JP2012520081A5 - - Google Patents

Info

Publication number

JP2012520081A5

JP2012520081A5 JP2011554211A JP2011554211A JP2012520081A5 JP 2012520081 A5 JP2012520081 A5 JP 2012520081A5 JP 2011554211 A JP2011554211 A JP 2011554211A JP 2011554211 A JP2011554211 A JP 2011554211A JP 2012520081 A5 JP2012520081 A5 JP 2012520081A5

Authority

JP

Japan

Prior art keywords

tumor

polypeptide

seq

angiogenesis

isolated

Prior art date

2010-03-11

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 108090000765 processed proteins & peptides Proteins 0.000 claims 32
• 229920001184 polypeptide Polymers 0.000 claims 31
• 102000004196 processed proteins & peptides Human genes 0.000 claims 31
• 150000001413 amino acids Chemical class 0.000 claims 14
• 239000003814 drug Substances 0.000 claims 9
• 206010028980 Neoplasm Diseases 0.000 claims 8
• 230000033115 angiogenesis Effects 0.000 claims 8
• 230000002491 angiogenic effect Effects 0.000 claims 6
• 229940121369 angiogenesis inhibitor Drugs 0.000 claims 5
• 239000004037 angiogenesis inhibitor Substances 0.000 claims 5
• 150000007523 nucleic acids Chemical group 0.000 claims 5
• VEEGZPWAAPPXRB-BJMVGYQFSA-N (3e)-3-(1h-imidazol-5-ylmethylidene)-1h-indol-2-one Chemical compound O=C1NC2=CC=CC=C2\C1=C/C1=CN=CN1 VEEGZPWAAPPXRB-BJMVGYQFSA-N 0.000 claims 4
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
• 206010058558 Hypoperfusion Diseases 0.000 claims 3
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
• 210000004899 c-terminal region Anatomy 0.000 claims 3
• 108091033319 polynucleotide Proteins 0.000 claims 3
• 102000040430 polynucleotide Human genes 0.000 claims 3
• 239000002157 polynucleotide Substances 0.000 claims 3
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
• 238000011282 treatment Methods 0.000 claims 3
• 210000004027 cell Anatomy 0.000 claims 2
• 230000006862 enzymatic digestion Effects 0.000 claims 2
• 239000013604 expression vector Substances 0.000 claims 2
• 208000028867 ischemia Diseases 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 238000002560 therapeutic procedure Methods 0.000 claims 2
• 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 1
• 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 1
• 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
• 208000007860 Anus Neoplasms Diseases 0.000 claims 1
• 201000001320 Atherosclerosis Diseases 0.000 claims 1
• 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
• 208000018084 Bone neoplasm Diseases 0.000 claims 1
• 208000006274 Brain Stem Neoplasms Diseases 0.000 claims 1
• 206010006187 Breast cancer Diseases 0.000 claims 1
• 208000026310 Breast neoplasm Diseases 0.000 claims 1
• 239000012623 DNA damaging agent Substances 0.000 claims 1
• 208000002699 Digestive System Neoplasms Diseases 0.000 claims 1
• 208000001976 Endocrine Gland Neoplasms Diseases 0.000 claims 1
• 208000022072 Gallbladder Neoplasms Diseases 0.000 claims 1
• 206010061968 Gastric neoplasm Diseases 0.000 claims 1
• 208000032612 Glial tumor Diseases 0.000 claims 1
• 206010018338 Glioma Diseases 0.000 claims 1
• 206010019695 Hepatic neoplasm Diseases 0.000 claims 1
• 208000017604 Hodgkin disease Diseases 0.000 claims 1
• 208000021519 Hodgkin lymphoma Diseases 0.000 claims 1
• 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
• 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
• 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 1
• 206010027476 Metastases Diseases 0.000 claims 1
• 208000034578 Multiple myelomas Diseases 0.000 claims 1
• 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 1
• ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 1
• 206010029098 Neoplasm skin Diseases 0.000 claims 1
• 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
• 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
• 229930012538 Paclitaxel Natural products 0.000 claims 1
• 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
• 208000000821 Parathyroid Neoplasms Diseases 0.000 claims 1
• 208000002471 Penile Neoplasms Diseases 0.000 claims 1
• 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
• 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
• 206010060862 Prostate cancer Diseases 0.000 claims 1
• 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
• 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
• 206010039491 Sarcoma Diseases 0.000 claims 1
• 208000000453 Skin Neoplasms Diseases 0.000 claims 1
