JP2012512262A5 - - Google Patents
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- Publication number
- JP2012512262A5 JP2012512262A5 JP2011542458A JP2011542458A JP2012512262A5 JP 2012512262 A5 JP2012512262 A5 JP 2012512262A5 JP 2011542458 A JP2011542458 A JP 2011542458A JP 2011542458 A JP2011542458 A JP 2011542458A JP 2012512262 A5 JP2012512262 A5 JP 2012512262A5
- Authority
- JP
- Japan
- Prior art keywords
- species
- aminomethyl
- benzo
- propoxy
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 5
- 125000001137 3-hydroxypropoxy group Chemical group [H]OC([H])([H])C([H])([H])C([H])([H])O* 0.000 claims 4
- 241000894006 Bacteria Species 0.000 claims 4
- 206010035664 Pneumonia Diseases 0.000 claims 4
- 239000013078 crystal Substances 0.000 claims 4
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 238000002424 x-ray crystallography Methods 0.000 claims 3
- FXQIIDINBDJDKL-UHFFFAOYSA-N 3-[[3-(aminomethyl)-1-hydroxy-3h-2,1-benzoxaborol-7-yl]oxy]propan-1-ol Chemical compound C1=CC=C(OCCCO)C2=C1C(CN)OB2O FXQIIDINBDJDKL-UHFFFAOYSA-N 0.000 claims 2
- 208000031729 Bacteremia Diseases 0.000 claims 2
- 241000606161 Chlamydia Species 0.000 claims 2
- 206010040047 Sepsis Diseases 0.000 claims 2
- 208000037386 Typhoid Diseases 0.000 claims 2
- 206010014665 endocarditis Diseases 0.000 claims 2
- 238000001704 evaporation Methods 0.000 claims 2
- 230000008020 evaporation Effects 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 238000001953 recrystallisation Methods 0.000 claims 2
- 241000894007 species Species 0.000 claims 2
- 201000008297 typhoid fever Diseases 0.000 claims 2
- 206010053555 Arthritis bacterial Diseases 0.000 claims 1
- 241000606125 Bacteroides Species 0.000 claims 1
- 241000588807 Bordetella Species 0.000 claims 1
- 241000589562 Brucella Species 0.000 claims 1
- 206010006500 Brucellosis Diseases 0.000 claims 1
- 241000589876 Campylobacter Species 0.000 claims 1
- 206010008631 Cholera Diseases 0.000 claims 1
- 206010061788 Corneal infection Diseases 0.000 claims 1
- 206010011409 Cross infection Diseases 0.000 claims 1
- 206010012735 Diarrhoea Diseases 0.000 claims 1
- 241000588914 Enterobacter Species 0.000 claims 1
- 241000588722 Escherichia Species 0.000 claims 1
- 208000010201 Exanthema Diseases 0.000 claims 1
- 208000002633 Febrile Neutropenia Diseases 0.000 claims 1
- 206010016936 Folliculitis Diseases 0.000 claims 1
- 241000589601 Francisella Species 0.000 claims 1
- 208000007882 Gastritis Diseases 0.000 claims 1
- 208000005577 Gastroenteritis Diseases 0.000 claims 1
- 206010018612 Gonorrhoea Diseases 0.000 claims 1
- 241000606790 Haemophilus Species 0.000 claims 1
- 241000589989 Helicobacter Species 0.000 claims 1
- 208000004575 Infectious Arthritis Diseases 0.000 claims 1
- 241000588748 Klebsiella Species 0.000 claims 1
- 241000589248 Legionella Species 0.000 claims 1
- 208000007764 Legionnaires' Disease Diseases 0.000 claims 1
- 208000016604 Lyme disease Diseases 0.000 claims 1
- 201000009906 Meningitis Diseases 0.000 claims 1
- 241000588653 Neisseria Species 0.000 claims 1
- 206010029803 Nosocomial infection Diseases 0.000 claims 1
- 206010031252 Osteomyelitis Diseases 0.000 claims 1
- 208000005141 Otitis Diseases 0.000 claims 1
- 241000606860 Pasteurella Species 0.000 claims 1
- 206010058674 Pelvic Infection Diseases 0.000 claims 1
