JP2012519692A5 - - Google Patents
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- Publication number
- JP2012519692A5 JP2012519692A5 JP2011553061A JP2011553061A JP2012519692A5 JP 2012519692 A5 JP2012519692 A5 JP 2012519692A5 JP 2011553061 A JP2011553061 A JP 2011553061A JP 2011553061 A JP2011553061 A JP 2011553061A JP 2012519692 A5 JP2012519692 A5 JP 2012519692A5
- Authority
- JP
- Japan
- Prior art keywords
- suspension
- composition
- peg
- item
- active agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000725 suspension Substances 0.000 claims description 85
- 239000000203 mixture Substances 0.000 claims description 44
- 239000013543 active substance Substances 0.000 claims description 26
- 229920001223 polyethylene glycol Polymers 0.000 claims description 20
- 229920002538 Polyethylene Glycol 20000 Polymers 0.000 claims description 14
- 102000027426 receptor tyrosine kinases Human genes 0.000 claims description 14
- 108091008598 receptor tyrosine kinases Proteins 0.000 claims description 14
- 239000003112 inhibitor Substances 0.000 claims description 12
- 239000002245 particle Substances 0.000 claims description 10
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 10
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 10
- 229920000053 polysorbate 80 Polymers 0.000 claims description 10
- 229940068968 polysorbate 80 Drugs 0.000 claims description 10
- 206010029113 Neovascularisation Diseases 0.000 claims description 9
- 208000022873 Ocular disease Diseases 0.000 claims description 9
- 229920002560 Polyethylene Glycol 3000 Polymers 0.000 claims description 8
- 239000004037 angiogenesis inhibitor Substances 0.000 claims description 8
- MPVGZUGXCQEXTM-UHFFFAOYSA-N linifanib Chemical group CC1=CC=C(F)C(NC(=O)NC=2C=CC(=CC=2)C=2C=3C(N)=NNC=3C=CC=2)=C1 MPVGZUGXCQEXTM-UHFFFAOYSA-N 0.000 claims description 8
- 238000002347 injection Methods 0.000 claims description 7
- 239000007924 injection Substances 0.000 claims description 7
- 239000002202 Polyethylene glycol Substances 0.000 claims description 6
- 229920001664 tyloxapol Polymers 0.000 claims description 6
- MDYZKJNTKZIUSK-UHFFFAOYSA-N tyloxapol Chemical compound O=C.C1CO1.CC(C)(C)CC(C)(C)C1=CC=C(O)C=C1 MDYZKJNTKZIUSK-UHFFFAOYSA-N 0.000 claims description 6
- 229960004224 tyloxapol Drugs 0.000 claims description 6
- 229940100654 ophthalmic suspension Drugs 0.000 claims description 5
- 239000008118 PEG 6000 Substances 0.000 claims description 4
- 229920002584 Polyethylene Glycol 6000 Polymers 0.000 claims description 4
- 229920001213 Polysorbate 20 Polymers 0.000 claims description 4
- 206010064930 age-related macular degeneration Diseases 0.000 claims description 4
- 239000002736 nonionic surfactant Substances 0.000 claims description 4
- 239000008389 polyethoxylated castor oil Substances 0.000 claims description 4
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims description 4
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims description 4
- 229940068977 polysorbate 20 Drugs 0.000 claims description 4
- 229940124617 receptor tyrosine kinase inhibitor Drugs 0.000 claims description 4
- 230000008728 vascular permeability Effects 0.000 claims description 4
- 206010012689 Diabetic retinopathy Diseases 0.000 claims description 2
- 208000008069 Geographic Atrophy Diseases 0.000 claims description 2
- 208000001344 Macular Edema Diseases 0.000 claims description 2
- 206010025415 Macular oedema Diseases 0.000 claims description 2
- 206010046851 Uveitis Diseases 0.000 claims description 2
- 229940121363 anti-inflammatory agent Drugs 0.000 claims description 2
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 2
