JP2013046616A5 - - Google Patents
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- Publication number
- JP2013046616A5 JP2013046616A5 JP2012202508A JP2012202508A JP2013046616A5 JP 2013046616 A5 JP2013046616 A5 JP 2013046616A5 JP 2012202508 A JP2012202508 A JP 2012202508A JP 2012202508 A JP2012202508 A JP 2012202508A JP 2013046616 A5 JP2013046616 A5 JP 2013046616A5
- Authority
- JP
- Japan
- Prior art keywords
- base sequence
- seq
- sequence represented
- rna strand
- rna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 32
- 108091033319 polynucleotide Proteins 0.000 claims description 10
- 102000040430 polynucleotide Human genes 0.000 claims description 10
- 239000002157 polynucleotide Substances 0.000 claims description 10
- 108091030071 RNAI Proteins 0.000 claims description 8
- 230000009368 gene silencing by RNA Effects 0.000 claims description 8
- 230000000295 complement effect Effects 0.000 claims description 3
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 10
- 210000004027 cell Anatomy 0.000 claims 7
- 239000000411 inducer Substances 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 210000004881 tumor cell Anatomy 0.000 claims 2
- 108091027967 Small hairpin RNA Proteins 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 230000033228 biological regulation Effects 0.000 claims 1
- 239000002771 cell marker Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 239000004055 small Interfering RNA Substances 0.000 claims 1
- 210000001082 somatic cell Anatomy 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 230000000694 effects Effects 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012202508A JP2013046616A (ja) | 2010-07-12 | 2012-09-14 | ｓｉＲＮＡ導入による新規ｈｉＰＳＣ作製法 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010158194 | 2010-07-12 | ||
| JP2010158192 | 2010-07-12 | ||
| JP2010158192 | 2010-07-12 | ||
| JP2010158193 | 2010-07-12 | ||
| JP2010158194 | 2010-07-12 | ||
| JP2010158193 | 2010-07-12 | ||
| JP2012202508A JP2013046616A (ja) | 2010-07-12 | 2012-09-14 | ｓｉＲＮＡ導入による新規ｈｉＰＳＣ作製法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011530188A Division JP5099570B2 (ja) | 2010-07-12 | 2011-06-28 | ｓｉＲＮＡ導入による新規ｈｉＰＳＣ作製法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013046616A JP2013046616A (ja) | 2013-03-07 |
| JP2013046616A5 true JP2013046616A5 (enExample) | 2014-08-14 |
Family
ID=45469308
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011530189A Expired - Fee Related JP5099571B2 (ja) | 2010-07-12 | 2011-06-28 | ｍｉＲＮＡ導入による新規ｈｉＰＳＣ作製法 |
| JP2011530188A Expired - Fee Related JP5099570B2 (ja) | 2010-07-12 | 2011-06-28 | ｓｉＲＮＡ導入による新規ｈｉＰＳＣ作製法 |
| JP2012202509A Pending JP2013034479A (ja) | 2010-07-12 | 2012-09-14 | ｍｉＲＮＡ導入による新規ｈｉＰＳＣ作製法 |
| JP2012202508A Pending JP2013046616A (ja) | 2010-07-12 | 2012-09-14 | ｓｉＲＮＡ導入による新規ｈｉＰＳＣ作製法 |