- 201000005702 Pertussis Diseases 0.000 claims 1
- 206010035148 Plague Diseases 0.000 claims 1
- 206010054161 Pontiac fever Diseases 0.000 claims 1
- 241000588769 Proteus <enterobacteria> Species 0.000 claims 1
- 241000589516 Pseudomonas Species 0.000 claims 1
- 206010037596 Pyelonephritis Diseases 0.000 claims 1
- 238000001069 Raman spectroscopy Methods 0.000 claims 1
- 241000606701 Rickettsia Species 0.000 claims 1
- 241000607142 Salmonella Species 0.000 claims 1
- 241000607768 Shigella Species 0.000 claims 1
- 206010044314 Tracheobronchitis Diseases 0.000 claims 1
- 208000034784 Tularaemia Diseases 0.000 claims 1
- 206010046914 Vaginal infection Diseases 0.000 claims 1
- 201000008100 Vaginitis Diseases 0.000 claims 1
- 241000607598 Vibrio Species 0.000 claims 1
- 206010048038 Wound infection Diseases 0.000 claims 1
- 241000607734 Yersinia <bacteria> Species 0.000 claims 1
- 241000607479 Yersinia pestis Species 0.000 claims 1
- 208000023652 chronic gastritis Diseases 0.000 claims 1
- 208000019258 ear infection Diseases 0.000 claims 1
- 208000028104 epidemic louse-borne typhus Diseases 0.000 claims 1
- 208000001606 epiglottitis Diseases 0.000 claims 1
- 201000005884 exanthem Diseases 0.000 claims 1
- 210000004907 gland Anatomy 0.000 claims 1
- 208000001786 gonorrhea Diseases 0.000 claims 1
- 238000007912 intraperitoneal administration Methods 0.000 claims 1
- 230000001617 migratory effect Effects 0.000 claims 1
- 206010033072 otitis externa Diseases 0.000 claims 1
- 208000028169 periodontal disease Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 206010037844 rash Diseases 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 201000001223 septic arthritis Diseases 0.000 claims 1
- 201000009890 sinusitis Diseases 0.000 claims 1
- 230000009747 swallowing Effects 0.000 claims 1
- 208000006379 syphilis Diseases 0.000 claims 1
- 206010061393 typhus Diseases 0.000 claims 1
- 208000000143 urethritis Diseases 0.000 claims 1
- 208000019206 urinary tract infection Diseases 0.000 claims 1
- 210000001215 vagina Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13849008P | 2008-12-17 | 2008-12-17 | |
| US61/138,490 | 2008-12-17 | ||
| PCT/US2009/068609 WO2010080558A1 (en) | 2008-12-17 | 2009-12-17 | Polymorphs of (s)-3-aminomethyl-7-(3-hydroxy-propoxy)-3h-benzo[c][1,2] oxaborol-1-ol |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012512262A JP2012512262A (ja) | 2012-05-31 |
| JP2012512262A5 true JP2012512262A5 (https=) | 2012-12-27 |
Family
ID=42316734
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011542458A Pending JP2012512262A (ja) | 2008-12-17 | 2009-12-17 | （ｓ）−３−アミノメチル−７−（３−ヒドロキシ−プロポキシ）−３ｈ−ベンゾ［ｃ］［１，２］オキサボロール−１−オールの多形体 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8461364B2 (https=) |
| EP (1) | EP2378886A4 (https=) |
| JP (1) | JP2012512262A (https=) |
| KR (1) | KR20110111407A (https=) |
| CN (1) | CN102256494A (https=) |
| AU (1) | AU2009335744A1 (https=) |
| BR (1) | BRPI0922566A2 (https=) |
| CA (1) | CA2744231A1 (https=) |
| CO (1) | CO6390029A2 (https=) |
| CR (1) | CR20110357A (https=) |
| DO (1) | DOP2011000183A (https=) |
| EA (1) | EA201190034A1 (https=) |
| IL (1) | IL213060A0 (https=) |
| MA (1) | MA32977B1 (https=) |
| MX (1) | MX2011006334A (https=) |
| PE (1) | PE20120052A1 (https=) |
| SG (1) | SG172040A1 (https=) |
