JP2012516342A5 - - Google Patents

Download PDF

Info

Publication number
JP2012516342A5
JP2012516342A5 JP2011548261A JP2011548261A JP2012516342A5 JP 2012516342 A5 JP2012516342 A5 JP 2012516342A5 JP 2011548261 A JP2011548261 A JP 2011548261A JP 2011548261 A JP2011548261 A JP 2011548261A JP 2012516342 A5 JP2012516342 A5 JP 2012516342A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2011548261A
Other versions
JP2012516342A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2010/022277 external-priority patent/WO2010088300A1/en
Publication of JP2012516342A publication Critical patent/JP2012516342A/ja
Publication of JP2012516342A5 publication Critical patent/JP2012516342A5/ja
Pending legal-status Critical Current

Links

JP2011548261A 2009-01-28 2010-01-27 結晶性インスリン複合体 Pending JP2012516342A (ja)

Applications Claiming Priority (17)

Application Number Priority Date Filing Date Title
US14787809P 2009-01-28 2009-01-28
US61/147,878 2009-01-28
US15964309P 2009-03-12 2009-03-12
US61/159,643 2009-03-12
US16210709P 2009-03-20 2009-03-20
US61/162,107 2009-03-20
US16308409P 2009-03-25 2009-03-25
US61/163,084 2009-03-25
US21989609P 2009-06-24 2009-06-24
US21989709P 2009-06-24 2009-06-24
US61/219,896 2009-06-24
US61/219,897 2009-06-24
US22357209P 2009-07-07 2009-07-07
US61/223,572 2009-07-07
US25285709P 2009-10-19 2009-10-19
US61/252,857 2009-10-19
PCT/US2010/022277 WO2010088300A1 (en) 2009-01-28 2010-01-27 Crystalline insulin-conjugates

Publications (2)

Publication Number Publication Date
JP2012516342A JP2012516342A (ja) 2012-07-19
JP2012516342A5 true JP2012516342A5 (ja) 2012-08-30

Family

ID=42395990

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011548261A Pending JP2012516342A (ja) 2009-01-28 2010-01-27 結晶性インスリン複合体

Country Status (17)

