JP2012524070A - 抗接着剤 - Google Patents

抗接着剤 Download PDF

Info

Publication number
JP2012524070A
JP2012524070A JP2012505953A JP2012505953A JP2012524070A JP 2012524070 A JP2012524070 A JP 2012524070A JP 2012505953 A JP2012505953 A JP 2012505953A JP 2012505953 A JP2012505953 A JP 2012505953A JP 2012524070 A JP2012524070 A JP 2012524070A
Authority
JP
Japan
Prior art keywords
group
enyl
chroman
yloxy
dimethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2012505953A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012524070A5 (enExample
Inventor
チン−シー チェン，
ダシェン ワン，
サミュエル ケー． カルプ，
Original Assignee
ザ オハイオ ステート ユニバーシティー リサーチ ファウンデーション
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ザ オハイオ ステート ユニバーシティー リサーチ ファウンデーション filed Critical ザ オハイオ ステート ユニバーシティー リサーチ ファウンデーション
Publication of JP2012524070A publication Critical patent/JP2012524070A/ja
Publication of JP2012524070A5 publication Critical patent/JP2012524070A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
JP2012505953A 2009-04-17 2010-04-16 抗接着剤 Pending JP2012524070A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17031609P 2009-04-17 2009-04-17
US61/170,316 2009-04-17
PCT/US2010/031363 WO2010121111A1 (en) 2009-04-17 2010-04-16 Antiadhesion agents

Publications (2)

Publication Number Publication Date
JP2012524070A true JP2012524070A (ja) 2012-10-11
JP2012524070A5 JP2012524070A5 (enExample) 2013-03-28

Family

ID=42981455

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012505953A Pending JP2012524070A (ja) 2009-04-17 2010-04-16 抗接着剤

Country Status (6)

Country Link
US (1) US8362071B2 (enExample)
EP (1) EP2418948B1 (enExample)
JP (1) JP2012524070A (enExample)
AU (1) AU2010236323A1 (enExample)
CA (1) CA2759011A1 (enExample)
WO (1) WO2010121111A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012523458A (ja) * 2009-04-13 2012-10-04 ザ オハイオ ステート ユニバーシティー リサーチ ファウンデーション タンパク質ホスファターゼ２ａ活性化剤

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2414205T3 (es) 2006-06-02 2013-07-18 The Ohio State University Research Foundation Agentes terapéuticos para el tratamiento de linfoma de células del manto
CA2759011A1 (en) 2009-04-17 2010-10-21 The Ohio State University Research Foundation Antiadhesion agents
US8309768B2 (en) 2010-11-29 2012-11-13 The Ohio State University Research Foundation FTY720-derived anticancer agents
US9220706B2 (en) 2012-06-01 2015-12-29 National Institutes Of Health (Nih) Inhibition of leukemic stem cells by PP2A activating agents
US20180092874A1 (en) * 2016-10-03 2018-04-05 Lincoln Memorial University Identification and use of very long chain dicarboxylic acids for disease diagnosis, chemoprevention, and treatment

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009538823A (ja) * 2006-02-21 2009-11-12 ザ オハイオ ステート ユニバーシティー リサーチ ファウンデーション 抗癌剤
JP2012523458A (ja) * 2009-04-13 2012-10-04 ザ オハイオ ステート ユニバーシティー リサーチ ファウンデーション タンパク質ホスファターゼ２ａ活性化剤

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2680749A (en) * 1951-12-01 1954-06-08 Eastman Kodak Co Water-soluble tocopherol derivatives
DE2822324C3 (de) * 1978-05-22 1981-02-26 Basf Ag, 6700 Ludwigshafen Herstellung von Vitamin-E-Trockenpulver
JPS59222415A (ja) 1983-05-31 1984-12-14 Kuraray Co Ltd 免疫調節剤
WO1997024112A1 (en) * 1995-12-28 1997-07-10 Yoshitomi Pharmaceutical Industries, Ltd. External preparation
US6476004B1 (en) * 1996-07-18 2002-11-05 Mitsubishi Pharma Corporation Pharmaceutical composition
JPH1180026A (ja) * 1997-09-02 1999-03-23 Yoshitomi Pharmaceut Ind Ltd 新規免疫抑制剤、その使用方法およびその同定方法
US6770672B1 (en) * 1998-09-23 2004-08-03 Research Development Foundation Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof
US6703384B2 (en) * 1998-09-23 2004-03-09 Research Development Foundation Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof
IL142082A (en) * 1998-09-23 2005-12-18 Res Dev Tocoflowers, tocotrinols, derivatives as a novel and other side-chain and their uses
RU2263672C2 (ru) * 2000-02-11 2005-11-10 Рисерч Дивелопмент Фаундейшн Токоферолы, токотриенолы, другие хроманы и производные по боковым цепям и их применение
US20040248971A1 (en) * 2001-07-27 2004-12-09 Shuyuan Yeh Use of vitamin e succinate and antiandrogen combination
US6858227B1 (en) * 2001-11-21 2005-02-22 Sonus Pharmaceuticals, Inc. Vitamin E conjugates
US20050215531A1 (en) * 2002-05-16 2005-09-29 Thomas Baumruker Use of edg receptor binding agents in cancer
WO2005025553A2 (en) * 2003-09-12 2005-03-24 Neuronova Ab Treatment of disorders of nervous systemsystem with fty720
WO2005033092A1 (en) * 2003-09-19 2005-04-14 Galileo Pharmaceuticals, Inc. Chroman derivatives
RU2433117C2 (ru) * 2005-12-15 2011-11-10 Мицубиси Танабе Фарма Корпорейшн Аминное соединение и его применение в медицинских целях
ES2414205T3 (es) * 2006-06-02 2013-07-18 The Ohio State University Research Foundation Agentes terapéuticos para el tratamiento de linfoma de células del manto
BRPI0715950A2 (pt) 2006-08-17 2013-07-30 Univ Chicago tratamento de doenÇas inflamatàrias
BRPI0813683A2 (pt) * 2007-06-14 2019-09-24 Mitsubishi Tanabe Pharma Corp composto amina e uso farmacêutico do mesmo
CA2739901A1 (en) 2008-10-17 2010-04-22 Akaal Pharma Pty Ltd S1p receptors modulators
CA2759011A1 (en) 2009-04-17 2010-10-21 The Ohio State University Research Foundation Antiadhesion agents

