JP2012527487A5 - - Google Patents
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- Publication number
- JP2012527487A5 JP2012527487A5 JP2012512188A JP2012512188A JP2012527487A5 JP 2012527487 A5 JP2012527487 A5 JP 2012527487A5 JP 2012512188 A JP2012512188 A JP 2012512188A JP 2012512188 A JP2012512188 A JP 2012512188A JP 2012527487 A5 JP2012527487 A5 JP 2012527487A5
- Authority
- JP
- Japan
- Prior art keywords
- trifluoromethyl
- compound
- group
- phenyl
- pyridin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910043501 | 2009-05-25 | ||
| CN200910043501.7 | 2009-05-25 | ||
| PCT/CN2010/073105 WO2010135972A1 (zh) | 2009-05-25 | 2010-05-24 | 1-(取代芳基)-5-三氟甲基-2-（1h）吡啶酮化合物及其盐的制备方法及其用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012527487A JP2012527487A (ja) | 2012-11-08 |
| JP2012527487A5 true JP2012527487A5 (https=) | 2013-07-11 |
| JP5583758B2 JP5583758B2 (ja) | 2014-09-03 |
Family
ID=43222160
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012512188A Expired - Fee Related JP5583758B2 (ja) | 2009-05-25 | 2010-05-24 | １−（置換アリール）−５−トリフルオロメチル−２−（１ｈ）ピリドン化合物及びその塩、並びにその製造方法及びその用途 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8426407B2 (https=) |
| EP (1) | EP2436670B1 (https=) |
| JP (1) | JP5583758B2 (https=) |
| KR (1) | KR101522924B1 (https=) |
| CN (1) | CN102149682B (https=) |
| AU (1) | AU2010252447B2 (https=) |
| WO (1) | WO2010135972A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5587184B2 (ja) | 2007-06-20 | 2014-09-10 | オースペックス・ファーマシューティカルズ・インコーポレイテッド | 繊維症阻害剤としての置換ｎ−アリールピリジノン |
| US9434695B2 (en) | 2012-07-18 | 2016-09-06 | Sunshine Lake Pharma Co., Ltd | Nitrogenous heterocyclic derivatives and their application in drugs |
| CN102786467A (zh) * | 2012-08-15 | 2012-11-21 | 浙江省医学科学院 | 一种n-取代芳基吡啶酮化合物及其制备方法和应用 |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| ES2663806T3 (es) | 2013-12-19 | 2018-04-17 | unshine Lake Pharma Co., Ltd. | Derivados heterocíclicos nitrogenados y su aplicación en el tratamiento de la fibrosis tisular |
| MX382781B (es) | 2014-04-02 | 2025-03-13 | Intermune Inc | Piridinonas anti-fibroticas. |
| WO2015171345A1 (en) * | 2014-04-30 | 2015-11-12 | Auspex Pharmaceuticals, Inc. | N-aryl pyridinones modulators of fibrosis and/or collagen infiltration |
| CN106466318B (zh) * | 2015-08-21 | 2019-01-01 | 中南大学 | 1-杂环取代苄基吡啶酮类化合物在制备治疗糖尿病肾病药物中的应用 |
| CN113476447A (zh) * | 2021-07-09 | 2021-10-08 | 中南大学 | 一种美氟尼酮在制备急性肝损伤药物中的应用 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4042699A (en) | 1972-12-18 | 1977-08-16 | Affiliated Medical Research, Inc. | Method for reducing serum glucose levels |
| US4052509A (en) | 1972-12-18 | 1977-10-04 | Affiliated Medical Research, Inc. | Method for reducing serum uric acid levels |
| US3839346A (en) | 1972-12-18 | 1974-10-01 | Affiliated Med Res | N-substituted pyridone and general method for preparing pyridones |
| GB8523126D0 (en) | 1985-09-19 | 1985-10-23 | Ici Plc | Aryl pyridones |
| GB8621217D0 (en) | 1986-09-03 | 1986-10-08 | Ici Plc | Chemical compounds |
| GB8825314D0 (en) | 1988-10-28 | 1988-11-30 | Ici Plc | Chemical compounds |
| GB9006479D0 (en) | 1989-04-17 | 1990-05-23 | Ici Plc | Novel compounds |
