JP2012522814A5 - - Google Patents
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- Publication number
- JP2012522814A5 JP2012522814A5 JP2012503892A JP2012503892A JP2012522814A5 JP 2012522814 A5 JP2012522814 A5 JP 2012522814A5 JP 2012503892 A JP2012503892 A JP 2012503892A JP 2012503892 A JP2012503892 A JP 2012503892A JP 2012522814 A5 JP2012522814 A5 JP 2012522814A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- alkyl
- substituted
- fluorine
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102009016553.3 | 2009-04-06 | ||
| DE102009016553A DE102009016553A1 (de) | 2009-04-06 | 2009-04-06 | Sulfonamid- und Sulfoximin-substituierte Diaryldihydropyrimidinone und ihre Verwendung |
| PCT/EP2010/002000 WO2010115548A1 (de) | 2009-04-06 | 2010-03-30 | Sulfonamid- und sulfoximin-substituierte diaryldihydropyrimidinone und ihre verwendung |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012522814A JP2012522814A (ja) | 2012-09-27 |
| JP2012522814A5 true JP2012522814A5 (OSRAM) | 2013-05-02 |
| JP5608217B2 JP5608217B2 (ja) | 2014-10-15 |
Family
ID=42138772
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012503892A Expired - Fee Related JP5608217B2 (ja) | 2009-04-06 | 2010-03-30 | スルホン酸アミドおよびスルホキシイミン置換ジアリール−シヒドロピリミジノンおよびその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8691817B2 (OSRAM) |
| EP (1) | EP2417112B1 (OSRAM) |
| JP (1) | JP5608217B2 (OSRAM) |
| CN (1) | CN102482231B (OSRAM) |
| CA (1) | CA2757654C (OSRAM) |
| DE (1) | DE102009016553A1 (OSRAM) |
| ES (1) | ES2499417T3 (OSRAM) |
| WO (1) | WO2010115548A1 (OSRAM) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0821027B8 (pt) * | 2007-12-20 | 2021-05-25 | Bayer Ip Gmbh | 4-(4-ciano-2-tioaril)di-hidropirimidinonas para tratamento e/ou prevenção de lesões do pulmão e do sistema cardiovascular, seu processo de preparação e seu uso, e medicamento |
| US20140221335A1 (en) | 2013-02-06 | 2014-08-07 | Boehringer Ingelheim International Gmbh | Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity |
| US9115093B2 (en) | 2013-03-04 | 2015-08-25 | Boehringer Ingelheim International Gmbh | Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity |
| USRE47493E1 (en) | 2014-02-20 | 2019-07-09 | Boehringer Ingelheim International Gmbh | Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity |
| EP3126358A1 (de) | 2014-04-03 | 2017-02-08 | Bayer Pharma Aktiengesellschaft | 2,5-disubstituierte cyclopentancarbonsäuren zur behandlung von atemwegserkrankungen |
| WO2015150362A2 (de) | 2014-04-03 | 2015-10-08 | Bayer Pharma Aktiengesellschaft | Chirale 2,5-disubstituierte cyclopentancarbonsäure-derivate und ihre verwendung |
| US20170022171A1 (en) | 2014-04-03 | 2017-01-26 | Bayer Pharma Aktiengesellschaft | 2,5-disubstituted cyclopentanecarboxylic acids and their use |
| US9440930B2 (en) | 2014-07-31 | 2016-09-13 | Boehringer Ingelheim International Gmbh | Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity |
| US9290457B2 (en) * | 2014-07-31 | 2016-03-22 | Boehringer Ingelheim International Gmbh | Substituted dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity |
| US9458113B2 (en) | 2014-07-31 | 2016-10-04 | Boehringer Ingelheim International Gmbh | Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity |
| US9657015B2 (en) | 2014-07-31 | 2017-05-23 | Boehringer Ingelheim International Gmbh | Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity |
| US9475779B2 (en) | 2014-07-31 | 2016-10-25 | Boehringer Ingelheim International Gmbh | Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity |
| CN110981815A (zh) | 2015-03-18 | 2020-04-10 | Ph制药有限公司 | 用于生产化合物的方法 |
| WO2017081044A1 (en) | 2015-11-13 | 2017-05-18 | Bayer Pharma Aktiengesellschaft | 4-(4-cyano-2-thioaryl)dihydropyrimidinones for treating chronic wounds |
| WO2024161371A1 (en) * | 2023-02-02 | 2024-08-08 | Gt Gain Therapeutics Sa | Substituted azoles their use in the treatment of diseases associated with alpha-1 -antitrypsin (a1at) deficiency |