Country Link
US (3) US8906850B2 (ja)
EP (1) EP2391646B1 (ja)
JP (1) JP2012516342A (ja)
KR (2) KR20110110253A (ja)
CN (1) CN102341409A (ja)
AU (1) AU2010208319A1 (ja)
BR (1) BRPI1007466A2 (ja)
CA (1) CA2750269A1 (ja)
CO (1) CO6400230A2 (ja)
EC (1) ECSP11011241A (ja)
IL (1) IL214126A0 (ja)
MX (1) MX2011007930A (ja)
PE (1) PE20120582A1 (ja)
RU (1) RU2011135730A (ja)
SG (1) SG173117A1 (ja)
WO (1) WO2010088300A1 (ja)
ZA (1) ZA201105462B (ja)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105753965A (zh) 2009-01-28 2016-07-13 斯马特塞尔斯公司 用于受控药物递送的基于缀合物的系统
WO2010088268A1 (en) 2009-01-28 2010-08-05 Smartcells, Inc. Exogenously triggered controlled release materials and uses thereof
JP2012516340A (ja) 2009-01-28 2012-07-19 スマートセルズ・インコーポレイテツド 合成コンジュゲートおよびその使用
US9095623B2 (en) 2009-03-20 2015-08-04 Smartcells, Inc. Terminally-functionalized conjugates and uses thereof
EP2408808A4 (en) 2009-03-20 2015-05-06 Smartcells Inc TERMINAL-FUNCTIONALIZED CONJUGATES AND THEIR USE
AU2011282987A1 (en) 2010-07-28 2013-02-21 Smartcells, Inc. Recombinant lectins, binding-site modified lectins and uses thereof
AU2011282983A1 (en) * 2010-07-28 2013-02-21 Smartcells, Inc. Drug-ligand conjugates, synthesis thereof, and intermediates thereto
AU2011282988A1 (en) 2010-07-28 2013-01-31 Smartcells, Inc. Recombinantly expressed insulin polypeptides and uses thereof
CA2805739A1 (en) * 2010-07-28 2012-02-02 Smartcells, Inc. Drug-ligand conjugates, synthesis thereof, and intermediates thereto
CN102188367B (zh) * 2011-01-05 2012-11-07 山东新时代药业有限公司 一种甘精胰岛素注射液及其制备方法
US9457096B2 (en) 2012-07-06 2016-10-04 Consejo Nacional De Investigaciones Cientificas Y Tecnicas (Concet) Protozoan variant-specific surface proteins (VSP) as carriers for oral drug delivery
KR20160065930A (ko) 2013-10-04 2016-06-09 머크 샤프 앤드 돔 코포레이션 글루코스-반응성 인슐린 접합체
US9672328B2 (en) 2014-07-10 2017-06-06 Companion Medical, Inc. Medicine administering system including injection pen and companion device
EP3280450A4 (en) * 2015-04-08 2018-12-12 Merck Sharp & Dohme Corp. Glucose-responsive insulin conjugates
CA2983289C (en) 2015-04-21 2023-10-03 North Carolina State University Glucose-responsive insulin delivery system using hypoxia-sensitive nanocomposites
WO2017124102A1 (en) 2016-01-14 2017-07-20 North Carolina State University Glucose responsive insulin delivery compositions and methods
US10864327B2 (en) 2016-01-29 2020-12-15 Companion Medical, Inc. Automatic medication delivery tracking
WO2017207754A1 (en) 2016-06-02 2017-12-07 Sanofi Conjugates of a pharmaceutical agent and a moiety capable of binding to a glucose sensing protein
CN110167537A (zh) 2016-11-07 2019-08-23 北卡罗来纳州立大学 用于增强葡萄糖反应性胰岛素的递送的装有双敏感囊泡的贴剂
EP3635591A4 (en) 2017-06-09 2021-03-24 Companion Medical, Inc. SMART DRUG DELIVERY SYSTEMS AND PROCESSES
EP3694583A4 (en) * 2017-10-12 2021-08-04 Companion Medical, Inc. INTELLIGENT DRUG DELIVERY SYSTEMS AND METHODS FOR DOSAGE RECOMMENDATION AND ADMINISTRATION
KR20200095507A (ko) 2017-12-01 2020-08-10 사노피 글루코오스 감지 단백질에 결합할 수 있는 모이어티 및 약제의 신규 접합체
CN112041936A (zh) 2017-12-12 2020-12-04 比格福特生物医学有限公司 治疗辅助信息和/或跟踪设备及相关方法和系统
US11464459B2 (en) 2017-12-12 2022-10-11 Bigfoot Biomedical, Inc. User interface for diabetes management systems including flash glucose monitor
US10987464B2 (en) 2017-12-12 2021-04-27 Bigfoot Biomedical, Inc. Pen cap for insulin injection pens and associated methods and systems
US11077243B2 (en) 2017-12-12 2021-08-03 Bigfoot Biomedical, Inc. Devices, systems, and methods for estimating active medication from injections
US11116899B2 (en) 2017-12-12 2021-09-14 Bigfoot Biomedical, Inc. User interface for diabetes management systems and devices
US11083852B2 (en) 2017-12-12 2021-08-10 Bigfoot Biomedical, Inc. Insulin injection assistance systems, methods, and devices
WO2019125878A1 (en) * 2017-12-18 2019-06-27 Merck Sharp & Dohme Corp. Conjugate based systems for controlled insulin delivery
EP3740212A4 (en) * 2017-12-18 2021-10-27 Merck Sharp & Dohme Corp. CONJUGATE-BASED SYSTEMS FOR CONTROLLED INSULIN DELIVERY
US10898653B2 (en) 2018-05-08 2021-01-26 Companion Medical, Inc. Intelligent medication delivery systems and methods for dose setting and dispensing monitoring
US11664107B2 (en) 2018-05-08 2023-05-30 Medtronic Minimed, Inc. Intelligent medication delivery systems and methods using a prescription-regulated software application
USD893020S1 (en) 2018-05-11 2020-08-11 Companion Medical, Inc. Injection pen
US11587663B2 (en) 2018-06-20 2023-02-21 Medtronic Minimed, Inc. Intelligent medication delivery systems and methods for medicine dose calculation and reporting
USD892819S1 (en) 2018-06-20 2020-08-11 Companion Medical, Inc. Display screen with graphical user interface
CN110922437B (zh) * 2018-09-20 2023-11-03 凯惠科技发展(上海)有限公司 一种葡萄糖类化合物、药物组合物及其应用
US11948671B2 (en) 2019-04-11 2024-04-02 Medtronic Minimed, Inc. Intelligent accessories for medicine dispensing device
WO2021021535A1 (en) * 2019-07-30 2021-02-04 Merck Sharp & Dohme Corp. Glucose-responsive insulin conjugates
US11701473B2 (en) 2021-06-23 2023-07-18 Medtronic Minimed, Inc. Reusable injection pens