| WO (1) | WO2010080558A1 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1976536A4 (en) | 2005-12-30 | 2011-03-02 | Anacor Pharmaceuticals Inc | SMALL MOLECULES CONTAINING BORON |
| ME02188B (me) | 2006-02-16 | 2016-02-20 | Anacor Pharmaceuticals Inc | Mali molekuli koji sadrže boron kao antiinflamatorni agensi |
| US8716478B2 (en) | 2010-01-27 | 2014-05-06 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
| CA2807546C (en) * | 2010-08-10 | 2022-08-23 | Rempex Pharmaceuticals, Inc. | Cyclic boronic acid ester derivatives and therapeutic uses thereof |
| WO2012033858A2 (en) | 2010-09-07 | 2012-03-15 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
| US8530452B2 (en) | 2011-12-22 | 2013-09-10 | Micurx Pharmaceuticals, Inc. | Tricyclic boron compounds for antimicrobial therapy |
| US10070649B2 (en) | 2013-01-30 | 2018-09-11 | Agrofresh Inc. | Volatile applications against pathogens |
| US11039617B2 (en) | 2013-01-30 | 2021-06-22 | Agrofresh Inc. | Large scale methods of uniformly coating packaging surfaces with a volatile antimicrobial to preserve food freshness |
| US8669207B1 (en) | 2013-01-30 | 2014-03-11 | Dow Agrosciences, Llc. | Compounds and compositions |
| US9138001B2 (en) | 2013-01-30 | 2015-09-22 | Agrofresh Inc. | Use of benzoxaboroles as volatile antimicrobial agents on meats, plants, or plant parts |
| US9585396B2 (en) | 2013-01-30 | 2017-03-07 | Agrofresh Inc. | Volatile applications against pathogens |
| WO2014121124A1 (en) | 2013-02-01 | 2014-08-07 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as antiprotozoal agents |
| EA032844B1 (ru) | 2013-08-09 | 2019-07-31 | Глаксосмитклайн Интеллекчуал Проперти (№2) Лимитед | Трициклические соединения бензоксаборола и их применение |
| JP6605513B2 (ja) | 2014-07-01 | 2019-11-13 | 第一三共株式会社 | 抗菌剤としての三環式ベンゾオキサボロール |
| MA41494B1 (fr) | 2015-02-12 | 2020-10-28 | Glaxosmithkline Ip No 2 Ltd | Composés benzoxaborole substitués en position 4 et utilisations associées |
| WO2017155879A1 (en) | 2016-03-07 | 2017-09-14 | Agrofresh Inc. | Synergistic methods of using benzoxaborole compounds and preservative gases as an antimicrobial for crops |
| US10961261B2 (en) | 2017-03-01 | 2021-03-30 | Anacor Pharmaceuticals, Inc. | Oxaborole analogs and uses thereof |
| EP4204012A1 (en) | 2020-08-31 | 2023-07-05 | Pfizer Inc. | Methods of protecting rna |
| WO2022133233A2 (en) | 2020-12-17 | 2022-06-23 | Idexx Laboratories, Inc. | Rocky mountain spotted fever detection and treatment |
| CN119233977B (zh) | 2022-06-23 | 2026-03-17 | 上海盟科药业股份有限公司 | 硼化合物的前药及其在治疗细菌感染中的用途 |
| CN120361018A (zh) * | 2025-05-08 | 2025-07-25 | 扬州大学 | 一种治疗和/或抑制沙门氏菌感染的药物组合物或疫苗和小分子化合物Epetraborole hydrochloride的应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2260336A (en) | 1939-10-16 | 1941-10-28 | Dow Chemical Co | Method of preparation of organic borates |
| GB1396904A (en) | 1972-08-11 | 1975-06-11 | Ici Ltd | Method for the control of micro-organisms |
| US4766113A (en) | 1975-10-24 | 1988-08-23 | Chapman Chemical Company | Antimicrobial compositions and methods of using same |
| US4602011A (en) | 1975-10-24 | 1986-07-22 | Chapman Chemical Company | Antimicrobial compositions and methods of using same |
| US4716035A (en) | 1985-05-24 | 1987-12-29 | The Procter & Gamble Company | Oral compositions and methods for treating gingivitis |
