JP2012519707A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012519707A5 JP2012519707A5 JP2011553146A JP2011553146A JP2012519707A5 JP 2012519707 A5 JP2012519707 A5 JP 2012519707A5 JP 2011553146 A JP2011553146 A JP 2011553146A JP 2011553146 A JP2011553146 A JP 2011553146A JP 2012519707 A5 JP2012519707 A5 JP 2012519707A5
- Authority
- JP
- Japan
- Prior art keywords
- epha3
- antibody
- cells
- cell
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15828509P | 2009-03-06 | 2009-03-06 | |
| US61/158,285 | 2009-03-06 | ||
| US16813009P | 2009-04-09 | 2009-04-09 | |
| US61/168,130 | 2009-04-09 | ||
| PCT/US2010/026413 WO2010102244A1 (en) | 2009-03-06 | 2010-03-05 | Treatment of leukemias and chronic myeloproliferative diseases with antibodies to epha3 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015122537A Division JP2015231994A (ja) | 2009-03-06 | 2015-06-18 | ＥｐｈＡ３に対する抗体を用いた、白血病および慢性骨髄増殖性疾患の治療方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012519707A JP2012519707A (ja) | 2012-08-30 |
| JP2012519707A5 true JP2012519707A5 (https=) | 2013-04-18 |
| JP5876728B2 JP5876728B2 (ja) | 2016-03-02 |
Family
ID=42370943
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011553146A Expired - Fee Related JP5876728B2 (ja) | 2009-03-06 | 2010-03-05 | ＥｐｈＡ３に対する抗体を用いた、白血病および慢性骨髄増殖性疾患の治療方法 |
| JP2015122537A Pending JP2015231994A (ja) | 2009-03-06 | 2015-06-18 | ＥｐｈＡ３に対する抗体を用いた、白血病および慢性骨髄増殖性疾患の治療方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015122537A Pending JP2015231994A (ja) | 2009-03-06 | 2015-06-18 | ＥｐｈＡ３に対する抗体を用いた、白血病および慢性骨髄増殖性疾患の治療方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US8834870B2 (https=) |
| EP (1) | EP2403879A1 (https=) |
| JP (2) | JP5876728B2 (https=) |
| CN (1) | CN102405237A (https=) |
| AU (1) | AU2010221159B2 (https=) |
| CA (1) | CA2753995A1 (https=) |
| EA (1) | EA201101241A1 (https=) |
| NZ (1) | NZ594950A (https=) |
| WO (1) | WO2010102244A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8470966B2 (en) | 2007-08-10 | 2013-06-25 | Protelica, Inc. | Universal fibronectin type III binding-domain libraries |
| WO2009023184A2 (en) * | 2007-08-10 | 2009-02-19 | Protelix, Inc. | Universal fibronectin type iii binding-domain libraries |
| US8680019B2 (en) * | 2007-08-10 | 2014-03-25 | Protelica, Inc. | Universal fibronectin Type III binding-domain libraries |
| CA2777068C (en) | 2009-10-14 | 2020-05-26 | Humanigen, Inc. | Antibodies to epha3 |
| EP2517555A4 (en) | 2009-12-25 | 2014-09-24 | Chugai Pharmaceutical Co Ltd | SEARCHING AND SCREENING METHOD FOR A TARGET MOLECULE OF A CANCER WITH A NON-MENTAL ANIMAL MODEL WITH A NO-CANCER LINE OF TRANSPLANTED LINE |
| JP6230789B2 (ja) | 2010-10-06 | 2017-11-15 | 中外製薬株式会社 | 癌幹細胞集団及びその作製方法 |
| GB201021623D0 (en) * | 2010-12-21 | 2011-02-02 | Isis Innovation | Detection of acute myeloid leukaemia |
| US9109032B2 (en) | 2011-08-12 | 2015-08-18 | Kalobios Pharmaceuticals, Inc. | Methods of treating hematological proliferative disorders by targeting EphA3 expressed on aberrant vasculature in bone marrow |
| EP2749641B1 (en) | 2011-09-07 | 2021-06-02 | Chugai Seiyaku Kabushiki Kaisha | Cancer stem cell isolation |
| EP2772268B8 (en) | 2011-10-28 | 2020-01-08 | Chugai Seiyaku Kabushiki Kaisha | Cancer stem cell-specific molecule |
| WO2015093949A2 (en) * | 2013-12-17 | 2015-06-25 | Aimm Therapeutics B.V. | Means and methods for counteracting myeloproliferative or lymphoproliferative disorders |
