JP2012524902A5 - - Google Patents

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Publication number
JP2012524902A5
JP2012524902A5 JP2012507255A JP2012507255A JP2012524902A5 JP 2012524902 A5 JP2012524902 A5 JP 2012524902A5 JP 2012507255 A JP2012507255 A JP 2012507255A JP 2012507255 A JP2012507255 A JP 2012507255A JP 2012524902 A5 JP2012524902 A5 JP 2012524902A5
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JP
Japan
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mer unit
seq
identity
heterodimer
mer
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JP2012507255A
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English (en)
Japanese (ja)
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JP2012524902A (ja
JP5882196B2 (ja
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Priority claimed from PCT/US2010/030836 external-priority patent/WO2010123720A1/en
Publication of JP2012524902A publication Critical patent/JP2012524902A/ja
Publication of JP2012524902A5 publication Critical patent/JP2012524902A5/ja
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Publication of JP5882196B2 publication Critical patent/JP5882196B2/ja
Expired - Fee Related legal-status Critical Current
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JP2012507255A 2009-04-23 2010-04-13 アディポネクチン受容体フラグメントの単量体及び二量体形態ならびに使用の方法 Expired - Fee Related JP5882196B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17197909P 2009-04-23 2009-04-23
US61/171,979 2009-04-23
PCT/US2010/030836 WO2010123720A1 (en) 2009-04-23 2010-04-13 Monomeric and dimeric forms of adiponectin receptor fragments and methods of use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015209307A Division JP2016035470A (ja) 2009-04-23 2015-10-23 アディポネクチン受容体フラグメントの単量体及び二量体形態ならびに使用の方法

Publications (3)

Publication Number Publication Date
JP2012524902A JP2012524902A (ja) 2012-10-18
JP2012524902A5 true JP2012524902A5 (enExample) 2013-04-04
JP5882196B2 JP5882196B2 (ja) 2016-03-09

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JP2012507255A Expired - Fee Related JP5882196B2 (ja) 2009-04-23 2010-04-13 アディポネクチン受容体フラグメントの単量体及び二量体形態ならびに使用の方法
JP2015209307A Pending JP2016035470A (ja) 2009-04-23 2015-10-23 アディポネクチン受容体フラグメントの単量体及び二量体形態ならびに使用の方法

Family Applications After (1)

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JP2015209307A Pending JP2016035470A (ja) 2009-04-23 2015-10-23 アディポネクチン受容体フラグメントの単量体及び二量体形態ならびに使用の方法

Country Status (6)

Country Link
US (3) US8865648B2 (enExample)
EP (2) EP2422199B1 (enExample)
JP (2) JP5882196B2 (enExample)
CN (1) CN102388308B (enExample)
ES (1) ES2693165T3 (enExample)
WO (1) WO2010123720A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20110565A1 (es) 2008-08-12 2011-09-02 Zinfandel Pharmaceuticals Inc Metodo de identificacion de factores de riesgo de la enfermedad
US8846315B2 (en) 2008-08-12 2014-09-30 Zinfandel Pharmaceuticals, Inc. Disease risk factors and methods of use
EP2391377A2 (en) 2009-02-02 2011-12-07 Ramot at Tel-Aviv University Ltd. Peptides, pharmaceutical compositions comprising same and uses thereof
EP2422199B1 (en) 2009-04-23 2018-07-25 Siemens Healthcare Diagnostics Inc. Monomeric and dimeric forms of adiponectin receptor fragments and methods of use
US8901074B2 (en) 2010-08-04 2014-12-02 Ramot At Tel-Aviv University Methods of treating autoimmune diseases of the central nervous system (CNS) and neurodegenerative diseases
EA201391017A1 (ru) 2011-01-10 2014-04-30 Зинфандел Фармасьютикалз, Инк. Способы и готовые лекарственные формы для лечения болезни альцгеймера
US9291629B2 (en) 2011-04-11 2016-03-22 Siemens Healthcare Diagnostics Inc. Adiponectin receptor C-terminal fragments (CTF)-immunoglobulin
DK2771364T3 (da) * 2011-10-27 2019-08-19 Genmab As Fremstilling af heterodimere proteiner
DE102015201100B4 (de) * 2015-01-22 2018-05-17 Friedrich-Alexander-Universität Erlangen-Nürnberg Antivirale Mittel

