JP2012509860A5 - - Google Patents
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- Publication number
- JP2012509860A5 JP2012509860A5 JP2011536892A JP2011536892A JP2012509860A5 JP 2012509860 A5 JP2012509860 A5 JP 2012509860A5 JP 2011536892 A JP2011536892 A JP 2011536892A JP 2011536892 A JP2011536892 A JP 2011536892A JP 2012509860 A5 JP2012509860 A5 JP 2012509860A5
- Authority
- JP
- Japan
- Prior art keywords
- disorder
- stereoisomers
- disorders
- oxide
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 11
- 208000035475 disorder Diseases 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 150000001204 N-oxides Chemical class 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- XOZGEXKQMVAILQ-UHFFFAOYSA-N 3-phenylazetidine Chemical class C1NCC1C1=CC=CC=C1 XOZGEXKQMVAILQ-UHFFFAOYSA-N 0.000 claims 3
- 206010012289 Dementia Diseases 0.000 claims 3
- 150000001539 azetidines Chemical class 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 230000000642 iatrogenic effect Effects 0.000 claims 3
- -1 3,4-difluorophenyl Chemical group 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 208000020925 Bipolar disease Diseases 0.000 claims 2
- 208000012661 Dyskinesia Diseases 0.000 claims 2
- 208000011688 Generalised anxiety disease Diseases 0.000 claims 2
- 208000004547 Hallucinations Diseases 0.000 claims 2
- 208000028017 Psychotic disease Diseases 0.000 claims 2
- 230000032683 aging Effects 0.000 claims 2
- GMWFCJXSQQHBPI-UHFFFAOYSA-N azetidin-3-ol Chemical compound OC1CNC1 GMWFCJXSQQHBPI-UHFFFAOYSA-N 0.000 claims 2
- 208000010877 cognitive disease Diseases 0.000 claims 2
- 208000029364 generalized anxiety disease Diseases 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 201000000980 schizophrenia Diseases 0.000 claims 2
- 208000019116 sleep disease Diseases 0.000 claims 2
- IIMJENATWISUEQ-UHFFFAOYSA-N 3-(2,3-difluorophenyl)-1-ethyl-1-oxidoazetidin-1-ium-3-ol Chemical compound C1[N+](CC)([O-])CC1(O)C1=CC=CC(F)=C1F IIMJENATWISUEQ-UHFFFAOYSA-N 0.000 claims 1
- KCALIDHAVNYABJ-UHFFFAOYSA-N 3-(2,3-difluorophenyl)-1-ethyl-3-methoxyazetidine Chemical compound C1N(CC)CC1(OC)C1=CC=CC(F)=C1F KCALIDHAVNYABJ-UHFFFAOYSA-N 0.000 claims 1
- MGUIZZKQEHAKCI-UHFFFAOYSA-N 3-(2,3-difluorophenyl)-1-ethylazetidin-3-ol Chemical compound C1N(CC)CC1(O)C1=CC=CC(F)=C1F MGUIZZKQEHAKCI-UHFFFAOYSA-N 0.000 claims 1
- CWKGAUCSNBQSRW-UHFFFAOYSA-N 3-(2,3-difluorophenyl)-3-methoxyazetidine Chemical compound C=1C=CC(F)=C(F)C=1C1(OC)CNC1 CWKGAUCSNBQSRW-UHFFFAOYSA-N 0.000 claims 1
- JOMARVLVCHGVNH-UHFFFAOYSA-N 3-(3,4-difluorophenyl)-1-ethylazetidin-3-ol Chemical compound C1N(CC)CC1(O)C1=CC=C(F)C(F)=C1 JOMARVLVCHGVNH-UHFFFAOYSA-N 0.000 claims 1
- NFRYGGMWFYDWAI-UHFFFAOYSA-N 3-(3,5-difluorophenyl)-1-ethylazetidin-3-ol Chemical compound C1N(CC)CC1(O)C1=CC(F)=CC(F)=C1 NFRYGGMWFYDWAI-UHFFFAOYSA-N 0.000 claims 1
- WTURPIIUMVVBNR-UHFFFAOYSA-N 3-(3-chloro-2-fluorophenyl)-1-ethylazetidin-3-ol Chemical compound C1N(CC)CC1(O)C1=CC=CC(Cl)=C1F WTURPIIUMVVBNR-UHFFFAOYSA-N 0.000 claims 1
- YJVAEBCJEVBOTP-UHFFFAOYSA-N 3-(3-chloro-5-fluorophenyl)-1-ethylazetidin-3-ol Chemical compound C1N(CC)CC1(O)C1=CC(F)=CC(Cl)=C1 YJVAEBCJEVBOTP-UHFFFAOYSA-N 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 1
- 206010003805 Autism Diseases 0.000 claims 1
- 208000020706 Autistic disease Diseases 0.000 claims 1
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims 1
- 206010013654 Drug abuse Diseases 0.000 claims 1
- 208000014094 Dystonic disease Diseases 0.000 claims 1
