JP2012532857A5 - - Google Patents
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- Publication number
- JP2012532857A5 JP2012532857A5 JP2012519065A JP2012519065A JP2012532857A5 JP 2012532857 A5 JP2012532857 A5 JP 2012532857A5 JP 2012519065 A JP2012519065 A JP 2012519065A JP 2012519065 A JP2012519065 A JP 2012519065A JP 2012532857 A5 JP2012532857 A5 JP 2012532857A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- group
- compound according
- disease
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 phenoxy, benzyl Chemical group 0.000 claims 30
- 150000001875 compounds Chemical class 0.000 claims 21
- 241000124008 Mammalia Species 0.000 claims 8
- 208000006011 Stroke Diseases 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 208000024827 Alzheimer disease Diseases 0.000 claims 3
- 208000019901 Anxiety disease Diseases 0.000 claims 3
- 208000020925 Bipolar disease Diseases 0.000 claims 3
- 201000006474 Brain Ischemia Diseases 0.000 claims 3
- 206010008120 Cerebral ischaemia Diseases 0.000 claims 3
- 208000028698 Cognitive impairment Diseases 0.000 claims 3
- 208000010412 Glaucoma Diseases 0.000 claims 3
- 206010019196 Head injury Diseases 0.000 claims 3
- 206010019233 Headaches Diseases 0.000 claims 3
- 206010065390 Inflammatory pain Diseases 0.000 claims 3
- 208000019695 Migraine disease Diseases 0.000 claims 3
- 208000026072 Motor neurone disease Diseases 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 208000018737 Parkinson disease Diseases 0.000 claims 3
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 3
- 206010046851 Uveitis Diseases 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 230000003432 anti-folate effect Effects 0.000 claims 3
- 229940127074 antifolate Drugs 0.000 claims 3
- 230000036506 anxiety Effects 0.000 claims 3
- 210000000467 autonomic pathway Anatomy 0.000 claims 3
- 125000001246 bromo group Chemical group Br* 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 206010008118 cerebral infarction Diseases 0.000 claims 3
- 230000001684 chronic effect Effects 0.000 claims 3
- 208000010877 cognitive disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 3
- 206010015037 epilepsy Diseases 0.000 claims 3
- 239000004052 folic acid antagonist Substances 0.000 claims 3
- 125000001188 haloalkyl group Chemical group 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 231100000869 headache Toxicity 0.000 claims 3
- 208000014674 injury Diseases 0.000 claims 3
- 201000004792 malaria Diseases 0.000 claims 3
- 206010027599 migraine Diseases 0.000 claims 3
- 230000036651 mood Effects 0.000 claims 3
- 208000005264 motor neuron disease Diseases 0.000 claims 3
- 201000006417 multiple sclerosis Diseases 0.000 claims 3
- 125000001624 naphthyl group Chemical group 0.000 claims 3
- 208000004296 neuralgia Diseases 0.000 claims 3
- 230000004770 neurodegeneration Effects 0.000 claims 3
- 208000015122 neurodegenerative disease Diseases 0.000 claims 3
- 208000021722 neuropathic pain Diseases 0.000 claims 3
- 201000000980 schizophrenia Diseases 0.000 claims 3
- 239000003195 sodium channel blocking agent Substances 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 3
- 208000020431 spinal cord injury Diseases 0.000 claims 3
- 230000008733 trauma Effects 0.000 claims 3
- 210000003901 trigeminal nerve Anatomy 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 claims 2
- 125000002178 anthracenyl group Chemical group C1(=CC=CC2=CC3=CC=CC=C3C=C12)* 0.000 claims 2
- 125000005605 benzo group Chemical group 0.000 claims 2
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000003983 fluorenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3CC12)* 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 125000005647 linker group Chemical group 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 claims 1
- 125000006276 2-bromophenyl group Chemical group [H]C1=C([H])C(Br)=C(*)C([H])=C1[H] 0.000 claims 1
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 claims 1
- 125000005809 3,4,5-trimethoxyphenyl group Chemical group [H]C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 claims 1
