JP2012525124A5 - - Google Patents
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- Publication number
- JP2012525124A5 JP2012525124A5 JP2012507644A JP2012507644A JP2012525124A5 JP 2012525124 A5 JP2012525124 A5 JP 2012525124A5 JP 2012507644 A JP2012507644 A JP 2012507644A JP 2012507644 A JP2012507644 A JP 2012507644A JP 2012525124 A5 JP2012525124 A5 JP 2012525124A5
- Authority
- JP
- Japan
- Prior art keywords
- absent
- nucleic acid
- nucleotides
- nucleotide sequence
- stretch
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002773 nucleotide Substances 0.000 claims 132
- 125000003729 nucleotide group Chemical group 0.000 claims 131
- 150000007523 nucleic acids Chemical class 0.000 claims 67
- 102000039446 nucleic acids Human genes 0.000 claims 63
- 108020004707 nucleic acids Proteins 0.000 claims 63
- 239000000523 sample Substances 0.000 claims 13
- XJOTXKZIRSHZQV-RXHOOSIZSA-N (3S)-3-amino-4-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S,3S)-1-[[(1R,6R,12R,17R,20S,23S,26R,31R,34R,39R,42S,45S,48S,51S,59S)-51-(4-aminobutyl)-31-[[(2S)-6-amino-1-[[(1S,2R)-1-carboxy-2-hydroxypropyl]amino]-1-oxohexan-2-yl]carbamoyl]-20-benzyl-23-[(2S)-butan-2-yl]-45-(3-carbamimidamidopropyl)-48-(hydroxymethyl)-42-(1H-imidazol-4-ylmethyl)-59-(2-methylsulfanylethyl)-7,10,19,22,25,33,40,43,46,49,52,54,57,60,63,64-hexadecaoxo-3,4,14,15,28,29,36,37-octathia-8,11,18,21,24,32,41,44,47,50,53,55,58,61,62,65-hexadecazatetracyclo[32.19.8.26,17.212,39]pentahexacontan-26-yl]amino]-3-methyl-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-oxobutanoic acid Chemical compound CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(O)=O)[C@@H](C)O)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@@H]4CSSC[C@H](NC(=O)[C@H](Cc5ccccc5)NC(=O)[C@@H](NC1=O)[C@@H](C)CC)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1cnc[nH]1)NC3=O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N2)C(=O)NCC(=O)N4)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O XJOTXKZIRSHZQV-RXHOOSIZSA-N 0.000 claims 12
- 102000018511 hepcidin Human genes 0.000 claims 12
- 108060003558 hepcidin Proteins 0.000 claims 12
- 229940066919 hepcidin Drugs 0.000 claims 12
- 239000005557 antagonist Substances 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 239000000556 agonist Substances 0.000 claims 5
- 101000716721 Homo sapiens Suprabasin Proteins 0.000 claims 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 4
- 102100020889 Suprabasin Human genes 0.000 claims 4
- 230000000295 complement effect Effects 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 238000001514 detection method Methods 0.000 claims 4
- 238000009396 hybridization Methods 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 2
- 229910052742 iron Inorganic materials 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 208000019505 Deglutition disease Diseases 0.000 claims 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 1
- 101001021253 Homo sapiens Hepcidin Proteins 0.000 claims 1
- 206010065973 Iron Overload Diseases 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 208000007502 anemia Diseases 0.000 claims 1
- 230000003110 anti-inflammatory effect Effects 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000008030 elimination Effects 0.000 claims 1
- 238000003379 elimination reaction Methods 0.000 claims 1
- 230000010437 erythropoiesis Effects 0.000 claims 1
- 210000000987 immune system Anatomy 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000000297 inotrophic effect Effects 0.000 claims 1
- 230000014759 maintenance of location Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 239000013589 supplement Substances 0.000 claims 1
- 235000019195 vitamin supplement Nutrition 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09006028.6 | 2009-04-30 | ||
| EP09006028 | 2009-04-30 | ||
| EP10000635.2 | 2010-01-22 | ||
| EP10000635 | 2010-01-22 | ||