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
SE462454B (sv) 1988-11-10 1990-06-25 Pharmacia Ab Maetyta foer anvaendning i biosensorer
US20020173474A1 (en) 1993-02-12 2002-11-21 President And Fellows Of Harvard College Methods & materials involving dimerization-mediated regulation of biological events
WO1994028418A1 (en) 1993-05-28 1994-12-08 Baylor College Of Medicine Method and apparatus for desorption and ionization of analytes
SE9400088D0 (sv) 1994-01-14 1994-01-14 Kabi Pharmacia Ab Bacterial receptor structures
NZ516848A (en) 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
EP1033134B8 (en) 1997-10-29 2007-09-19 Otsuka Pharmaceutical Co., Ltd. Compositions inhibiting smooth muscle proliferation and method for the diagnosis of arteriosclerosis
EP1068356B8 (en) 1998-04-03 2007-01-03 Adnexus Therapeutics, Inc. Addressable protein arrays
US6406921B1 (en) 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
WO2000056934A1 (en) 1999-03-24 2000-09-28 Packard Bioscience Company Continuous porous matrix arrays
US20040067490A1 (en) 2001-09-07 2004-04-08 Mei Zhong Therapeutic polypeptides, nucleic acids encoding same, and methods of use
CA2382015A1 (en) 1999-08-17 2001-02-22 Incyte Genomics, Inc. Membrane associated proteins
AU2001274888A1 (en) 2000-05-19 2001-12-03 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
US20020102617A1 (en) 2000-08-03 2002-08-01 Macbeath Gavin Protein microarrays
CA2440219A1 (en) 2001-02-21 2002-10-17 Curagen Corporation Proteins, polynucleotides encoding them and methods of using the same
CA2440144A1 (en) 2001-03-14 2002-09-19 Oklahoma Medical Research Foundation Methods for reducing fat by administration of adiponectin
US20030083261A1 (en) 2001-04-30 2003-05-01 Hongtao Yu Class of 12mer peptides that inhibit the function of the mitotic check point protein Mad2
CA2459489C (en) 2001-08-17 2010-02-02 Rebio Gen, Inc. Method for diagnosing or monitoring carbohydrate metabolism disorders
WO2004022596A1 (en) 2002-09-05 2004-03-18 Komed Co., Ltd. Monoclonal antibody against adiponectin, preparation method and use thereof
US20030153013A1 (en) 2002-11-07 2003-08-14 Ruo-Pan Huang Antibody-based protein array system
JP4347874B2 (ja) * 2002-12-29 2009-10-21 株式会社東京大学Tlo アディポネクチン受容体及びそれをコードする遺伝子
DE60335216D1 (de) 2002-12-29 2011-01-13 Nissan Chemical Ind Ltd Adiponektin-rezeptor und dafür kodierendes gen
DE602004022632D1 (de) * 2003-01-09 2009-10-01 Beth Israel Hospital Verwendung von adiponectin zur diagnose von krebs
EP1607742B1 (en) 2003-03-24 2011-11-23 Mitsubishi Chemical Medience Corporation Latex reagent for adiponectin analysis and method of adiponectin analysis
EP1718327B1 (en) 2003-06-20 2015-01-07 University of Florida Biomarkers for differentiating between type 1 and type 2 diabetes
US7435808B2 (en) * 2003-06-25 2008-10-14 Bristol-Myers Squibb Company Polynucleotides encoding novel adiponectin receptor variant, AdipoR2v2
ES2347562T3 (es) * 2003-09-27 2010-11-02 Siemens Healthcare Diagnostics Inc. Disagnosticos y terapias para enfermedades asociados con receptor emparejado de proteina g adipor1 (adipor1).
WO2005031345A2 (en) 2003-09-27 2005-04-07 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g-protein coupled receptor adipor2 (adipor2)
DE602004022575D1 (de) 2003-10-15 2009-09-24 Sekisui Medical Co Ltd Verfahren zum selektiven testen von adiponectinmultimeren
JP4397934B2 (ja) 2003-11-07 2010-01-13 メルク エンド カムパニー インコーポレーテッド インスリン感作薬での処置に対する反応者を識別する方法
EP1733733A1 (en) * 2004-03-04 2006-12-20 Takashi Kadowaki Regulator for adiponectin receptor expression
GB0426798D0 (en) 2004-12-07 2005-01-12 Emtelle Uk Ltd Optical fibre tube and method of manufacturing same
US8093017B2 (en) 2005-12-07 2012-01-10 Siemens Heathcare Diagnostics Inc. Detection of soluble adiponectin receptor peptides and use in diagnostics and therapeutics
CA2707182C (en) * 2007-11-30 2017-12-12 Siemens Healthcare Diagnostics Inc. Adiponectin receptor fragments and methods of use
EP2422199B1 (en) 2009-04-23 2018-07-25 Siemens Healthcare Diagnostics Inc. Monomeric and dimeric forms of adiponectin receptor fragments and methods of use

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