JP2012530765A5 - - Google Patents
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- Publication number
- JP2012530765A5 JP2012530765A5 JP2012516757A JP2012516757A JP2012530765A5 JP 2012530765 A5 JP2012530765 A5 JP 2012530765A5 JP 2012516757 A JP2012516757 A JP 2012516757A JP 2012516757 A JP2012516757 A JP 2012516757A JP 2012530765 A5 JP2012530765 A5 JP 2012530765A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- phenyl
- unsubstituted
- alkoxy
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 C 1 -C 6 -alkoxy Chemical group 0.000 claims 50
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 44
- 229910052736 halogen Inorganic materials 0.000 claims 29
- 125000001424 substituent group Chemical group 0.000 claims 28
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 28
- 150000002367 halogens Chemical class 0.000 claims 19
- 150000001875 compounds Chemical class 0.000 claims 18
- 239000008194 pharmaceutical composition Substances 0.000 claims 14
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 12
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 12
- 229910052760 oxygen Inorganic materials 0.000 claims 12
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 11
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 11
- 229910052739 hydrogen Inorganic materials 0.000 claims 11
- 239000001257 hydrogen Substances 0.000 claims 11
- 125000001041 indolyl group Chemical group 0.000 claims 11
- 125000003682 3-furyl group Chemical group O1C([H])=C([*])C([H])=C1[H] 0.000 claims 8
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 claims 8
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 claims 8
- RWRDLPDLKQPQOW-UHFFFAOYSA-N pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 8
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 7
- 125000004076 pyridyl group Chemical group 0.000 claims 7
- 229910052717 sulfur Inorganic materials 0.000 claims 7
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 claims 6
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 6
- 229910052757 nitrogen Inorganic materials 0.000 claims 6
- 125000006559 (C1-C3) alkylamino group Chemical group 0.000 claims 5
- 150000002431 hydrogen Chemical class 0.000 claims 5
- YNAVUWVOSKDBBP-UHFFFAOYSA-N morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 4
- 229940113083 morpholine Drugs 0.000 claims 4
- 125000004433 nitrogen atoms Chemical group N* 0.000 claims 4
- NQRYJNQNLNOLGT-UHFFFAOYSA-N piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 4
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 3
- 125000004455 (C1-C3) alkylthio group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000006597 (C1-C3) alkylcarbonylamino group Chemical group 0.000 claims 1
- UJDLUMCNDPKJME-JZWPEALZSA-N 1-[(3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3-[4-(3-methylbutoxy)phenyl]thiourea Chemical compound C1=CC(OCCC(C)C)=CC=C1NC(=S)NC1[C@@H](O)[C@H](O)[C@@H](CO)O1 UJDLUMCNDPKJME-JZWPEALZSA-N 0.000 claims 1
- AEOCXXJPGCBFJA-UHFFFAOYSA-N Ethionamide Chemical compound CCC1=CC(C(N)=S)=CC=N1 AEOCXXJPGCBFJA-UHFFFAOYSA-N 0.000 claims 1
- SRVJKTDHMYAMHA-WUXMJOGZSA-N Thioacetazone Chemical compound CC(=O)NC1=CC=C(\C=N\NC(N)=S)C=C1 SRVJKTDHMYAMHA-WUXMJOGZSA-N 0.000 claims 1
- BWBONKHPVHMQHE-UHFFFAOYSA-N Thiocarlide Chemical group C1=CC(OCCC(C)C)=CC=C1NC(=S)NC1=CC=C(OCCC(C)C)C=C1 BWBONKHPVHMQHE-UHFFFAOYSA-N 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 229960002001 ethionamide Drugs 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 125000006301 indolyl methyl group Chemical group 0.000 claims 1
- 229960003231 thioacetazone Drugs 0.000 claims 1
- 229960002171 tiocarlide Drugs 0.000 claims 1
- 201000008827 tuberculosis Diseases 0.000 claims 1
- 0 ****C(*=C)=N Chemical compound ****C(*=C)=N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09163765.2 | 2009-06-25 | ||
| EP09163765 | 2009-06-25 | ||
| PCT/EP2010/059044 WO2010149761A1 (en) | 2009-06-25 | 2010-06-25 | Composition for treatment of tuberculosis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012530765A JP2012530765A (ja) | 2012-12-06 |