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009538823A (ja) * 2006-02-21 2009-11-12 ザ オハイオ ステート ユニバーシティー リサーチ ファウンデーション 抗癌剤
JP2012523458A (ja) * 2009-04-13 2012-10-04 ザ オハイオ ステート ユニバーシティー リサーチ ファウンデーション タンパク質ホスファターゼ２ａ活性化剤

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
JPN5012013389; Ｇａｎｇ　Ｌｉｕ: 'Ｓｍａｌｌ　ｍｏｌｅｃｕｌｅ　ａｎｔａｇｏｎｉｓｔｓ　ｏｆ　ｔｈｅ　ＬＦＡ-１／ＩＣＡＭ-１　ｉｎｔｅｒａｃｔｉｏｎ　ａｓ　ｐｏｔｅｎｔｉａｌ　ｔｈｅｒａｐｅｕｔｉｃ　ａｇｅｎｔｓ' Ｅｘｐｅｒｔ　Ｏｐｉｎｉｏｎ　ｏｎ　Ｔｈｅｒａｐｅｕｔｉｃ　Ｐａｔｅｎｔｓ ｖｏｌ．１１，　Ｎｏ．９, 2001, ｐ．１３８３-１３９３, Ａｓｈｌｅｙ　Ｐｕｂｌｉｃａｔｉｏｎｓ，　Ｌｔｄ． *
JPN6014025154; Ｃｈｕｎｇ-Ｗａｉ　Ｓｈｉａｕ，　Ｊｕｉ-Ｗｅｎ　Ｈｕａｎｇ，　Ｄａ-Ｓｈｅｎｇ　Ｗａｎｇ，　Ｊｉｎｇ-Ｒｕ　Ｗｅｎｇ，　Ｃｈｉｈ-Ｃｈｅｎｇ　Ｙａｎｇ，　Ｃｈｉａ-Ｈｕｉ　Ｌｉｎ，　Ｃｈｅｎｇｌｏｎ: 'alpha-Ｔｏｃｏｐｈｅｒｙｌ　Ｓｕｃｃｉｎａｔｅ　Ｉｎｄｕｃｅｓ　Ａｐｏｐｔｏｓｉｓ　ｉｎ　Ｐｒｏｓｔａｔｅ　Ｃａｎｃｅｒ　Ｃｅｌｌｓ　ｉｎ　Ｐａｒｔ　ｔｈｒｏｕｇｈ　Ｉｎｈｉｂｉｔｉｏｎ　ｏｆ　Ｂｃｌ' Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｂｉｏｌｏｇｉｃａｌ　Ｃｈｅｍｉｓｔｒｙ ｖｏｌ．２８１，　Ｎｏ．１７, 20060428, ｐ&#x *
JPN6014025155; Ｐａｕｌ　Ｌ．　Ｃｒｉｓｐｅｎ，　Ｒｏｂｅｒｔ　Ｇ．　Ｕｚｚｏ，　Ｋｏｎｓｔａｎｔｉｎ　Ｇｏｌｏｖｉｎｅ，　Ｐｅｔｅｒ　Ｍａｋｈｏｖ，　Ａｌａｎ　Ｐｏｌｌａｃｋ，　Ｅｒｉｃ　Ｍ．　Ｈｏｒｗｉｔｚ，　Ｒ: 'Ｖｉｔａｍｉｎ　Ｅ　Ｓｕｃｃｉｎａｔｅ　Ｉｎｈｉｂｉｔｓ　ＮＦ-ｋＢ　ａｎｄ　Ｐｒｅｖｅｎｔｓ　ｔｈｅ　Ｄｅｖｅｌｏｐｍｅｎｔ　ｏｆ　ａ　Ｍｅｔａｓｔａｔｉｃ　Ｐｈｅｎｏｔｙｐｅ　ｉｎ　Ｐｒｏｓｔａｔ' Ｔｈｅ　Ｐｒｏｓｔａｔｅ ｖｏｌ．６７，　Ｎｏ．６, 20070501, ｐ．５８２-５９０, Ｊｏｈｎ　Ｗｉｌｅｙ　＆　Ｓｏ&#x *
JPN6014025156; Ｄａｓｈｅｎｇ　Ｗａｎｇ，　Ｈｓｉａｏ-Ｃｈｉｎｇ　Ｃｈｕａｎｇ，　Ｓｈｕ-Ｃｈｕａｎ　Ｗｅｎｇ，　Ｐｏ-Ｈｓｉｅｎ　Ｈｕａｎｇ，　Ｈａｏ-Ｙｕ　Ｈｓｉｅｈ，　Ｓａｍｕｅｌ　Ｋ．　Ｋｕｌｐ，　Ｃｈｉｎ: 'alpha-Ｔｏｃｏｐｈｅｒｙｌ　Ｓｕｃｃｉｎａｔｅ　ａｓ　ａ　Ｓｃａｆｆｏｌｄ　ｔｏ　Ｄｅｖｅｌｏｐ　Ｐｏｔｅｎｔ　Ｉｎｈｉｂｉｔｏｒｓ　ｏｆ　Ｂｒｅａｓｔ　Ｃａｎｃｅｒ　Ｃｅｌｌ　Ａｄｈｅｓｉｏｎ' Ｊｏｕｒｎａｌ　ｏｆ　Ｍｅｄｉｃｉｎａｌ　Ｃｈｅｍｉｓｔｒｙ ｖｏｌ．５２，　Ｎｏ．１８, 20090924, ｐ．５６４２-５６４&# *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012523458A (ja) * 2009-04-13 2012-10-04 ザ オハイオ ステート ユニバーシティー リサーチ ファウンデーション タンパク質ホスファターゼ２ａ活性化剤