| WO2021068040A1 (en) * | 2019-10-09 | 2021-04-15 | The Council Of The Queensland Institute Of Medical Research | Targeting epha3 and uses thereof |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JP3101690B2 (ja) | 1987-03-18 | 2000-10-23 | エス・ビィ・２・インコーポレイテッド | 変性抗体の、または変性抗体に関する改良 |
| US5677425A (en) | 1987-09-04 | 1997-10-14 | Celltech Therapeutics Limited | Recombinant antibody |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| ATE158021T1 (de) | 1990-08-29 | 1997-09-15 | Genpharm Int | Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5674691A (en) | 1991-06-21 | 1997-10-07 | Amrad Corporation Limited | Method of screening for ligands to a receptor-type tyrosine kinase |
| US5714350A (en) | 1992-03-09 | 1998-02-03 | Protein Design Labs, Inc. | Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region |
| CA2118508A1 (en) | 1992-04-24 | 1993-11-11 | Elizabeth S. Ward | Recombinant production of immunoglobulin-like domains in prokaryotic cells |
| NO175798C (no) | 1992-07-22 | 1994-12-07 | Sinvent As | Fremgangsmåte og anordning til aktiv stöydemping i et lokalt område |
| US5885573A (en) | 1993-06-01 | 1999-03-23 | Arch Development Corporation | Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies |
| US6121022A (en) | 1995-04-14 | 2000-09-19 | Genentech, Inc. | Altered polypeptides with increased half-life |
| US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
| US5770380A (en) | 1996-09-13 | 1998-06-23 | University Of Pittsburgh | Synthetic antibody mimics--multiple peptide loops attached to a molecular scaffold |
| US6277375B1 (en) | 1997-03-03 | 2001-08-21 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
| US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| DK1071700T3 (da) | 1998-04-20 | 2010-06-07 | Glycart Biotechnology Ag | Glykosylerings-modifikation af antistoffer til forbedring af antistofafhængig cellulær cytotoksicitet |
| GB9809951D0 (en) | 1998-05-08 | 1998-07-08 | Univ Cambridge Tech | Binding molecules |
| AU776910B2 (en) | 1998-12-08 | 2004-09-23 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Modifying protein immunogenicity |
| US7115396B2 (en) | 1998-12-10 | 2006-10-03 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
| US6818418B1 (en) | 1998-12-10 | 2004-11-16 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| PL209392B1 (pl) | 1999-01-15 | 2011-08-31 | Genentech Inc | Przeciwciało, komórka gospodarza, sposób wytwarzania przeciwciała oraz zastosowanie przeciwciała |
| WO2000060070A1 (en) | 1999-04-01 | 2000-10-12 | Innogenetics N.V. | A polypeptide structure for use as a scaffold |
| CA2704600C (en) | 1999-04-09 | 2016-10-25 | Kyowa Kirin Co., Ltd. | A method for producing antibodies with increased adcc activity |
| EP1094110A1 (en) | 1999-10-21 | 2001-04-25 | Leadd B.V. | Apoptosis inducing proteinaceous substance |
| ES2252261T3 (es) | 2000-06-28 | 2006-05-16 | Glycofi, Inc. | Metodos para producir glicoproteinas modificadas. |
| CA2953239A1 (en) | 2000-10-06 | 2002-04-18 | Kyowa Hakko Kirin Co., Ltd. | Antibody composition-producing cell |
| US6946292B2 (en) | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
| CA2424977C (en) | 2000-10-06 | 2008-03-18 | Kyowa Hakko Kogyo Co., Ltd. | Process for purifying antibody |
| US7083784B2 (en) | 2000-12-12 | 2006-08-01 | Medimmune, Inc. | Molecules with extended half-lives, compositions and uses thereof |
| US7317091B2 (en) | 2002-03-01 | 2008-01-08 | Xencor, Inc. | Optimized Fc variants |
| CN101613705A (zh) | 2002-03-19 | 2009-12-30 | 国际植物研究所 | 在植物中优化聚糖生成 |
