JP2012532901A5 - - Google Patents
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- Publication number
- JP2012532901A5 JP2012532901A5 JP2012519902A JP2012519902A JP2012532901A5 JP 2012532901 A5 JP2012532901 A5 JP 2012532901A5 JP 2012519902 A JP2012519902 A JP 2012519902A JP 2012519902 A JP2012519902 A JP 2012519902A JP 2012532901 A5 JP2012532901 A5 JP 2012532901A5
- Authority
- JP
- Japan
- Prior art keywords
- het
- atoms
- nha
- proportions
- unsubstituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102009033392A DE102009033392A1 (de) | 2009-07-16 | 2009-07-16 | Heterocyclische Verbindungen als Autotaxin-Inhibitoren II |
| DE102009033392.4 | 2009-07-16 | ||
| PCT/EP2010/003661 WO2011006569A1 (de) | 2009-07-16 | 2010-06-17 | Heterocyclische verbindungen als autotaxin-inhibitoren |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012532901A JP2012532901A (ja) | 2012-12-20 |
| JP2012532901A5 true JP2012532901A5 (en:Method) | 2013-08-08 |
Family
ID=42646326
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012519902A Pending JP2012532901A (ja) | 2009-07-16 | 2010-06-17 | オートタキシン阻害剤としての複素環式化合物 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20120115852A1 (en:Method) |
| EP (1) | EP2454258A1 (en:Method) |
| JP (1) | JP2012532901A (en:Method) |
| KR (1) | KR20120090031A (en:Method) |
| CN (1) | CN102471343A (en:Method) |
| AR (1) | AR077488A1 (en:Method) |
| AU (1) | AU2010272922A1 (en:Method) |
| BR (1) | BR112012000792A2 (en:Method) |
| CA (1) | CA2768095A1 (en:Method) |
| DE (1) | DE102009033392A1 (en:Method) |
| EA (1) | EA201200119A1 (en:Method) |
| IL (1) | IL217466A0 (en:Method) |
| MX (1) | MX2012000609A (en:Method) |
| SG (1) | SG177522A1 (en:Method) |
| WO (1) | WO2011006569A1 (en:Method) |
| ZA (1) | ZA201201124B (en:Method) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112014030473A2 (pt) | 2012-06-13 | 2017-06-27 | Hoffmann La Roche | novo diazaespirocicloalcano e azaespirocicloalcano |
| SI2900669T1 (sl) * | 2012-09-25 | 2019-12-31 | F. Hoffmann-La Roche Ag | Derivati heksahidropirolo(3,4-C)pirola in sorodne spojine kot zaviralci avtotaksina (ATX) in kot zaviralci tvorbe lizofosfatidne kisline (LPA) za zdravljenje npr. bolezni ledvic |
| US9409895B2 (en) | 2012-12-19 | 2016-08-09 | Novartis Ag | Autotaxin inhibitors |
| CA2895448A1 (en) | 2012-12-19 | 2014-06-26 | Novartis Ag | Autotaxin inhibitors |
| AR095079A1 (es) * | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
| TW201446768A (zh) * | 2013-03-15 | 2014-12-16 | Biogen Idec Inc | S1p及/或atx調節劑 |
| WO2015042053A1 (en) | 2013-09-17 | 2015-03-26 | Pharmakea, Inc. | Vinyl autotaxin inhibitor compounds |
| WO2015042052A1 (en) | 2013-09-17 | 2015-03-26 | Pharmakea, Inc. | Heterocyclic vinyl autotaxin inhibitor compounds |
| WO2015048301A1 (en) | 2013-09-26 | 2015-04-02 | Pharmakea, Inc. | Autotaxin inhibitor compounds |
| WO2015077503A1 (en) | 2013-11-22 | 2015-05-28 | Pharmakea, Inc. | Autotaxin inhibitor compounds |
| MX2016006688A (es) | 2013-11-22 | 2016-11-29 | Pharmakea Inc | Inhibidores tetraciclicos de autotaxina. |
| JP6496730B2 (ja) | 2013-11-26 | 2019-04-03 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 新規なオクタヒドロ−シクロブタ［１，２−ｃ；３，４−ｃ’］ジピロール−２−イル |
| MX373236B (es) * | 2014-03-26 | 2020-05-08 | Hoffmann La Roche | Compuestos condensados de [1,4]diazepina como inhibidores de producción de la autotaxina (atx) y ácido lisofosfatidico (lpa). |
| MX370659B (es) | 2014-03-26 | 2019-12-19 | Hoffmann La Roche | Compuestos bicíclicos como inhibidores de producción de autotaxina (atx) y ácido lisofosfatídico (lpa). |
| AU2015240519B2 (en) | 2014-04-04 | 2019-08-15 | X-Rx, Inc. | Substituted spirocyclic inhibitors of autotaxin |
| EP3134079A4 (en) * | 2014-04-23 | 2017-12-20 | X-RX Discovery, Inc. | Substituted n-(2-(amino)-2-oxoethyl)benzamide inhibitors of autotaxin and their preparation and use in the treatment of lpa-dependent or lpa-mediated diseases |
| US9051320B1 (en) | 2014-08-18 | 2015-06-09 | Pharmakea, Inc. | Methods for the treatment of metabolic disorders by a selective small molecule autotaxin inhibitor |
| GB201501870D0 (en) | 2015-02-04 | 2015-03-18 | Cancer Rec Tech Ltd | Autotaxin inhibitors |
| GB201502020D0 (en) | 2015-02-06 | 2015-03-25 | Cancer Rec Tech Ltd | Autotaxin inhibitory compounds |
| MA41898A (fr) | 2015-04-10 | 2018-02-13 | Hoffmann La Roche | Dérivés de quinazolinone bicyclique |
