JP2013142061A - Dentifrice composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a dentifrice composition having high stain adhesion inhibiting effect, imparting excellent actual feeling of stain adhesion inhibition, and excellent in sustainability of foam when toothbrushing and a preparation appearance.SOLUTION: This dentifrice composition includes (A) an acylamino acid salt, (B) a nonion type surfactant, (C) a betaine type amphoteric surfactant and (D) an alkyl sulfate.

Description

  The present invention relates to a dentifrice composition having a high stain adhesion-suppressing effect, giving an excellent feeling of stain adhesion inhibition, and having good foam persistence and a good appearance of the preparation, particularly a gloss of toothpaste.

  Stain, a kind of colored stain on teeth, is formed by tannin pigments contained in coffee, tea, etc., oral proteins such as albumin, metal ions, and the like. Stain adhesion to the tooth surface is one of the major problems in oral aesthetics.

  One effective means for solving this problem due to stain is suppression of stain adhesion. The applicant has so far proposed a composition for removing stain by chemical action (Patent Document 1; JP-A-9-12438, Patent Document 2; JP-A-11-343220, Patent Document 3). JP 2002-471161 A). In Patent Document 3, as a liquid dentifrice containing phenoxyethanol, which is a chemical cleaning base for tooth surfaces and tongue surfaces, 0.2% by mass of sodium N-lauroylglutamate and 0.1% by mass of sodium lauroylglycine in Example 4 were used. A composition containing 1.0% by mass of sodium lauryl sulfate, 4.0% by mass of tetrasodium pyrophosphate, 1.5% by mass of sodium tripolyphosphate, and 1.0% by mass of polyethylene glycol is described. However, although this dentifrice has a high stain adhesion suppressing effect, a satisfactory feeling of stain adhesion suppression has not been obtained. Furthermore, it is difficult to say that the feeling of use such as irritation to the oral mucosa and foaming is sufficient, and there is room for improvement. Many dentifrice compositions have been proposed so far to solve the problem caused by stain.

  In addition, since stain is formed on the teeth over a long period of time due to the influence of food and drink, etc., the adhesion suppression effect is also exhibited by the accumulation of long-term oral cleaning. Therefore, in order to promote the user's continuous use, it is required to provide an effect feeling for each use. Conventionally, compositions for oral cavity that can satisfactorily impart a stain adhesion inhibitory effect have not been proposed, and there is room for improvement in this regard.

  Furthermore, as a dentifrice composition having a high aesthetic function, it is desirable that the appearance of the formulation such as the persistence of foam during brushing and the gloss of kneading is good.

Japanese Patent Laid-Open No. 9-12438 JP 11-343220 A JP 2002-471161 A

  Therefore, there is a need for a technique that provides a high stain adhesion inhibitory effect, gives a stain adhesion suppression feeling, and provides a dentifrice composition with good foam persistence and good formulation appearance, but the conventional techniques satisfy all these effects. The current situation is that we cannot do it.

  The present invention has been made in view of the above circumstances, and provides a dentifrice composition having a high stain adhesion-suppressing effect, giving an excellent feeling of stain adhesion inhibition, and having good foam persistence and appearance of the preparation when brushing teeth. For the purpose.

  As a result of intensive studies to achieve the above object, the present inventor has (A) acyl amino acid salt, (B) nonionic surfactant, (C) betaine amphoteric surfactant, and (D) alkyl sulfate. In addition to having a high stain adhesion-suppressing effect, a stain-adhesion-suppressing effect is imparted, and the foam persistence is good when brushing teeth. As a result, the present invention has been made.

