JP2012520085A5 - - Google Patents

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Publication number
JP2012520085A5
JP2012520085A5 JP2011554275A JP2011554275A JP2012520085A5 JP 2012520085 A5 JP2012520085 A5 JP 2012520085A5 JP 2011554275 A JP2011554275 A JP 2011554275A JP 2011554275 A JP2011554275 A JP 2011554275A JP 2012520085 A5 JP2012520085 A5 JP 2012520085A5
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JP
Japan
Prior art keywords
sequence
polynucleotide
expression vector
cell
promoter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2011554275A
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English (en)
Japanese (ja)
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JP2012520085A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2010/027365 external-priority patent/WO2010105277A1/en
Publication of JP2012520085A publication Critical patent/JP2012520085A/ja
Publication of JP2012520085A5 publication Critical patent/JP2012520085A5/ja
Pending legal-status Critical Current

Links

JP2011554275A 2009-03-13 2010-03-15 生物活性rnaの送達のための組成物及び方法 Pending JP2012520085A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US16028809P 2009-03-13 2009-03-13
US16028709P 2009-03-13 2009-03-13
US61/160,288 2009-03-13
US61/160,287 2009-03-13
PCT/US2010/027365 WO2010105277A1 (en) 2009-03-13 2010-03-15 Compositions and methods for the delivery of biologically active rnas

Publications (2)

Publication Number Publication Date
JP2012520085A JP2012520085A (ja) 2012-09-06
JP2012520085A5 true JP2012520085A5 (cg-RX-API-DMAC7.html) 2013-02-21

Family

ID=42728852

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011554275A Pending JP2012520085A (ja) 2009-03-13 2010-03-15 生物活性rnaの送達のための組成物及び方法

Country Status (8)

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US (2) US8569065B2 (cg-RX-API-DMAC7.html)
EP (1) EP2406379A4 (cg-RX-API-DMAC7.html)
JP (1) JP2012520085A (cg-RX-API-DMAC7.html)
KR (1) KR20110128345A (cg-RX-API-DMAC7.html)
CN (1) CN102625842A (cg-RX-API-DMAC7.html)
AU (1) AU2010223888A1 (cg-RX-API-DMAC7.html)
CA (1) CA2755245A1 (cg-RX-API-DMAC7.html)
WO (1) WO2010105277A1 (cg-RX-API-DMAC7.html)

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US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
RU2648950C2 (ru) 2011-10-03 2018-04-02 Модерна Терапьютикс, Инк. Модифицированные нуклеозиды, нуклеотиды и нуклеиновые кислоты и их применение
AU2012352180A1 (en) 2011-12-16 2014-07-31 Moderna Therapeutics, Inc. Modified nucleoside, nucleotide, and nucleic acid compositions
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WO2013101690A1 (en) * 2011-12-29 2013-07-04 modeRNA Therapeutics Modified mrnas encoding cell-penetrating polypeptides
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WO2013151663A1 (en) 2012-04-02 2013-10-10 modeRNA Therapeutics Modified polynucleotides for the production of membrane proteins
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
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US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
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EP3052106A4 (en) 2013-09-30 2017-07-19 ModernaTX, Inc. Polynucleotides encoding immune modulating polypeptides
KR20160067219A (ko) 2013-10-03 2016-06-13 모더나 세라퓨틱스, 인코포레이티드 저밀도 지단백질 수용체를 암호화하는 폴리뉴클레오타이드
EP3184641B1 (en) 2013-10-28 2020-07-08 University of Pittsburgh - Of the Commonwealth System of Higher Education Oncolytic hsv vector
CA2939541C (en) 2014-02-14 2022-11-08 Symvivo Corporation Hybrid proteins and uses thereof
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US9816080B2 (en) * 2014-10-31 2017-11-14 President And Fellows Of Harvard College Delivery of CAS9 via ARRDC1-mediated microvesicles (ARMMs)
US10078092B2 (en) 2015-03-18 2018-09-18 Northwestern University Assays for measuring binding kinetics and binding capacity of acceptors for lipophilic or amphiphilic molecules
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US11639371B2 (en) * 2016-02-17 2023-05-02 The Chinese University Of Hong Kong Peptidylic inhibitors of nucleolin (NCL) targeting CAG-repeat RNA toxicity and methods for reducing polyQ-mediated toxicity in polyQ diseases
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