JP2012526140A5 - - Google Patents

Info

Publication number

JP2012526140A5

JP2012526140A5 JP2012509968A JP2012509968A JP2012526140A5 JP 2012526140 A5 JP2012526140 A5 JP 2012526140A5 JP 2012509968 A JP2012509968 A JP 2012509968A JP 2012509968 A JP2012509968 A JP 2012509968A JP 2012526140 A5 JP2012526140 A5 JP 2012526140A5

Authority

JP

Japan

Prior art keywords

package

storage

less

pharmaceutical product

storage method

Prior art date

2010-05-06

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 238000000034 method Methods 0.000 claims description 47
• 239000000825 pharmaceutical preparation Substances 0.000 claims description 34
• 229940127557 pharmaceutical product Drugs 0.000 claims description 34
• 238000009472 formulation Methods 0.000 claims description 25
• 239000000203 mixture Substances 0.000 claims description 25
• 239000007787 solid Substances 0.000 claims description 23
• 239000002274 desiccant Substances 0.000 claims description 20
• 239000013543 active substance Substances 0.000 claims description 16
• 239000000546 pharmaceutical excipient Substances 0.000 claims description 16
• 238000002360 preparation method Methods 0.000 claims description 16
• 229920002774 Maltodextrin Polymers 0.000 claims description 8
• 239000005913 Maltodextrin Substances 0.000 claims description 8
• TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 8
• 229940035034 maltodextrin Drugs 0.000 claims description 8
• HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 8
• 238000004321 preservation Methods 0.000 claims description 8
• HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 8
• 229960002675 xylitol Drugs 0.000 claims description 8
• 235000010447 xylitol Nutrition 0.000 claims description 8
• 239000000811 xylitol Substances 0.000 claims description 8
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
• 238000009512 pharmaceutical packaging Methods 0.000 claims description 4
• RHWRWEUCEXUUAV-ZSESPEEFSA-N 2-[[(1r,2r,3as,9as)-2-hydroxy-1-[(3s)-3-hydroxyoctyl]-2,3,3a,4,9,9a-hexahydro-1h-cyclopenta[g]naphthalen-5-yl]oxy]acetic acid;2-(2-hydroxyethylamino)ethanol Chemical group OCCNCCO.C1=CC=C(OCC(O)=O)C2=C1C[C@@H]1[C@@H](CC[C@@H](O)CCCCC)[C@H](O)C[C@@H]1C2 RHWRWEUCEXUUAV-ZSESPEEFSA-N 0.000 claims 4
• 239000003814 drug Substances 0.000 claims 1
• 238000004806 packaging method and process Methods 0.000 claims 1
• PAJMKGZZBBTTOY-ZFORQUDYSA-N treprostinil Chemical compound C1=CC=C(OCC(O)=O)C2=C1C[C@@H]1[C@@H](CC[C@@H](O)CCCCC)[C@H](O)C[C@@H]1C2 PAJMKGZZBBTTOY-ZFORQUDYSA-N 0.000 description 20
• 229960005032 treprostinil Drugs 0.000 description 16
• 150000003839 salts Chemical class 0.000 description 12
• 229910019142 PO4 Inorganic materials 0.000 description 4
• 150000001413 amino acids Chemical class 0.000 description 4
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 4
• ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 4
• 150000002148 esters Chemical class 0.000 description 4
• -1 glycolamide ester Chemical class 0.000 description 4
• NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 4
• 239000010452 phosphate Substances 0.000 description 4
• 102000004169 proteins and genes Human genes 0.000 description 4
• 108090000623 proteins and genes Proteins 0.000 description 4
• 0 CCCCC[C@](*)CC[C@]1[C@](*)CC(C2)C1Cc1c2c(*)ccc1 Chemical compound CCCCC[C@](*)CC[C@]1[C@](*)CC(C2)C1Cc1c2c(*)ccc1 0.000 description 1