More specifically, when the present inventor has studied to solve the above problems, it is known that acylamino acid salts have an effect on dental stain adhesion. Even if it mix | blends D), it is inferior to the stain adhesion inhibitory effect, and the satisfactory effect realization imparting effect that the stain adhesion was suppressed is not acquired, and even if it mix | blends a component (B), a stain adhesion inhibitory effect and stain adhesion actual feeling The imparting effect did not improve, and in this case, the problem of poor foam persistence occurred. Moreover, even if a component (C) is mix | blended with a component (A) and (D), the adhesion inhibitory effect of a stain and the adhesion imparting effect are not improved, In this case, the subject that it was inferior to the gloss of kneading arose. Therefore, as a result of further studies to solve such problems, when the components (A) are combined with the components (B), (C), and (D), all of the above problems are unexpectedly solved. It has been found that the surface is smooth and gives a high effect that stain adherence is suppressed, so that it is possible to obtain a preparation excellent in stain adhesion suppression effect, stain adhesion suppression effect imparting effect, foam persistence, and kneading gloss. It was.
Here, the stain adhesion suppression feeling is an effect feeling that the user feels that the tooth surface is smooth after oral cleaning, and that it becomes difficult for stain to adhere to the tooth, This is felt by the sensuality of the tongue after cleaning the tooth surface. Such a stain adhesion suppression feeling could not be achieved only by normal toothbrushing behavior, and could not be satisfactorily imparted by conventional techniques, but according to the present invention, the combined use of components (A) to (D), In particular, by blending polyoxyethylene hydrogenated castor oil as the component (B), it is possible to achieve a high stain adhesion suppression feeling imparting effect and to give the above-mentioned special effects.

Therefore, the present invention
A dentifrice composition comprising (A) an acylamino acid salt, (B) a nonionic surfactant, (C) a betaine amphoteric surfactant and (D) an alkyl sulfate is provided.

  According to the present invention, it is possible to provide a dentifrice composition having a high stain adhesion inhibiting effect, giving an excellent feeling of stain adhesion inhibition, and having good foam persistence and good appearance of the toothbrushing.

The present invention will be described in further detail below. The dentifrice composition of the present invention comprises (A) an acylamino acid salt,
It comprises (B) a nonionic surfactant, (C) a betaine amphoteric surfactant, and (D) an alkyl sulfate.

  As the acyl amino acid salt of component (A), an acyl group having 8 to 20 carbon atoms, particularly 12 to 16 carbon atoms is preferable. Examples of the amino acid group include glutamic acid, aspartic acid, glycine, sarcosine, alanine, methionine, phenylalanine, leucine, and isoleucine, with glutamic acid being particularly preferred. Examples of the salt include alkali metal salts such as sodium and potassium, alkaline earth metal salts, and organic amine salts.

  Examples of acyl amino acid salts include acyl glutamates such as sodium N-lauroyl-L-glutamate, sodium N-myristoyl-L-glutamate, potassium N-coconut fatty acid acyl-L-glutamate, and N-lauroyl-L-aspartic acid. Examples include acyl aspartates such as sodium, acyl glycine salts such as N-coconut oil fatty acid acyl glycine potassium, and the like. These may be used alone or in combination of two or more.

  Specifically, Amino Surfact ALMS-P1 (N-lauroyl-L-glutamate sodium, Asahi Kasei Chemicals Corporation), Amisoft LS-11 (N-lauroyl-L-glutamate sodium, Ajinomoto Healthy Supply Co., Ltd.), Amino Surf Fact AMMS-P1 (N-myristoyl-L-glutamate sodium, Asahi Kasei Chemicals Corporation), Amisoft MS-11 (N-myristoyl-L-glutamate sodium, Ajinomoto Healthy Supply Co., Ltd.), Aminoformer FLDS-L (N- Products that have been commercialized under trade names such as Lauroyl-L-sodium aspartate, Asahi Kasei Chemicals Corporation), Amilite GCK-12K (N-coconut oil fatty acid acylglycine potassium, Ajinomoto Healthy Supply Co., Ltd.) You can use.

  As the component (A), acyl glutamate is more preferable because it is superior to those having other amino acid residues in terms of an effect of imparting a stain adhesion suppression feeling.

  The amount of component (A) is preferably 0.1 to 2% (mass%, the same shall apply hereinafter), more preferably 0.2 to 1.5%. If it is less than 0.1%, a satisfactory stain adhesion inhibitory effect, a feeling of stain adhesion suppression, and foam persistence may not be obtained, and if it exceeds 2%, kneading may be reduced.

