JP2012520268A - グラム陰性細菌の除去のための組成物及び方法 - Google Patents

グラム陰性細菌の除去のための組成物及び方法 Download PDF

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Publication number
JP2012520268A
JP2012520268A JP2011553474A JP2011553474A JP2012520268A JP 2012520268 A JP2012520268 A JP 2012520268A JP 2011553474 A JP2011553474 A JP 2011553474A JP 2011553474 A JP2011553474 A JP 2011553474A JP 2012520268 A JP2012520268 A JP 2012520268A
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JP
Japan
Prior art keywords
colon
bacteria
gram
composition
agent
Prior art date
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JP2011553474A
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English (en)
Japanese (ja)
Inventor
アンドレモン,アントワーヌ
ドゥ・ギュンツブール,ジャン
レスキュール,フランソワ
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Assistance Publique Hopitaux de Paris APHP
Universite Paris Diderot Paris 7
Original Assignee
Assistance Publique Hopitaux de Paris APHP
Universite Paris Diderot Paris 7
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Publication of JP2012520268A publication Critical patent/JP2012520268A/ja
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5026Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
JP2011553474A 2009-03-13 2010-03-12 グラム陰性細菌の除去のための組成物及び方法 Withdrawn JP2012520268A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16016209P 2009-03-13 2009-03-13
US61/160,162 2009-03-13
PCT/EP2010/053231 WO2010103119A1 (en) 2009-03-13 2010-03-12 Compositions and methods for elimination of gram-negative bacteria

Publications (1)

Publication Number Publication Date
JP2012520268A true JP2012520268A (ja) 2012-09-06

Family

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Family Applications (1)

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JP2011553474A Withdrawn JP2012520268A (ja) 2009-03-13 2010-03-12 グラム陰性細菌の除去のための組成物及び方法

Country Status (12)

Country Link
US (1) US20120058936A1 (pt)
EP (1) EP2405909A1 (pt)
JP (1) JP2012520268A (pt)
KR (1) KR20120004448A (pt)
CN (1) CN102413826A (pt)
AU (1) AU2010223233A1 (pt)
BR (1) BRPI1009823A2 (pt)
CA (1) CA2754604A1 (pt)
EA (1) EA201101319A1 (pt)
IL (1) IL214979A0 (pt)
MX (1) MX2011009548A (pt)
WO (1) WO2010103119A1 (pt)

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WO2012061902A1 (en) * 2010-11-12 2012-05-18 Monash University Micronised spray-dried particles comprising polymyxin
US20130323217A1 (en) 2010-12-22 2013-12-05 Da Volterra Compositions and methods for the controlled repopulation of gram-negative bacteria in the colon
CN103130881B (zh) * 2013-02-06 2014-09-10 王冬国 一种肺炎克雷伯菌的耐药新基因
WO2015112977A1 (en) * 2014-01-27 2015-07-30 Susanne Gardner Antimicrobial formulations and applications thereof
CA3018328A1 (en) 2014-10-31 2016-04-30 Purdue Pharma Methods and compositions particularly for treatment of attention deficit disorder
KR101995622B1 (ko) * 2015-04-03 2019-07-02 건국대학교 글로컬산학협력단 Adk 단백질을 유효성분으로 포함하는 카바페넴 내성 그람음성균에 대한 항균용 조성물
US11174288B2 (en) 2016-12-06 2021-11-16 Northeastern University Heparin-binding cationic peptide self-assembling peptide amphiphiles useful against drug-resistant bacteria
CN107184953A (zh) * 2017-05-22 2017-09-22 山东省科学院生物研究所 一种抗菌脂肽皮脂膜修复组合物及其应用
US10722473B2 (en) 2018-11-19 2020-07-28 Purdue Pharma L.P. Methods and compositions particularly for treatment of attention deficit disorder
CN110179967A (zh) * 2019-05-28 2019-08-30 中国医药集团总公司四川抗菌素工业研究所 多粘菌素母核和一种抗生素的组合物及其应用
CN112316112A (zh) * 2020-11-30 2021-02-05 河南农业大学 阿奇霉素在逆转食品动物源致病菌抗生素耐药性的用途

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US3494308A (en) 1967-11-14 1970-02-10 George S Perrin Composite article having portions simulating wood
US4474768A (en) 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
WO1989000576A1 (en) 1987-07-09 1989-01-26 Pfizer Inc. Azithromycin dihydrate
US6235313B1 (en) 1992-04-24 2001-05-22 Brown University Research Foundation Bioadhesive microspheres and their use as drug delivery and imaging systems
US5840332A (en) * 1996-01-18 1998-11-24 Perio Products Ltd. Gastrointestinal drug delivery system
CA2245398C (en) 1998-08-21 2002-01-29 Apotex Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
ES2229804T3 (es) 1998-11-30 2005-04-16 Teva Pharmaceutical Industries Ltd. Etannolato de azitromicina, procedimiento para su fabricacion y composiciones farmaceuticas que lo contienen.
WO2001000640A1 (en) 1999-06-29 2001-01-04 Biochemie S.A. Macrolides
US6586576B2 (en) 2000-01-04 2003-07-01 Teva Pharmaceutical Industries Ltd Preparation method of azithromycin hydrates
ES2260047T3 (es) 2000-07-25 2006-11-01 Laboratorio Silanes, S.A. De C.V. Proceso de etapa unica para la preparacion de 7,16-deoxi-2-aza-10-o-cladinosil-12-o-desosaminil-4,5-dihidroxi-6-etil-3,5,9,11,13,15-hexametilbiciclo(11.2.1)hexadeca-1(2)-en-ona y obtencion de una forma nueva de 9-deoxo-9a-metil-9a-homoeritromicina a.
ES2172417B1 (es) 2000-07-31 2003-09-16 Sint Quimica Sa Nueva forma mejorada de azitromicina monohidrato de menor higroscopicidad, procedimiento de preparacion y composiciones farmaceuticas que la comprenden.
WO2002015842A2 (en) 2000-08-23 2002-02-28 Wockhardt Limited Process for preparation of anhydrous azithromycin
AU2002221895A1 (en) 2000-11-27 2002-06-03 Biochemie S.A. Macrolide solvates
DK1390377T3 (da) 2001-05-22 2006-06-19 Pfizer Prod Inc Ny krystalform af azithromycin
WO2006045156A1 (en) * 2004-10-29 2006-05-04 Monash University Therapy for multi-drug resistant microorganisms
US9149439B2 (en) * 2005-03-21 2015-10-06 Sandoz Ag Multi-particulate, modified-release composition
WO2008076806A2 (en) * 2006-12-15 2008-06-26 Trustees Of Boston University Compositions and methods to potentiate colistin activity
DE102007009242A1 (de) 2007-02-22 2008-09-18 Evonik Röhm Gmbh Pellets mit magensaftresistenter Wirkstoff-Matix
WO2009037264A2 (en) * 2007-09-17 2009-03-26 Da Volterra Colonic delivery of antimicrobial agents

Also Published As

Publication number Publication date
CA2754604A1 (en) 2010-09-16
US20120058936A1 (en) 2012-03-08
EA201101319A1 (ru) 2012-04-30
MX2011009548A (es) 2011-12-14
WO2010103119A1 (en) 2010-09-16
EP2405909A1 (en) 2012-01-18
KR20120004448A (ko) 2012-01-12
CN102413826A (zh) 2012-04-11
IL214979A0 (en) 2011-11-30
AU2010223233A1 (en) 2011-10-06
BRPI1009823A2 (pt) 2019-09-24

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