| IL280863B2 (en) | 2015-05-27 | 2024-07-01 | Sabre Therapeutics Llc | Autotaxin inhibitors and uses thereof |
| EP3302465A1 (en) | 2015-06-05 | 2018-04-11 | Vertex Pharmaceuticals Incorporated | Triazoles for the treatment of demyelinating diseases |
| GB201510010D0 (en) | 2015-06-09 | 2015-07-22 | King S College London | PDD and BPD compounds |
| GB201514928D0 (en) | 2015-08-21 | 2015-10-07 | King S College London | PDD compounds |
| US20180339985A1 (en) | 2015-08-21 | 2018-11-29 | Femtogenix Limited | Pdd compounds |
| MX387736B (es) | 2015-09-04 | 2025-03-18 | Hoffmann La Roche | Derivados de fenoximetilo. |
| PE20180461A1 (es) | 2015-09-24 | 2018-03-06 | Hoffmann La Roche | Nuevos compuestos biciclicos como inhibidores de la atx |
| KR20180054634A (ko) | 2015-09-24 | 2018-05-24 | 에프. 호프만-라 로슈 아게 | 이중 오토탁신(atx)/탄산 무수화효소(ca) 억제제로서 신규한 이환형 화합물 |
| CA2984585A1 (en) | 2015-09-24 | 2017-03-30 | F. Hoffmann-La Roche Ag | New bicyclic compounds as dual atx/ca inhibitors |
| KR20180054635A (ko) | 2015-09-24 | 2018-05-24 | 에프. 호프만-라 로슈 아게 | 오토탁신(atx) 억제제로서 이환형 화합물 |
| WO2018106643A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Heterocyclic azoles for the treatment of demyelinating diseases |
| WO2018106641A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Pyrazoles for the treatment of demyelinating diseases |
| WO2018106646A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Aminotriazoles for the treatment of demyelinating diseases |
| CN110392679B (zh) | 2017-03-16 | 2023-04-07 | 豪夫迈·罗氏有限公司 | 可用作双重atx/ca抑制剂的杂环化合物 |
| WO2018167113A1 (en) | 2017-03-16 | 2018-09-20 | F. Hoffmann-La Roche Ag | New bicyclic compounds as atx inhibitors |
| JP6687816B1 (ja) * | 2018-05-21 | 2020-04-28 | 株式会社アシックス | ブラジャー |
| KR102623218B1 (ko) * | 2018-08-23 | 2024-01-11 | 가천대학교 산학협력단 | 페닐아세트산 유도체 및 이를 유효성분으로 함유하는 자가면역질환 예방 또는 치료용 조성물 |
| US12048678B2 (en) * | 2018-10-02 | 2024-07-30 | Case Western Reserve University | Compounds for treating myelin related disorders |
| US20250134907A1 (en) * | 2022-02-10 | 2025-05-01 | The United States Of America,As Represented By The Secretary,Department Of Health And Human Services | Fused diazepines as agonists of the insulin-like 3 (insl3) peptide receptor rxfp2 and methods of use thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5747469A (en) | 1991-03-06 | 1998-05-05 | Board Of Regents, The University Of Texas System | Methods and compositions comprising DNA damaging agents and p53 |
| ME00129B (me) * | 1999-01-19 | 2010-10-10 | Ortho Mcneil Janssen Pharmaceuticals Inc | Triciklicnj benzodiazepini kao antagonisti receptora vazopresina |
| GB9904387D0 (en) | 1999-02-25 | 1999-04-21 | Pharmacia & Upjohn Spa | Antitumour synergistic composition |
| EP1187633A4 (en) | 1999-04-08 | 2005-05-11 | Arch Dev Corp | USE OF ANTI-VEGF ANTIBODIES TO ENHANCE RADIATION IN ANTICANCER THERAPY |
| AU1400401A (en) * | 1999-11-09 | 2001-06-06 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Product inhibiting transduction of G heterotrimeric protein signals combined with another anti-cancer agent for therapeutic use in cancer treatment |
-
2009
- 2009-07-16 DE DE102009033392A patent/DE102009033392A1/de not_active Withdrawn
-
2010
- 2010-06-17 EA EA201200119A patent/EA201200119A1/ru unknown
- 2010-06-17 EP EP10725398A patent/EP2454258A1/de not_active Withdrawn
- 2010-06-17 MX MX2012000609A patent/MX2012000609A/es not_active Application Discontinuation
- 2010-06-17 US US13/383,908 patent/US20120115852A1/en not_active Abandoned
- 2010-06-17 JP JP2012519902A patent/JP2012532901A/ja active Pending
- 2010-06-17 WO PCT/EP2010/003661 patent/WO2011006569A1/de not_active Ceased
- 2010-06-17 CA CA2768095A patent/CA2768095A1/en not_active Abandoned
- 2010-06-17 CN CN2010800318870A patent/CN102471343A/zh active Pending
- 2010-06-17 BR BR112012000792A patent/BR112012000792A2/pt not_active Application Discontinuation
- 2010-06-17 AU AU2010272922A patent/AU2010272922A1/en not_active Abandoned
- 2010-06-17 SG SG2012000774A patent/SG177522A1/en unknown
- 2010-06-17 KR KR1020127004105A patent/KR20120090031A/ko not_active Withdrawn
- 2010-07-16 AR ARP100102610A patent/AR077488A1/es unknown
-
2012
- 2012-01-10 IL IL217466A patent/IL217466A0/en unknown
- 2012-02-15 ZA ZA2012/01124A patent/ZA201201124B/en unknown
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