Family Cites Families (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3591574A (en) 1968-05-29 1971-07-06 American Home Prod Tri-n-phenylglycyl derivatives of insulin
DE1793517C3 (de) 1968-09-28 1974-12-05 Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt N(Al),N(B29>Bis-(tert.-butyloxycarbonyl)-insulin und Verfahren zu seiner Herstellung
US3847890A (en) 1971-11-01 1974-11-12 A Green Acidic monosaccharide-substituted proteins
US4377567A (en) 1978-10-02 1983-03-22 The Procter & Gamble Company Lipid membrane drug delivery
EP0009842B1 (en) 1978-10-02 1982-11-10 THE PROCTER & GAMBLE COMPANY Liposomes for drug delivery and composition containing a liposome drug system
US4348387A (en) 1979-07-31 1982-09-07 The Rockefeller University Method and system for the controlled release of biologically active substances to a body fluid
JPS608000B2 (ja) 1980-04-11 1985-02-28 呉羽化学工業株式会社 アミノフエニル誘導体及び該誘導体を含有する生理活性剤
US4444683A (en) 1982-11-17 1984-04-24 University Of Utah Glycosylated insulin derivatives
US4603044A (en) 1983-01-06 1986-07-29 Technology Unlimited, Inc. Hepatocyte Directed Vesicle delivery system
EP0119650A3 (en) 1983-03-21 1987-09-30 THE PROCTER & GAMBLE COMPANY Galactosyl-insulin conjugates useful in treating diabetics
US4863896A (en) 1984-05-03 1989-09-05 Technology Unlimited, Inc. Diabetic control by combined insulin forms
US5239062A (en) 1986-03-20 1993-08-24 Dana-Farber Cancer Institute, Inc. Blocked lectins, methods and affinity support for making same using affinity ligands, and method of killing selected cell populations having reduced nonselective cytotoxicity
US5395924A (en) 1986-03-20 1995-03-07 Dana-Farber Cancer Institute, Inc. Blocked lectins; methods and affinity support for making the same using affinity ligands; and method of killing selected cell populations having reduced non-selective cytotoxicity
US5527524A (en) * 1986-08-18 1996-06-18 The Dow Chemical Company Dense star polymer conjugates
DK111489D0 (da) 1989-03-08 1989-03-08 Novo Nordisk As Peptider
AU628674B2 (en) 1989-10-19 1992-09-17 Nippon Oil And Fats Company, Limited Polymer complexes of a sugar response type
GB9200638D0 (en) 1992-01-10 1992-03-11 Leicester Polytechnic Drug system
DE69328523T2 (de) 1992-02-13 2000-09-21 Surmodics Inc Immobilisierung eines chemischen spezies in einer vernetzten matrix
GB9316895D0 (en) 1993-08-13 1993-09-29 Guy S And St Thomas Hospitals Hepatoselective insulin analogues
GB9313484D0 (en) 1993-06-30 1993-08-11 Univ Montfort Drug system ii
US6342225B1 (en) 1993-08-13 2002-01-29 Deutshces Wollforschungsinstitut Pharmaceutical active conjugates
US6869930B1 (en) 1993-09-17 2005-03-22 Novo Nordisk A/S Acylated insulin
US6500645B1 (en) 1994-06-17 2002-12-31 Novo Nordisk A/S N-terminally extended proteins expressed in yeast
US5693609A (en) 1994-11-17 1997-12-02 Eli Lilly And Company Acylated insulin analogs
TW520293B (en) 1995-11-22 2003-02-11 Univ Johns Hopkins Med Delivery system to enhance cellular uptake of biomolecules