• 206010041067 Small cell lung cancer Diseases 0.000 claims 1
• 229940123237 Taxane Drugs 0.000 claims 1
• 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
• 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
• 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
• 208000004354 Vulvar Neoplasms Diseases 0.000 claims 1
• 239000003242 anti bacterial agent Substances 0.000 claims 1
• 230000000340 anti-metabolite Effects 0.000 claims 1
• 229940088710 antibiotic agent Drugs 0.000 claims 1
• 239000002256 antimetabolite Substances 0.000 claims 1
• 229940100197 antimetabolite Drugs 0.000 claims 1
• 229940045985 antineoplastic platinum compound Drugs 0.000 claims 1
• 238000003556 assay Methods 0.000 claims 1
• 230000015572 biosynthetic process Effects 0.000 claims 1
• 210000000988 bone and bone Anatomy 0.000 claims 1
• 210000000845 cartilage Anatomy 0.000 claims 1
• 201000007455 central nervous system cancer Diseases 0.000 claims 1
• 208000025997 central nervous system neoplasm Diseases 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 238000009104 chemotherapy regimen Methods 0.000 claims 1
• 230000001684 chronic effect Effects 0.000 claims 1
• 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 1
• 208000029742 colonic neoplasm Diseases 0.000 claims 1
• 208000023963 corpus uteri neoplasm Diseases 0.000 claims 1
• 230000004069 differentiation Effects 0.000 claims 1
• 229960003668 docetaxel Drugs 0.000 claims 1
• 201000011523 endocrine gland cancer Diseases 0.000 claims 1
• 239000004052 folic acid antagonist Substances 0.000 claims 1
• 210000004392 genitalia Anatomy 0.000 claims 1
• 208000014829 head and neck neoplasm Diseases 0.000 claims 1
• 239000005556 hormone Substances 0.000 claims 1
• 229940088597 hormone Drugs 0.000 claims 1
• 239000000411 inducer Substances 0.000 claims 1
• 239000003112 inhibitor Substances 0.000 claims 1
• 201000004959 laryngeal benign neoplasm Diseases 0.000 claims 1
• 206010023841 laryngeal neoplasm Diseases 0.000 claims 1
• 208000032839 leukemia Diseases 0.000 claims 1
• 230000002197 limbic effect Effects 0.000 claims 1
• 208000014018 liver neoplasm Diseases 0.000 claims 1
• 208000020816 lung neoplasm Diseases 0.000 claims 1
• 208000037841 lung tumor Diseases 0.000 claims 1
• 208000026045 malignant tumor of parathyroid gland Diseases 0.000 claims 1
• 201000001441 melanoma Diseases 0.000 claims 1
• 230000009401 metastasis Effects 0.000 claims 1
• 230000000394 mitotic effect Effects 0.000 claims 1
• 208000025113 myeloid leukemia Diseases 0.000 claims 1
• 208000031225 myocardial ischemia Diseases 0.000 claims 1
• 208000025402 neoplasm of esophagus Diseases 0.000 claims 1
• 208000025189 neoplasm of testis Diseases 0.000 claims 1
• 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
• 208000025303 orbit neoplasm Diseases 0.000 claims 1
• 201000000890 orbital cancer Diseases 0.000 claims 1
• 229960001592 paclitaxel Drugs 0.000 claims 1
• 201000002528 pancreatic cancer Diseases 0.000 claims 1
• 208000011252 penile benign neoplasm Diseases 0.000 claims 1
• 208000023974 pharynx neoplasm Diseases 0.000 claims 1
• 150000003058 platinum compounds Chemical class 0.000 claims 1
• 230000000861 pro-apoptotic effect Effects 0.000 claims 1
• 208000023958 prostate neoplasm Diseases 0.000 claims 1
• 230000005855 radiation Effects 0.000 claims 1
• 208000013718 rectal benign neoplasm Diseases 0.000 claims 1
• 201000008946 renal pelvis neoplasm Diseases 0.000 claims 1
• 210000002345 respiratory system Anatomy 0.000 claims 1
• 208000037803 restenosis Diseases 0.000 claims 1
• 208000000587 small cell lung carcinoma Diseases 0.000 claims 1
• 208000014680 small intestine neoplasm Diseases 0.000 claims 1
• 230000004936 stimulating effect Effects 0.000 claims 1
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
• 201000003120 testicular cancer Diseases 0.000 claims 1
• 208000013076 thyroid tumor Diseases 0.000 claims 1
• 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
• 208000026517 ureter neoplasm Diseases 0.000 claims 1
• 201000011476 ureteral benign neoplasm Diseases 0.000 claims 1
• 208000029584 urinary system neoplasm Diseases 0.000 claims 1
• 208000024719 uterine cervix neoplasm Diseases 0.000 claims 1
• 206010046885 vaginal cancer Diseases 0.000 claims 1
• 208000013139 vaginal neoplasm Diseases 0.000 claims 1
• 201000005102 vulva cancer Diseases 0.000 claims 1