JP2012525332A5 - - Google Patents

Download PDF

Info

Publication number
JP2012525332A5
JP2012525332A5 JP2012507460A JP2012507460A JP2012525332A5 JP 2012525332 A5 JP2012525332 A5 JP 2012525332A5 JP 2012507460 A JP2012507460 A JP 2012507460A JP 2012507460 A JP2012507460 A JP 2012507460A JP 2012525332 A5 JP2012525332 A5 JP 2012525332A5
Authority
JP
Japan
Prior art keywords
phenyl
piperazin
pyrimidin
pyrrolo
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2012507460A
Other languages
English (en)
Japanese (ja)
Other versions
JP5807971B2 (ja
JP2012525332A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2010/032347 external-priority patent/WO2010126811A1/en
Publication of JP2012525332A publication Critical patent/JP2012525332A/ja
Publication of JP2012525332A5 publication Critical patent/JP2012525332A5/ja
Application granted granted Critical
Publication of JP5807971B2 publication Critical patent/JP5807971B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2012507460A 2009-04-27 2010-04-26 Ｃｘｃｒ３受容体アンタゴニスト Expired - Fee Related JP5807971B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US17287309P 2009-04-27 2009-04-27
US61/172,873 2009-04-27
US31948210P 2010-03-31 2010-03-31
US61/319,482 2010-03-31
PCT/US2010/032347 WO2010126811A1 (en) 2009-04-27 2010-04-26 Cxcr3 receptor antagonists

Publications (3)

Publication Number Publication Date
JP2012525332A JP2012525332A (ja) 2012-10-22
JP2012525332A5 true JP2012525332A5 (enExample) 2013-06-20
JP5807971B2 JP5807971B2 (ja) 2015-11-10

Family

ID=42313117

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012507460A Expired - Fee Related JP5807971B2 (ja) 2009-04-27 2010-04-26 Ｃｘｃｒ３受容体アンタゴニスト

Country Status (4)

Country Link
US (1) US8450317B2 (enExample)
EP (1) EP2424840B1 (enExample)
JP (1) JP5807971B2 (enExample)
WO (1) WO2010126811A1 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009289649B2 (en) 2008-09-03 2016-05-05 Biomarin Pharmaceutical Inc. Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors
JP5807971B2 (ja) 2009-04-27 2015-11-10 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｘｃｒ３受容体アンタゴニスト
US8362249B2 (en) * 2009-04-27 2013-01-29 Boehringer Ingelheim International Gmbh CXCR3 receptor antagonists
JP2011057661A (ja) * 2009-08-14 2011-03-24 Bayer Cropscience Ag 殺虫性カルボキサミド類
US8952004B2 (en) 2010-01-07 2015-02-10 Boehringer Ingelheim International Gmbh CXCR3 receptor antagonists
WO2012118782A1 (en) 2011-02-28 2012-09-07 Repligen Corporation Histone deacetylase inhibitors
US8957066B2 (en) 2011-02-28 2015-02-17 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
US10059723B2 (en) 2011-02-28 2018-08-28 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
US8822464B2 (en) 2011-11-28 2014-09-02 Boehringer Ingelheim International Gmbh N-aryl-piperazine derivatives and their use as positive allosteric modulators of mGluR5 receptors
US8741892B2 (en) 2011-12-05 2014-06-03 Boehringer Ingelheim International Gmbh Compounds
US8642774B2 (en) 2011-12-08 2014-02-04 Boehringer Ingelheim International Gmbh Compounds
US8796467B2 (en) 2011-12-13 2014-08-05 Boehringer Ingelheim International Gmbh Compounds
US8846948B2 (en) * 2011-12-13 2014-09-30 Boehringer Ingelheim International Gmbh Compounds
US8883789B2 (en) 2011-12-14 2014-11-11 Boehringer Ingelheim International Gmbh Piperazine derivatives and their use as positive allosteric modulators of mGluR5 receptors
US8937176B2 (en) 2011-12-14 2015-01-20 Boehringer Ingelheim International Gmbh Compounds
US8716277B2 (en) 2011-12-14 2014-05-06 Boehringer Ingelheim International Gmbh Substituted imidazole compounds useful as positive allosteric modulators of mGlu5 receptor activity
US8889677B2 (en) 2012-01-17 2014-11-18 Boehringer Ingellheim International GmbH Substituted triazoles useful as mGlu5 receptor modulators
MX352181B (es) * 2012-02-02 2017-11-13 Idorsia Pharmaceuticals Ltd Compuestos 4- (benzoimidazol-2-il) -tiazol y derivados aza relacionados.
RU2665554C2 (ru) 2013-03-15 2018-08-31 Байомарин Фармасьютикал Инк. Ингибиторы hdac
TR201807959T4 (tr) * 2013-07-22 2018-06-21 Idorsia Pharmaceuticals Ltd 1-(Piperazın-1-il)-2- ([1,2,4] triazol-1-il)-etanon türevleri.
AR099789A1 (es) * 2014-03-24 2016-08-17 Actelion Pharmaceuticals Ltd Derivados de 8-(piperazin-1-il)-1,2,3,4-tetrahidro-isoquinolina
AR103399A1 (es) * 2015-01-15 2017-05-10 Actelion Pharmaceuticals Ltd Derivados de (r)-2-metil-piperazina como moduladores del receptor cxcr3
RS58349B1 (sr) 2015-01-15 2019-03-29 Idorsia Pharmaceuticals Ltd Hidroksialkil-piperazinski derivati kao modulatori cxcr3 receptora
WO2018011265A1 (en) 2016-07-13 2018-01-18 Idorsia Pharmaceuticals Ltd Hydroxyalkyl-piperazine derivatives as cxcr3 receptor modulators

