JP2012512645A5 - - Google Patents

Info

Publication number

JP2012512645A5

JP2012512645A5 JP2011541497A JP2011541497A JP2012512645A5 JP 2012512645 A5 JP2012512645 A5 JP 2012512645A5 JP 2011541497 A JP2011541497 A JP 2011541497A JP 2011541497 A JP2011541497 A JP 2011541497A JP 2012512645 A5 JP2012512645 A5 JP 2012512645A5

Authority

JP

Japan

Prior art keywords

seq

factor

protein

replaced

derivative

Prior art date

2009-12-21

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 108010014173 Factor X Proteins 0.000 claims 10
• 229920001184 polypeptide Polymers 0.000 claims 9
• 108090000765 processed proteins & peptides Proteins 0.000 claims 9
• 102000004196 processed proteins & peptides Human genes 0.000 claims 9
• 150000001413 amino acids Chemical group 0.000 claims 8
• 108090000190 Thrombin Proteins 0.000 claims 7
• 235000004279 alanine Nutrition 0.000 claims 7
• 229960004072 thrombin Drugs 0.000 claims 7
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 6
• QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 6
• 108020001507 fusion proteins Proteins 0.000 claims 6
• 102000037865 fusion proteins Human genes 0.000 claims 6
• DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 5
• KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 5
• 101800004937 Protein C Proteins 0.000 claims 5
• 101800001700 Saposin-D Proteins 0.000 claims 5
• 102400000827 Saposin-D Human genes 0.000 claims 5
• KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 5
• 229960001230 asparagine Drugs 0.000 claims 5
• 235000009582 asparagine Nutrition 0.000 claims 5
• 230000002265 prevention Effects 0.000 claims 5
• 229960000856 protein c Drugs 0.000 claims 5
• 235000018102 proteins Nutrition 0.000 claims 5
• 102000004169 proteins and genes Human genes 0.000 claims 5
• 108090000623 proteins and genes Proteins 0.000 claims 5
• 239000004474 valine Substances 0.000 claims 5
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
• COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 4
• 230000004988 N-glycosylation Effects 0.000 claims 4
• COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 4
• 239000004471 Glycine Substances 0.000 claims 3
• DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 3
• MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 3
• MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 2
• 101800001401 Activation peptide Proteins 0.000 claims 2
• 102400000069 Activation peptide Human genes 0.000 claims 2
• 108010074860 Factor Xa Proteins 0.000 claims 2
• 208000032843 Hemorrhage Diseases 0.000 claims 2
• AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 2
• ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 2
• ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 2
• ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 2
• 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 claims 2
• 208000034158 bleeding Diseases 0.000 claims 2
• 229960000310 isoleucine Drugs 0.000 claims 2
• AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 2
• 239000003055 low molecular weight heparin Substances 0.000 claims 2
• 229940127215 low-molecular weight heparin Drugs 0.000 claims 2
• 239000004475 Arginine Substances 0.000 claims 1
• 102100022641 Coagulation factor IX Human genes 0.000 claims 1
• 102100026735 Coagulation factor VIII Human genes 0.000 claims 1
• 201000003542 Factor VIII deficiency Diseases 0.000 claims 1
• 208000009292 Hemophilia A Diseases 0.000 claims 1
• 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 claims 1
• 206010020608 Hypercoagulation Diseases 0.000 claims 1
• CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 1
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
• 239000004472 Lysine Substances 0.000 claims 1
• 208000007536 Thrombosis Diseases 0.000 claims 1
• 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 1
• 239000003146 anticoagulant agent Substances 0.000 claims 1
• 229940127219 anticoagulant drug Drugs 0.000 claims 1
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
• 229940009098 aspartate Drugs 0.000 claims 1
• 230000000740 bleeding effect Effects 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 208000009429 hemophilia B Diseases 0.000 claims 1
• 230000003027 hypercoagulation Effects 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 102000039446 nucleic acids Human genes 0.000 claims 1
• 108020004707 nucleic acids Proteins 0.000 claims 1
• 150000007523 nucleic acids Chemical class 0.000 claims 1
• 230000008685 targeting Effects 0.000 claims 1