- 230000002137 anti-vascular effect Effects 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims description 2
- 230000003902 lesion Effects 0.000 claims description 2
- 208000002780 macular degeneration Diseases 0.000 claims description 2
- 201000010230 macular retinal edema Diseases 0.000 claims description 2
- 208000035475 disorder Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 description 12
- 230000033115 angiogenesis Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000002207 retinal effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15698409P | 2009-03-03 | 2009-03-03 | |
| US61/156,984 | 2009-03-03 | ||
| PCT/US2010/025998 WO2010101971A1 (en) | 2009-03-03 | 2010-03-03 | Pharmaceutical composition for delivery of receptor tyrosine kinase inhibiting (rtki) compounds to the eye |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012519692A JP2012519692A (ja) | 2012-08-30 |
| JP2012519692A5 true JP2012519692A5 (cg-RX-API-DMAC7.html) | 2013-03-07 |
| JP5583145B2 JP5583145B2 (ja) | 2014-09-03 |
Family
ID=42678477
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011553061A Expired - Fee Related JP5583145B2 (ja) | 2009-03-03 | 2010-03-03 | レセプターチロシンキナーゼ阻害（ＲＴＫｉ）化合物の眼への送達のための薬学的組成物 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20100226992A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2403342A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5583145B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20110123789A (cg-RX-API-DMAC7.html) |
| CN (2) | CN105362221A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2010221438C1 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI1008920A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2753837A1 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2011008680A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2010101971A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201105506B (cg-RX-API-DMAC7.html) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7973142B2 (en) | 2006-04-07 | 2011-07-05 | Warner Chilcott Company | Antibodies that bind human protein tyrosine phosphatase beta (HPTPβ) |
| US7622593B2 (en) | 2006-06-27 | 2009-11-24 | The Procter & Gamble Company | Human protein tyrosine phosphatase inhibitors and methods of use |
| TW201023912A (en) | 2008-12-05 | 2010-07-01 | Alcon Res Ltd | Pharmaceutical suspension |
| WO2010101989A1 (en) | 2009-03-03 | 2010-09-10 | Alcon Research, Ltd. | PHARMACEUTICAL COMPOSITION FOR DELIVERY OF RECEPTOR TYROSINE KINASE INHIBITING (RTKi) COMPOUNDS TO THE EYE |
| MX2011007420A (es) | 2009-07-06 | 2011-12-14 | Akebia Therapeutics Inc | Compuestos, composiciones y metodos para prevenir la metastasis de las celulas cancerigenas. |
| EP3505182A1 (en) | 2011-10-13 | 2019-07-03 | Aerpio Therapeutics, Inc. | Methods for treating vascular leak syndrome and cancer |
| CA2857337A1 (en) * | 2011-12-14 | 2013-06-20 | Abbvie Inc. | Compositions containing kinase inhibitors |
| EP2825166A1 (en) * | 2012-03-12 | 2015-01-21 | Allergan, Inc. | Method of treating ophthalmic conditions with kinase inhibitors |
| US20150050277A1 (en) | 2013-03-15 | 2015-02-19 | Aerpio Therapeutics Inc. | Compositions and methods for treating ocular diseases |
| TW201518291A (zh) | 2013-09-20 | 2015-05-16 | 參天製藥股份有限公司 | 含聚乙二醇之組成物 |
| CN106456614A (zh) | 2014-03-14 | 2017-02-22 | 爱尔皮奥治疗有限公司 | HPTP‑β抑制剂 |
| RU2768652C1 (ru) * | 2014-09-17 | 2022-03-24 | Паноптика, Инк. | Офтальмологические составы для доставки лекарств и защиты переднего отдела глаза |
| WO2016197005A1 (en) * | 2015-06-05 | 2016-12-08 | Kato Pharmaceuticals, Inc. | Extended release urea compositions |
