JP2012532624A5 - - Google Patents
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- JP2012532624A5 JP2012532624A5 JP2012520100A JP2012520100A JP2012532624A5 JP 2012532624 A5 JP2012532624 A5 JP 2012532624A5 JP 2012520100 A JP2012520100 A JP 2012520100A JP 2012520100 A JP2012520100 A JP 2012520100A JP 2012532624 A5 JP2012532624 A5 JP 2012532624A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- itnk
- cell
- pro
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004027 cell Anatomy 0.000 claims 22
- 210000001744 T-lymphocyte Anatomy 0.000 claims 21
- 230000014509 gene expression Effects 0.000 claims 6
- 101150106964 Bcl11b gene Proteins 0.000 claims 5
- 101100493744 Mus musculus Bcl11b gene Proteins 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- -1 IL2Rβ Proteins 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 230000002265 prevention Effects 0.000 claims 4
- 238000012217 deletion Methods 0.000 claims 3
- 230000037430 deletion Effects 0.000 claims 3
- 210000000822 natural killer cell Anatomy 0.000 claims 3
- 238000011282 treatment Methods 0.000 claims 3
- 208000036142 Viral infection Diseases 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 239000003443 antiviral agent Substances 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 210000000130 stem cell Anatomy 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 230000009385 viral infection Effects 0.000 claims 2
- 102100026210 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 Human genes 0.000 claims 1
- 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 claims 1
- 210000003967 CLP Anatomy 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 101150092640 HES1 gene Proteins 0.000 claims 1
- 101150003775 HNF1A gene Proteins 0.000 claims 1
- 101000691589 Homo sapiens 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 Proteins 0.000 claims 1
- 101001043809 Homo sapiens Interleukin-7 receptor subunit alpha Proteins 0.000 claims 1
- 101000764535 Homo sapiens Lymphotoxin-alpha Proteins 0.000 claims 1
- 101001109501 Homo sapiens NKG2-D type II integral membrane protein Proteins 0.000 claims 1
- 101000971513 Homo sapiens Natural killer cells antigen CD94 Proteins 0.000 claims 1
- 101000979599 Homo sapiens Protein NKG7 Proteins 0.000 claims 1
- 101000713602 Homo sapiens T-box transcription factor TBX21 Proteins 0.000 claims 1
- 101000997835 Homo sapiens Tyrosine-protein kinase JAK1 Proteins 0.000 claims 1
- 101000760175 Homo sapiens Zinc finger protein 35 Proteins 0.000 claims 1
- 101150111463 ID2 gene Proteins 0.000 claims 1
- 102000008070 Interferon-gamma Human genes 0.000 claims 1
- 108010074328 Interferon-gamma Proteins 0.000 claims 1
- 102100021593 Interleukin-7 receptor subunit alpha Human genes 0.000 claims 1
- 101150069255 KLRC1 gene Proteins 0.000 claims 1
- 101001089108 Lotus tetragonolobus Anti-H(O) lectin Proteins 0.000 claims 1
- 101100404845 Macaca mulatta NKG2A gene Proteins 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 101100013967 Mus musculus Gata3 gene Proteins 0.000 claims 1
- 101001049180 Mus musculus Killer cell lectin-like receptor subfamily B member 1C Proteins 0.000 claims 1
- 101100181101 Mus musculus Klra3 gene Proteins 0.000 claims 1
- 101100537555 Mus musculus Tnfrsf9 gene Proteins 0.000 claims 1
- 101100369993 Mus musculus Tnfsf10 gene Proteins 0.000 claims 1
- 102100022682 NKG2-A/NKG2-B type II integral membrane protein Human genes 0.000 claims 1
- 102100022680 NKG2-D type II integral membrane protein Human genes 0.000 claims 1
- 108010004217 Natural Cytotoxicity Triggering Receptor 1 Proteins 0.000 claims 1
- 102100032870 Natural cytotoxicity triggering receptor 1 Human genes 0.000 claims 1
- 102100021462 Natural killer cells antigen CD94 Human genes 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 102000001759 Notch1 Receptor Human genes 0.000 claims 1