| US5962498A (en) | 1986-06-11 | 1999-10-05 | Procyon Pharmaceuticals, Inc. | Protein kinase C modulators. C. indolactam structural-types with anti-inflammatory activity |
| US4894220A (en) | 1987-01-30 | 1990-01-16 | Colgate-Palmolive Company | Antibacterial antiplaque oral composition |
| SG47101A1 (en) | 1992-07-31 | 1998-03-20 | Us Bioscience | Crystalline amifostine compositions and methods for the preparation and use of same |
| US5348948A (en) | 1993-05-07 | 1994-09-20 | American Cyanamid Company | 2,2-diaryl-1-(oxa and thia)-2a-azonia-2-borataacenaphthene fungicidal |
| US5348947A (en) | 1993-05-07 | 1994-09-20 | American Cyanamid Company | Diarylboron ester and thioester fungicidal agents |
| US5594151A (en) | 1994-01-28 | 1997-01-14 | Prolinx, Inc. | Phenylboronic acid complexing reagents derived from aminosalicylic acid |
| GB9411587D0 (en) * | 1994-06-09 | 1994-08-03 | Zeneca Ltd | Compound, composition and use |
| US6083903A (en) | 1994-10-28 | 2000-07-04 | Leukosite, Inc. | Boronic ester and acid compounds, synthesis and uses |
| GB9604926D0 (en) | 1996-03-08 | 1996-05-08 | Sandoz Ltd | Organic compounds |
| CA2258728C (en) | 1996-06-19 | 2011-09-27 | Rhone Poulenc Rorer Limited | Substituted azabicylic compounds and their use as inhibitors of the production of tnf and cyclic amp phosphodiesterase |
| US5831046A (en) | 1996-08-05 | 1998-11-03 | Prolinx, Incorporated | Boronic acid-contaning nucleic acid monomers |
| WO1998012206A1 (en) | 1996-09-19 | 1998-03-26 | The Board Of Trustees Of Leland Stanford Jr. University | Dna adenine methyltransferases and uses thereof |
| DE19829947A1 (de) | 1998-07-04 | 2000-01-05 | Bayer Ag | Elektrolumineszierende Anordnungen mit Bor-Chelaten |
| EP1155698A4 (en) | 1999-01-29 | 2003-01-15 | Nitto Kasei Co Ltd | ORGANOBORAL COMPOUNDS HAVING COCCIDIOSTAT ACTIVITY |
| EP1181291A2 (en) | 1999-05-25 | 2002-02-27 | The Penn State Research Foundation | Dna methyltransferase inhibitors |
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| DE60124759T2 (de) | 2000-11-30 | 2007-03-15 | The Penn State Research Foundation | Dna methyl transferase inhibitoren |
| DE10110051C2 (de) | 2001-03-02 | 2003-07-03 | Clariant Gmbh | Verfahren zur Herstellung von Boron- und Borinsäuren |
| GB0117645D0 (en) | 2001-07-19 | 2001-09-12 | Isis Innovation | Therapeutic stratergies for prevention and treatment of alzheimers disease |
| DE10143979A1 (de) | 2001-09-07 | 2003-03-27 | Clariant Gmbh | Verfahren zur Herstellung von Bisallylboranen und nicht-aromatischen Boronsäuren |
| EP1444981A1 (en) | 2001-10-11 | 2004-08-11 | Katsuhiko Mikoshiba | Intracellular calcium concentration increase inhibitors |
| JP4138662B2 (ja) | 2002-01-10 | 2008-08-27 | ザ・ペンシルバニア・ステイト・リサーチ・フアウンデイシヨン | アルキルジアリールボリネートおよび錯化ジアリールボロン酸を調製するための方法。 |
| US7390806B2 (en) | 2002-12-18 | 2008-06-24 | Anacor Pharmaceuticals, Inc. | Antibiotics containing borinic acid complexes and methods of use |
| JP2006511613A (ja) | 2002-12-18 | 2006-04-06 | アナコア ファーマシューティカルズ インコーポレイテッド | ボロン酸複合体を含む抗生物質および使用法 |
| WO2005000200A2 (en) | 2003-05-09 | 2005-01-06 | Sugen, Inc. | Novel kinases |
| AU2004262524C1 (en) | 2003-06-16 | 2010-08-19 | Anacor Pharmaceuticals, Inc. | Hydrolytically-resistant boron-containing therapeutics and methods of use |
| KR101300929B1 (ko) | 2004-05-12 | 2013-08-27 | 더 브리검 앤드 우먼즈 하스피털, 인크. | 감염 치료를 위한 겔솔린의 용도 |