  (B) Nonionic surfactants include polyoxyethylene fatty acid esters such as polyoxyethylene hydrogenated castor oil, sucrose fatty acid esters, maltose fatty acid esters, sugar fatty acid esters such as lactose fatty acid esters, maltitol fatty acid esters, and lactitol fatty acids. Sugar alcohol fatty acid ester such as ester, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan fatty acid ester such as polyoxyethylene sorbitan monostearate, lauric acid mono- or diethanolamide, sorbitan fatty acid ester, polyoxyethylene higher alcohol ether, Polyoxyethylene polyoxypropylene copolymers, polyoxyethylene polyoxypropylene fatty acid esters, and the like are used. These may be used alone or in combination of two or more. Of these, polyoxyethylene fatty acid esters, particularly polyoxyethylene hydrogenated castor oil are preferred.

  The polyoxyethylene hydrogenated castor oil is preferably one having an average addition mole number of ethylene oxide (EO) of 5 to 100 moles, particularly 10 to 50 moles, particularly 20 to 40 moles in terms of effect expression. Can be used more suitably. If the average added mole number of ethylene oxide exceeds 100 moles, the taste may be strong. If the amount is less than 5 mol, a satisfactory stain adhesion suppression feeling may not be obtained.

A commercially available nonionic surfactant can be used.
Specifically, as polyoxyethylene hydrogenated castor oil, for example, HCO-10, HCO-20, HCO-30, HCO-40 manufactured by Nikko Chemicals Co., Ltd., HC-5, HC-10, HC manufactured by Nihon Emulsion Co., Ltd. -20, HC-30, HC-40, BLAUNON CW-10, CW-25 manufactured by Aoki Oil & Fat Co., Ltd. and the like.

  The amount of component (B) is preferably 0.1 to 5%, more preferably 0.5 to 2%. If it is less than 0.1%, a satisfactory stain adhesion inhibiting effect, a stain adhesion inhibiting feeling, and a kneading gloss may not be obtained. If it exceeds 5%, a nasty taste may occur and a satisfactory feeling of use may not be obtained.

Component (C) betaine-type amphoteric surfactants include alkylbetaines such as lauryldimethylaminoacetic acid betaine, fatty acid amidepropylbetaines such as coconut oil fatty acid amidepropylbetaine, 2-alkyl-N-carboxymethyl-N- Alkyl imidazolinium betaine type | system | groups, such as a hydroxyethyl imidazolinium betaine, are mentioned, These can be mix | blended individually by 1 type or in combination of 2 or more types.
Specifically, Ricavion A-100 (Lauryldimethylaminoacetic acid betaine, Shin Nippon Rika Co., Ltd.), Tego Betain CK (coconut oil fatty acid amidopropyl betaine, EVONIK), Enazicol C-40H (alkyl imidazolinium betaine, Lion That have been commercialized under a trade name such as Co., Ltd. can be used.

  The component (C) is preferably a fatty acid amidopropyl betaine type, and particularly preferably palm oil fatty acid amidopropyl betaine is superior to other betaine-type amphoteric surfactants in terms of a stain adhesion-suppressing effect. Can be used.

  The amount of component (C) is preferably 0.1 to 2%, more preferably 0.5 to 1.5%. If it is less than 0.1%, a satisfactory stain adhesion inhibitory effect, a stain adhesion suppression effect, and foam persistence may not be obtained. If it exceeds 2%, the kneading gloss may decrease.

Examples of the alkyl sulfate of component (D) include alkali metal salts of alkyl sulfates such as lauryl sulfate and myristyl sulfate, and one or more of them can be used. As the alkyl sulfate, sodium lauryl sulfate is particularly preferable.
As the alkyl sulfate, commercially available products manufactured by Toho Chemical Co., Ltd. can be used.

  The amount of component (D) is preferably 0.1 to 2%, more preferably 0.2 to 1.5%. If it is less than 0.1%, a satisfactory stain adhesion suppressing effect and foam persistence may not be obtained. If it exceeds 2%, a satisfactory feeling of stain adhesion suppression may not be obtained.

