JP2012512237A5 - - Google Patents
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- Publication number
- JP2012512237A5 JP2012512237A5 JP2011541590A JP2011541590A JP2012512237A5 JP 2012512237 A5 JP2012512237 A5 JP 2012512237A5 JP 2011541590 A JP2011541590 A JP 2011541590A JP 2011541590 A JP2011541590 A JP 2011541590A JP 2012512237 A5 JP2012512237 A5 JP 2012512237A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- dichloro
- formula
- anagrelide
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 Cc1c(*)cc(C=O)c(*)c1* Chemical compound Cc1c(*)cc(C=O)c(*)c1* 0.000 description 3
- OTBXOEAOVRKTNQ-UHFFFAOYSA-N O=C(CN1Cc2c3Cl)NC1=Nc2ccc3Cl Chemical compound O=C(CN1Cc2c3Cl)NC1=Nc2ccc3Cl OTBXOEAOVRKTNQ-UHFFFAOYSA-N 0.000 description 2
- HMZHEECHJWHZJX-UHFFFAOYSA-N CC(C)(C(OC)=O)N Chemical compound CC(C)(C(OC)=O)N HMZHEECHJWHZJX-UHFFFAOYSA-N 0.000 description 1
- PLLYNUUCBINGLY-UHFFFAOYSA-N CCOC(CN(Cc(c(Cl)c(cc1)Cl)c1N1)C1=N)=O Chemical compound CCOC(CN(Cc(c(Cl)c(cc1)Cl)c1N1)C1=N)=O PLLYNUUCBINGLY-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0822970.0A GB0822970D0 (en) | 2008-12-17 | 2008-12-17 | Process for the preparation of anagrelide and analogues |
| GB0822970.0 | 2008-12-17 | ||
| PCT/GB2009/051621 WO2010070318A1 (en) | 2008-12-17 | 2009-11-30 | Process for the preparation of anagrelide and analogues |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012512237A JP2012512237A (ja) | 2012-05-31 |
| JP2012512237A5 true JP2012512237A5 (https=) | 2013-01-24 |
Family
ID=40326232
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011541590A Pending JP2012512237A (ja) | 2008-12-17 | 2009-11-30 | アナグレリドの製造法 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8530651B2 (https=) |
| EP (1) | EP2373654A1 (https=) |
| JP (1) | JP2012512237A (https=) |
| KR (1) | KR20110100628A (https=) |
| CN (1) | CN102256981A (https=) |
| AU (1) | AU2009329320A1 (https=) |
| BR (1) | BRPI0922992A2 (https=) |
| CA (1) | CA2746145A1 (https=) |
| GB (1) | GB0822970D0 (https=) |
| IL (1) | IL213146A0 (https=) |
| MX (1) | MX2011006469A (https=) |
| NZ (1) | NZ593814A (https=) |
| RU (1) | RU2011121240A (https=) |
| SG (1) | SG172267A1 (https=) |
| WO (1) | WO2010070318A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8304420B2 (en) | 2006-11-28 | 2012-11-06 | Shire Llc | Substituted quinazolines for reducing platelet count |
| GB201017783D0 (en) * | 2010-10-21 | 2010-12-01 | Shire Llc | Process for the preparation of anagrelide and analogues thereof |
| EP3013831A1 (en) | 2013-06-28 | 2016-05-04 | Synthon BV | Process for making anagrelide |
| CN107903217B (zh) * | 2017-11-16 | 2021-11-23 | 湖北省宏源药业科技股份有限公司 | 一种阿那格雷杂质b的制备方法 |
| CN107903269B (zh) * | 2017-11-16 | 2021-05-04 | 湖北省宏源药业科技股份有限公司 | 一种阿那格雷三氯衍生物的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7807507A (nl) | 1977-07-25 | 1979-01-29 | Hoffmann La Roche | Tricyclische verbindingen. |
| CA2171073A1 (en) | 1995-12-04 | 1997-06-05 | Philip C. Lang | Process for the preparation of ethyl-n-(2,3 dichloro-6- nitrobenzyl) glycine |
| US6388073B1 (en) | 2000-07-26 | 2002-05-14 | Shire Us Inc. | Method for the manufacture of anagrelide |
| GB0623750D0 (en) | 2006-11-28 | 2007-01-10 | Shire Llc | Substituted quinazolines |
| GB0623749D0 (en) * | 2006-11-28 | 2007-01-10 | Shire Llc | Substituted quinazolines |
| EP2114856A1 (en) * | 2007-02-06 | 2009-11-11 | Cipla Limited | Process for the preparation of ethyl-n-(2, 3-dichloro-6-nitrobenzyl) glycine hydrochloride |
-
2008
- 2008-12-17 GB GBGB0822970.0A patent/GB0822970D0/en active Pending
-
2009
- 2009-11-30 JP JP2011541590A patent/JP2012512237A/ja active Pending
- 2009-11-30 WO PCT/GB2009/051621 patent/WO2010070318A1/en not_active Ceased
- 2009-11-30 RU RU2011121240/04A patent/RU2011121240A/ru not_active Application Discontinuation
- 2009-11-30 AU AU2009329320A patent/AU2009329320A1/en not_active Abandoned
- 2009-11-30 BR BRPI0922992A patent/BRPI0922992A2/pt not_active IP Right Cessation
- 2009-11-30 EP EP09760970A patent/EP2373654A1/en not_active Withdrawn
- 2009-11-30 KR KR1020117014167A patent/KR20110100628A/ko not_active Withdrawn
- 2009-11-30 CN CN2009801513257A patent/CN102256981A/zh active Pending
- 2009-11-30 SG SG2011044930A patent/SG172267A1/en unknown
- 2009-11-30 US US13/132,001 patent/US8530651B2/en not_active Expired - Fee Related
- 2009-11-30 MX MX2011006469A patent/MX2011006469A/es not_active Application Discontinuation
- 2009-11-30 CA CA2746145A patent/CA2746145A1/en not_active Abandoned
- 2009-11-30 NZ NZ593814A patent/NZ593814A/xx not_active IP Right Cessation
-
2011
- 2011-05-26 IL IL213146A patent/IL213146A0/en unknown
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