JP2012528824A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012528824A5 JP2012528824A5 JP2012513590A JP2012513590A JP2012528824A5 JP 2012528824 A5 JP2012528824 A5 JP 2012528824A5 JP 2012513590 A JP2012513590 A JP 2012513590A JP 2012513590 A JP2012513590 A JP 2012513590A JP 2012528824 A5 JP2012528824 A5 JP 2012528824A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- benzamide
- phenyl
- compound
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- KXDAEFPNCMNJSK-UHFFFAOYSA-N benzene carboxamide Natural products NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 7
- -1 4-methylpiperazin-1-ylmethyl Chemical group 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 208000010412 Glaucoma Diseases 0.000 claims 4
- 206010019233 Headaches Diseases 0.000 claims 4
- 201000006792 Lennox-Gastaut syndrome Diseases 0.000 claims 4
- 208000008589 Obesity Diseases 0.000 claims 4
- 102000001708 Protein Isoforms Human genes 0.000 claims 4
- 108010029485 Protein Isoforms Proteins 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 208000035475 disorder Diseases 0.000 claims 4
- 206010015037 epilepsy Diseases 0.000 claims 4
- 231100000869 headache Toxicity 0.000 claims 4
- 230000001404 mediated effect Effects 0.000 claims 4
- 235000020824 obesity Nutrition 0.000 claims 4
- 206010020772 Hypertension Diseases 0.000 claims 3
- KPCZJLGGXRGYIE-UHFFFAOYSA-N [C]1=CC=CN=C1 Chemical group [C]1=CC=CN=C1 KPCZJLGGXRGYIE-UHFFFAOYSA-N 0.000 claims 3
- 208000008445 altitude sickness Diseases 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 201000001119 neuropathy Diseases 0.000 claims 3
- 230000007823 neuropathy Effects 0.000 claims 3
- 208000033808 peripheral neuropathy Diseases 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 3
- 102000003846 Carbonic anhydrases Human genes 0.000 claims 1
- 108090000209 Carbonic anhydrases Proteins 0.000 claims 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 1
- 208000012902 Nervous system disease Diseases 0.000 claims 1
- 208000025966 Neurological disease Diseases 0.000 claims 1
- 206010030043 Ocular hypertension Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- DKAGJZJALZXOOV-UHFFFAOYSA-N hydrate;hydrochloride Chemical compound O.Cl DKAGJZJALZXOOV-UHFFFAOYSA-N 0.000 claims 1
- XLSZMDLNRCVEIJ-UHFFFAOYSA-N methylimidazole Natural products CC1=CNC=N1 XLSZMDLNRCVEIJ-UHFFFAOYSA-N 0.000 claims 1
- HHZIURLSWUIHRB-UHFFFAOYSA-N nilotinib Chemical compound C1=NC(C)=CN1C1=CC(NC(=O)C=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)=CC(C(F)(F)F)=C1 HHZIURLSWUIHRB-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09161720.9 | 2009-06-02 | ||
| EP09161720 | 2009-06-02 | ||
| PCT/EP2010/057598 WO2010139678A1 (en) | 2009-06-02 | 2010-06-01 | Treatment of mammalian disorders mediated by alpha-carbonic anhydrase isoforms |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015189993A Division JP2016020375A (ja) | 2009-06-02 | 2015-09-28 | アルファ−炭酸脱水酵素アイソフォームにより媒介される哺乳動物の障害の処置 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012528824A JP2012528824A (ja) | 2012-11-15 |
| JP2012528824A5 true JP2012528824A5 (cg-RX-API-DMAC7.html) | 2013-07-18 |
Family
ID=40902237
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012513590A Withdrawn JP2012528824A (ja) | 2009-06-02 | 2010-06-01 | アルファ−炭酸脱水酵素アイソフォームにより媒介される哺乳動物の障害の処置 |
| JP2015189993A Ceased JP2016020375A (ja) | 2009-06-02 | 2015-09-28 | アルファ−炭酸脱水酵素アイソフォームにより媒介される哺乳動物の障害の処置 |
| JP2017146753A Withdrawn JP2017203037A (ja) | 2009-06-02 | 2017-07-28 | アルファ−炭酸脱水酵素アイソフォームにより媒介される哺乳動物の障害の処置 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015189993A Ceased JP2016020375A (ja) | 2009-06-02 | 2015-09-28 | アルファ−炭酸脱水酵素アイソフォームにより媒介される哺乳動物の障害の処置 |