- 108010029755 Notch1 Receptor Proteins 0.000 claims 1
- 108010056995 Perforin Proteins 0.000 claims 1
- KHGNFPUMBJSZSM-UHFFFAOYSA-N Perforine Natural products COC1=C2CCC(O)C(CCC(C)(C)O)(OC)C2=NC2=C1C=CO2 KHGNFPUMBJSZSM-UHFFFAOYSA-N 0.000 claims 1
- 102100023370 Protein NKG7 Human genes 0.000 claims 1
- 102100036840 T-box transcription factor TBX21 Human genes 0.000 claims 1
- 102100033438 Tyrosine-protein kinase JAK1 Human genes 0.000 claims 1
- 102100024672 Zinc finger protein 35 Human genes 0.000 claims 1
- 230000000840 anti-viral effect Effects 0.000 claims 1
- 238000011319 anticancer therapy Methods 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000022534 cell killing Effects 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 229960003130 interferon gamma Drugs 0.000 claims 1
- 210000003810 lymphokine-activated killer cell Anatomy 0.000 claims 1
- 238000011275 oncology therapy Methods 0.000 claims 1
- 229930192851 perforin Natural products 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000008707 rearrangement Effects 0.000 claims 1
- 210000002536 stromal cell Anatomy 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22577909P | 2009-07-15 | 2009-07-15 | |
| GB0912287.0 | 2009-07-15 | ||
| US61/225,779 | 2009-07-15 | ||
| GB0912287A GB0912287D0 (en) | 2009-07-15 | 2009-07-15 | Cells, compositions and methods |
| GB1006649.6 | 2010-04-21 | ||
| GBGB1006649.6A GB201006649D0 (en) | 2010-04-21 | 2010-04-21 | Cells, compositions and methods |
| PCT/GB2010/051158 WO2011007176A1 (en) | 2009-07-15 | 2010-07-15 | Cells, compositions and methods |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012532624A JP2012532624A (ja) | 2012-12-20 |
| JP2012532624A5 true JP2012532624A5 (https=) | 2013-09-05 |
Family
ID=43448979
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012520100A Pending JP2012532624A (ja) | 2009-07-15 | 2010-07-15 | 細胞、組成物および方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20120288484A1 (https=) |
| EP (1) | EP2454361A1 (https=) |
| JP (1) | JP2012532624A (https=) |
| WO (1) | WO2011007176A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103409466B (zh) * | 2013-05-27 | 2015-01-21 | 中国科学院广州生物医药与健康研究院 | 一种使bcl11b蛋白降解的方法 |
| US20190185852A1 (en) * | 2016-05-05 | 2019-06-20 | M. Mahmood Hussain | Therapeutically modulating apob and apoai |
| CN112574952B (zh) * | 2019-09-30 | 2025-04-15 | 英基生物医药(香港)有限公司 | 一种工程化人体免疫细胞、其制备方法及应用 |
| NZ789406A (en) * | 2019-12-27 | 2026-03-27 | Zhaotai Immugene Biomedicine Hong Kong Ltd | Engineered immune killer cell, preparation method therefor and use thereof |
| CN111607569A (zh) * | 2020-06-01 | 2020-09-01 | 广东昭泰体内生物医药科技有限公司 | 一种基于CRISPR/Cas9重编程ITNK细胞的方法 |
| CN111849919A (zh) * | 2020-07-24 | 2020-10-30 | 英基生物医药(香港)有限公司 | 一种具有抗病毒活性的工程化免疫细胞及其构建方法和应用 |
| US20240261402A1 (en) * | 2021-05-13 | 2024-08-08 | Memorial Sloan Kettering Cancer Center | Nkg2c+ t cells and methods of use thereof |
| KR102604208B1 (ko) * | 2021-09-10 | 2023-11-23 | 한국생명공학연구원 | 유도 자연살해세포의 제조방법 및 그의 용도 |
| CN119909172B (zh) * | 2025-01-15 | 2026-03-13 | 华中科技大学同济医学院附属协和医院 | 过表达slc29a1用于增强t细胞内外活性的应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7396681B1 (en) * | 1998-03-27 | 2008-07-08 | Gabriele Multhoff | Application of Hsp70 proteins |
| JP2005320309A (ja) * | 2004-05-02 | 2005-11-17 | Hokkaido Technology Licence Office Co Ltd | 癌抗原非特異的な標的化ｔ細胞の製造方法及び医薬 |
-
2010
- 2010-07-15 US US13/384,081 patent/US20120288484A1/en not_active Abandoned
- 2010-07-15 WO PCT/GB2010/051158 patent/WO2011007176A1/en not_active Ceased
- 2010-07-15 EP EP10735072A patent/EP2454361A1/en not_active Withdrawn
- 2010-07-15 JP JP2012520100A patent/JP2012532624A/ja active Pending
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