvants to vaccination therapy for brain tumors |
US20130183343A1 (en) * | 2010-03-15 | 2013-07-18 | The Trustees Of The University Of Pennsylvania | System and Method of Preparing and Storing Activated Mature Dendritic Cells |
CA2843200A1 (en) * | 2011-07-27 | 2013-01-31 | Baylor Research Institute | Dendritic cell (dc)-vaccine therapy for pancreatic cancer |
AU2012325758A1 (en) * | 2011-10-20 | 2014-04-24 | Neostem Oncology, Llc | Antigen presenting cancer vaccine with gamma interferon |
EP2591798B1 (en) | 2011-11-09 | 2014-11-19 | Werner Lubitz | Vaccine for use in tumor immunotherapy |
EP2938354A1 (en) | 2012-12-28 | 2015-11-04 | Amphera B.V. | Method for preparing an immunogenic lysate, the lysate obtained, dendritic cells loaded with such lysate and a pharmaceutical composition comprising the lysate or the dendritic cells |
EP2787005A1 (en) | 2013-04-02 | 2014-10-08 | Activartis Biotech GmbH | Targeted cancer immune therapy |
EP3714898A1 (en) * | 2014-07-17 | 2020-09-30 | Brian J. Czerniecki | Dendritic cell vaccines in combination with therapy for blocking her2 and her3 |
SG11201701728PA (en) * | 2014-09-04 | 2017-04-27 | Agency Science Tech & Res | A method to up-regulate cancer stem cell markers for the generation of antigen specific cytotoxic effector t cells |
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CN101511384A (zh) | 2009-08-19 |
EP2037957A4 (en) | 2010-09-08 |
CA2691346A1 (en) | 2008-01-10 |
EP2630968A1 (en) | 2013-08-28 |
WO2008005859A3 (en) | 2008-11-20 |
KR20090033375A (ko) | 2009-04-02 |
JP2016041725A (ja) | 2016-03-31 |
AU2007269245B2 (en) | 2012-04-12 |
JP2009542714A (ja) | 2009-12-03 |
EP2037957A2 (en) | 2009-03-25 |
WO2008005859A2 (en) | 2008-01-10 |
US20080031900A1 (en) | 2008-02-07 |
AU2007269245A1 (en) | 2008-01-10 |
JP6134763B2 (ja) | 2017-05-24 |
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