| WO2006062731A1 (en) | 2004-11-19 | 2006-06-15 | University Of North Texas Health Science Center At Fort Worth | Phenanthroline and derivatives thereof used to lower intraocular pressure in an affected eye |
| GB0501944D0 (en) | 2005-01-31 | 2005-03-09 | Univ Cambridge Tech | Compounds for use in chemical detection and/or quantitation |
| NZ578297A (en) | 2005-02-16 | 2010-11-26 | Anacor Pharmaceuticals Inc | Boron-containing small molecules |
| US20060229347A1 (en) | 2005-03-30 | 2006-10-12 | Astion Development A/S | Treatment of eczemas |
| WO2007022437A2 (en) | 2005-08-18 | 2007-02-22 | Auspex Pharmaceuticals, Inc. | Therapeutic agents for the treatment of cancer and metabolic disorders |
| EP1976536A4 (en) | 2005-12-30 | 2011-03-02 | Anacor Pharmaceuticals Inc | SMALL MOLECULES CONTAINING BORON |
| ME02188B (me) | 2006-02-16 | 2016-02-20 | Anacor Pharmaceuticals Inc | Mali molekuli koji sadrže boron kao antiinflamatorni agensi |
| US20070286822A1 (en) | 2006-06-12 | 2007-12-13 | Anacor Pharmaceuticals Inc. | Compounds for the Treatment of Periodontal Disease |
| RU2008152367A (ru) | 2006-06-12 | 2010-07-20 | Анакор Фармасьютикалз, Инк. (Us) | Соединения для лечения периодонтального заболевания |
| JO3396B1 (ar) * | 2007-06-20 | 2019-10-20 | Anacor Pharmaceuticals Inc | جزيئات صغيرة تحتوي على البورون |
| KR100895300B1 (ko) | 2007-07-20 | 2009-05-07 | 한국전자통신연구원 | 생체신호 측정의복과 생체신호 처리시스템 |
| WO2009111676A2 (en) | 2008-03-06 | 2009-09-11 | Anacor Pharmaceuticals, Inc | Boron-containing small molecules as anti-inflammatory agents |
| WO2009140309A2 (en) | 2008-05-12 | 2009-11-19 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
| US8461336B2 (en) | 2008-09-04 | 2013-06-11 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
| US9493489B2 (en) | 2008-10-15 | 2016-11-15 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as anti-protozoal agents |
| WO2010045505A1 (en) | 2008-10-15 | 2010-04-22 | Anacor Pharmaceuticals, Inc | Boron-containing small molecules as anti-protozoal agents |
-
2009
- 2009-12-17 MX MX2011006334A patent/MX2011006334A/es not_active Application Discontinuation
- 2009-12-17 KR KR1020117016565A patent/KR20110111407A/ko not_active Withdrawn
- 2009-12-17 BR BRPI0922566A patent/BRPI0922566A2/pt not_active IP Right Cessation
- 2009-12-17 WO PCT/US2009/068609 patent/WO2010080558A1/en not_active Ceased
- 2009-12-17 EP EP09837955A patent/EP2378886A4/en not_active Withdrawn
- 2009-12-17 EA EA201190034A patent/EA201190034A1/ru unknown
- 2009-12-17 MA MA34028A patent/MA32977B1/fr unknown
- 2009-12-17 AU AU2009335744A patent/AU2009335744A1/en not_active Abandoned
- 2009-12-17 PE PE2011001246A patent/PE20120052A1/es not_active Application Discontinuation
- 2009-12-17 JP JP2011542458A patent/JP2012512262A/ja active Pending
- 2009-12-17 CN CN2009801506662A patent/CN102256494A/zh active Pending
- 2009-12-17 SG SG2011041894A patent/SG172040A1/en unknown
- 2009-12-17 CA CA2744231A patent/CA2744231A1/en not_active Abandoned
- 2009-12-17 US US12/641,318 patent/US8461364B2/en not_active Expired - Fee Related
-
2011
- 2011-05-23 IL IL213060A patent/IL213060A0/en unknown
- 2011-06-09 CO CO11071901A patent/CO6390029A2/es not_active Application Discontinuation
- 2011-06-13 DO DO2011000183A patent/DOP2011000183A/es unknown
- 2011-06-23 CR CR20110357A patent/CR20110357A/es unknown
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