- 208000030814 Eating disease Diseases 0.000 claims 1
- 208000027534 Emotional disease Diseases 0.000 claims 1
- 208000019454 Feeding and Eating disease Diseases 0.000 claims 1
- 201000004311 Gilles de la Tourette syndrome Diseases 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 206010020852 Hypertonia Diseases 0.000 claims 1
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 claims 1
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 208000019022 Mood disease Diseases 0.000 claims 1
- 208000016285 Movement disease Diseases 0.000 claims 1
- 208000029726 Neurodevelopmental disease Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 208000027089 Parkinsonian disease Diseases 0.000 claims 1
- 206010034010 Parkinsonism Diseases 0.000 claims 1
- 206010034912 Phobia Diseases 0.000 claims 1
- 208000005793 Restless legs syndrome Diseases 0.000 claims 1
- 208000000323 Tourette Syndrome Diseases 0.000 claims 1
- 208000016620 Tourette disease Diseases 0.000 claims 1
- 206010044565 Tremor Diseases 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 230000003542 behavioural effect Effects 0.000 claims 1
- 208000029028 brain injury Diseases 0.000 claims 1
- 150000003943 catecholamines Chemical class 0.000 claims 1
- 210000003710 cerebral cortex Anatomy 0.000 claims 1
- 206010008129 cerebral palsy Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229910052805 deuterium Inorganic materials 0.000 claims 1
- 235000014632 disordered eating Nutrition 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000013843 drug-induced mental disease Diseases 0.000 claims 1
- 208000010118 dystonia Diseases 0.000 claims 1
- 231100000869 headache Toxicity 0.000 claims 1
- 201000003631 narcolepsy Diseases 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 208000019906 panic disease Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 208000012201 sexual and gender identity disease Diseases 0.000 claims 1
- 208000015891 sexual disease Diseases 0.000 claims 1
- 208000020685 sleep-wake disease Diseases 0.000 claims 1
- 201000001716 specific phobia Diseases 0.000 claims 1
- 201000009032 substance abuse Diseases 0.000 claims 1
- 208000011117 substance-related disease Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200801656 | 2008-11-24 | ||
| DKPA200801656 | 2008-11-24 | ||
| US11781808P | 2008-11-25 | 2008-11-25 | |
| US61/117,818 | 2008-11-25 | ||
| PCT/EP2009/065675 WO2010058017A1 (en) | 2008-11-24 | 2009-11-24 | Novel 3-phenyl-azetidine derivatives useful as modulators of cortical catecholaminergic neurotransmission |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012509860A JP2012509860A (ja) | 2012-04-26 |
| JP2012509860A5 true JP2012509860A5 (https=) | 2013-01-17 |
| JP5621087B2 JP5621087B2 (ja) | 2014-11-05 |
Family
ID=41649970
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011536892A Expired - Fee Related JP5621087B2 (ja) | 2008-11-24 | 2009-11-24 | 皮質のカテコールアミン作動性神経伝達のモジュレーターとして有用な新規な３−フェニル−アゼチジン誘導体 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8586572B2 (https=) |
| EP (1) | EP2367785B1 (https=) |
| JP (1) | JP5621087B2 (https=) |
| CN (1) | CN102224135A (https=) |
| AU (1) | AU2009317155A1 (https=) |
| CA (1) | CA2744307A1 (https=) |
| MX (1) | MX2011005034A (https=) |
| WO (1) | WO2010058017A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2367787B1 (en) | 2008-11-24 | 2013-01-09 | NSAB, Filial af NeuroSearch Sweden AB, Sverige | 3-phenyl-3-methoxypyrrolidine derivatives as modulators of cortical catecholaminergic neurotransmission |