| JP2012530765A5 true JP2012530765A5 (US07981874-20110719-C00313.png) | 2013-08-08 |
| JP5685247B2 JP5685247B2 (ja) | 2015-03-18 |
Family
ID=41128169
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012516757A Active JP5685247B2 (ja) | 2009-06-25 | 2010-06-25 | 結核を処置するための組成物 |
Country Status (6)
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3000064A1 (fr) | 2012-12-21 | 2014-06-27 | Univ Lille Ii Droit & Sante | Composes de type spiroisoxazoline ayant une activite potentialisatrice de l'activite d'un antibiotique-composition et produit pharmaceutiques comprenant de tels composes |
| FR3000065A1 (fr) | 2012-12-21 | 2014-06-27 | Univ Lille Ii Droit & Sante | Composes bicycliques ayant une activite potentialisatrice de l'activite d'un antibiotique actif contre les mycobacteries-composition et produit pharmaceutiques comprenant de tels composes |
| WO2014107622A1 (en) | 2013-01-07 | 2014-07-10 | University Of Southern California | Deoxyuridine triphosphatase inhibitors |
| MA40759A (fr) | 2014-09-26 | 2017-08-01 | Pfizer | Modulateurs de rorc2 de type pyrrolopyridine substitué par un méthyle et trifluorométhyle et leurs procédés d'utilisation |
| US10544105B2 (en) | 2015-07-08 | 2020-01-28 | Cv6 Therapeutics (Ni) Limited | Deoxyuridine triphosphatase inhibitors containing cyclopropano linkage |
| WO2017006271A1 (en) | 2015-07-08 | 2017-01-12 | University Of Southern California | Deoxyuridine triphosphatase inhibitors containing amino sulfonyl linkage |
| US10577321B2 (en) | 2015-07-08 | 2020-03-03 | University Of Southern California | Deoxyuridine triphosphatase inhibitors |
| EP3319939A1 (en) | 2015-07-08 | 2018-05-16 | CV6 Therapeutics (NI) Limited | Hydantoin containing deoxyuridine triphosphatase inhibitors |
| US10829457B2 (en) | 2016-11-23 | 2020-11-10 | Cv6 Therapeutics (Ni) Limited | Nitrogen ring linked deoxyuridine triphosphatase inhibitors |
| US11168059B2 (en) | 2016-11-23 | 2021-11-09 | Cv6 Therapeutics (Ni) Limited | Amino sulfonyl compounds |
| WO2018098207A1 (en) | 2016-11-23 | 2018-05-31 | Cv6 Therapeutics (Ni) Limited | Hydantoin containing deoxyuridine triphosphatase inhibitors |
| US11174271B2 (en) | 2016-11-23 | 2021-11-16 | Cv6 Therapeutics (Ni) Limited | 6-membered uracil isosteres |
| WO2018098206A1 (en) | 2016-11-23 | 2018-05-31 | Cv6 Therapeutics (Ni) Limited | Hydantoin containing deoxyuridine triphosphatase inhibitors |
| US11247984B2 (en) | 2017-01-05 | 2022-02-15 | Cv6 Therapeutics (Ni) Limited | Uracil containing compounds |
| CN108624641A (zh) * | 2018-04-10 | 2018-10-09 | 佛山科学技术学院 | 一种通过合成生物学制备乙硫异烟胺烟酰胺腺嘌呤二核苷酸的方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB872448A (en) * | 1958-12-23 | 1961-07-12 | Lepetit Spa | 1-acyl-3 substituted azetidines |
| GB872488A (en) | 1959-01-19 | 1961-07-12 | Nat Res Dev | Improvements in or relating to voltage-measuring circuits |
| DE4127111A1 (de) | 1990-08-24 | 1992-02-27 | Basf Ag | Verfahren zur herstellung von 3-pyrrolin-2-onen |
| US6372752B1 (en) | 2000-02-07 | 2002-04-16 | Genzyme Corporation | Inha inhibitors and methods of use thereof |
| CN101001836B (zh) * | 2004-05-07 | 2010-12-22 | 詹森药业有限公司 | 作为11-β羟基类固醇脱氢酶抑制剂的吡咯烷-2-酮和哌啶-2-酮衍生物 |
| FR2903405B1 (fr) * | 2006-07-04 | 2011-09-09 | Pasteur Institut | Composes a effet potentialisateur de l'activite de l'ethionamide et leurs applications |
| EP2234643B1 (en) | 2007-12-21 | 2013-01-09 | ETH Zurich | Composition for treatment of tuberculosis |
| DE102007062691A1 (de) | 2007-12-21 | 2009-06-25 | Beiersdorf Ag | Wirkstoffkombinationen aus Anisfruchtextrakt und einem oder mehreren 2,3-Dibenzylbutyrolactonen |
| AU2008345225A1 (en) * | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
-
2010
- 2010-06-25 JP JP2012516757A patent/JP5685247B2/ja active Active
- 2010-06-25 WO PCT/EP2010/059044 patent/WO2010149761A1/en active Application Filing
- 2010-06-25 CN CN201080028995.2A patent/CN102458393B/zh active Active
- 2010-06-25 EP EP10726108A patent/EP2445495A1/en not_active Withdrawn
- 2010-06-25 US US13/380,597 patent/US8912329B2/en active Active
-
2012
- 2012-07-19 HK HK12107097.3A patent/HK1166280A1/xx unknown