US5723589A (en) 1995-12-21 1998-03-03 Icn Pharmaceuticals Carbohydrate conjugated bio-active compounds
US5866538A (en) 1996-06-20 1999-02-02 Novo Nordisk A/S Insulin preparations containing NaCl
US5948751A (en) 1996-06-20 1999-09-07 Novo Nordisk A/S X14-mannitol
US5905140A (en) 1996-07-11 1999-05-18 Novo Nordisk A/S, Novo Alle Selective acylation method
JP2001527387A (ja) 1997-01-24 2001-12-25 ノボ ノルディスク アクティーゼルスカブ 合成リーダーペプチド配列
ZA984697B (en) 1997-06-13 1999-12-01 Lilly Co Eli Stable insulin formulations.
ATE299889T1 (de) 1998-04-15 2005-08-15 Novo Nordisk As Neues verfahren zur trennung von proteinen unter verwendung eines ca++ enthaltenden elutionsmittels
US6844166B1 (en) 1998-09-11 2005-01-18 Sensor Technologies Inc. Recombinant reduced valency carbohydrate binding ligands
US6323311B1 (en) 1999-09-22 2001-11-27 University Of Utah Research Foundation Synthesis of insulin derivatives
US6777207B2 (en) 1999-12-29 2004-08-17 Novo Nordisk A/S Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast
US6521738B2 (en) 1999-12-29 2003-02-18 Novo Nordisk A/S Method for making insulin precursors and insulin precursor analogs
JP2003535106A (ja) 2000-06-02 2003-11-25 ノボ ノルディスク アクティーゼルスカブ グルコース検知性インスリン誘導体からの、インスリンのグルコース依存性放出
US7316999B2 (en) 2000-06-02 2008-01-08 Novo Nordisk A/S Glucose dependent release of insulin from glucose sensing insulin derivatives
US7060675B2 (en) 2001-02-15 2006-06-13 Nobex Corporation Methods of treating diabetes mellitus
US20020192182A1 (en) 2001-03-12 2002-12-19 Stephen Massia Polysaccharide-based polymerizable hydrogels
US7105314B2 (en) 2001-04-02 2006-09-12 Novo Nordisk A/S Method for making human insulin precursors
US7311892B2 (en) 2001-10-26 2007-12-25 The Uab Research Foundation Multidrug multiligand conjugates for targeted drug delivery
US7317000B2 (en) 2001-12-02 2008-01-08 Novo Nordisk A/S Glucose-dependent insulins
EP1452950A4 (en) 2001-12-07 2009-07-08 Ntt Docomo Inc MOBILE COMMUNICATION SENDING DEVICE, METHOD FOR CONTROLLING THE PERFORMANCE OF AN APPLICATION PROGRAM, APPLICATION PROGRAM AND RECORDING MEDIA RECORDED FOR AN APPLICATION PROGRAM
DE10209821A1 (de) 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung von Proteinen an ein modifiziertes Polysaccharid
WO2004009666A2 (en) * 2002-07-19 2004-01-29 The Regents Of The University Of California Dendrimers as molecular translocators
WO2004056311A2 (en) 2002-12-17 2004-07-08 Massachusetts Institute Of Technology Stimuli-responsive systems for controlled drug delivery
CA2549932C (en) 2002-12-20 2013-08-20 Greenovation Biotech Gmbh Production of heterologous glycosylated proteins in bryophyte cells
JPWO2004101619A1 (ja) 2003-05-15 2006-10-26 塩野義製薬株式会社 機能的糖ペプチドの合理的設計および合成
US20080102114A1 (en) 2004-04-23 2008-05-01 Panduranga Rao Koritala Microparticles and Nanoparticles for the Transmucosal Delivery of Therapeutic and Diagnostic Agents
WO2006008238A1 (en) 2004-07-16 2006-01-26 Novo Nordisk A/S Method for selective acylation
EP2626368B1 (en) * 2004-07-19 2016-12-21 Biocon Limited Insulin-oligomer conjugates, formulations and uses thereof