- 125000006275 3-bromophenyl group Chemical group [H]C1=C([H])C(Br)=C([H])C(*)=C1[H] 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 claims 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 150000001721 carbon Chemical group 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 125000004188 dichlorophenyl group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Chemical group CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000004970 halomethyl group Chemical group 0.000 claims 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 claims 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 claims 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 229910052757 nitrogen Chemical group 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Chemical group 0.000 claims 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0911991A GB0911991D0 (en) | 2009-07-08 | 2009-07-08 | Cyclic triazo sodium channel blockers 1 |
| GB0911991.8 | 2009-07-08 | ||
| GB0911925A GB0911925D0 (en) | 2009-07-09 | 2009-07-09 | Cyclic triazo sodium channel blockers 1A |
| GB0911925.6 | 2009-07-09 | ||
| GB0912271A GB2471729A (en) | 2009-07-08 | 2009-07-15 | 1,2,4-triazine derivatives and their use as sodium channel blockers |
| GB0912271.4 | 2009-07-15 | ||
| PCT/GB2010/051126 WO2011004195A2 (en) | 2009-07-08 | 2010-07-08 | Cyclic triazo sodium channel blockers |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012532857A JP2012532857A (ja) | 2012-12-20 |
| JP2012532857A5 true JP2012532857A5 (https=) | 2013-08-22 |
| JP5731496B2 JP5731496B2 (ja) | 2015-06-10 |
Family
ID=41057979
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012519065A Expired - Fee Related JP5731496B2 (ja) | 2009-07-08 | 2010-07-08 | 環状トリアゾナトリウムチャネル遮断薬 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US8748599B2 (https=) |
| EP (1) | EP2451806B1 (https=) |
| JP (1) | JP5731496B2 (https=) |
| KR (1) | KR101776346B1 (https=) |
| CN (1) | CN102596942B (https=) |
| AU (1) | AU2010269981B2 (https=) |
| CA (1) | CA2767296C (https=) |
| ES (1) | ES2573506T3 (https=) |
| GB (1) | GB2471729A (https=) |
| IL (1) | IL217331A (https=) |
| IN (1) | IN2012DN00870A (https=) |
| WO (1) | WO2011004195A2 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0800741D0 (en) * | 2008-01-16 | 2008-02-20 | Univ Greenwich | Cyclic triazo and diazo sodium channel blockers |
| GB2471729A (en) * | 2009-07-08 | 2011-01-12 | Univ Greenwich | 1,2,4-triazine derivatives and their use as sodium channel blockers |
| EP3307273B1 (en) * | 2015-06-12 | 2020-12-09 | University of Greenwich | Triazine derivatives as interferon-gamma inhibitors |
| GB202006076D0 (en) * | 2020-04-24 | 2020-06-10 | Univ Greenwich | Interleukin inhibitors |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK153787C (da) | 1979-06-01 | 1989-01-16 | Wellcome Found | Analogifremgangsmaade til fremstilling af substituerede 3,5-diamino-6-phenyl-1,2,4-triaziner og alfa-cyanobenzyliden-aminoguanidinforbindelser til anvendelse som mellemprodukter herved |
| GB8328757D0 (en) * | 1983-10-27 | 1983-11-30 | Wellcome Found | Chemical compounds |
| HU225667B1 (en) | 2002-09-20 | 2007-05-29 | Richter Gedeon Nyrt | Method for producing high-purity 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine |
| GB0613836D0 (en) * | 2006-07-13 | 2006-08-23 | Univ Greenwich | New medical use of triazine derivatives |
| GB0800741D0 (en) * | 2008-01-16 | 2008-02-20 | Univ Greenwich | Cyclic triazo and diazo sodium channel blockers |
| GB2471713A (en) * | 2009-07-08 | 2011-01-12 | Univ Greenwich | 1,2,4-triazine derivatives and their use as sodium channel blockers |
| GB2471729A (en) * | 2009-07-08 | 2011-01-12 | Univ Greenwich | 1,2,4-triazine derivatives and their use as sodium channel blockers |
-
2009
- 2009-07-15 GB GB0912271A patent/GB2471729A/en not_active Withdrawn
-
2010
- 2010-07-08 IN IN870DEN2012 patent/IN2012DN00870A/en unknown
- 2010-07-08 CN CN201080030908.7A patent/CN102596942B/zh not_active Expired - Fee Related
- 2010-07-08 KR KR1020127002939A patent/KR101776346B1/ko not_active Expired - Fee Related
- 2010-07-08 ES ES10732407.1T patent/ES2573506T3/es active Active
- 2010-07-08 JP JP2012519065A patent/JP5731496B2/ja not_active Expired - Fee Related
- 2010-07-08 CA CA2767296A patent/CA2767296C/en not_active Expired - Fee Related
- 2010-07-08 WO PCT/GB2010/051126 patent/WO2011004195A2/en not_active Ceased
- 2010-07-08 AU AU2010269981A patent/AU2010269981B2/en not_active Ceased
- 2010-07-08 EP EP10732407.1A patent/EP2451806B1/en not_active Not-in-force
- 2010-07-08 US US13/382,720 patent/US8748599B2/en active Active
-
2012
- 2012-01-02 IL IL217331A patent/IL217331A/en not_active IP Right Cessation
-
2014
- 2014-04-30 US US14/266,398 patent/US9000155B2/en not_active Expired - Fee Related
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