JP2012522196A - 薬物送達デバイス用のスプリングエレメント、その使用及び薬物送達デバイス - Google Patents
薬物送達デバイス用のスプリングエレメント、その使用及び薬物送達デバイス Download PDFInfo
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- JP2012522196A JP2012522196A JP2012502667A JP2012502667A JP2012522196A JP 2012522196 A JP2012522196 A JP 2012522196A JP 2012502667 A JP2012502667 A JP 2012502667A JP 2012502667 A JP2012502667 A JP 2012502667A JP 2012522196 A JP2012522196 A JP 2012522196A
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- VXKHXGOKWPXYNA-PGBVPBMZSA-N triptorelin Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 VXKHXGOKWPXYNA-PGBVPBMZSA-N 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Images
Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16F—SPRINGS; SHOCK-ABSORBERS; MEANS FOR DAMPING VIBRATION
- F16F1/00—Springs
- F16F1/02—Springs made of steel or other material having low internal friction; Wound, torsion, leaf, cup, ring or the like springs, the material of the spring not being relevant
- F16F1/04—Wound springs
- F16F1/12—Attachments or mountings
- F16F1/122—Attachments or mountings where coils, e.g. end coils, of the spring are rigidly clamped or similarly fixed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- General Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Mechanical Engineering (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Springs (AREA)
Abstract
【選択図】 図2
Description
H−(Lys)4−desPro36,desPro37エキセンジン−4(1−39)−NH2、
H−(Lys)5−desPro36,desPro37エキセンジン−4(1−39)−NH2、
desPro36[Asp28]エキセンジン−4(1−39)、
desPro36[IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,IsoAsp28]エキセンジン−4(1−39)、
desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Trp(O2)25,IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14Trp(O2)25,IsoAsp28]エキセンジン−4(1−39);又は
desPro36[Asp28]エキセンジン−4(1−39)、
desPro36[IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,IsoAsp28]エキセンジン−(1−39)、
desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Trp(O2)25,IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Trp(O2)25,IsoAsp28]エキセンジン−4(1−39)、
ここで、基−Lys6−NH2は、エキセンジン−4誘導体のC−末端と結合してもよく;
H−(Lys)6−desPro36[Asp28]エキセンジン−4(1−39)−Lys6−NH2、
desAsp28,Pro36,Pro37,Pro38エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro38[Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)−Lys6−NH2、
H−desAsp28 Pro36,Pro37,Pro38[Trp(O2)25]エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−des Pro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)−Lys6−NH2、
desMet(O)14,Asp28,Pro36,Pro37,Pro38 エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Asn−(Glu)5,desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Lys6−desPro36[Met(O)14,Trp(O2)25, Asp28]エキセンジン−4(1−39)−Lys6−NH2、
H−desAsp28,Pro36,Pro37,Pro38[Met(O)14,Trp(O2)25]エキセンジン−4(1−39)−NH2、
H−(Lys)6−des Pro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(S1−39)−(Lys)6−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
又は前述のエキセンジン−4誘導体のいずれか1つの薬学的に許容される塩若しくは溶媒和物;
から選択される。
2.スプリングエレメント
4a、4b.スプリングエレメントの軸端
6a、6b.末端巻線
8a、8b.末端巻線の自由端
10.溶接部
12a、12b.第一及び第三クラッチ部材
14a、14b.第二及び第四クラッチ部材
L.(主)縦軸
D1.第一軸方向距離
D2.第二軸方向距離
Claims (15)
- 強固な横の接続により、互いに機械的に連結される2つの巻線を備えた多重巻線を含む、薬物送達デバイス用スプリングエレメント(2)。
- 少なくとも1つの追加の巻線が、機械的に連結される2つの巻線に対して弾性的に移動可能であるように、多重巻線が設計されている、請求項1に記載のスプリングエレメント(2)。
- 強固な横の接続が材料接続部を含む、請求項1または2に記載のスプリングエレメント(2)。
- 強固な横の接続が溶接部(10)を含む、請求項1〜3のいずれか1項に記載のスプリングエレメント(2)。
- 2つの巻線が所定の位置で互いに強固な横の接続により連結されるように、強固な横の接続が設計される、請求項1〜4のいずれか1項に記載のスプリングエレメント(2)。
