JP2013028559A5 - - Google Patents
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- Publication number
- JP2013028559A5 JP2013028559A5 JP2011165361A JP2011165361A JP2013028559A5 JP 2013028559 A5 JP2013028559 A5 JP 2013028559A5 JP 2011165361 A JP2011165361 A JP 2011165361A JP 2011165361 A JP2011165361 A JP 2011165361A JP 2013028559 A5 JP2013028559 A5 JP 2013028559A5
- Authority
- JP
- Japan
- Prior art keywords
- chloro
- methylbenzoic acid
- reaction
- isopropyl
- represented
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 36
- 238000006243 chemical reaction Methods 0.000 claims description 14
- GANDSBWEBNXLMG-UHFFFAOYSA-N 3-chloro-4-methylbenzoyl chloride Chemical compound CC1=CC=C(C(Cl)=O)C=C1Cl GANDSBWEBNXLMG-UHFFFAOYSA-N 0.000 claims description 9
- 239000002904 solvent Substances 0.000 claims description 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 4
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 4
- 239000007795 chemical reaction product Substances 0.000 claims description 4
- 238000005660 chlorination reaction Methods 0.000 claims description 4
- 239000000460 chlorine Substances 0.000 claims description 4
- 229910052801 chlorine Inorganic materials 0.000 claims description 4
- 239000011968 lewis acid catalyst Substances 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 4
- GPZXFICWCMCQPF-UHFFFAOYSA-N 2-methylbenzoyl chloride Chemical compound CC1=CC=CC=C1C(Cl)=O GPZXFICWCMCQPF-UHFFFAOYSA-N 0.000 claims description 3
- NQUVCRCCRXRJCK-UHFFFAOYSA-N 4-methylbenzoyl chloride Chemical compound CC1=CC=C(C(Cl)=O)C=C1 NQUVCRCCRXRJCK-UHFFFAOYSA-N 0.000 claims description 2
- 229910021578 Iron(III) chloride Inorganic materials 0.000 claims description 2
- 238000005886 esterification reaction Methods 0.000 claims description 2
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 229910052757 nitrogen Inorganic materials 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- SDKUOEOJAXGCLU-UHFFFAOYSA-N 3-chloro-4-methylbenzoic acid Chemical compound CC1=CC=C(C(O)=O)C=C1Cl SDKUOEOJAXGCLU-UHFFFAOYSA-N 0.000 claims 1
- 150000004678 hydrides Chemical class 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- RODCVSHNESCUTL-UHFFFAOYSA-N propan-2-yl 3-chloro-4-methylbenzoate Chemical compound CC(C)OC(=O)C1=CC=C(C)C(Cl)=C1 RODCVSHNESCUTL-UHFFFAOYSA-N 0.000 claims 1
- RKIDDEGICSMIJA-UHFFFAOYSA-N 4-chlorobenzoyl chloride Chemical compound ClC(=O)C1=CC=C(Cl)C=C1 RKIDDEGICSMIJA-UHFFFAOYSA-N 0.000 description 1
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011165361A JP2013028559A (ja) | 2011-07-28 | 2011-07-28 | ３−クロロ−４−メチル安息香酸イソプロピル及びその製造方法 |
| TW101124026A TW201305104A (zh) | 2011-07-28 | 2012-07-04 | ３－氯－４－甲基苯甲酸異丙酯及其製造方法 |
| CN201280036985.2A CN103917515A (zh) | 2011-07-28 | 2012-07-20 | 3-氯-4-甲基苯甲酸异丙基酯及其制造方法 |
| PCT/JP2012/068409 WO2013015203A1 (ja) | 2011-07-28 | 2012-07-20 | 3-クロロ-4-メチル安息香酸イソプロピル及びその製造方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011165361A JP2013028559A (ja) | 2011-07-28 | 2011-07-28 | ３−クロロ−４−メチル安息香酸イソプロピル及びその製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013028559A JP2013028559A (ja) | 2013-02-07 |
| JP2013028559A5 true JP2013028559A5 (enExample) | 2014-09-04 |
Family
ID=47601050
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011165361A Pending JP2013028559A (ja) | 2011-07-28 | 2011-07-28 | ３−クロロ−４−メチル安息香酸イソプロピル及びその製造方法 |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JP2013028559A (enExample) |
| CN (1) | CN103917515A (enExample) |
| TW (1) | TW201305104A (enExample) |
| WO (1) | WO2013015203A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108218708B (zh) * | 2016-12-15 | 2021-01-05 | 利尔化学股份有限公司 | 5-氯-4-甲基-2-硝基苯甲酸的制备方法及其用途 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8400254D0 (en) * | 1984-01-06 | 1984-02-08 | Searle & Co | Substituted alklidene imidazoles |
| JP2527961B2 (ja) * | 1987-04-24 | 1996-08-28 | 日本農薬株式会社 | 安息香酸エステル誘導体及びその製造方法 |
| DE4339208A1 (de) * | 1993-11-17 | 1995-05-18 | Hoechst Ag | Verfahren zur Herstellung von Fluorbenzoesäurealkylestern in hoher Reinheit und Ausbeute |
| JPH07330663A (ja) * | 1994-06-08 | 1995-12-19 | Nippon Light Metal Co Ltd | ２−クロロテレフタル酸クロライドの製造方法 |
| EP0995742A4 (en) * | 1997-06-27 | 2004-08-25 | Fujisawa Pharmaceutical Co | SULPHONAMIDE COMPOUNDS AND THEIR MEDICAL USE |
| WO1999016743A1 (en) * | 1997-09-30 | 1999-04-08 | Korea Research Institute Of Chemical Technology | A PROCESS FOR PREPARING o-(CARBOALKOXY) PHENYLMETHANESULFONYL CHLORIDE DERIVATIVES |
| ITMI20020974A1 (it) * | 2002-05-09 | 2003-11-10 | Miteni Spa | Procedimento per la preparazione dell'acido 4-fluoro-antranilico |
| US20040132726A1 (en) * | 2002-08-09 | 2004-07-08 | Astrazeneca Ab And Nps Pharmaceuticals, Inc. | New compounds |
| CN1762970A (zh) * | 2005-09-13 | 2006-04-26 | 上海大学 | 羧酸酯的合成方法 |
| DE102005050376A1 (de) * | 2005-10-21 | 2007-05-31 | Bayer Healthcare Ag | Dicarbonsäure-Derivate und ihre Verwendung |
| JP5558352B2 (ja) * | 2008-07-15 | 2014-07-23 | 日本化薬株式会社 | ６−アリールオキシキノリン誘導体の製造方法およびその中間体 |
-
2011
- 2011-07-28 JP JP2011165361A patent/JP2013028559A/ja active Pending
-
2012
- 2012-07-04 TW TW101124026A patent/TW201305104A/zh unknown
- 2012-07-20 CN CN201280036985.2A patent/CN103917515A/zh active Pending
- 2012-07-20 WO PCT/JP2012/068409 patent/WO2013015203A1/ja not_active Ceased
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