| EP1553975B8 (en) | 2002-09-27 | 2023-04-12 | Xencor, Inc. | Optimized fc variants and methods for their generation |
| AU2003900541A0 (en) * | 2003-02-07 | 2003-02-20 | Ludwig Institute For Cancer Research | Modulation of cell adhesion and tumour cell metastasis |
| EP1761561B1 (en) | 2004-01-20 | 2015-08-26 | KaloBios Pharmaceuticals, Inc. | Antibody specificity transfer using minimal essential binding determinants |
| EP1778726A4 (en) | 2004-08-16 | 2009-03-18 | Medimmune Inc | INTEGRIN ANTAGONISTS WITH IMPROVED ANTIBODY-DEPENDENT CELL-ASSAYED CYTOTOXICITY ACTIVITY |
| WO2006052409A2 (en) * | 2004-10-23 | 2006-05-18 | Case Western Reserve University | Peptide and small molecule agonists of epha and their uses |
| PT2343380T (pt) | 2004-11-16 | 2019-09-18 | Humanigen Inc | Permuta de cassetes da região variável de imunoglobulina |
| JP2009526520A (ja) | 2006-01-17 | 2009-07-23 | バイオレックス セラピュティックス インク | 植物中でのｎ−グリカンのヒト化及び最適化のための組成物及び方法 |
| US7846724B2 (en) | 2006-04-11 | 2010-12-07 | Hoffmann-La Roche Inc. | Method for selecting CHO cell for production of glycosylated antibodies |
| PL3199180T3 (pl) * | 2007-03-08 | 2022-08-08 | Humanigen, Inc. | Przeciwciała przeciwko epha3 do leczenia guzów litych |
-
2010
- 2010-03-05 AU AU2010221159A patent/AU2010221159B2/en not_active Ceased
- 2010-03-05 US US12/718,768 patent/US8834870B2/en active Active
- 2010-03-05 EA EA201101241A patent/EA201101241A1/ru unknown
- 2010-03-05 CA CA2753995A patent/CA2753995A1/en not_active Abandoned
- 2010-03-05 NZ NZ594950A patent/NZ594950A/xx not_active IP Right Cessation
- 2010-03-05 JP JP2011553146A patent/JP5876728B2/ja not_active Expired - Fee Related
- 2010-03-05 EP EP10708675A patent/EP2403879A1/en not_active Withdrawn
- 2010-03-05 CN CN2010800176719A patent/CN102405237A/zh active Pending
- 2010-03-05 WO PCT/US2010/026413 patent/WO2010102244A1/en not_active Ceased
-
2014
- 2014-08-29 US US14/473,821 patent/US20140370010A1/en not_active Abandoned
-
2015
- 2015-06-18 JP JP2015122537A patent/JP2015231994A/ja active Pending
-
2016
- 2016-09-14 US US15/265,625 patent/US20170226227A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2012519707A5 (https=) | ||
| CO6260105A2 (es) | Anticuerpos humanos contra cd20 humano y metodo para utilizarlos | |
| NZ740686A (en) | Therapeutic cd47 antibodies | |
| EA201070596A1 (ru) | Гуманизированные антитела против tl1a | |
| WO2011139974A3 (en) | Anti-pai-1 antibodies and methods of use thereof | |
| ES2523194T3 (es) | Anticuerpo monoclonal humano específico para cada tumor | |
| JP2014240385A5 (https=) | ||
| JP2014205674A5 (https=) | ||
| JP2017535257A5 (https=) | ||
| JP2018534933A5 (https=) | ||
| JP2015520758A5 (https=) | ||
| NZ608206A (en) | Antibodies that bind myostatin, compositions and methods | |
| JP2017507652A5 (https=) | ||
| FI3332006T3 (fi) | Uusia anti-PD-L1-vasta-aineita | |
| JP2013227339A5 (https=) | ||
| NO20091712L (no) | Nye anti-CD38-antistoffer for behandling av cancer | |
| JP2013538057A5 (https=) | ||
| RU2016101109A (ru) | Медицинское применение агонистов cd38 | |
| JP2008537778A5 (https=) | ||
| JP2013542194A5 (https=) | ||
| MX2011009312A (es) | Formulaciones de anticuerpos humanizados anti-cd19. | |
| WO2010059969A8 (en) | Use of anti-vegf antibody in combination with chemotherapy for treating breast cancer | |
| JP2008507530A5 (https=) | ||
| RS59605B1 (sr) | Kombinacija anti-cd19 antitela i inhibitora brutonove tirozin kinaze i njene upotrebe | |
| JP2015530399A5 (https=) |