- 機械的に連結している2つの巻線の1つが、スプリングエレメント(2)の末端巻線(6a)を含む、請求項1〜5のいずれか1項に記載のスプリングエレメント(2)。
- 強固な横の接続が、末端巻線(6a)の自由端(8a、8b)に対して、位置を変える、請求項1〜5のいずれか1項に記載のスプリングエレメント(2)。
- 請求項6の末端巻線(6a)が、請求項7の末端巻線(6a)と同一である、請求項6または7記載のスプリングエレメント(2)。
- 2つより多くの巻線が、強固な横の接続により、互いに、機械的に連結されている、請求項1〜8のいずれか1項に記載のスプリングエレメント(2)。
- 多重巻線が、連続巻線間の軸方向の距離(D1、D2)がスプリングエレメント(2)に沿って変化するように配置されている、請求項1〜9のいずれか1項に記載のスプリングエレメント(2)。
- スプリングエレメント(2)の2つの更なる巻線が、スプリングエレメント(2)の更なる末端巻線(6b)を含む2つの更なる巻線の1つとの更なる強固な横の接続により、互いに機械的に連結されている、請求項1〜10のいずれか1項に記載のスプリングエレメント(2)。
- スプリングエレメント(2)が、コイルスプリングとして設計される、請求項1〜11のいずれか1項に記載のスプリングエレメント(2)。
- スプリングエレメント(2)が、圧力スプリングとして設計される、請求項1〜12のいずれか1項に記載のスプリングエレメント(2)。
- 薬物送達デバイスがペン型デバイスである、請求項1〜13のいずれか1項に記載のスプリングエレメント(2)を含む薬物送達デバイス。
- 薬物送達デバイスにおける、請求項1〜14のいずれか1項に記載のスプリングエレメント(2)の使用。
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EP09004663 | 2009-03-31 | ||
EP09004663.2 | 2009-03-31 | ||
US16898009P | 2009-04-14 | 2009-04-14 | |
US61/168,980 | 2009-04-14 | ||
PCT/EP2010/054339 WO2010112559A1 (en) | 2009-03-31 | 2010-03-31 | Spring element for a drug delivery device, use thereof and drug delivery device |
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GB2501897B (en) | 2012-05-09 | 2014-09-03 | Owen Mumford Ltd | Injection devices |
JP6348170B2 (ja) * | 2013-04-18 | 2018-06-27 | ノボ・ノルデイスク・エー/エス | ねじりばねの固定 |
CN106505348B (zh) * | 2016-11-16 | 2018-06-29 | 李慧敏 | 一种笼式双曲线弹簧结构及插座 |
CH715110A2 (de) * | 2018-06-19 | 2019-12-30 | Tecpharma Licensing Ag | Injektionsvorrichtung zum Verabreichen einer medizinischen Substanz, umfassend eine Schraubenfeder, sowie eine solche Schraubenfeder. |
CN113417957B (zh) * | 2021-07-31 | 2022-09-16 | 杭州聚能弹簧科技有限公司 | 一种混振变频弹簧 |
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JPH0461854A (ja) * | 1990-06-29 | 1992-02-27 | Olympus Optical Co Ltd | 内視鏡用処置具装置 |
JPH10267062A (ja) * | 1997-03-24 | 1998-10-06 | Marujiyuu Kasei Kk | コイルスプリングのばね圧調整装置 |
JP2008516713A (ja) * | 2004-10-21 | 2008-05-22 | ノボ・ノルデイスク・エー/エス | 内部投与量表示器を備えた注射器 |
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US3198508A (en) * | 1964-08-07 | 1965-08-03 | Jamco Inc | Spacer for insertion between adjacent convolutions of a coil spring |
US3336842A (en) * | 1965-08-19 | 1967-08-22 | Echlin Mfg Company | Hydraulic actuator |
US4930605A (en) * | 1988-11-23 | 1990-06-05 | Orscheln Co. | Brake apparatus with blind cable installing means |
US5180149A (en) * | 1991-12-05 | 1993-01-19 | Twist Inc. | Brake cylinder piston spring |
EP0992605A3 (en) * | 1998-10-02 | 2002-11-13 | Sumitomo Special Metals Co., Ltd. | Support member, holder, process, and apparatus in the field of surface-treatment |
EP1802889A1 (en) * | 2004-09-10 | 2007-07-04 | Danfoss A/S | A spring and a valve incorporating such a spring |
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0461854A (ja) * | 1990-06-29 | 1992-02-27 | Olympus Optical Co Ltd | 内視鏡用処置具装置 |
JPH10267062A (ja) * | 1997-03-24 | 1998-10-06 | Marujiyuu Kasei Kk | コイルスプリングのばね圧調整装置 |
JP2008516713A (ja) * | 2004-10-21 | 2008-05-22 | ノボ・ノルデイスク・エー/エス | 内部投与量表示器を備えた注射器 |
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JP5690808B2 (ja) | 2015-03-25 |
HK1166836A1 (zh) | 2012-11-09 |
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EP2414700B1 (en) | 2016-05-04 |
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R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
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R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |