JP2012525335A5 - - Google Patents

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Publication number
JP2012525335A5
JP2012525335A5 JP2012507474A JP2012507474A JP2012525335A5 JP 2012525335 A5 JP2012525335 A5 JP 2012525335A5 JP 2012507474 A JP2012507474 A JP 2012507474A JP 2012507474 A JP2012507474 A JP 2012507474A JP 2012525335 A5 JP2012525335 A5 JP 2012525335A5
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JP
Japan
Prior art keywords
alkyl
piperazin
benzamide
pyridin
acetyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2012507474A
Other languages
English (en)
Japanese (ja)
Other versions
JP5741574B2 (ja
JP2012525335A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2010/032477 external-priority patent/WO2010126851A1/en
Publication of JP2012525335A publication Critical patent/JP2012525335A/ja
Publication of JP2012525335A5 publication Critical patent/JP2012525335A5/ja
Application granted granted Critical
Publication of JP5741574B2 publication Critical patent/JP5741574B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2012507474A 2009-04-27 2010-04-27 Ｃｘｃｒ３受容体アンタゴニスト Expired - Fee Related JP5741574B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US17286909P 2009-04-27 2009-04-27
US61/172,869 2009-04-27
US31735110P 2010-03-25 2010-03-25
US61/317,351 2010-03-25
PCT/US2010/032477 WO2010126851A1 (en) 2009-04-27 2010-04-27 Cxcr3 receptor antagonists

Publications (3)

Publication Number Publication Date
JP2012525335A JP2012525335A (ja) 2012-10-22
JP2012525335A5 true JP2012525335A5 (enExample) 2013-06-20
JP5741574B2 JP5741574B2 (ja) 2015-07-01

Family

ID=42272001

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012507474A Expired - Fee Related JP5741574B2 (ja) 2009-04-27 2010-04-27 Ｃｘｃｒ３受容体アンタゴニスト

Country Status (7)

Country Link
US (1) US8362249B2 (enExample)
EP (1) EP2424858B1 (enExample)
JP (1) JP5741574B2 (enExample)
AR (1) AR076460A1 (enExample)
TW (1) TW201103933A (enExample)
UY (1) UY32574A (enExample)
WO (1) WO2010126851A1 (enExample)

Families Citing this family (21)

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Publication number Priority date Publication date Assignee Title
AU2009289649B2 (en) 2008-09-03 2016-05-05 Biomarin Pharmaceutical Inc. Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors
JP5807971B2 (ja) * 2009-04-27 2015-11-10 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｘｃｒ３受容体アンタゴニスト
JP2011057661A (ja) * 2009-08-14 2011-03-24 Bayer Cropscience Ag 殺虫性カルボキサミド類
US8952004B2 (en) 2010-01-07 2015-02-10 Boehringer Ingelheim International Gmbh CXCR3 receptor antagonists
US8957066B2 (en) 2011-02-28 2015-02-17 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
US10059723B2 (en) 2011-02-28 2018-08-28 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
WO2012118782A1 (en) 2011-02-28 2012-09-07 Repligen Corporation Histone deacetylase inhibitors
EP2508511A1 (en) * 2011-04-07 2012-10-10 Laboratoire Biodim Inhibitors of viral replication, their process of preparation and their therapeutical uses
MX352181B (es) 2012-02-02 2017-11-13 Idorsia Pharmaceuticals Ltd Compuestos 4- (benzoimidazol-2-il) -tiazol y derivados aza relacionados.
RU2665554C2 (ru) 2013-03-15 2018-08-31 Байомарин Фармасьютикал Инк. Ингибиторы hdac
WO2014182688A1 (en) * 2013-05-07 2014-11-13 Arena Pharmaceuticals, Inc. Modulators of the g protein-coupled mas receptor and the treatment of disorders related thereto
WO2014182673A1 (en) * 2013-05-07 2014-11-13 Arena Pharmaceuticals, Inc. Modulators of the g protein-coupled mas receptor and the treatment of disorders related thereto
WO2015002926A1 (en) 2013-07-02 2015-01-08 Bristol-Myers Squibb Company Tricyclic pyrido-carboxamide derivatives as rock inhibitors
JP6434968B2 (ja) 2013-07-02 2018-12-05 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｒｏｃｋ阻害剤としての三環式ピリド−カルボキサミド誘導体
TR201807959T4 (tr) 2013-07-22 2018-06-21 Idorsia Pharmaceuticals Ltd 1-(Piperazın-1-il)-2- ([1,2,4] triazol-1-il)-etanon türevleri.
AR099789A1 (es) * 2014-03-24 2016-08-17 Actelion Pharmaceuticals Ltd Derivados de 8-(piperazin-1-il)-1,2,3,4-tetrahidro-isoquinolina
SG10201900631TA (en) * 2014-08-01 2019-02-27 Nuevolution As Compounds active towards bromodomains
TWI689497B (zh) * 2014-09-04 2020-04-01 南北兄弟藥業投資有限公司 芳雜環類衍生物及其在藥物中的應用
AR103399A1 (es) * 2015-01-15 2017-05-10 Actelion Pharmaceuticals Ltd Derivados de (r)-2-metil-piperazina como moduladores del receptor cxcr3
RS58349B1 (sr) 2015-01-15 2019-03-29 Idorsia Pharmaceuticals Ltd Hidroksialkil-piperazinski derivati kao modulatori cxcr3 receptora
KR20250119664A (ko) 2018-08-29 2025-08-07 아세르타 파마. 비.브이. 4-｛8-아미노-3-[(2S)-1-(부트-2-이노일)-피롤리딘-2-일]이미다조[1,5-a]-피라진-1-일｝N-(피리딘-2-일)-벤즈아미드의제조 공정

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050256130A1 (en) * 2002-06-12 2005-11-17 Chemocentryx, Inc. Substituted piperazines
DK1531822T3 (da) * 2002-06-12 2009-12-07 Chemocentryx Inc 1-aryl-4-substituerede piperazin derivater til anvendelse som CCR1 antagonister til behandlingen af inflammation og immunforstyrrelser
TW200505450A (en) * 2003-02-03 2005-02-16 Janssen Pharmaceutica Nv Quinoline-derived amide modulators of vanilloid VR1 receptor
US20070010523A1 (en) * 2005-06-22 2007-01-11 Chemocentryx, Inc. Azaindazole compounds and methods of use
EP1988900A2 (en) * 2006-02-23 2008-11-12 Merck & Co., Inc. Pyridine, pyrimidine and pyrazine derivatives as cxcr3 receptor modulators
JP5182088B2 (ja) * 2006-04-19 2013-04-10 アステラス製薬株式会社 アゾールカルボキサミド誘導体
JP5286646B2 (ja) * 2006-04-19 2013-09-11 トヨタ自動車株式会社 スルホン基含有モノマーの重合方法
US20090099201A1 (en) * 2007-05-22 2009-04-16 David Robert Bolin Diacylglycerol Acyltransferase Inhibitors
JO2972B1 (en) * 2007-06-08 2016-03-15 جانسين فارماسوتيكا ان. في Piperidine / piperazine derivatives
JP5807971B2 (ja) * 2009-04-27 2015-11-10 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｘｃｒ３受容体アンタゴニスト

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