| PCT/EP2010/002659 WO2010124874A1 (en) | 2009-04-30 | 2010-04-30 | Hepcidin binding nucleic acids |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012525124A JP2012525124A (ja) | 2012-10-22 |
| JP2012525124A5 true JP2012525124A5 (enExample) | 2013-06-20 |
| JP5798549B2 JP5798549B2 (ja) | 2015-10-21 |
Family
ID=42374984
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012507644A Expired - Fee Related JP5798549B2 (ja) | 2009-04-30 | 2010-04-30 | ヘプシジン結合核酸 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US8841431B2 (enExample) |
| EP (1) | EP2424985A1 (enExample) |
| JP (1) | JP5798549B2 (enExample) |
| KR (1) | KR20120004487A (enExample) |
| CN (2) | CN104450691A (enExample) |
| AR (1) | AR076518A1 (enExample) |
| AU (1) | AU2010243831B2 (enExample) |
| BR (1) | BRPI1014625A2 (enExample) |
| CA (1) | CA2760244A1 (enExample) |
| EA (1) | EA022539B1 (enExample) |
| IL (1) | IL216010A0 (enExample) |
| MX (1) | MX2011011531A (enExample) |
| SG (2) | SG175814A1 (enExample) |
| TW (1) | TWI578992B (enExample) |
| WO (1) | WO2010124874A1 (enExample) |
| ZA (1) | ZA201107530B (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI578992B (zh) | 2009-04-30 | 2017-04-21 | 諾克森製藥股份有限公司 | 與鐵調節激素（ｈｅｐｃｉｄｉｎ）結合之核酸類 |
| WO2012055573A1 (en) * | 2010-10-29 | 2012-05-03 | Noxxon Pharma Ag | Use of hepcidin binding nucleic acids for depletion of hepcidin from the body |
| EP4091624A1 (en) * | 2013-03-15 | 2022-11-23 | Protagonist Therapeutics, Inc. | Hepcidin analogues and uses thereof |
| WO2015113776A1 (en) * | 2014-02-03 | 2015-08-06 | Noxxon Pharma Ag | Methods for the preparation of a polyalkoxylated nucleic acid molecule |
| CA2949215C (en) | 2014-05-16 | 2023-03-14 | Protagonist Therapeutics, Inc. | .alpha.4.beta.7 integrin thioether peptide antagonists |
| SG10201810154WA (en) | 2014-07-17 | 2018-12-28 | Protagonist Therapeutics Inc | Oral peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory bowel diseases |
| WO2016054445A1 (en) | 2014-10-01 | 2016-04-07 | Protagonist Therapeutics, Inc. | Novel cyclic monomer and dimer peptides having integrin antagonist activity |
| JP2017535527A (ja) | 2014-10-01 | 2017-11-30 | プロタゴニスト セラピューティクス， インコーポレイテッド | 新規のα４β７ペプチド単量体及び二量体拮抗薬 |
| WO2016146587A1 (en) | 2015-03-13 | 2016-09-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Hepcidin antagonists for use in the treatment of inflammation |
| US10787490B2 (en) | 2015-07-15 | 2020-09-29 | Protaganist Therapeutics, Inc. | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases |
| CA3009834A1 (en) | 2015-12-30 | 2017-07-06 | Protagonist Therapeutics, Inc. | Analogues of hepcidin mimetics with improved in vivo half lives |
| WO2018022937A1 (en) | 2016-07-27 | 2018-02-01 | Protagonist Therapeutics, Inc. | Peptide inhibitors of interleukin-23 and their use to treat inflammatory diseases |
| KR102687627B1 (ko) | 2016-08-29 | 2024-07-23 | 엘지전자 주식회사 | 냉장고 |
| BR112019009373A8 (pt) | 2016-11-30 | 2023-04-11 | Noxxon Pharma Ag | Método para polialcoxilação de ácidos nucleicos que permite recuperação e reutilização do excesso de reagente de polialcoxilação |
| WO2018234538A1 (en) | 2017-06-23 | 2018-12-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | ANTAGONIST OR AGONIST OF HEPCIDINE FOR USE IN THE TREATMENT OF DYSREGULATION OF MO AND / OR MN METABOLISM |
| EP3681900A4 (en) | 2017-09-11 | 2021-09-08 | Protagonist Therapeutics, Inc. | OPIOID AGONIST PEPTIDES AND THEIR USES |
| WO2019157268A1 (en) | 2018-02-08 | 2019-08-15 | Protagonist Therapeutics, Inc. | Conjugated hepcidin mimetics |
| CA3104418A1 (en) | 2018-07-12 | 2020-01-16 | Protagonist Therapeutics, Inc. | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases |
| AU2020311395A1 (en) | 2019-07-10 | 2022-02-03 | Protagonist Therapeutics, Inc. | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases |
| CA3156007A1 (en) | 2019-09-27 | 2021-04-01 | Disc Medicine, Inc. | METHODS OF TREATING MYELOFIBROSE AND ASSOCIATED CONDITIONS |
| MX2022008740A (es) | 2020-01-15 | 2022-09-23 | Janssen Biotech Inc | Peptidos inhibidores del receptor de interleucina-23 y su uso para tratar enfermedades inflamatorias. |