| EP3297987B1 (en) * | 2015-05-20 | 2019-05-15 | Integrative Research Laboratories Sweden AB | Novel azetidine derivatives useful as modulators of cortical cathecolaminergic neurotransmission |
| EP3541784B1 (en) * | 2016-11-18 | 2023-09-13 | Integrative Research Laboratories Sweden AB | Novel azetidine derivatives useful as modulators of cortical catecholaminergic neurotransmission |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3481920A (en) | 1965-10-22 | 1969-12-02 | Lilly Co Eli | Azetidinones |
| US3668196A (en) | 1965-10-22 | 1972-06-06 | Lilly Co Eli | 3-azetidinols |
| CH511227A (de) | 1968-06-28 | 1971-08-15 | Scherico Ltd | Verfahren zur Herstellung neuer Azetidinolderivate |
| US3822252A (en) | 1968-06-28 | 1974-07-02 | Schering Corp | 3-azetidinols |
| GB1236078A (en) | 1968-07-04 | 1971-06-16 | Beecham Group Ltd | Substituted azetidinols |
| US3494964A (en) | 1969-01-13 | 1970-02-10 | Lilly Co Eli | Alpha-halo-alpha-amino ketones |
| AU2178099A (en) * | 1998-01-23 | 1999-08-09 | Vernalis Research Limited | Azetidinecarboxamide derivatives for treating cns disorders |
| GB9917384D0 (en) * | 1999-07-23 | 1999-09-22 | Cerebrus Ltd | Chemical compounds-III |
| AU2002363236A1 (en) | 2001-10-30 | 2003-05-12 | Millennium Pharmaceuticals, Inc. | Compounds, pharmaceutical compositions and methods of use therefor |
| WO2005026146A1 (en) * | 2003-09-12 | 2005-03-24 | Warner-Lambert Company Llc | Azetidinyl quinolones as antibacterial agents |
| WO2005026153A1 (en) | 2003-09-12 | 2005-03-24 | Warner-Lambert Company Llc | Quinazoline-2, 4-diones as antibacterial agents |
| CN1902169A (zh) * | 2003-11-10 | 2007-01-24 | 迈克罗比亚公司 | 4－联芳基－1－苯基氮杂环丁烷－2－酮 |
| SE0401465D0 (sv) | 2004-06-08 | 2004-06-08 | Carlsson A Research Ab | New substituted piperdines as modulators of dopamine neurotransmission |
| EP1893593A1 (en) | 2005-06-15 | 2008-03-05 | Pfizer Limited | 3-phenylazetidine derivatives as dopamine agonists |
| WO2007140200A2 (en) * | 2006-05-25 | 2007-12-06 | Bristol-Myers Squibb Company | Cyclopropyl fused indolobenzazepine hcv ns5b inhibitors |
| AU2008258599B2 (en) | 2007-06-05 | 2013-06-13 | Nsab, Filial Af Neurosearch Sweden Ab, Sverige | Disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission |
| JP2010529080A (ja) | 2007-06-05 | 2010-08-26 | エヌエスエイビー、フィリアル アヴ ノイロサーチ スウェーデン エービー、スヴェーリエ | 皮質カテコールアミン作動性神経伝達の調節因子としての新規な二置換フェニルピロリジン |
| EP2367786B1 (en) | 2008-11-24 | 2013-01-09 | NSAB, Filial af NeuroSearch Sweden AB, Sverige | Novel 1 -alkyl- 3 -hydroxy- 3 -phenylazetidine derivatives useful as modulators of cortical catecholaminergic neurotransmission |
| EP2367787B1 (en) | 2008-11-24 | 2013-01-09 | NSAB, Filial af NeuroSearch Sweden AB, Sverige | 3-phenyl-3-methoxypyrrolidine derivatives as modulators of cortical catecholaminergic neurotransmission |
-
2009
- 2009-11-24 CN CN2009801464443A patent/CN102224135A/zh active Pending
- 2009-11-24 US US13/130,384 patent/US8586572B2/en not_active Expired - Fee Related
- 2009-11-24 CA CA2744307A patent/CA2744307A1/en not_active Abandoned
- 2009-11-24 MX MX2011005034A patent/MX2011005034A/es not_active Application Discontinuation
- 2009-11-24 WO PCT/EP2009/065675 patent/WO2010058017A1/en not_active Ceased
- 2009-11-24 AU AU2009317155A patent/AU2009317155A1/en not_active Abandoned
- 2009-11-24 EP EP09756501.4A patent/EP2367785B1/en not_active Not-in-force
- 2009-11-24 JP JP2011536892A patent/JP5621087B2/ja not_active Expired - Fee Related
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