Also Published As

Publication number Publication date
US20100267820A1 (en) 2010-10-21
CA2759011A1 (en) 2010-10-21
EP2418948A1 (en) 2012-02-22
WO2010121111A9 (en) 2011-12-22
EP2418948B1 (en) 2013-09-04
US8362071B2 (en) 2013-01-29
AU2010236323A1 (en) 2011-11-24
WO2010121111A1 (en) 2010-10-21
EP2418948A4 (en) 2012-08-08

Similar Documents

Publication Publication Date Title
KR20230003981A (ko) DYRK1 억제제인 피롤로[3,2-c]피리딘 유도체 및 이의 용도
JP2021073253A (ja) Ｈｄａｃ６阻害剤での多嚢胞性疾患の治療
US8362071B2 (en) Antiadhesion agents
US20110071147A1 (en) 4-amino-thieno[3,2-c]pyridine-7-carboxylic acid amides
WO2012139010A1 (en) Grp94 inhibitors
EP3060562B1 (en) Substituted pyrimidine compounds and their use as syk inhibitors
US8461362B2 (en) Protein phosphatase 2A-activating agents
WO2011085261A1 (en) Hedgehog inhibitors
EP2542239A1 (fr) Utilisation d'isoquinolones pour la preparation de medicaments, nouvelles isoquinolones et leur procede de synthese
US9061994B1 (en) Materials and methods useful to induce vacuolization, cell death, or a combination thereof
US20030236294A1 (en) Compounds and methods for inducing apoptosis in proliferating cells
US8008344B2 (en) Compounds for the inhibition of histone deacetylase
WO2022005961A1 (en) Prpk inhibitors
CA2726666C (fr) Derives de 2-oxo-alkyl-1-piperazin-2-one, leur preparation et leur application en therapeutique
WO2016037171A1 (en) Flavonoid il-17a inhibitors
WO2016011022A1 (en) Substituted thioxanthenone autophagy inhibitors
JP2006502995A (ja) ホスホジエステラーゼ４阻害剤としての６−アミノ−１ｈ−インダゾール及び４−アミノベンゾフラン化合物
US11345692B1 (en) 3-vinylquinolines as cancer cells inhibitors
EP2642856B1 (en) Integrin-linked kinase inhibitors
US20240254135A1 (en) Polyphenol compounds
EP2045247A1 (en) Compounds for the inhibition of histone deacetylase
WO2017002898A1 (ja) ストライガ発芽調節剤
KR100983318B1 (ko) 메조-비스(오쏘-하이드록시페닐)비스(오쏘-하이드록시)살렌의 항암제로서의 용도
US20060142368A1 (en) Compounds and methods for inducing apoptosis in proliferating cells
WO2026036036A1 (en) Therapeutic compounds and methods

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130208

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20130208

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20140617

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20150126