| JP2013264240A Expired - Fee Related JP5845493B2 (ja) | 2010-07-12 | 2013-12-20 | ｍｉＲＮＡ導入による新規ｈｉＰＳＣ作製法 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011530189A Expired - Fee Related JP5099571B2 (ja) | 2010-07-12 | 2011-06-28 | ｍｉＲＮＡ導入による新規ｈｉＰＳＣ作製法 |
| JP2011530188A Expired - Fee Related JP5099570B2 (ja) | 2010-07-12 | 2011-06-28 | ｓｉＲＮＡ導入による新規ｈｉＰＳＣ作製法 |
| JP2012202509A Pending JP2013034479A (ja) | 2010-07-12 | 2012-09-14 | ｍｉＲＮＡ導入による新規ｈｉＰＳＣ作製法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013264240A Expired - Fee Related JP5845493B2 (ja) | 2010-07-12 | 2013-12-20 | ｍｉＲＮＡ導入による新規ｈｉＰＳＣ作製法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US9476041B2 (enExample) |
| EP (2) | EP2594644B1 (enExample) |
| JP (5) | JP5099571B2 (enExample) |
| CN (2) | CN103189511B (enExample) |
| WO (2) | WO2012008302A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012008302A1 (ja) | 2010-07-12 | 2012-01-19 | 国立大学法人鳥取大学 | ｍｉＲＮＡ導入による新規ｈｉＰＳＣ作製法 |
| EP4086338A1 (en) | 2011-03-17 | 2022-11-09 | Minerva Biotechnologies Corporation | Method for making pluripotent stem cells |
| WO2013059373A2 (en) | 2011-10-17 | 2013-04-25 | Minerva Biotechnologies Corporation | Media for stem cell proliferation and induction |
| US10034902B2 (en) * | 2012-02-22 | 2018-07-31 | Exostem Biotec Ltd. | MicroRNAs for the generation of astrocytes |
| JP6748430B2 (ja) * | 2012-07-13 | 2020-09-02 | ミネルバ バイオテクノロジーズ コーポレーション | より未分化状態への細胞の誘導方法 |
| US10265347B2 (en) | 2013-08-29 | 2019-04-23 | Norimasa Miura | Biomolecular group related to cell anti-aging |
| US20160289678A1 (en) * | 2013-11-22 | 2016-10-06 | Dcb-Usa Llc | Use of microrna 146-a in the diagnosis, treatment and prevention of picornavirus infection and microrna 146-a antagonists |
| CN104109670B (zh) * | 2014-03-12 | 2018-01-05 | 首都医科大学附属北京安定医院 | 一种双链siRNA分子及其应用 |
| SG11201610745XA (en) | 2014-06-27 | 2017-01-27 | Rhizen Pharmaceuticals Sa | Substituted chromene derivatives as selective dual inhibitors of pi3 delta and gamma protein kinases |
| EP3286335A4 (en) | 2015-04-24 | 2018-10-17 | The Johns Hopkins University | Compositions and methods related to characterizing proviral reservoirs |
| WO2017073689A1 (ja) * | 2015-10-30 | 2017-05-04 | 国立大学法人鳥取大学 | Ｄｎａ損傷を修復するｒｎａ分子 |
| KR102011336B1 (ko) * | 2015-12-31 | 2019-08-16 | 인터올리고 주식회사 | 약물 전달 및 안정화를 위한 복합체 및 그 제조방법 |
| WO2018203553A1 (ja) * | 2017-05-02 | 2018-11-08 | 株式会社ペジィー・ファーマ | 分化細胞の品質改善方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1452594A4 (en) * | 2001-11-15 | 2007-01-10 | Kyowa Hakko Kogyo Kk | INDUCTOR FOR DIFFERENTIATING EMBRYOONAL STEM CELLS TO EODODERMAL CELLS, METHOD FOR OBTAINING THEM AND USE THEREOF |
| WO2004024940A2 (en) | 2002-09-16 | 2004-03-25 | University Of Southern California | Rna-mediated gene modulation |
| KR20050115231A (ko) | 2003-02-10 | 2005-12-07 | 내셔날 인스티튜트 오브 어드밴스드 인더스트리얼 사이언스 앤드 테크놀로지 | 포유동물 세포의 조절 |
| US9453219B2 (en) | 2003-05-15 | 2016-09-27 | Mello Biotech Taiwan Co., Ltd. | Cosmetic designs and products using intronic RNA |