| TWI664965B (zh) * | 2015-06-22 | 2019-07-11 | 新源生物科技股份有限公司 | 酪胺酸激酶抑制劑之眼用調配物、其使用方法、及其製備方法 |
| EP4414032A3 (en) | 2015-09-23 | 2024-11-06 | EyePoint Pharmaceuticals, Inc. | Methods of treating intraocular pressure with activators of tie-2 |
| AU2020264969B2 (en) | 2019-04-29 | 2025-06-05 | EyePoint, Inc. | Tie-2 activators targeting the schlemm's canal |
| US20220370460A1 (en) * | 2019-09-13 | 2022-11-24 | Aldeyra Therapeutics, Inc. | Ophthalmic formulations of methotrexate |
| CA3151433C (en) * | 2019-09-27 | 2023-05-16 | Virginia Commonwealth University | Compositions and methods for restoring or increasing tissue perfusion |
| CN116251186B (zh) * | 2021-12-09 | 2025-04-25 | 成都瑞沐生物医药科技有限公司 | 一种酪氨酸激酶抑制剂眼用制剂及其制备方法和用途 |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3856919A (en) * | 1970-06-08 | 1974-12-24 | Burton Parsons Chemicals Inc | Ophthalmic solution |
| US3931319A (en) * | 1974-10-29 | 1976-01-06 | Millmaster Onyx Corporation | Capped polymers |
| US4027020A (en) * | 1974-10-29 | 1977-05-31 | Millmaster Onyx Corporation | Randomly terminated capped polymers |
| US4409205A (en) * | 1979-03-05 | 1983-10-11 | Cooper Laboratories, Inc. | Ophthalmic solution |
| US4525346A (en) * | 1981-09-28 | 1985-06-25 | Alcon Laboratories, Inc. | Aqueous antimicrobial ophthalmic solutions |
| US4407791A (en) * | 1981-09-28 | 1983-10-04 | Alcon Laboratories, Inc. | Ophthalmic solutions |
| US4727064A (en) * | 1984-04-25 | 1988-02-23 | The United States Of America As Represented By The Department Of Health And Human Services | Pharmaceutical preparations containing cyclodextrin derivatives |
| US4836986A (en) * | 1984-09-28 | 1989-06-06 | Bausch & Lomb Incorporated | Disinfecting and preserving systems and methods of use |
| US5002935A (en) * | 1987-12-30 | 1991-03-26 | University Of Florida | Improvements in redox systems for brain-targeted drug delivery |
| US5037647A (en) * | 1988-09-15 | 1991-08-06 | Alcon Laboratories, Inc. | Aqueous antimicrobial opthalmic solutions comprised of quaternary ammonium compound, citric acid, citrate and sodium chloride |
| US5461081A (en) * | 1989-09-28 | 1995-10-24 | Alcon Laboratories, Inc. | Topical ophthalmic pharmaceutical vehicles |
| US5932572A (en) * | 1992-02-21 | 1999-08-03 | Alcon Laboratories, Inc. | Topical anti-glaucoma compositions |
| US5300287A (en) * | 1992-11-04 | 1994-04-05 | Alcon Laboratories, Inc. | Polymeric antimicrobials and their use in pharmaceutical compositions |
| HU220864B1 (en) * | 1993-04-16 | 2002-06-29 | Wakamoto Pharma Co Ltd | Reversible, thermally gelling water-base medicinal compositions |
| CN1126545C (zh) * | 1996-05-07 | 2003-11-05 | 东丽株式会社 | 眼科用制剂 |
| PT970175E (pt) * | 1997-07-29 | 2003-02-28 | Alcon Lab Inc | Solucoes de acondicionamento para cuidar de lentes de contacto rigidas |
| EP1213018A4 (en) * | 1999-09-06 | 2004-04-14 | Ono Pharmaceutical Co | AGENTS FOR THE PREVENTION AND TREATMENT OF EYE DISEASES |
| MXPA02003130A (es) * | 1999-09-24 | 2004-04-21 | Alcon Inc | Formulaciones topicas en suspension que contienen ciprofloxacino y dexametasona. |
| AU4511201A (en) * | 1999-12-03 | 2001-06-12 | Ista Pharmaceuticals, Inc | Compositions and methods for the induction and treatment of retinal detachments |
| JP2003533464A (ja) * | 2000-05-15 | 2003-11-11 | フアルマシア・イタリア・エツセ・ピー・アー | 安定化ステロイド懸濁液 |
| WO2002007767A2 (en) * | 2000-07-26 | 2002-01-31 | Alcon Universal Ltd. | Pharmaceutical suspension compositions lacking a polymeric suspending agent |
| JP3450805B2 (ja) * | 2000-08-08 | 2003-09-29 | わかもと製薬株式会社 | 水性医薬組成物 |
| US20040256749A1 (en) * | 2000-12-22 | 2004-12-23 | Mahesh Chaubal | Process for production of essentially solvent-free small particles |