WO2006062685A2 (en) * 2004-11-11 2006-06-15 Affymax, Inc. Novel peptides that bind to the erythropoietin receptor
EP1843790A2 (en) * 2005-01-27 2007-10-17 Novo Nordisk A/S Insulin derivatives conjugated with structurally well defined branched polymers
TWI376234B (en) 2005-02-01 2012-11-11 Msd Oss Bv Conjugates of a polypeptide and an oligosaccharide
US20070207498A1 (en) 2005-02-24 2007-09-06 Lifescan, Inc. Design and construction of dimeric concanavalin a mutants
US20060247154A1 (en) 2005-02-24 2006-11-02 Lifescan, Inc. Concanavalin a, methods of expressing, purifying and characterizing concanavalina, and sensors including the same
WO2006102762A1 (en) 2005-04-01 2006-10-05 Mcmaster University Glucose responsive microgels
CA2624867A1 (en) 2005-10-10 2007-04-19 N.V. Organon Antithrombotic compound
US7517856B2 (en) 2005-10-11 2009-04-14 Ben-Gurion University Of The Negev Research And Development Authority Bioconjugates comprising sulfated polysaccharides and their uses
WO2007047997A2 (en) 2005-10-19 2007-04-26 Smartcells, Inc. Methods for reducing the mitogenicity of lectin compositions
JP5202338B2 (ja) 2006-02-27 2013-06-05 ノボ・ノルデイスク・エー／エス 新規インシュリン誘導体
WO2008036147A2 (en) 2006-07-24 2008-03-27 Duke University Drug delivery with stimulus responsive biopolymers
CN103169984B (zh) 2006-07-25 2016-08-03 利普生技术有限公司 N末端聚唾液酸化
FR2904315B1 (fr) 2006-07-26 2012-12-14 Centre Nat Rech Scient Composes pyridaziniques et pyrroliques, procedes d'obtention et applications
CN101273961A (zh) 2007-03-30 2008-10-01 中国人民解放军总医院 葡萄糖敏感水凝胶
US20090053167A1 (en) 2007-05-14 2009-02-26 Neose Technologies, Inc. C-, S- and N-glycosylation of peptides
WO2009033588A2 (en) 2007-09-11 2009-03-19 F. Hoffmann-La-Roche Ag Self-controlled insulin delivery system
WO2009059450A1 (en) 2007-11-05 2009-05-14 Shanghai Jiaotong University Peptide ligand directed drug delivery
JP5647899B2 (ja) 2008-01-08 2015-01-07 ラツィオファルム ゲーエムベーハーｒａｔｉｏｐｈａｒｍ ＧｍｂＨ オリゴサッカリルトランスフェラーゼを使用するポリペプチドの複合糖質化
RU2381238C2 (ru) 2008-01-31 2010-02-10 Ордена Трудового Красного Знамени Институт нефтехимического синтеза им. А.В. Топчиева Российской академии наук (статус государственного учреждения) Способ получения глюкозочувствительных полимерных гидрогелей
KR101556514B1 (ko) 2008-02-19 2015-10-02 바이오콘 리미티드 효모에서 발현된 정제된 이형 인슐린을 수득하는 방법
WO2011000823A1 (en) 2009-06-30 2011-01-06 Novo Nordisk A/S Insulin derivatives

Similar Documents

Publication Publication Date Title
BR112013013385A2 (ja)
BR112013008959A2 (ja)
BR112012031500A2 (ja)
BR112012029986A2 (ja)
BR112012026492A2 (ja)
BR112012019354A2 (ja)
BR112012002126A2 (ja)
BR112012017960A2 (ja)
BR112013006400A2 (ja)
JP2012516342A5 (ja)
BR112012031826A2 (ja)
BR112012023249A2 (ja)
BR112012016456A2 (ja)
BR112012018256A2 (ja)
BR112012023265A2 (ja)
BR112013010949A2 (ja)
BR112013003284A2 (ja)
BR112013002646A2 (ja)
BR112012022788A2 (ja)
BR112013012726A2 (ja)
BR112012023446A2 (ja)
BR112013006825A2 (ja)
BR112012016895A2 (ja)
BR112013007728A2 (ja)
BR112012030078A2 (ja)