  The dentifrice composition of the present invention is particularly suitably prepared as a toothpaste. In this case, if necessary, known components other than the above components can be blended within a range not impeding the effects of the present invention. For example, abrasives, thickeners, binders, surfactants, sweeteners, preservatives, colorants, fragrances, various active ingredients, and the like are blended.

Examples of the abrasive include silica-based abrasives such as silica gel, precipitated silica, and aluminosilicate, dicalcium phosphate dihydrate and anhydrous, tertiary calcium phosphate, tertiary magnesium phosphate, tetrabasic calcium phosphate, calcium pyrophosphate, etc. Examples thereof include calcium phosphate compounds, calcium carbonate, aluminum hydroxide, alumina, magnesium carbonate, zirconium silicate, hydroxyapatite, and synthetic resin abrasives.
The blending amount of these abrasives is usually 10 to 50%, preferably 10 to 30% of the entire composition.

  Examples of the thickener include sugar alcohols such as sorbit and xylit, and polyhydric alcohols such as glycerin and propylene glycol. These compounding amounts are usually 5 to 50%, particularly 20 to 45%.

  A known binder can be blended as the binder. Examples include carrageenan, xanthan gum, sodium polyacrylate, sodium hydroxyethylcellulose, polyvinyl alcohol, guar gum, sodium alginate, cationized cellulose, thickening silica, montmorillonite, gelatin, carboxymethylcellulose sodium and the like. The amount of these binders is preferably in the range of 0.2 to 5%.

As the surfactant, known surfactants other than the components (A), (B), (C), and (D) can be blended within a range that does not hinder the effects of the present invention. Specific examples of the anionic surfactant include sodium N-acyl sarcosine such as sodium N-lauroyl sarcosine and sodium N-myristoyl sarcosine. Examples of the cationic surfactant include alkyl ammonium.
The blending amount of these surfactants is preferably 15% or less, particularly 0.5 to 10%.

Examples of the sweetener include saccharin sodium, and examples of the preservative include paraoxybenzoic acid ester and sodium benzoate.
Examples of the colorant include blue No. 1, yellow No. 4, titanium dioxide and the like.

  Perfumes include peppermint oil, spearmint oil, anise oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, Lime oil, lavender oil, rosemary oil, laurel oil, camomil oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, grapefruit oil, sweetie Natural fragrances such as oil, bran oil, Iris concrete, absolute peppermint, absolute rose, orange flower, and processing of these natural fragrances (front reservoir cut, rear reservoir cut, fractional distillation, liquid-liquid extraction, essence, powder Perfumes, etc.) and menthol, Rubon, Anethole, Cineol, Methyl salicylate, Synamic aldehyde, Eugenol, 3-1-Mentoxypropane-1,2-diol, Thymol, Linalol, Linarel acetate, Limonene, Menthone, Menthyl acetate, N-Substituted paramenthane 3-carboxamide, pinene, octyl aldehyde, citral, pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allylcyclohexane propionate, methyl anthranilate, ethyl methyl phenyl glycidate, vanillin, undecalactone, Hexanal, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cycloten, furfural, trimethylpyrazine, ethyl lactate, ethyl Toothpaste compositions such as single flavors such as oacetate, and other flavors such as strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavor, tropical fruit flavor, etc. The known perfume materials used can be used in combination.

  Various active ingredients include fluorides such as sodium fluoride and sodium monofluorophosphate, water-soluble phosphate compounds such as potassium salt and sodium salt of orthophosphate, glucanases such as dextranase and mutanase, and allantochlorhydroxyaluminum. , Hinokitiol, ascorbic acid, lysozyme chloride, glycyrrhizic acid and its salts, sodium chloride, tranexamic acid, epsilon aminocaproic acid, acetic acid dl-tocophenol, α-bisabolol, isopropylmethylphenol, chlorohexidine salts, cetylpyridinium chloride, azulene, glycyrrhetinic acid , Copper compounds such as copper chlorophyllin sodium, copper gluconate, aluminum lactate, strontium chloride, potassium nitrate, berberine, hydroxamic acid and its derivatives, zeo Ito, amylase, methoxyethylene, maleic anhydride copolymer, polyvinylpyrrolidone, epidihydrocholesterin, benzethonium chloride, dihydrocholesterol, trichlorocarbanilide, zinc citrate, sweet cherry extract, buckwheat extract, clove, rosemary, ougone And extracts such as safflower. In addition, the said active ingredient can be mix | blended in an effective amount in the range which does not prevent the effect of this invention.