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE230740T1 (de) * 1996-04-12 2003-01-15 Sumitomo Pharma Piperidinylpyrimidine derivate
US5948786A (en) * 1996-04-12 1999-09-07 Sumitomo Pharmaceuticals Company, Limited Piperidinylpyrimidine derivatives
TW200300686A (en) * 2001-11-30 2003-06-16 Schering Corp Adenosine A2a receptor antagonists
CA2483306A1 (en) 2002-04-23 2003-11-06 Shionogi & Co., Ltd. Pyrazolo[1,5-a]pyrimidine derivative and nad(p)h oxidase inhibitor containing the same
DK1531822T3 (da) * 2002-06-12 2009-12-07 Chemocentryx Inc 1-aryl-4-substituerede piperazin derivater til anvendelse som CCR1 antagonister til behandlingen af inflammation og immunforstyrrelser
TW200505450A (en) 2003-02-03 2005-02-16 Janssen Pharmaceutica Nv Quinoline-derived amide modulators of vanilloid VR1 receptor
US20070010523A1 (en) * 2005-06-22 2007-01-11 Chemocentryx, Inc. Azaindazole compounds and methods of use
US20080312215A1 (en) 2005-06-28 2008-12-18 Pharmacopeia Drug Discovery, Inc. Substituted [1,4]-diazepanes as CXCR3 antagonists and their use in the treatment of inflammatory disorders
US7790726B2 (en) * 2005-08-16 2010-09-07 Chemocentryx, Inc. Monocyclic and bicyclic compounds and methods of use
EP1988900A2 (en) * 2006-02-23 2008-11-12 Merck & Co., Inc. Pyridine, pyrimidine and pyrazine derivatives as cxcr3 receptor modulators
JP5182088B2 (ja) 2006-04-19 2013-04-10 アステラス製薬株式会社 アゾールカルボキサミド誘導体
US7807671B2 (en) * 2006-04-25 2010-10-05 Bristol-Myers Squibb Company Diketo-piperazine and piperidine derivatives as antiviral agents
EP2078003B1 (en) 2006-10-31 2017-03-08 Merck Sharp & Dohme Corp. Anilinopiperazine derivatives and methods of use thereof
US20090099201A1 (en) 2007-05-22 2009-04-16 David Robert Bolin Diacylglycerol Acyltransferase Inhibitors
JO2972B1 (en) 2007-06-08 2016-03-15 جانسين فارماسوتيكا ان. في Piperidine / piperazine derivatives
CA2709203A1 (en) * 2007-12-13 2009-06-18 Siena Biotech S.P.A. Hedgehog pathway antagonists and therapeutic applications thereof
PE20091576A1 (es) 2008-02-19 2009-11-05 Sanofi Aventis DERIVADOS DE 3-(AMIDO O SULFAMIDO)-4-(4-AZINIL SUSTITUIDO)BENZAMIDA COMO INHIBIDORES DEL RECEPTOR DE QUIMIOQUINAS CxCR3
JP5807971B2 (ja) 2009-04-27 2015-11-10 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｘｃｒ３受容体アンタゴニスト
US8362249B2 (en) 2009-04-27 2013-01-29 Boehringer Ingelheim International Gmbh CXCR3 receptor antagonists
US8952004B2 (en) 2010-01-07 2015-02-10 Boehringer Ingelheim International Gmbh CXCR3 receptor antagonists

Similar Documents

Publication Publication Date Title
JP3822494B2 (ja) チロシンキナーゼ阻害剤
JP6193922B2 (ja) ハロアルキルヘテロアリールベンズアミド化合物
JP4723242B2 (ja) 炎症および免疫障害治療用ｃｃｒ１アンタゴニストとして使用するための１−アリール−４−置換ピペラジン誘導体
JP2012525335A5 (enExample)
CN105189484B (zh) Cxcr7拮抗剂
CN113412259A (zh) 通过泛素蛋白酶体途径降解btk的双官能化合物
JP2008513499A5 (enExample)
ME01462B (me) Vinilindazolilna jedinjenja"
AU2016314898B2 (en) 2,4-bis(nitrogen-containing group)-substituted pyrimidine compound, preparation method and use thereof
WO2020210828A1 (en) (aza)indazolyl-aryl sulfonamide and related compounds and their use in treating medical conditions
JP2010529991A5 (enExample)
AU2015291478B2 (en) Novel substituted pyrimidine compounds
RS62570B1 (sr) Inhibitori kinaze pirazolil hinoksalina
JP2008513506A5 (enExample)
BR112015012555B1 (pt) Derivados de benzimidazol, seus usos, e medicamentos
JP2012525431A5 (enExample)
JP2008513498A5 (enExample)
JP2010018616A (ja) チロシンキナーゼおよびセリン／スレオニンキナーゼのインヒビターとしてのインダゾールベンズイミダゾール化合物
RU2006102508A (ru) Производные бензимидазола, бензотиазола и бензоксазола и их применение в качестве модуляторов lta4h
JP2010514689A5 (enExample)
JP2013508382A5 (enExample)
WO2023284838A1 (zh) Aak1抑制剂及其用途
JP2009530274A5 (enExample)
RU2017146835A (ru) Модуляторы ядерных рецепторов
RU2463294C2 (ru) 1,3-дизамещенные 4-метил-1н-пиррол-2-карбоксамиды и их применение для изготовления лекарственных средств