JP2012526844A - Ｍｃｉおよびアルツハイマー病の処置 - Google Patents
Ｍｃｉおよびアルツハイマー病の処置 Download PDFInfo
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- nifedipine
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| US61/234,551 | 2009-08-17 | ||
| PCT/US2010/034721 WO2010132671A1 (en) | 2009-05-15 | 2010-05-13 | Treatment of mci and alzheimer's disease |
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| MX (1) | MX2011012015A (enExample) |
| WO (1) | WO2010132671A1 (enExample) |
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| US8067008B2 (en) | 2004-08-23 | 2011-11-29 | Yeda Research And Development Co. | Peptide inhibitors for mediating stress responses |
| CA2623638A1 (en) | 2005-09-30 | 2007-04-12 | Vitae Pharmaceuticals, Inc. | Treatment of cancer with specific rxr agonists |
| WO2012160563A2 (en) * | 2011-05-23 | 2012-11-29 | Yeda Research And Development Co. Ltd. | Use of akt phosphorylation as a biomarker for prognosing neurodegenerative diseases and treating same |
| EP2742155B1 (en) * | 2011-08-08 | 2018-01-24 | Advanced Genomic Technology LLC | Biomarker for alzheimer's disease and/or mild cognitively impairment |
| AU2012352149B2 (en) | 2011-12-13 | 2017-06-01 | Io Therapeutics, Inc. | Autoimmune disorder treatment using RXR agonists |
| US10653650B2 (en) | 2011-12-13 | 2020-05-19 | Io Therapeutics, Inc. | Treatment of diseases by concurrently eliciting remyelination effects and immunomodulatory effects using selective RXR agonists |
| SG11201408323RA (en) | 2012-06-15 | 2015-01-29 | Found Biomedical Res & Innov | Prophylactic and/or therapeutic agent for mild cognitive impairment |
| US8901305B2 (en) * | 2012-07-31 | 2014-12-02 | Bristol-Myers Squibb Company | Aryl lactam kinase inhibitors |
| US20150045353A1 (en) * | 2013-08-09 | 2015-02-12 | Neurogenetic Pharmaceuticals, Inc. | Formulations containing gamma secretase modulators, methods for preparation and delivery thereof |
| KR102489706B1 (ko) | 2015-10-31 | 2023-01-17 | 아이오 테라퓨틱스, 인크. | Rxr 아고니스트와 갑상선 호르몬의 조합을 사용한 신경계 질환의 치료 |
| EP3426303B1 (en) | 2016-03-10 | 2022-06-15 | IO Therapeutics, Inc. | Treatment of muscular disorders with combinations of rxr agonists and thyroid hormones |
| MX386643B (es) | 2016-03-10 | 2025-03-19 | Io Therapeutics Inc | Tratamiento contra enfermedades autoinmunitarias con combinaciones de agonistas rxr y hormonas tiroideas. |
| US11517549B2 (en) * | 2017-09-20 | 2022-12-06 | Io Therapeutics, Inc. | Treatment of disease with esters of selective RXR agonists |
| US10966950B2 (en) | 2019-06-11 | 2021-04-06 | Io Therapeutics, Inc. | Use of an RXR agonist in treating HER2+ cancers |
| KR20240119103A (ko) | 2021-12-07 | 2024-08-06 | 아이오 테라퓨틱스, 인크. | Her2+ 암 치료에서의 rxr 작용제 및 탁산의 용도 |
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| WO2006109164A2 (en) * | 2005-04-15 | 2006-10-19 | Research & Innovation Soc. Coop. A R.L. | A method for preventing, delaying or reverting abnormal amyloid deposition |
| JP2007091664A (ja) * | 2005-09-29 | 2007-04-12 | Univ Of Tokushima | 細胞膜保護剤 |
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| JP2009073759A (ja) * | 2007-09-20 | 2009-04-09 | Univ Of Tokushima | Ｉｃａｍ−１発現抑制剤 |
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2010
- 2010-05-13 AU AU2010249015A patent/AU2010249015A1/en not_active Abandoned
- 2010-05-13 WO PCT/US2010/034721 patent/WO2010132671A1/en not_active Ceased
- 2010-05-13 EP EP10775535A patent/EP2429992A4/en not_active Withdrawn
- 2010-05-13 CA CA2761298A patent/CA2761298A1/en not_active Abandoned
- 2010-05-13 US US12/779,345 patent/US20100292281A1/en not_active Abandoned
- 2010-05-13 MX MX2011012015A patent/MX2011012015A/es not_active Application Discontinuation
- 2010-05-13 JP JP2012511013A patent/JP2012526844A/ja active Pending
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Also Published As
| Publication number | Publication date |
|---|---|
| EP2429992A4 (en) | 2012-11-28 |
| EP2429992A1 (en) | 2012-03-21 |
| AU2010249015A1 (en) | 2011-11-24 |
| CA2761298A1 (en) | 2010-11-18 |
| WO2010132671A1 (en) | 2010-11-18 |
| US20100292281A1 (en) | 2010-11-18 |
| MX2011012015A (es) | 2012-04-30 |
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