| EP2314688B1 (en) | 2004-11-12 | 2014-07-16 | Asuragen, Inc. | Methods and compositions involving miRNA and miRNA inhibitor molecules |
| WO2006084275A2 (en) | 2005-02-04 | 2006-08-10 | Auburn University | Contact drug delivery system |
| JP4982757B2 (ja) * | 2005-04-15 | 2012-07-25 | 国立大学法人鳥取大学 | ｈＴＥＲＴ発現調節遺伝子 |
| PL2002003T3 (pl) * | 2005-05-27 | 2016-06-30 | Ospedale San Raffaele Srl | Wektor genetyczny zawierający mi-RNA |
| WO2006137514A1 (ja) | 2005-06-23 | 2006-12-28 | Locomogene, Inc. | シノビオリンの発現もしくは機能阻害物質を有効成分とする癌治療剤、および癌治療剤のスクリーニング方法 |
| KR101420740B1 (ko) | 2005-12-13 | 2014-07-17 | 교또 다이가꾸 | 핵초기화 인자 |
| EP2487260B1 (en) | 2006-01-05 | 2015-07-08 | The Ohio State University Research Foundation | Microrna-based methods and compositions for the diagnosis and treatment of solid cancers |
| KR101407707B1 (ko) | 2006-04-03 | 2014-06-19 | 산타리스 팔마 에이/에스 | Ａｎｔｉ-ｍｉｒｎａ 안티센스 올리고뉴클레오타이드를 함유하는 약학적 조성물 |
| CN101980712B (zh) * | 2007-10-29 | 2015-02-18 | 雷古拉斯治疗公司 | 用于肝癌治疗的靶向微小rna |
| KR101564044B1 (ko) | 2007-10-31 | 2015-10-28 | 고쿠리츠 다이가쿠 호진 교토 다이가쿠 | 핵초기화 방법 |
| KR101532442B1 (ko) | 2007-12-10 | 2015-06-29 | 고쿠리츠 다이가쿠 호진 교토 다이가쿠 | 효율적인 핵 초기화 방법 |
| CA2710713C (en) * | 2007-12-27 | 2017-09-19 | Protiva Biotherapeutics, Inc. | Silencing of polo-like kinase expression using interfering rna |
| CN101970664B (zh) * | 2008-01-16 | 2013-08-21 | 林希龙 | 使用可诱导的重组核糖核酸因子生成不含肿瘤的类胚胎干细胞的多能性细胞 |
| CN101333524B (zh) * | 2008-06-25 | 2010-06-02 | 中山大学 | 一个小分子非编码RNA基因hsa-miR-101及其抗肿瘤用途 |
| CN101392251B (zh) * | 2008-11-03 | 2015-07-22 | 清华大学深圳研究生院 | 能诱导干细胞向成骨细胞分化的微小rna及其应用 |
| JP2010120881A (ja) * | 2008-11-19 | 2010-06-03 | Keio Gijuku | ヒト癌タンパク質ＭＤＭ２とヒト癌抑制タンパク質ｐ５３との相互作用阻害ペプチド及びその使用 |
| WO2012008302A1 (ja) | 2010-07-12 | 2012-01-19 | 国立大学法人鳥取大学 | ｍｉＲＮＡ導入による新規ｈｉＰＳＣ作製法 |
-
2011
- 2011-06-28 WO PCT/JP2011/064847 patent/WO2012008302A1/ja not_active Ceased
- 2011-06-28 WO PCT/JP2011/064846 patent/WO2012008301A1/ja not_active Ceased
- 2011-06-28 JP JP2011530189A patent/JP5099571B2/ja not_active Expired - Fee Related
- 2011-06-28 US US13/809,880 patent/US9476041B2/en not_active Expired - Fee Related
- 2011-06-28 US US13/809,882 patent/US9790491B2/en not_active Expired - Fee Related
- 2011-06-28 CN CN201180043814.8A patent/CN103189511B/zh not_active Expired - Fee Related
- 2011-06-28 JP JP2011530188A patent/JP5099570B2/ja not_active Expired - Fee Related
- 2011-06-28 CN CN201180043810XA patent/CN103097535A/zh active Pending
- 2011-06-28 EP EP11806632.3A patent/EP2594644B1/en not_active Not-in-force
- 2011-06-28 EP EP11806631.5A patent/EP2594643B1/en not_active Not-in-force
-
2012
- 2012-09-14 JP JP2012202509A patent/JP2013034479A/ja active Pending
- 2012-09-14 JP JP2012202508A patent/JP2013046616A/ja active Pending
-
2013
- 2013-12-20 JP JP2013264240A patent/JP5845493B2/ja not_active Expired - Fee Related
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