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, “%” means “% by mass” unless otherwise specified.

[Examples and comparative examples]
A dentifrice composition (toothpaste) having the composition shown in Tables 1 to 3 was prepared by a conventional method and evaluated by the following method. The results are shown in Tables 1-3.

<1> Evaluation Method for Stain Adhesion Inhibition Effect <1-1> Model Stain Adhesion Inhibition Test Untreated hydroxyapatite pellet (HAP) surface (HOYA Corporation, diameter 7 mm × thickness 3.5 mm) is treated with sandblast. Then, it wash | cleaned with the ultrasonic cleaner in neutral detergent aqueous solution. After washing with water and natural drying, the ΔE value (ΔE0) of HAP before the adhesion of stain was measured using a spectroscopic color difference meter (manufactured by Nippon Denshoku Industries Co., Ltd., model: SE-2000).
Further, the dentifrice composition was diluted with twice the amount of purified water and centrifuged at 3,000 rpm for 10 minutes to obtain a supernatant, which was used as a dentifrice dispersion. The toothpaste dispersion was allowed to stand in a 50 ° C. water bath for 10 minutes, then poured into an Epton tube that had been left in a 50 ° C. constant temperature bath for 30 minutes in advance, and shaken and mixed 20 times per minute. The hydroxyapatite plate described above was immersed in this solution, and then allowed to stand in a 50 ° C. thermostatic bath for 3 minutes. Thereafter, the hydroxyapatite plate was taken out from the dentifrice dispersion in a state where the surface of the dentifrice dispersion and the hydroxyapatite plate were parallel to each other, and left in a constant temperature bath at 40 ° C. for 3 minutes. Thereafter, it was washed with purified water. After removing moisture on the surface, an operation of repeatedly immersing in an order of 0.5% albumin solution → tannin extract → 0.6% iron (III) ammonium citrate solution at 50 ° C. for 5 minutes was performed. Tannin extract is made up of 1,200 mL of boiled ion-exchanged water, 50 g of Japanese tea (brand name: Oimatsu), 5 bags of black tea (trade name Blisk Teabag, manufactured by Unilever Japan), instant coffee (trade name Nescafe) Nestlé Japan Co., Ltd.) 12 g was added and allowed to stand overnight, and Japanese tea and black tea were removed by filtration. The above operation was repeated 7 times, the HAP surface was air-dried, and the ΔE value (ΔE1) of the surface was measured again.
Instead of the dentifrice dispersion, ΔE of the initial HAP when the same treatment was performed with purified water was ΔE0b, and ΔE after the treatment was ΔE1b. The stain adhesion inhibition rate was calculated by the following formula, and thereby the stain adhesion inhibition effect was evaluated.
Stain adhesion inhibition rate (%) =
[(ΔE1b−ΔE0b) − (ΔE1−ΔE0)] / (ΔE1b−ΔE0b) × 100

The stain adhesion inhibitory effect was determined according to the following criteria from the stain adhesion inhibition rate.
◎: Stain adhesion inhibition rate is 75% or more ○: Stain adhesion inhibition rate is 65% or more and less than 75% △: Stain adhesion inhibition rate is 50% or more and less than 65% ×: Stain adhesion inhibition rate is less than 50%

