JP2012519707A5 - - Google Patents
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- Publication number
- JP2012519707A5 JP2012519707A5 JP2011553146A JP2011553146A JP2012519707A5 JP 2012519707 A5 JP2012519707 A5 JP 2012519707A5 JP 2011553146 A JP2011553146 A JP 2011553146A JP 2011553146 A JP2011553146 A JP 2011553146A JP 2012519707 A5 JP2012519707 A5 JP 2012519707A5
- Authority
- JP
- Japan
- Prior art keywords
- epha3
- antibody
- cells
- cell
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15828509P | 2009-03-06 | 2009-03-06 | |
| US61/158,285 | 2009-03-06 | ||
| US16813009P | 2009-04-09 | 2009-04-09 | |
| US61/168,130 | 2009-04-09 | ||
| PCT/US2010/026413 WO2010102244A1 (en) | 2009-03-06 | 2010-03-05 | Treatment of leukemias and chronic myeloproliferative diseases with antibodies to epha3 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015122537A Division JP2015231994A (ja) | 2009-03-06 | 2015-06-18 | EphA3に対する抗体を用いた、白血病および慢性骨髄増殖性疾患の治療方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012519707A JP2012519707A (ja) | 2012-08-30 |
| JP2012519707A5 true JP2012519707A5 (cg-RX-API-DMAC10.html) | 2013-04-18 |
| JP5876728B2 JP5876728B2 (ja) | 2016-03-02 |
Family
ID=42370943
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011553146A Expired - Fee Related JP5876728B2 (ja) | 2009-03-06 | 2010-03-05 | EphA3に対する抗体を用いた、白血病および慢性骨髄増殖性疾患の治療方法 |
| JP2015122537A Pending JP2015231994A (ja) | 2009-03-06 | 2015-06-18 | EphA3に対する抗体を用いた、白血病および慢性骨髄増殖性疾患の治療方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015122537A Pending JP2015231994A (ja) | 2009-03-06 | 2015-06-18 | EphA3に対する抗体を用いた、白血病および慢性骨髄増殖性疾患の治療方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US8834870B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP2403879A1 (cg-RX-API-DMAC10.html) |
| JP (2) | JP5876728B2 (cg-RX-API-DMAC10.html) |
| CN (1) | CN102405237A (cg-RX-API-DMAC10.html) |
| AU (1) | AU2010221159B2 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2753995A1 (cg-RX-API-DMAC10.html) |
| EA (1) | EA201101241A1 (cg-RX-API-DMAC10.html) |
| NZ (1) | NZ594950A (cg-RX-API-DMAC10.html) |
| WO (1) | WO2010102244A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090176654A1 (en) * | 2007-08-10 | 2009-07-09 | Protelix, Inc. | Universal fibronectin type III binding-domain libraries |
| US8680019B2 (en) * | 2007-08-10 | 2014-03-25 | Protelica, Inc. | Universal fibronectin Type III binding-domain libraries |
| US8470966B2 (en) | 2007-08-10 | 2013-06-25 | Protelica, Inc. | Universal fibronectin type III binding-domain libraries |
| AU2010313621C1 (en) | 2009-10-14 | 2015-11-26 | Humanigen, Inc. | Antibodies to EphA3 |
| US11536713B2 (en) | 2009-12-25 | 2022-12-27 | Chugai Seiyaku Kabushiki Kaisha | Method for searching and screening for target of anti-cancer agent using non-human animal model having NOG established cancer cell line transplanted therein |
| SG189302A1 (en) | 2010-10-06 | 2013-05-31 | Pharmalogicals Res Pte Ltd | Cancer stem cell population and method for production thereof |
| GB201021623D0 (en) * | 2010-12-21 | 2011-02-02 | Isis Innovation | Detection of acute myeloid leukaemia |
| AU2012295334A1 (en) * | 2011-08-12 | 2013-05-02 | Kalobios Pharmaceuticals, Inc. | Methods of treating hematological proliferative disorders by targeting EphA3 expressed on aberrant vasculature in bone marrow |
| JP6077997B2 (ja) | 2011-09-07 | 2017-02-08 | 中外製薬株式会社 | 癌幹細胞の分離 |
| EP3603671A3 (en) * | 2011-10-28 | 2020-07-29 | Chugai Seiyaku Kabushiki Kaisha | Cancer stem cell-specific molecule |
| EP3572425A1 (en) * | 2013-12-17 | 2019-11-27 | AIMM Therapeutics B.V. | Means and methods for counteracting myeloproliferative or lymphoproliferative disorders |
| US20260055195A1 (en) * | 2019-10-09 | 2026-02-26 | The Council Of The Queensland Institute Of Medical Research | Targeting epha3 and uses thereof |
| CN117192121A (zh) * | 2023-08-30 | 2023-12-08 | 北京大学人民医院 | 用于mds和/或aml微小残留病检测的抗体组合物及其应用 |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JP3101690B2 (ja) | 1987-03-18 | 2000-10-23 | エス・ビィ・2・インコーポレイテッド | 変性抗体の、または変性抗体に関する改良 |
| US5677425A (en) | 1987-09-04 | 1997-10-14 | Celltech Therapeutics Limited | Recombinant antibody |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| ES2246502T3 (es) | 1990-08-29 | 2006-02-16 | Genpharm International, Inc. | Animales no humanos transgenicos capaces de producir anticuerpos heterologos. |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| ATE278019T1 (de) | 1991-06-21 | 2004-10-15 | Inst Medical W & E Hall | Neuartige rezeptor-typ tyrosinkinase und deren verwendung |
| US5714350A (en) | 1992-03-09 | 1998-02-03 | Protein Design Labs, Inc. | Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region |
| AU4116793A (en) | 1992-04-24 | 1993-11-29 | Board Of Regents, The University Of Texas System | Recombinant production of immunoglobulin-like domains in prokaryotic cells |