| JP2017146753A Withdrawn JP2017203037A (ja) | 2009-06-02 | 2017-07-28 | アルファ−炭酸脱水酵素アイソフォームにより媒介される哺乳動物の障害の処置 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9623025B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2437745B1 (cg-RX-API-DMAC7.html) |
| JP (3) | JP2012528824A (cg-RX-API-DMAC7.html) |
| TW (2) | TW201102068A (cg-RX-API-DMAC7.html) |
| WO (2) | WO2010141427A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101386697B1 (ko) * | 2012-06-18 | 2014-04-18 | 아주대학교산학협력단 | 이매티닙 또는 이의 약학적으로 허용되는 염을 유효성분으로 포함하는 혈관 투과성 관련 질환의 치료 또는 예방용 조성물 |
| KR101778004B1 (ko) * | 2015-06-22 | 2017-09-15 | (주) 에빅스젠 | 이마티닙을 유효성분으로 포함하는 안구 건조 질환 예방 및 치료용 약학 조성물 |
| US11439869B2 (en) | 2017-05-19 | 2022-09-13 | Trudell Medical International | Positive expiratory pressure device |
| USD874064S1 (en) | 2018-05-18 | 2020-01-28 | Trudell Medical International | Mask |
| USD903097S1 (en) | 2018-05-18 | 2020-11-24 | Trudell Medical International | Mask |
| CN115569137A (zh) | 2018-06-15 | 2023-01-06 | 汉达癌症医药责任有限公司 | 激酶抑制剂的盐类及其组合物 |
| USD893806S1 (en) | 2018-11-09 | 2020-08-18 | Trudell Medical Internationl | Mask and shroud |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW225528B (cg-RX-API-DMAC7.html) | 1992-04-03 | 1994-06-21 | Ciba Geigy Ag | |
| US5521184A (en) | 1992-04-03 | 1996-05-28 | Ciba-Geigy Corporation | Pyrimidine derivatives and processes for the preparation thereof |
| US5798380A (en) * | 1996-02-21 | 1998-08-25 | Wisconsin Alumni Research Foundation | Cytoskeletal active agents for glaucoma therapy |
| CO4940418A1 (es) * | 1997-07-18 | 2000-07-24 | Novartis Ag | Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso |
| WO2003072090A2 (en) | 2002-02-27 | 2003-09-04 | Ab Science | Use of tyrosine kinase inhibitors for treating cns disorders |
| GB0215676D0 (en) * | 2002-07-05 | 2002-08-14 | Novartis Ag | Organic compounds |
| WO2005107708A1 (en) * | 2004-04-30 | 2005-11-17 | Allergan, Inc. | Biodegradable intravitreal tyrosine kinase inhibitors implants |
| RU2430727C2 (ru) * | 2005-06-03 | 2011-10-10 | Новартис Аг | Комбинация производных пиримидиламинобензамида и иматиниба для лечения или профилактики пролиферативных заболеваний |
| GT200600316A (es) | 2005-07-20 | 2007-04-02 | Sales de 4-metilo-n-(3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo)-3-(4-piridina-3-ilo-pirimidina-2-iloamino)- benzamida. | |
| GT200600315A (es) | 2005-07-20 | 2007-03-19 | Formas cristalinas de 4-metilo-n-[3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo]-3-(4-pyridina-3-ilo-pirimidina-2-iloamino)-benzamida | |
| EA019595B1 (ru) * | 2007-04-17 | 2014-04-30 | Имклоун Элэлси | СПЕЦИФИЧНЫЕ ИНГИБИТОРЫ PDGFRβ |
| PE20090368A1 (es) * | 2007-06-19 | 2009-04-28 | Boehringer Ingelheim Int | Anticuerpos anti-igf |
| JP6623812B2 (ja) * | 2016-02-17 | 2019-12-25 | セイコーエプソン株式会社 | 位置検出装置、及び、そのコントラスト調整方法 |
-
2010
- 2010-05-31 TW TW099117452A patent/TW201102068A/zh unknown
- 2010-06-01 WO PCT/US2010/036836 patent/WO2010141427A1/en not_active Ceased
- 2010-06-01 EP EP10722356.2A patent/EP2437745B1/en not_active Not-in-force
- 2010-06-01 TW TW099117619A patent/TWI565466B/zh not_active IP Right Cessation
- 2010-06-01 WO PCT/EP2010/057598 patent/WO2010139678A1/en not_active Ceased
- 2010-06-01 JP JP2012513590A patent/JP2012528824A/ja not_active Withdrawn
- 2010-06-01 US US13/375,946 patent/US9623025B2/en not_active Expired - Fee Related
-
2015
- 2015-09-28 JP JP2015189993A patent/JP2016020375A/ja not_active Ceased
-
2017
- 2017-07-28 JP JP2017146753A patent/JP2017203037A/ja not_active Withdrawn