| SMT202500254T1 (it) | 2020-01-15 | 2025-09-12 | Janssen Biotech Inc | Inibitori peptidici del recettore dell'interleuchina-23 e loro uso per trattare malattie infiammatorie |
| WO2021178923A1 (en) | 2020-03-06 | 2021-09-10 | Drinksavvy, Inc. | Devices and methods for detecting a target analyte of interest |
| US12508262B2 (en) | 2020-04-30 | 2025-12-30 | Keros Therapeutics, Inc. | Methods of using ALK2 inhibitors |
| ES3075793T3 (en) | 2020-05-13 | 2026-08-07 | Disc Medicine Inc | Anti-hemojuvelin (hjv) antibodies for treating myelofibrosis |
| AU2021273014A1 (en) | 2020-05-13 | 2022-11-17 | AbbVie Deutschland GmbH & Co. KG | Anti-hemojuvelin (HJV) antibodies for treating anemia of chronic disease |
| WO2022098812A1 (en) | 2020-11-04 | 2022-05-12 | Keros Therapeutics, Inc. | Methods of treating iron overload |
| AU2021383828A1 (en) | 2020-11-20 | 2023-07-06 | Janssen Pharmaceutica Nv | Compositions of peptide inhibitors of interleukin-23 receptor |
| KR20240034224A (ko) | 2021-07-14 | 2024-03-13 | 얀센 바이오테크 인코포레이티드 | 인터류킨-23 수용체의 지질화된 펩티드 억제제 |
| WO2023154452A1 (en) | 2022-02-11 | 2023-08-17 | Waypoint Bio, Inc. | Cellular staining probes for analyte detection |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE318832T1 (de) * | 1990-06-11 | 2006-03-15 | Gilead Sciences Inc | Verfahren zur vervendung von nukleinsäureliganden |
| IE920562A1 (en) * | 1991-02-21 | 1992-08-26 | Gilead Sciences | Aptamer specific for biomolecules and method of making |
| US5840867A (en) | 1991-02-21 | 1998-11-24 | Gilead Sciences, Inc. | Aptamer analogs specific for biomolecules |
| US5582981A (en) | 1991-08-14 | 1996-12-10 | Gilead Sciences, Inc. | Method for identifying an oligonucleotide aptamer specific for a target |
| AU2003245676A1 (en) * | 2002-06-24 | 2004-01-06 | Cornell Research Foundation, Inc. | Exhaustive selection or rna aptamers against complex targets |
| WO2007120883A2 (en) | 2006-04-12 | 2007-10-25 | Isis Pharmaceuticals, Inc. | Compositions and their uses directed to hepcidin |
| JP5380287B2 (ja) * | 2006-07-18 | 2014-01-08 | ノクソン・ファルマ・アクチエンゲゼルシャフト | Ｓｄｆ−１結合核酸 |
| US20090209478A1 (en) | 2006-09-21 | 2009-08-20 | Tomoko Nakayama | Compositions and methods for inhibiting expression of the hamp gene |
| PE20130588A1 (es) * | 2007-02-02 | 2013-05-21 | Amgen Inc | Hepcidina, antagonistas de la hepcidina y metodos de uso |
| TWI578992B (zh) | 2009-04-30 | 2017-04-21 | 諾克森製藥股份有限公司 | 與鐵調節激素（ｈｅｐｃｉｄｉｎ）結合之核酸類 |
-
2010
- 2010-04-29 TW TW099113693A patent/TWI578992B/zh not_active IP Right Cessation
- 2010-04-30 SG SG2011079183A patent/SG175814A1/en unknown
- 2010-04-30 AU AU2010243831A patent/AU2010243831B2/en not_active Ceased
- 2010-04-30 CA CA2760244A patent/CA2760244A1/en not_active Abandoned
- 2010-04-30 JP JP2012507644A patent/JP5798549B2/ja not_active Expired - Fee Related
- 2010-04-30 CN CN201410657828.4A patent/CN104450691A/zh active Pending
- 2010-04-30 MX MX2011011531A patent/MX2011011531A/es active IP Right Grant
- 2010-04-30 US US13/318,144 patent/US8841431B2/en not_active Expired - Fee Related
- 2010-04-30 EA EA201171325A patent/EA022539B1/ru not_active IP Right Cessation
- 2010-04-30 EP EP10722585A patent/EP2424985A1/en not_active Withdrawn
- 2010-04-30 SG SG10201401925VA patent/SG10201401925VA/en unknown
- 2010-04-30 CN CN201080025093.3A patent/CN102459587B/zh not_active Expired - Fee Related
- 2010-04-30 AR ARP100101478A patent/AR076518A1/es unknown
- 2010-04-30 BR BRPI1014625A patent/BRPI1014625A2/pt not_active IP Right Cessation
- 2010-04-30 WO PCT/EP2010/002659 patent/WO2010124874A1/en not_active Ceased
- 2010-04-30 KR KR1020117025594A patent/KR20120004487A/ko not_active Ceased
-
2011
- 2011-10-13 ZA ZA2011/07530A patent/ZA201107530B/en unknown
- 2011-10-27 IL IL216010A patent/IL216010A0/en unknown
-
2014
- 2014-09-23 US US14/493,435 patent/US20160257958A1/en not_active Abandoned
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