| NO175798C (no) | 1992-07-22 | 1994-12-07 | Sinvent As | Fremgangsmåte og anordning til aktiv stöydemping i et lokalt område |
| US5885573A (en) | 1993-06-01 | 1999-03-23 | Arch Development Corporation | Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies |
| US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
| US6121022A (en) | 1995-04-14 | 2000-09-19 | Genentech, Inc. | Altered polypeptides with increased half-life |
| US5770380A (en) | 1996-09-13 | 1998-06-23 | University Of Pittsburgh | Synthetic antibody mimics--multiple peptide loops attached to a molecular scaffold |
| US6277375B1 (en) | 1997-03-03 | 2001-08-21 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
| US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| JP4334141B2 (ja) | 1998-04-20 | 2009-09-30 | グリカート バイオテクノロジー アクチェンゲゼルシャフト | 抗体依存性細胞傷害性を改善するための抗体のグリコシル化操作 |
| GB9809951D0 (en) | 1998-05-08 | 1998-07-08 | Univ Cambridge Tech | Binding molecules |
| AU776910B2 (en) | 1998-12-08 | 2004-09-23 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Modifying protein immunogenicity |
| US6818418B1 (en) | 1998-12-10 | 2004-11-16 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
| US7115396B2 (en) | 1998-12-10 | 2006-10-03 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
| HUP0104865A3 (en) | 1999-01-15 | 2004-07-28 | Genentech Inc | Polypeptide variants with altered effector function |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| WO2000060070A1 (en) | 1999-04-01 | 2000-10-12 | Innogenetics N.V. | A polypeptide structure for use as a scaffold |
| EP2275540B1 (en) | 1999-04-09 | 2016-03-23 | Kyowa Hakko Kirin Co., Ltd. | Method for controlling the activity of immunologically functional molecule |
| EP1094110A1 (en) | 1999-10-21 | 2001-04-25 | Leadd B.V. | Apoptosis inducing proteinaceous substance |
| US7029872B2 (en) | 2000-06-28 | 2006-04-18 | Glycofi, Inc | Methods for producing modified glycoproteins |
| US6946292B2 (en) | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
| JPWO2002030954A1 (ja) | 2000-10-06 | 2004-02-19 | 協和醗酵工業株式会社 | 抗体を精製する方法 |
| CN103333860B (zh) | 2000-10-06 | 2015-07-08 | 协和发酵麒麟株式会社 | 产生抗体组合物的细胞 |
| EP1355919B1 (en) | 2000-12-12 | 2010-11-24 | MedImmune, LLC | Molecules with extended half-lives, compositions and uses thereof |
| US7317091B2 (en) | 2002-03-01 | 2008-01-08 | Xencor, Inc. | Optimized Fc variants |
| CA2923247A1 (en) | 2002-03-19 | 2003-09-25 | Stichting Dienst Landbouwkundig Onderzoek | Optimizing glycan processing in plants |
| CA2832136C (en) | 2002-09-27 | 2015-11-17 | Xencor | Optimized fc variants and methods for their generation |
| AU2003900541A0 (en) | 2003-02-07 | 2003-02-20 | Ludwig Institute For Cancer Research | Modulation of cell adhesion and tumour cell metastasis |
| US7981843B2 (en) | 2004-01-20 | 2011-07-19 | Kalobios Pharmaceuticals, Inc. | Antibody specificity transfer using minimal essential binding determinants |
| AU2005277641A1 (en) | 2004-08-16 | 2006-03-02 | Medimmune, Llc | Eph receptor Fc variants with enhanced antibody dependent cell-mediated cytotoxicity activity |
| US8222253B2 (en) * | 2004-10-23 | 2012-07-17 | Case Western Reserve University | Peptide and small molecule agonists of EphA and their uses |
| PL2343380T3 (pl) | 2004-11-16 | 2020-03-31 | Humanigen, Inc. | Wymiana kasety dla regionu zmiennego immunoglobuliny |
| MX2008009220A (es) | 2006-01-17 | 2008-10-10 | Biolex Therapeutics Inc | Composiciones y metodos para la humanizacion y optimizacion de n-glicanos en plantas. |
| US7846724B2 (en) | 2006-04-11 | 2010-12-07 | Hoffmann-La Roche Inc. | Method for selecting CHO cell for production of glycosylated antibodies |
| EP3199180B1 (en) * | 2007-03-08 | 2022-01-05 | Humanigen, Inc. | Epha3 antibodies for the treatment of solid tumors |
-
2010
- 2010-03-05 US US12/718,768 patent/US8834870B2/en active Active
- 2010-03-05 JP JP2011553146A patent/JP5876728B2/ja not_active Expired - Fee Related
- 2010-03-05 EA EA201101241A patent/EA201101241A1/ru unknown
- 2010-03-05 NZ NZ594950A patent/NZ594950A/xx not_active IP Right Cessation
- 2010-03-05 WO PCT/US2010/026413 patent/WO2010102244A1/en not_active Ceased
- 2010-03-05 EP EP10708675A patent/EP2403879A1/en not_active Withdrawn
- 2010-03-05 CN CN2010800176719A patent/CN102405237A/zh active Pending
- 2010-03-05 AU AU2010221159A patent/AU2010221159B2/en not_active Ceased
- 2010-03-05 CA CA2753995A patent/CA2753995A1/en not_active Abandoned
-
2014
- 2014-08-29 US US14/473,821 patent/US20140370010A1/en not_active Abandoned
-
2015
- 2015-06-18 JP JP2015122537A patent/JP2015231994A/ja active Pending
-
2016
- 2016-09-14 US US15/265,625 patent/US20170226227A1/en not_active Abandoned
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