| US5716632A (en) | 1989-11-22 | 1998-02-10 | Margolin; Solomon B. | Compositions and methods for reparation and prevention of fibrotic lesions |
| US5310562A (en) | 1989-11-22 | 1994-05-10 | Margolin Solomon B | Composition and method for reparation and prevention of fibrotic lesions |
| US5518729A (en) | 1989-11-22 | 1996-05-21 | Margolin; Solomon B. | Compositions and methods for reparation and prevention of fibrotic lesions |
| US5238906A (en) | 1990-11-27 | 1993-08-24 | Sumitomo Chemical Company, Limited | Pyridone derivatives and use |
| DE4343528A1 (de) | 1993-12-16 | 1995-06-22 | Schering Ag | Zweifach heterocyclisch substituierte Benzole und Pyridine, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel |
| RS52392B (sr) | 2002-02-14 | 2013-02-28 | Pharmacia Corporation | Supstituisani piridinoni kao modulatori p38 map kinaze |
| CN1218942C (zh) * | 2002-06-11 | 2005-09-14 | 中南大学湘雅医学院 | 抗纤维化吡啶酮化合物及其生产工艺方法 |
| US7166603B2 (en) | 2003-07-23 | 2007-01-23 | Bristol-Myers Squibb Co. | Dihydropyrimidone inhibitors of calcium channel function |
| JP4614884B2 (ja) * | 2003-11-14 | 2011-01-19 | シャンハイ ゲノミックス インク | ピリドンの誘導体とその使用 |
| DE102004027359A1 (de) | 2004-06-04 | 2005-12-29 | Abbott Gmbh & Co. Kg | Pyridin-2-onverbindungen und deren Verwendung |
| ES2524922T3 (es) | 2005-05-10 | 2014-12-15 | Intermune, Inc. | Derivados de piridona para modular el sistema de proteína cinasa activada por estrés |
| ZA200709593B (en) | 2005-05-10 | 2009-06-24 | Intermune Inc | Pyridone derivatives for modulating stress-activated protein kinase system |
| WO2007053610A2 (en) | 2005-11-01 | 2007-05-10 | The Regents Of The University Of California | Methods of treating atrial fibrillation wtih pirfenidone |
| JP2009517390A (ja) | 2005-11-23 | 2009-04-30 | インターミューン インコーポレイテッド | ストレス活性化プロテインキナーゼ系を調節する方法 |
| CN101235030A (zh) * | 2007-01-30 | 2008-08-06 | 中南大学 | 1-取代-5-三氟甲基-2-(1h)吡啶酮化合物、制备方法及其用途 |
| US20090118135A1 (en) | 2007-06-08 | 2009-05-07 | The Burnham Institute | Methods and compounds for regulating apoptosis |
| CN101371833A (zh) | 2007-08-23 | 2009-02-25 | 中南大学 | 1-芳基-2(1h)-吡啶酮类化合物在制备治疗皮肤瘙痒药物中的应用 |
| CA2726588C (en) * | 2008-06-03 | 2019-04-16 | Karl Kossen | Compounds and methods for treating inflammatory and fibrotic disorders |
| AU2010206543A1 (en) | 2009-01-26 | 2011-07-07 | Intermune, Inc. | Methods for treating acute myocardial infarctions and associated disorders |
| WO2010135470A1 (en) | 2009-05-19 | 2010-11-25 | Intermune, Inc. | Pifenidone derivatives for treating bronchial asthma |
-
2010
- 2010-05-24 WO PCT/CN2010/073105 patent/WO2010135972A1/zh not_active Ceased
- 2010-05-24 JP JP2012512188A patent/JP5583758B2/ja not_active Expired - Fee Related
- 2010-05-24 KR KR1020117030518A patent/KR101522924B1/ko not_active Expired - Fee Related
- 2010-05-24 AU AU2010252447A patent/AU2010252447B2/en not_active Ceased
- 2010-05-24 US US13/322,152 patent/US8426407B2/en not_active Expired - Fee Related
- 2010-05-24 CN CN2010800025583A patent/CN102149682B/zh active Active
- 2010-05-24 EP EP10780053.4A patent/EP2436670B1/en not_active Not-in-force