| CN118845775B (zh) * | 2024-09-24 | 2024-12-20 | 四川大学华西第二医院 | Iacs-010759在制备预防和/或治疗原发性纤毛不动综合征的药物中的用途 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19834044A1 (de) | 1998-07-29 | 2000-02-03 | Bayer Ag | Neue substituierte Pyrazolderivate |
| DE19834047A1 (de) | 1998-07-29 | 2000-02-03 | Bayer Ag | Substituierte Pyrazolderivate |
| DE19943634A1 (de) | 1999-09-13 | 2001-04-12 | Bayer Ag | Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| DE19943639A1 (de) | 1999-09-13 | 2001-03-15 | Bayer Ag | Dicarbonsäurederivate mit neuartigen pharmazeutischen Eigenschaften |
| DE19943635A1 (de) | 1999-09-13 | 2001-03-15 | Bayer Ag | Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| DE19943636A1 (de) | 1999-09-13 | 2001-03-15 | Bayer Ag | Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| AR031176A1 (es) | 2000-11-22 | 2003-09-10 | Bayer Ag | Nuevos derivados de pirazolpiridina sustituidos con piridina |
| DE10110749A1 (de) | 2001-03-07 | 2002-09-12 | Bayer Ag | Substituierte Aminodicarbonsäurederivate |
| DE10110750A1 (de) | 2001-03-07 | 2002-09-12 | Bayer Ag | Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| DE10220570A1 (de) | 2002-05-08 | 2003-11-20 | Bayer Ag | Carbamat-substituierte Pyrazolopyridine |
| GB2392910A (en) * | 2002-09-10 | 2004-03-17 | Bayer Ag | 2-Oxopyrimidine derivatives and their use as human leukocyte elastase inhibitors |
| CA2498052C (en) | 2002-09-10 | 2011-05-17 | Bayer Healthcare Ag | Heterocyclic derivatives |
| KR20050042190A (ko) | 2002-09-10 | 2005-05-04 | 바이엘 헬스케어 아게 | 급성 및 만성 염증성, 허혈성 및 재형성 과정에 대한 치료제로서의 피리미디논 유도체 |
| US7166603B2 (en) | 2003-07-23 | 2007-01-23 | Bristol-Myers Squibb Co. | Dihydropyrimidone inhibitors of calcium channel function |
| CA2557272C (en) | 2004-02-26 | 2012-09-11 | Bayer Healthcare Ag | Heterocyclic derivatives |
| CA2557271C (en) | 2004-02-26 | 2012-08-21 | Bayer Healthcare Ag | 1,4-diaryl-dihydropyrimidin-2-ones and their use as human neutrophil elastase inhibitors |
| WO2006015035A1 (en) | 2004-08-02 | 2006-02-09 | Smithkline Beecham Corporation | Useful compounds for hpv infection |
| GB0502258D0 (en) | 2005-02-03 | 2005-03-09 | Argenta Discovery Ltd | Compounds and their use |
| GB0512940D0 (en) | 2005-06-24 | 2005-08-03 | Argenta Discovery Ltd | Compounds and their use |
| GB0520743D0 (en) | 2005-10-12 | 2005-11-23 | Argenta Discovery Ltd | Compounds and their use |
| US20100010024A1 (en) | 2006-07-01 | 2010-01-14 | Bayer Healthcare Ag | Use of1,4-diaryl-dihydropyrimidine-2-on derivatives for treating pulmonary arterial hypertension |
| DE102006031314A1 (de) | 2006-07-01 | 2008-01-03 | Bayer Healthcare Aktiengesellschaft | Verwendung von 1,4-Diaryl-dihydropyrimidin-2-on-Derivaten zur Behandlung der pulmonalen arteriellen Hyptertonie |
| EP2064184A1 (en) | 2006-09-04 | 2009-06-03 | AstraZeneca AB | Multimeric heterocyclic compounds useful as neutrophil elastase inhibitors |
| BRPI0821027B8 (pt) * | 2007-12-20 | 2021-05-25 | Bayer Ip Gmbh | 4-(4-ciano-2-tioaril)di-hidropirimidinonas para tratamento e/ou prevenção de lesões do pulmão e do sistema cardiovascular, seu processo de preparação e seu uso, e medicamento |
-
2009
- 2009-04-06 DE DE102009016553A patent/DE102009016553A1/de not_active Withdrawn
-
2010
- 2010-03-30 JP JP2012503892A patent/JP5608217B2/ja not_active Expired - Fee Related
- 2010-03-30 US US13/262,159 patent/US8691817B2/en active Active
- 2010-03-30 CA CA2757654A patent/CA2757654C/en active Active
- 2010-03-30 EP EP10713311.8A patent/EP2417112B1/de active Active
- 2010-03-30 WO PCT/EP2010/002000 patent/WO2010115548A1/de not_active Ceased
- 2010-03-30 ES ES10713311.8T patent/ES2499417T3/es active Active
- 2010-03-30 CN CN201080024887.8A patent/CN102482231B/zh not_active Expired - Fee Related
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