<1-2> Method for Evaluating the Effect of Stain Adhesion Suppression Feeling Using 10 subjects, about 1 g of the dentifrice composition is taken on a toothbrush, and the tooth surface is not less than twice a day for 3 minutes and continuously used for 30 days. The smooth feeling was answered in four stages: (i) very felt, (ii) slightly felt, (iii) not felt very much, and (iv) not felt. Of these answers, 4 points were felt very much, 3 points were felt slightly, 2 points were not felt very much, and 1 point was not felt.
◎: Average point 3.5 points or more and 4.0 points or less ○: Average point 3.0 points or more and less than 3.5 points △: Average point 2.0 points or more and less than 3.0 points ×: Average point 1.0 points More than 2.0 points

<2> Method for evaluating the persistence of foam when brushing teeth Using 10 subjects, about 1 g of the dentifrice composition was put on a toothbrush, and the persistence of foam when brushing for 3 minutes. (I) The persistence of foam Answers were obtained in four stages: very good, (ii) good foam persistence, (iii) poor foam persistence, and (iv) poor foam persistence. Out of this answer, 4 points for very good foam persistence, 3 points for good foam persistence, 2 points for poor foam persistence, 1 point for poor foam persistence The feeling of use was evaluated from the average score of 10 people according to the following criteria.
◎: Average point 3.5 points or more and 4.0 points or less ○: Average point 3.0 points or more and less than 3.5 points △: Average point 2.0 points or more and less than 3.0 points ×: Average point 1.0 points More than 2.0 points

<3> Evaluation method of kneading luster Using 10 subjects, the dentifrice composition was placed on the entire front and rear ends of the brush of a toothbrush (clinicaha brush flat 4-row compact, manufactured by Lion Corporation), and one fluorescent lamp (Parook Premier L) (Panasonic, Inc.) 1.5 m directly below, and kneading gloss, (i) Gloss due to reflection is strongly recognized on the kneaded surface, (ii) Gloss due to reflection is recognized on the kneaded surface, (iii) On the kneaded surface Responses were obtained in four stages: slight gloss due to reflection, (iv) no gloss on the kneaded surface. Of these answers, 4 points were observed for reflection gloss on the kneaded surface, 3 points for reflection gloss on the kneaded surface, 2 points for slight reflection gloss on the kneaded surface, 2 points for gloss on the kneaded surface. Was evaluated from the average score of 10 people based on the following criteria.
◎: Average point 3.5 or more and 4.0 point or less ○: Average point 3.0 or more and less than 3.5 point △: Average point 2.5 or more and less than 3.0 point ×: Average point 2.5 point Less than

Details of the raw materials used are as follows.
(A) sodium N-lauroyl-L-glutamate;
Amino Surfact ALMS-P1 (Asahi Kasei Chemicals Corporation)
N-lauroyl-L-sodium aspartate;
Aminoformer FLDS-L (Asahi Kasei Chemicals Corporation)
N-coconut oil fatty acid-cocoyl glycine potassium;
Amilite GCK-12K (Ajinomoto Healthy Supply Co., Ltd.)
(B) POE hydrogenated castor oil (polyoxyethylene hydrogenated castor oil);
HCO-20 (EO average added mole number 20) (Nikko Chemicals Corporation)
POE stearyl ether (polyoxyethylene stearyl ether);
(Lion Chemical Co., Ltd.)
Glycerin fatty acid ester;
SY Glister ML-750 (Sakamoto Pharmaceutical Co., Ltd.)
(C) Palm oil fatty acid amidopropyl betaine;
Tego Betain CK (EVONIK)
Alkyl imidazolinium betaines;
Enajkor C-40H (Lion Corporation)
(D) Sodium lauryl sulfate; (Toho Chemical Industry Co., Ltd.)
For other ingredients, those conforming to the Quasi-drug Raw Material Standard 2006 were used.

Claims (4)

  A dentifrice composition comprising (A) an acylamino acid salt, (B) a nonionic surfactant, (C) a betaine amphoteric surfactant and (D) an alkyl sulfate.   The dentifrice composition according to claim 1, wherein component (A) is an acyl glutamate.   The dentifrice composition according to claim 1 or 2, wherein component (B) is polyoxyethylene hydrogenated castor oil.   The dentifrice composition according to claim 1, 2 or 3, wherein component (C) is coconut oil fatty acid amidopropyl betaine.