| US6743439B1 (en) * | 2001-06-27 | 2004-06-01 | Alcon, Inc. | Ophthalmic compositions containing copolymers of sulfonated styrene and maleic anhydride |
| DE60208216T2 (de) * | 2001-09-21 | 2006-06-29 | Alcon Inc. | Verfahren zur behandlung von mittelohrinfektionen |
| US7001615B1 (en) * | 2001-12-07 | 2006-02-21 | Alcon, Inc. | Sustained release ophthalmic, otic and nasal suspension |
| WO2004000284A1 (en) * | 2002-06-21 | 2003-12-31 | Transform Pharmaceuticals, Inc. | Pharmaceutical compositions with improved dissolution |
| SI1638941T1 (sl) * | 2003-05-22 | 2010-11-30 | Abbott Lab | Inhibitorji indazol benzizoksazol in benzizotiazol kinaze |
| US20040235892A1 (en) * | 2003-05-22 | 2004-11-25 | Yujia Dai | Indazole and benzisoxazole kinase inhibitors |
| EP1755616B1 (en) * | 2004-04-08 | 2013-08-14 | Advanced Ocular Systems Limited | Treatment of exudative retinopathy with mineralcorticoids |
| TWI358290B (en) * | 2004-12-02 | 2012-02-21 | Alcon Inc | Topical nepafenac formulations |
| TW200640443A (en) * | 2005-02-23 | 2006-12-01 | Alcon Inc | Methods for treating ocular angiogenesis, retinal edema, retinal ischemia, and diabetic retinopathy using selective RTK inhibitors |
| SI1906916T1 (sl) * | 2005-05-10 | 2009-02-28 | Alcon Inc | Oftalmična suspenzija, ki obsega oftalmično zdravilo, poloksamin in glikolno sredstvo za naravnavo toničnosti, uporaba sestavka za pripravo zdravila za zdravljenje oftalmičnih motenj |
| PL1885336T3 (pl) * | 2005-05-10 | 2009-08-31 | Alcon Inc | Kompozycja w postaci zawiesiny zawierająca substancję aktywną, poloksamerowy lub meroksapolowy surfaktant i glikol oraz zastosowanie kompozycji do wytwarzania leku do leczenia chorób oczu |
| US20070149480A1 (en) * | 2005-12-23 | 2007-06-28 | Alcon, Inc. | PHARMACEUTICAL COMPOSITION FOR DELIVERY OF RECEPTOR TYROSINE KINASE INHIBITING (RTKi) COMPOUNDS TO THE EYE |
| US20070149593A1 (en) * | 2005-12-23 | 2007-06-28 | Alcon, Inc. | PHARMACEUTICAL FORMULATION FOR DELIVERY OF RECEPTOR TYROSINE KINASE INHIBITING (RTKi) COMPOUNDS TO THE EYE |
| US20070173538A1 (en) * | 2005-12-23 | 2007-07-26 | Alcon, Inc. | PHARMACEUTICAL FORMULATION FOR DELIVERY OF RECEPTOR TYROSINE KINASE INHIBITING (RTKi) COMPOUNDS TO THE EYE |
| US20070249546A1 (en) * | 2006-04-22 | 2007-10-25 | Sawaya Assad S | Ophthalmic and related aqueous solutions containing antifungal agents, uses therefor and methods for preparing them |
| BRPI0721885A2 (pt) * | 2007-07-20 | 2014-02-25 | Alcon Inc | Formulação farmacêutica para distribuição de compostos inibidores de receptores de tirosina quinase (rtki) para os olhos |
| TW201023912A (en) * | 2008-12-05 | 2010-07-01 | Alcon Res Ltd | Pharmaceutical suspension |
-
2010
- 2010-03-03 KR KR1020117023002A patent/KR20110123789A/ko not_active Ceased
- 2010-03-03 CN CN201510767618.5A patent/CN105362221A/zh active Pending
- 2010-03-03 MX MX2011008680A patent/MX2011008680A/es active IP Right Grant
- 2010-03-03 JP JP2011553061A patent/JP5583145B2/ja not_active Expired - Fee Related
- 2010-03-03 AU AU2010221438A patent/AU2010221438C1/en not_active Ceased
- 2010-03-03 BR BRPI1008920-9A patent/BRPI1008920A2/pt not_active IP Right Cessation
- 2010-03-03 EP EP10749243.1A patent/EP2403342A4/en not_active Withdrawn
- 2010-03-03 WO PCT/US2010/025998 patent/WO2010101971A1/en not_active Ceased
- 2010-03-03 CA CA2753837A patent/CA2753837A1/en not_active Abandoned
- 2010-03-03 CN CN2010800101411A patent/CN102340993A/zh active Pending
- 2010-03-03 US US12/716,385 patent/US20100226992A1/en not_active Abandoned
-
2011
- 2011-07-26 ZA ZA2011/05506A patent/ZA201105506B/en unknown
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